JPH0141603B2 - - Google Patents
Info
- Publication number
- JPH0141603B2 JPH0141603B2 JP18098980A JP18098980A JPH0141603B2 JP H0141603 B2 JPH0141603 B2 JP H0141603B2 JP 18098980 A JP18098980 A JP 18098980A JP 18098980 A JP18098980 A JP 18098980A JP H0141603 B2 JPH0141603 B2 JP H0141603B2
- Authority
- JP
- Japan
- Prior art keywords
- sodium
- weight
- sodium chloride
- toothpaste
- ethylene oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 50
- 239000011780 sodium chloride Substances 0.000 claims description 25
- 239000000606 toothpaste Substances 0.000 claims description 24
- 229940034610 toothpaste Drugs 0.000 claims description 20
- -1 polyoxyethylene Polymers 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 13
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 12
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 11
- 239000000551 dentifrice Substances 0.000 claims description 9
- 239000011734 sodium Substances 0.000 claims description 9
- 229910052708 sodium Inorganic materials 0.000 claims description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- 239000002736 nonionic surfactant Substances 0.000 claims description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 6
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 6
- 239000004359 castor oil Substances 0.000 claims description 5
- 235000019438 castor oil Nutrition 0.000 claims description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 5
- 229950005425 sodium myristyl sulfate Drugs 0.000 claims description 5
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 4
- 239000004088 foaming agent Substances 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 238000005187 foaming Methods 0.000 description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 210000002200 mouth mucosa Anatomy 0.000 description 2
- 201000001245 periodontitis Diseases 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- 239000004604 Blowing Agent Substances 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 108010001682 Dextranase Proteins 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- SUIKYKCQRIJGTO-UHFFFAOYSA-N [Na].[Na].[Na].[Na].[Na].[Na].[Na].[Na].[Na].[Na] Chemical compound [Na].[Na].[Na].[Na].[Na].[Na].[Na].[Na].[Na].[Na] SUIKYKCQRIJGTO-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 150000004683 dihydrates Chemical class 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Description
本発明は塩化ナトリウム含有歯磨組成物、さら
に詳しくは、比較的高濃度の塩化ナトリウムを含
有する発泡性の良好な歯磨組成物に関する。
薬効剤として塩化ナトリウムを含有する歯磨は
歯槽膿漏の予防等に有効であり、最近、その効果
をさらに高めるため、塩化ナトリウムの配合量を
増大させる傾向にある。
しかし、塩化ナトリウムの配合量を増大させる
と、歯磨の発泡性が低下し、そのため、歯磨本来
の清浄作用や使用感が低下するなどの問題が生ず
る。
一方、従来、塩化ナトリウム含有歯磨には発泡
剤として、主に、ラウリル硫酸ナトリウムのよう
なアルキル硫酸ナトリウムが配合されており、か
かる塩化ナトリウムによる歯磨の発泡性低下を改
善するため、アルキル硫酸ナトリウムの配合量を
増大させることが考えられる。しかし、アルキル
硫酸ナトリウムは口腔粘膜刺激性などの点であま
り多量に使用することは望ましなく、高濃度の塩
化ナトリウムを含有する、かつ、口腔粘膜刺激等
の問題のない歯磨を得ることはなかなか困難であ
る。
本発明者らは、塩化ナトリウム含有歯磨におけ
る発泡性について種々検討する間に、アルキル硫
酸ナトリウムと特定の非イオン界面活性剤を併用
することにより、高濃度の塩化ナトリウムを含有
させても、アルキル硫酸ナトリウムの配合量を増
加させずに、発泡性の良好な歯磨が得られること
を見出し、本発明を完成するにいたつた。
すなわち、本発明は、塩化ナトリウムを10〜30
％（重量％、以下同じ）含有した歯磨において、
発泡剤として、ラウリル硫酸ナトリウムまたはミ
リスチル硫酸ナトリウムと、ポリオキシエチレン
硬化ヒマシ油誘導体（エチレンオキサイドの平均
付加モル数60）、ポリオキシエチレンステアリル
アルコールエーテル（エチレンオキサイドの平均
付加モル数40）ポリオキシエチレンシヨ糖ラウリ
ルエステル（エチレンオキサイドの平均付加モル
数10〜25）からなる群から選ばれる１種またはそ
