JPS5858323B2 - toothpaste - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides a dentifrice composition, more specifically, a method that improves foaming properties when using a more stable sucrose fatty acid ester as a foaming agent, and changes the taste of food after tooth brushing. The present invention relates to a dentifrice composition that does not cause irritation.

A foaming agent is blended into a dentifrice composition to impart a cleaning effect, a dispersing emulsification effect, a foaming effect, etc., and a surfactant is used for this purpose.

Surfactants used as foaming agents increase the cleaning effect of toothpaste by lowering the interfacial tension of the toothpaste during use, promote the dispersion and permeability of the medicinal agents contained in the toothpaste, and enhance its effectiveness. It can be said to be an essential ingredient as it plays a role such as providing a sense of stability through foaming during use.

These surfactants not only have good performance such as interfacial tension lowering ability and foaming properties, but since toothpaste is something that is put in the mouth, it is important that they are satisfactory in terms of taste, odor, etc. Conventionally, anionic surfactants such as sodium alkyl sulfate, sodium acyl sarcosine, α-olefin sulfonate, and sodium coconut monoglyceride sulfate have been used.

Among these, sodium alkyl sulfate, especially sodium lauryl sulfate, has excellent performance and taste, and is the most commonly used, but it has the major drawback of changing the taste of food after toothpaste is used. However, there are problems such as some irritation to the oral mucosa and inactivation of enzymes when they are added as medicinal agents to toothpaste.

α-olefin sulfonate and acyl sarcosine sodium have a good taste on their own and do not change the taste of food after brushing, but α-olefin sulfonate has safety issues and acyl sarcosine sodium Sarcosine sodium is highly safe as it is decomposed in the body into fatty acids and amino acids, but if it is used in excess of 0.5% (wt%, the same applies hereinafter), it will cause peeling of the oral mucosa, and if it is less than this, it will hardly foam. It cannot be used as the main component of a blowing agent.

On the other hand, nonionic surfactants have the advantage of being less irritating to the skin and mucous membranes than anionic surfactants, and do not deactivate enzymes even when coexisting with enzymes. Since it is one of the few surfactants approved for processing, it has been proposed to incorporate sucrose fatty acid ester into toothpaste due to its high safety.

However, sucrose fatty acid ester has the major drawback that it hardly foams when used, resulting in extremely poor toothbrushing effect and feel. , Fos.
ola and P. Rovesi, “Interr] at
ional Symposium on Sugar
ter l, Maison de la Chim
ie Paris (June 8, 1960)].

The present inventors have conducted various studies on the foaming properties of toothpaste compositions containing sucrose fatty acid esters, and have previously found that the foaming properties can be significantly improved by using them in combination with cyclodextrin (Japanese Patent Application No. 5 O- 110336
).

Subsequently, as a result of intensive research in order to further improve the foaming properties of such dentifrice compositions, the present inventors found that, together with cyclodextrin, sodium lauroylsarcosine, which is a type of sodium acylsarcosine that is relatively safe as described above, It was discovered that the objective could be achieved by blending the following, and the present invention was completed.

※※ That is, the present invention is characterized in that 0.2 to 5% of cyclodextrin and 0.2 to 0.5% of sodium lauroyl sarcosine are blended into a toothpaste composition containing sucrose fatty acid ester as a foaming agent. The dentifrice composition of the present invention has excellent foaming properties and does not change the taste of food after tooth brushing, unlike conventional dentifrice compositions containing sodium lauryl sulfate. Without a doubt, again.
Even if sodium lauroyl sarcosine is used, there is no problem such as Nikkei mucosal detachment, considering its amount.

The following Tables 1 and 2 show the results of tests regarding the relationship between the foaming agent to be blended and foaming properties.

The test was carried out by diluting toothpaste with various foaming agents in the composition of Example 1 described below to 1/10 with water, and diluting it to 1/10 using the Rosmailes method.
The foam height (CwL) after minutes was measured and defined as the foaming amount.

In addition, the volume was evaluated as follows. ◎: Sufficient foaming, ○: Foaming, △: Little foaming, ×: Almost no foaming. No effect was observed when using sucrose fatty acid ester in combination with cyclodextrin, and although foaming properties were improved by using sucrose fatty acid esters in combination with cyclodextrin, foaming properties were significantly increased when sodium lauroyl sarcosine was used in combination. It can be seen that the results are improved.

