JPS6158443B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention provides a dentifrice composition, more specifically, by incorporating so-called essence, which is made hydrophilic by dissolving a lipophilic fragrance called oil (hereinafter simply referred to as fragrance) in a water-compatible solvent. , relates to a toothpaste composition that suppresses irritation, bitterness, etc. derived from fragrances. In dentifrice compositions such as toothpaste, fragrances are added to suppress the irritation and odor of the dentifrice base ingredients such as abrasives, foaming agents, and wetting agents. Due to the action of the surfactant blended as a foaming agent, it is uniformly dispersed and emulsified throughout the dentifrice composition, which is originally an aqueous system, and exhibits its effects. In recent years, the oral mucosal irritation and other safety issues of anionic surfactants such as sodium alkyl sulfates, which are mainly used as foaming agents, have been raised. , or other safer surfactants should be used. For this purpose, it has been found that the use of highly safe nonionic surfactants such as sucrose fatty acid esters is useful (for example, JP-A-52-10427 and JP-A-52-79037; 1971-
(See No. 129013). However, the inventors
If the amount of anionic surfactant is reduced or a nonionic surfactant is used, the dispersion and emulsification of the flavoring agent in the dentifrice composition will be insufficient, and the bitterness and irritation of the flavoring agent itself will become noticeable. I learned that fragrances that are intended to suppress the irritation and odor of drugs actually have the disadvantage of causing irritation and bitterness. In view of these circumstances, the present inventors first considered suppressing the irritation and bitterness of fragrances by changing the component composition of the fragrance itself or lowering the flavoring rate, but this method has a wide range of effects. It has been found that there is a limit to the ability to incorporate various flavoring agents with good taste into dentifrice compositions. Therefore, as a result of further investigation, we used an ethanol-water mixture as a water-compatible solvent (hereinafter referred to as essence base), and used Essence with a specific composition in which fragrance was dissolved alone or as a foaming agent. We have discovered that by combining a flavoring agent in an amount that can be sufficiently dispersed and emulsified with a surfactant used as a dentifrice composition, it is possible to incorporate a wide range of flavoring agents with good taste into dentifrice compositions without causing irritation or bitterness. , we have completed the present invention. Essence has traditionally been used to flavor foods, but there have been no examples of it being used to flavor dentifrice compositions such as toothpaste. The desired effect of the present invention cannot be achieved even if the essence base or water and ethanol are separately blended into a dentifrice composition. That is, the present invention provides a dentifrice composition in which 100 parts (parts by weight, the same applies hereinafter) of an essence base having a weight ratio of ethanol:water of 8:2 to 4:6,
Essence, which is prepared by dissolving 10 parts of fragrance, is used alone or in combination with fragrance, and the concentration of the entire fragrance based on the total weight of the dentifrice composition is 1.0 to 0.3% (weight%, the same applies hereinafter).
The purpose of the present invention is to provide a dentifrice composition characterized in that the amount of anionic surfactant contained in the dentifrice composition of the present invention is reduced.
Even when a nonionic surfactant is used, it is possible to sufficiently suppress not only the irritation and odor of the dentifrice base but also the irritation and bitterness derived from fragrances. Furthermore, it has been found that the flavor can be improved by using the essence even in dentifrice compositions in which the amount of conventional anionic surfactants is not reduced. Table 1 below shows the results of testing the relationship between the composition of essence and the flavor when used in toothpaste. The results were obtained by adding and dissolving individual fragrances, spearmint oil, lemon oil, or orange oil in the amounts shown in Table 1 to 100 g of essence base with various weight ratios of ethanol (as 95% ethanol) and water. The obtained essence was blended into toothpaste according to the composition of Example 1 below (in the same composition, the type and amount of essence was varied and adjusted to 100% with water), and the flavor at the time of use was adjusted. This is an intuitive evaluation.