れ以上の非イオン界面活性剤を配合してなる塩化
ナトリウム含有歯磨組成物を提供するものであ
る。本発明の歯磨組成物は、高濃度の塩化ナトリ
ウムを配合してもすぐれた発泡性を示し、使用感
が良好で、歯槽膿漏等の歯周疾患の予防、治療上
きわめて有用である。
つぎの第１表〜第３表に、塩化ナトリウム含有
歯磨における発泡剤と発泡性の関係、歯磨性状お
よび歯磨としての総合評価を調べた結果を示す。
発泡性は、第１表および第２表については後記
実施例１、第３表については実施例２の処方に準
じ、塩化ナトリウム濃度および発泡剤の種類と濃
度を種々変えた練歯磨を調製し、これを水で1/3
に稀釈し、ロスマイレズ法により１分後の泡の高
さ（cm）を測定して発泡量とした。また、発泡性
の評価は目視によりつぎの基準で示した。
◎：泡立ち非常に良好、〇：泡立ち良好、△：
泡立ち少ない、×：泡立ちほとんどなし
性状は調製した練歯磨を40℃にて３カ月放置し
た後、外視を目視観察し、つぎの基準で示した。
〇：良好、△：ゲル化が認められる、×：分離
が認められる、
総合評価は発泡性、性状を考慮して歯磨として
の総合的な評価をつぎの基準で示した。
〇：良好、△：歯磨として問題なし、×：不良
The present invention relates to a dentifrice composition containing sodium chloride, and more particularly to a dentifrice composition containing a relatively high concentration of sodium chloride and having good foaming properties. Toothpaste containing sodium chloride as a medicinal agent is effective in preventing alveolar pyorrhea, and recently there has been a trend to increase the amount of sodium chloride blended in order to further enhance the effect. However, when the amount of sodium chloride is increased, the foaming properties of the toothpaste decrease, resulting in problems such as a decrease in the cleaning effect and feel of the toothpaste. On the other hand, conventionally, sodium chloride-containing toothpastes mainly contain sodium alkyl sulfates as foaming agents, such as sodium lauryl sulfate. It is conceivable to increase the blending amount. However, it is not desirable to use too much sodium alkyl sulfate due to its irritation to the oral mucosa, and it is difficult to obtain a toothpaste that contains a high concentration of sodium chloride and does not cause irritation to the oral mucosa. Have difficulty. While conducting various studies on the foaming properties of toothpaste containing sodium chloride, the present inventors found that by using sodium alkyl sulfate and a specific nonionic surfactant in combination, the foaming properties of toothpaste containing sodium chloride It was discovered that a toothpaste with good foaming properties can be obtained without increasing the amount of sodium blended, and the present invention was completed. That is, the present invention uses sodium chloride at 10 to 30
% (wt%, the same applies hereinafter),
As blowing agents, sodium lauryl sulfate or sodium myristyl sulfate, polyoxyethylene hydrogenated castor oil derivative (average number of added moles of ethylene oxide 60), polyoxyethylene stearyl alcohol ether (average number of added moles of ethylene oxide 40) polyoxyethylene Provided is a sodium chloride-containing dentifrice composition containing one or more nonionic surfactants selected from the group consisting of sucrose lauryl ester (average number of added moles of ethylene oxide: 10 to 25). . The dentifrice composition of the present invention exhibits excellent foaming properties even when containing a high concentration of sodium chloride, is pleasant to use, and is extremely useful for the prevention and treatment of periodontal diseases such as alveolar pyorrhea. The following Tables 1 to 3 show the results of investigating the relationship between foaming agents and foaming properties, toothpaste properties, and overall evaluation of toothpastes in sodium chloride-containing toothpastes. Foaming properties were determined by preparing toothpastes with various concentrations of sodium chloride and the type and concentration of foaming agents, according to the formulations in Example 1 (described later) for Tables 1 and 2, and Example 2 (for Table 3). , 1/3 of this with water