According to the present invention, 0.00% cyclodextrin is added to the toothpaste composition containing sucrose fatty acid ester.
2-5%, sodium lauroyl sarcosine 0.2-5%
Add 15% O.

If the amount of cyclodextrin is less than 0.2%, the addition effect will not be sufficient. On the other hand, adding more than necessary will be economically disadvantageous, and from the viewpoint of the properties of the resulting dentifrice composition, About 0.2 to 5%, preferably 0.2 to 5%.
It should be 5-2%.

In addition, the amount of sodium lauroyl sarcosine is 0.5%
If it exceeds 0.2%, oral mucosal peeling will occur, while if it is less than 0.2%, the effect of the addition will not be sufficient.
It shall be 0.5%.

There are three types of cyclodextrin, α, β, and heptadextrin, and as is clear from Table 2 above, any of them can be used in the same manner in the present invention.

In addition, the sucrose fatty acid ester used is a sucrose higher fatty acid ester in which the number of carbon atoms in the fatty acid residue is 12 or more, for example,
Commercially available DK ester F-50, F70, F-90, F
-110, F-140 or F-160 (all manufactured by Daiichi Kogyo Seiyaku Co., Ltd., containing fatty acids from hardened beef tallow as fatty acid components, and monoester contents of 30 and 40.50, respectively)
, 60 or 70%), or DK ester L-18 (
Examples include sucrose laurate (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.).

The blending ratio of this sucrose fatty acid ester is appropriately selected depending on the formulation of the dentifrice composition, but is usually 0.4 to 1.
A range of 0% is preferred.

The dentifrice composition of the present invention includes all conventional dosage forms such as toothpaste, toothpaste, dentifrice ointment, and water dentifrice.

In addition, other dentifrice base components may be those used in ordinary dentifrice compositions, for example, as an abrasive, calcium diphosphate (trihydrate, anhydride), calcium carbonate, silicate, insoluble sodium metaphosphate. etc; As a binder,
Sodium carboxymethyl cellulose, carrageenan, sodium alginate, bentonite, silicic anhydride, etc.; as wetting agents, glycerin, sorbitol, propylene glycol, sodium pyrrolidone carboxylate, polyethylene glycol, etc. are used.

Furthermore, the toothpaste composition of the present invention may contain various medicinal agents, such as fluoride, aluminum allantoinate, glycyrrhizinate, chlorhexidine, hinokitiol, dextranase, lysozyme, and salt. , tranexamic acid, ε-aminocaproic acid, and the like.

According to the present invention, as described above, it is possible to obtain a dentifrice composition that contains a foaming agent with higher safety, has extremely good foaming properties, and does not change the taste of food even after use.

Next, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited thereto.

Example 1 A toothpaste was prepared according to a conventional method using the following formulation.

Precepts Calcium diphosphate trihydrate carboxymethylcellulose carrageenan glycerin Sorbitol water Sucrose fatty acid ester β-cyclodextrin % 45.00 0.50 0.50 10,00 10.00 29, 20 2.00 1.00 Example 2 A toothpaste was prepared according to a conventional method using the following formulation.

Example 3 A toothpaste was prepared according to a conventional method using the following formulation.

The dentifrice composition of Example 1 was used to investigate the ``orange juice effect'' (a phenomenon in which the taste of a strongly acidic food, typically orange juice, is felt to be significantly different after using the dentifrice, Japanese Patent Publication No. 47-43830). Reference) was tested.

The test was conducted using a composition (Reference Example 1) in which the foaming agent (sucrose fatty acid ester, β-cyclodextrin, and sodium lauroyl sarcosine) in the composition of Example 1 was changed to 2% sodium lauryl sulfate (Reference Example 1) as a control. The flavor of orange juice drunk after using toothpaste was evaluated by a dedicated panel as follows.

0: No change in flavor, 1: Almost no change in flavor, 2: Slight change in flavor, 3: Significant change in flavor, 4: Significant change in flavor.

Next, Table 3 shows the results.

As is clear from Table 3, the dentifrice composition of the present invention hardly changes the taste of food after use.

Claims (1)

[Claims] 1. 0.2 to 5% by weight of cyclodextrino and 0.2 to 0.5% by weight of sodium lauroyl sarcosine are added to a toothpaste composition containing a sucrose higher fatty acid ester having fatty acid residues having 12 or more carbon atoms as a foaming agent. A dentifrice composition characterized in that it contains % by weight.