[Table] △ = Slightly poor flavor, × = Poor flavor As is clear from Table 1, the weight ratio of ethanol:water in the essence base was 8:2 to 4:
6 and 5 to 10 per 100 copies of essence base
It can be seen that a dentifrice essence exhibiting a good flavor can be obtained by dissolving the flavor in the above. This tendency is also observed in spearmint oil, lemon oil,
It was found that all orange oils were the same, and there was no difference depending on the type of fragrance. Therefore, in order to obtain the essence used in the dentifrice composition of the present invention, first, ethanol and water are mixed in a weight ratio of ethanol (as 95% ethanol):water: 8:
The essence base is prepared by mixing in a ratio of 2 to 4:6, preferably 6:4 to 5:5. Next, perfume is added and dissolved in this, cooled to about -5°C, and insoluble parts are removed, for example, by adsorption to asbestos, and 5 to 10 parts per 100 parts of essence base are added.
Preferably, an essence is obtained in which 9 to 10 parts of fragrance are dissolved (as shown in Table 1 above, when increasing the fragrance concentration, an essence base with a high ethanol concentration is required). The obtained essence may be used as it is, or may be mixed with an essence prepared in the same manner using other fragrances in an appropriate ratio. These essences are incorporated into toothpaste compositions either alone or in combination with fragrances. The fragrance used in the essence preparation and the fragrance used in combination may be the same or different; any lipophilic fragrance can be used, such as spearmint oil, peppermint oil, spice blend oil, lemon oil, orange oil, etc., and can be used in the dentifrice composition. is 0.3 to 1.0%, preferably based on the total weight of the dentifrice composition, as the entire fragrance (in the case of Essence alone, the fragrance in Essence, and in the case of using Essence and fragrance together, the fragrance in Essence + directly added fragrance). , 0.5-0.8%
Mix so that Advantageously, from 0.1 to 5.0% essence and from 0.4 to 5.0% based on the total amount of the dentifrice composition.
It is desirable to use 0.9% fragrance. The dentifrice composition of the present invention can be in the form of a toothpaste or a water toothpaste, which are manufactured by conventional methods, and essences and fragrances are added in the final step of manufacturing. The dentifrice base components used may be those normally used in dentifrice compositions, such as abrasives such as dicalcium phosphate (dihydrate, anhydride), calcium carbonate, silicate, insoluble sodium metaphosphate, etc. ; As a blowing agent, sodium alkyl sulfate, N-long chain acylamino acid salt, α-
Anionic surfactants such as olefin sulfonates, sucrose fatty acid esters, polyoxyethylene stearyl alcohol ether, polyoxyethylene monostearate, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil derivatives, polyoxyethylene Nonionic surfactants such as sugar fatty acid esters; as binders, sodium carboxymethyl cellulose, carrageenan, sodium alginate, bentonite, silicic anhydride, etc.; as wetting agents, glycerin, sorbitol, propylene glycol, sodium pyrrolidone carboxylate, polyethylene glycol etc. are used. The dentifrice composition of the present invention may also contain various medicinal agents, such as sodium monofluorophosphate, aluminum allantoinate, glycyrrhizinate, chlorhexidine, hinokitiol, and dextranase. , lysozyme, common salt, tranexamic acid, ε-aminocaproic acid, and the like. Next, the present invention will be explained in more detail with reference to reference examples and examples. Reference example 1 Essence composition 95% ethanol by weight 60 Water 40 Flavor (spearmint oil) 8 Mix ethanol and water, add and dissolve the flavor. Then, it is cooled to -5°C, and the insoluble portion is adsorbed and removed by asbestos to obtain a toothpaste essence. Reference Example 2 In the same manner as in Reference Example 1 above, a toothpaste essence was obtained according to the following composition. Essense composition 95% ethanol by weight 80 Water 20 Flavor (lemon oil) 10 Example 1 Toothpaste composition Weight % Dicalcium phosphate (dihydrate) 45.00 Sodium carboxymethyl cellulose 0.50 Carrageenan 0.50 Glycerin 10.00 Sorbitol 10.00 Water 29.99 Sugar fatty acid ester (monoester content 30%, unreacted fatty acid amount 2%) 1.00 Sodium N-lauroylsarcosine 0.50 Flavor (spearmint oil) 0.45 