The foam height (cm) was measured after 1 minute using the Rossmirez method to determine the foaming amount. In addition, the foamability was evaluated visually according to the following criteria. ◎: Very good foaming, 〇: Good foaming, △:
Little foaming, ×: Almost no foaming Properties of the prepared toothpaste were visually observed after being left at 40°C for 3 months, and evaluated according to the following criteria. ○: Good, △: Gelation observed, ×: Separation observed. Comprehensive evaluation as a toothpaste was given in consideration of foaming properties and properties using the following criteria. 〇: Good, △: No problem as toothpaste, ×: Poor
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【表】【table】
【表】【table】
【表】【table】
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【表】【table】
【表】【table】
【表】【table】
【表】
第１表〜第３表から明らかなごとく、ラウリル
硫酸ナトリウムまたはミリスチル硫酸ナトリウム
と前記の特定の非イオン界面活性剤を用いること
により、これらを増量せずとも10〜30％のいずれ
の濃度の塩化ナトリウムを含有する発泡性の良好
な歯磨が得られる。
かくして、本発明の歯磨組成物においては、10
〜30％、好ましくは、15〜30％の塩化ナトリウ
ム、１〜2.5％、好ましくは、1.5〜２％のラウリ
ル硫酸ナトリウムまたはミリスチル硫酸ナトリウ
ムおよび塩化ナトリウム濃度が10〜15％未満のと
き、0.2〜２％、15〜20％のとき、0.5〜２％、20
％を超え30％までのとき、１〜２％の該非イオン
界面活性剤を配合する。
該非イオン界面活性剤は単独でも、また、２種
以上を適宜の割合で混合して使用することがで
き、ポリオキシエチレン硬化ヒマシ油誘導体（エ
チレンオキシドの平均付加モル数60）としては、
例えば、市販のニツコールHCO―60（日本ケミカ
ル社製）、エマレツクスHC―60（日本エマルジヨ
ン社製）などが挙げられる。ポリオキシエチレン
ステアリルアルコールエーテル（エチレンオキサ
イドの平均付加モル数40）としては、例えぱ、市
販のエマレツクス640（日本エマルジヨン社製）な
ど、ポリオキシエチレンシヨ糖ラウリルエステル
（エチレンオキサイドの平均付加モル数10〜25）
としては、TOHOESTER―HL―15M（東邦化学
工業社製）などが挙げられる。ことに、風味の点
から、該非イオン界面活性剤としてポリオキシエ
チレン硬化ヒマシ油誘導体を用いることが好まし
い。
本発明の歯磨組成物は常法に従つて製造でき、
歯磨粉、練歯磨、歯磨軟膏、水歯磨などの通常の
剤形とすることができる。他の成分は通常用いら
れるものでよく、例えぱ、研磨剤として、第二リ
ン酸カルシウム（二水化物、無水物）、炭酸カル
シウム、ケイ酸塩、不溶性メタリン酸ナトリウ
ム、水酸化アルミニウムなど、粘結剤として、カ
ルボキシメチルセルロースナトリウム、カラギー
ナン、アルギン酸ナトリウム、ベントナイト、無
水ケイ酸など、湿潤剤として、グリセリン、ソル
ビトール、プロピレングリコール、ピロリドンカ
ルボン酸ナトリウム、ポリエチレングリコールな
どが用いられる。
また、本発明の歯磨組成物には、塩化ナトリウ
ムに加えて他の薬効剤を配合してもよく、かかる
薬効剤としてはモノフルオロリン酸ナトリウムの
ような水溶性フツ化物、アルミニウムアラントイ
ネート、グリチルレチン酸塩、クロルヘキシジ
ン、ヒノキチオール、デキストラナーゼ、リゾチ
ーム、トラネキサム酸、ε―アミノカプロン酸な
どが挙げられる。
つぎに実施例を挙げて本発明をさらに詳しく説
明する。
実施例 １
つぎの処方により、常法に従つて練歯磨を調製
した。
成 分 ％
第二リン酸カルシウム二水化物 40.00
カルボキシメチルセルロースナトリウム 0.50
カラギーナン 0.50
グリセリン 10.00
ソルビトール 10.00
塩化ナトリウム 15.00
ラウリル硫酸ナトリウム 1.50
ポリオキシエチレン硬化ヒマシ油誘導体
（エチレンオキサイドの平均付加モル数
60） 0.50
香料 1.00
サツカリンナトリウム 0.20
殺菌剤および防腐剤 0.10
水 残部
実施例 ２
つぎの処方により、常法に従つて練歯磨を調製
した。
成 分 ％
炭酸カルシウム 35.00
カルボキシメチルセルロースナトリウム 1.00
無水ケイ酸 1.50
グリセリン 13.00
ソルビトール 7.00
塩化ナトリウム 20.00
ラウリル硫酸ナトリウム 1.50
ポリオキシエチレンステアリルアルコ
ールエーテル（エチレンオキサイドの
平均付加モル数40） 1.00
香料 1.00
サツカリンナトリウム 0.20
殺菌剤および防腐剤 0.10
水 残部
実施例 ３
つぎの処方により、常法に従つて練歯磨を調製
した。
成分 ％
炭酸カルシウム 30.00
カルボキシメチルセルロースナトリウム 0.50
カラギーナン 0.50
無水ケイ酸 1.50
グリセリン 10.00
ソルビトール 5.00
塩化ナトリウム 30.00
ミリスチル硫酸ナトリウム 2.00
ポリオキシエチレンシヨ糖ラウリルエステル
（エチレンオキサイドの平均付加モル数15）0.50
香料 1.00
サツカリンナトリウム 0.20
殺菌剤および防腐剤 0.10
モノフルオロリン酸ナトリウム 0.76