Essense (from Reference Example 1 above) 1.00 Sodium saccharin 0.20 Bactericide and preservative 0.10 Sodium monofluorophosphate 0.76 According to this composition, fragrances and essences are added in the final step according to the conventional method to obtain a toothpaste with good flavor and no irritation or bitterness. Example 2 Toothpaste composition components Weight % Dicalcium phosphate (dihydrate) 45.00 Sodium carboxymethylcellulose 0.50 Carrageenan 0.50 Glycerin 10.00 Sorbitol 10.00 Water 29.64 Sucrose fatty acid ester (monoester content 30%, unreacted fatty acid amount 2%) 1.50 Sodium N-lauroylsarcosinate 0.50 Flavor (peppermint oil) 0.60 Essence (from Reference Example 1 above) 0.70 Sodium saccharin 0.20 Bactericide and preservative 0.10 Sodium monofluorophosphate 0.76 According to this composition, flavoring is added in the final step by a conventional method. , essence is added to obtain a toothpaste with good flavor and no irritation or bitterness. Example 3 Toothpaste composition components Weight % Dicalcium phosphate (dihydrate) 45.00 Sodium carboxymethyl cellulose 0.50 Carrageenan 0.50 Glycerin 10.00 Sorbitol 10.00 Water 29.94 Sodium lauryl sulfate 1.80 Flavor (spearmint oil) 0.70 Essence (from Reference Example 1) 0.50 Sodium saccharin 0.20 Bactericidal and preservative 0.10 Sodium monofluorophosphate 0.76 According to this composition, a flavoring agent and essence are added in the final step according to the conventional method to obtain a toothpaste with good flavor and no irritation or bitterness. Example 4 Ingredients Weight % Dicalcium phosphate (dihydrate) 45.00 Sodium carboxymethylcellulose 0.50 Carrageenan 0.50 Glycerin 10.00 Sorbitol 10.00 Water 26.94 Sucrose fatty acid ester (monoester content 30%, unreacted fatty acid amount 2%) 0.50 N-lauroyl Sodium sarcosine 0.50 Essence (from Reference Example 1) 5.00 Sodium saccharin 0.20 Bactericides and preservatives 0.10 Sodium monofluorophosphate 0.76 According to this composition, Essence is added in the final step by a conventional method to create a product with good flavor. Get toothpaste without irritation or bitterness. Table 2 below shows the results of a panel test regarding the flavor of the toothpastes obtained in Examples 1 and 3. The results were evaluated by 300 panel members regarding the irritation, bitterness, freshness, aftertaste, mouth feel, and overall evaluation of each toothpaste: +2: Very good, +1:
Good, 0: Fair, -1: Fairly bad, -2: Poor 5
It is shown as the average score when performing graded evaluation. In addition, the following toothpaste was used as a control. Control product A: The composition of Example 1, except that 0.52% of fragrance (spearmint oil) was used instead of fragrance and essence. Control product B: A toothpaste in which 0.52% of fragrance (spearmint oil) and 0.93% of essence base (95% ethanol:water = 6:4) were used in place of the fragrance and essence in the composition of Example 1. is the same amount of fragrance as in Example 1,
(contains ethanol and water). Control product C: The composition of Example 3, except that 0.74% of fragrance (spearmint oil) was used instead of fragrance and essence.

[Table] As shown in Table 2, the toothpaste using Essence as in the present invention showed positive scores in all evaluation items, whereas the control product showed positive scores in all evaluation items.
All samples showed negative scores in terms of bitterness, and it is clear that the addition of essence suppresses irritation and bitterness. Further, as described above, it can be seen that the intended purpose of the present invention cannot be achieved even if the fragrance and essence base are simply added separately (see Control Product B).

Claims (1)

[Claims] 1. A dentifrice composition comprising 100 parts by weight of a solvent having a weight ratio of ethanol (as 95% ethanol):water of 8:2 to 4:6, and 5 to 10 parts by weight of a lipophilic fragrance. 1. A dentifrice composition characterized in that Essence alone or the Essence and a lipophilic fragrance are further blended so that the total concentration of the lipophilic fragrance is 1.0 to 0.3% by weight based on the total weight of the dentifrice composition. 2. The first solvent has a weight ratio of ethanol (as 95% ethanol):water of 6:4 to 5:5.
dentifrice composition. 3. The dentifrice composition according to item 1 or 2 above, which further contains the essence and a lipophilic fragrance.