水 残部[Table] As is clear from Tables 1 to 3, by using sodium lauryl sulfate or sodium myristyl sulfate and the above-mentioned specific nonionic surfactant, it is possible to reduce the amount of 10 to 30% without increasing the amount of these. A toothpaste with good foaming properties containing a high concentration of sodium chloride is obtained. Thus, in the dentifrice composition of the present invention, 10
~30%, preferably 15-30% sodium chloride, 1-2.5%, preferably 1.5-2% sodium lauryl sulfate or sodium myristyl sulfate and when the sodium chloride concentration is less than 10-15%, 0.2- 2%, 15-20%, 0.5-2%, 20
% to 30%, 1 to 2% of the nonionic surfactant is added. The nonionic surfactant can be used alone or in a mixture of two or more in an appropriate ratio, and as a polyoxyethylene hydrogenated castor oil derivative (average number of added moles of ethylene oxide 60),
Examples include commercially available Nikkor HCO-60 (manufactured by Nippon Chemical Co., Ltd.) and Emalex HC-60 (manufactured by Nippon Emulsion Co., Ltd.). Examples of polyoxyethylene stearyl alcohol ether (average number of added moles of ethylene oxide: 40) include polyoxyethylene sucrose lauryl ester (average number of added moles of ethylene oxide: 10), such as commercially available Emalex 640 (manufactured by Nippon Emulsion Co., Ltd.). ~twenty five)
Examples include TOHOESTER-HL-15M (manufactured by Toho Chemical Industry Co., Ltd.). Particularly, from the viewpoint of flavor, it is preferable to use a polyoxyethylene hydrogenated castor oil derivative as the nonionic surfactant. The dentifrice composition of the present invention can be manufactured according to a conventional method,
It can be in the usual dosage forms such as toothpaste, toothpaste, toothpaste ointment, and water toothpaste. Other ingredients may be those commonly used, such as abrasives, dicalcium phosphate (dihydrate, anhydride), calcium carbonate, silicates, insoluble sodium metaphosphate, aluminum hydroxide, etc., and binders. As a wetting agent, glycerin, sorbitol, propylene glycol, sodium pyrrolidone carboxylate, polyethylene glycol, etc. are used as a wetting agent. Furthermore, the dentifrice composition of the present invention may contain other medicinal agents in addition to sodium chloride, such as water-soluble fluorides such as sodium monofluorophosphate, aluminum allantoinate, Examples include glycyrrhetinate, chlorhexidine, hinokitiol, dextranase, lysozyme, tranexamic acid, and ε-aminocaproic acid. Next, the present invention will be explained in more detail with reference to Examples. Example 1 A toothpaste was prepared according to a conventional method using the following formulation. Ingredients % Dicalcium phosphate dihydrate 40.00 Sodium carboxymethyl cellulose 0.50 Carrageenan 0.50 Glycerin 10.00 Sorbitol 10.00 Sodium chloride 15.00 Sodium lauryl sulfate 1.50 Polyoxyethylene hydrogenated castor oil derivative (average number of added moles of ethylene oxide 60) 0.50 Flavor 1.00 Satucarin sodium 0.20 Bactericide and preservative 0.10 Water Remainder Example 2 A toothpaste was prepared according to the following recipe according to a conventional method. Component calcium carbonate 35.00 carboximethylcelulose sodium 1.00 hydrogy acid 1.50 glycerin 1.50 glycerin 13.00 sorbitol 7.00 sorbitoltol 7.00 sodium sodium sodium sodium sodium sodium sodium sodium sodium sodium laurelil sulfate 1.50 polioxyethylance stage alcohol ether Mol number 40) 1.00 fragrance 1.00 Satsukarin sodium 0.20 bactericidal and preservative: 0.10% water.Remainder Example 3 A toothpaste was prepared according to the conventional method according to the following formulation. Ingredients % Calcium carbonate 30.00 Sodium carboxymethyl cellulose 0.50 Carrageenan 0.50 Silicic anhydride 1.50 Glycerin 10.00 Sorbitol 5.00 Sodium chloride 30.00 Sodium myristyl sulfate 2.00 Polyoxyethylene sucrose lauryl ester (average number of added moles of ethylene oxide 15) 0.50 Flavor 1.00 Satucalin sodium 0.20 Disinfectants and preservatives 0.10 Sodium monofluorophosphate 0.76 Water Balance
Claims (1)
磨において、発泡剤として、１〜2.5重量％のラ
ウリル硫酸ナトリウムまたはミリスチル硫酸ナト
リウムと、エチレンオキサイドの平均付加モル数
が60のポリオキシエチレン硬化ヒマシ油誘導体、
エチレンオキサイドの平均付加モル数が40のポリ
オキシエチレンステアリルアルコールエーテルお
よびエチレンオキサイドの平均付加モル数が10〜
25のポリオキシエチレンシヨ糖ラウリルエステル
からなる群から選ばれる１種またはそれ以上の非
イオン界面活性剤を、塩化ナトリウム含量が10重
量％〜15重量％未満のとき、0.2〜２重量％、塩
化ナトリウム含量が15重量％〜20重量％のとき、
0.5〜２重量％、塩化ナトリウム含量が20重量％
を超え、30重量％までのとき、１〜２重量％配合
したことを特徴とする塩化ナトリウム含有歯磨組
成物。1. In toothpaste containing 10-30% by weight of sodium chloride, 1-2.5% by weight of sodium lauryl sulfate or sodium myristyl sulfate as a foaming agent and polyoxyethylene hydrogenated castor oil with an average added mole number of ethylene oxide of 60. derivative,
Polyoxyethylene stearyl alcohol ether with an average number of added moles of ethylene oxide of 40 and an average number of added moles of ethylene oxide of 10~
One or more nonionic surfactants selected from the group consisting of 25 polyoxyethylene sucrose lauryl esters, when the sodium chloride content is 10% to less than 15% by weight, 0.2 to 2% by weight of chloride. When the sodium content is 15% to 20% by weight,
0.5-2% by weight, sodium chloride content 20% by weight
A dentifrice composition containing sodium chloride, characterized in that the sodium chloride-containing dentifrice composition contains 1 to 2% by weight when the amount exceeds 30% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18098980A JPS57106606A (en) | 1980-12-20 | 1980-12-20 | Dentifrice composition containing sodium chloride |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18098980A JPS57106606A (en) | 1980-12-20 | 1980-12-20 | Dentifrice composition containing sodium chloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57106606A JPS57106606A (en) | 1982-07-02 |
| JPH0141603B2 true JPH0141603B2 (en) | 1989-09-06 |
Family
ID=16092788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18098980A Granted JPS57106606A (en) | 1980-12-20 | 1980-12-20 | Dentifrice composition containing sodium chloride |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57106606A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0629172B2 (en) * | 1984-12-27 | 1994-04-20 | ライオン株式会社 | Oral composition |
| JPH0641424B2 (en) * | 1984-11-06 | 1994-06-01 | ライオン株式会社 | Caries preventive agent |
| JP3672696B2 (en) * | 1997-05-06 | 2005-07-20 | 三菱化学フーズ株式会社 | Soap bubble liquid and soap-like food |
| JP3660282B2 (en) | 2001-08-20 | 2005-06-15 | 独立行政法人科学技術振興機構 | Hydrogelator |
-
1980
- 1980-12-20 JP JP18098980A patent/JPS57106606A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS57106606A (en) | 1982-07-02 |
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