JP2845245B2 - Toothpaste composition - Google Patents

Description

The present invention relates to dentifrice compositions, and more particularly, to the taste of food after dentifrice when using a safer N-long-chain acylglutamate as a foaming agent. The present invention relates to a dentifrice composition that does not change the dentifrice.

[Conventional technology and its problems] A foaming agent is added to a dentifrice composition in order to impart a cleaning action, a dispersion emulsification action, a foaming action, and the like, and a surfactant is used for that purpose.

Surfactants used as foaming agents reduce the interfacial tension of the dentifrice when used to enhance the cleaning effect of the dentifrice, and promote the dispersion and penetration of the compounded medicinal agent to enhance its effect, It is an essential component because it plays a role such as giving a sense of stability by foaming.

These surfactants not only have good performance such as interfacial tension lowering ability and foaming property, but also because toothpaste is put in the mouth, it must satisfy taste, smell, etc. Conventionally, sodium alkyl sulfate, sodium acyl sarcosine, α-olefin sulfonate,
Anionic surfactants such as sodium coconut monoglyceride sulfate are used, and sodium alkyl sulfate is particularly popular in terms of performance, taste, etc., but it is adsorbed on taste buds of the tongue and oral mucosa It has the major drawback of changing the taste of food after use, which is thought to occur, and also has some irritation to the oral mucosa,
There are problems such as inactivating the enzyme blended in the toothpaste as a medicinal agent.

On the other hand, recently, the safety of these surfactants has been a problem, and various studies have been made to use surfactants having higher safety as a foaming agent.
It has been proposed to mix long-chain acylglutamic acid salts in toothpaste (Japanese Patent Publication No. 45-24480). N-long-chain acylglutamate is non-toxic, has very mild irritation to skin and mucous membranes, has good detergency, foaming power, emulsifying power, and has excellent hard water resistance. It is said to be very effective as a foaming agent for dentifrice compositions.

The taste of N-long-chain acylglutamate is relatively low in acyl groups (for example, coconut fatty acid acyl).
It has been reported that a high content of N-long-chain acylglutamate having a strong bitter taste causes strong bitterness (Japanese Patent Publication No. 58-58).
45402), but the effect of impurities in N-long chain acylglutamate was not known at all.

[Problem to be Solved by the Invention] An object of the present invention is to improve the taste of dentifrice containing N-long-chain acylglutamate. Here, the toothpaste is paste-like toothpaste, water toothpaste or the like.

[Means for Solving the Problems] The present inventor examined in detail the effect on taste when N-long-chain acylglutamate was added to toothpaste.
When a higher-purity N-long-chain acylglutamate containing 1.0% by weight or less, preferably 0.5% by weight or less of a higher fatty acid (free form and / or salt form) contained as an impurity in the long-chain acylglutamate is used, "Dustiness" and "juice effect" of toothpaste (a phenomenon that after eating toothpaste, a sour food, typically orange juice, tastes very different. See JP-B-47-43830). They have found that they can be solved, and have completed the present invention.

That is, the present invention has a higher fatty acid content as a blowing agent.
A dentifrice composition characterized in that, in the case of a paste-like dentifrice, 0.1-5.0% by weight, preferably 0.3-3.0% by weight, of high-purity N-long-chain acylglutamate of not more than 1.0% by weight. When the amount of the N-long-chain acylglutamate is less than 0.1% by weight, the foaming property is reduced, and when the amount is more than 5.0%, an appropriate softness required for the paste-like dentifrice composition is lost, which is not preferable. .

In the case of water toothpaste, for example, 0.05 to 10% by weight may be blended. In the case of water dentifrice applied directly to the oral cavity, preferably 0.
In the case of a water dentifrice which is blended in an amount of about 5 to 5% by weight and diluted about 10 times and then applied to the oral cavity, it is preferably blended in an amount of 1 to 10% by weight. If the amount of N-long-chain acylglutamate is less than 0.05%, flavor separation or the like may occur, which is not preferable. If the amount exceeds 10% by weight, it is difficult to design a formulation of water dentifrice. It is not preferable because it becomes difficult.

As a method for obtaining high-purity N-long-chain acylglutamate, when glutamic acid and higher fatty acid chloride are reacted in the presence of an alkali, glutamic acid is used in an amount of 1.1 to 1.3 times mol with respect to the higher fatty acid chloride to obtain a higher fatty acid chloride. A method for suppressing decomposition, or drying an impure N-long-chain acylglutamate containing several% of a higher fatty acid, and then removing the higher fatty acid with a hydrophobic organic solvent such as n-hexane, petroleum ether, petroleum benzene, toluene, etc. Extraction,
A purification method and the like can be mentioned. Glutamic acid may be an L-form, a D-form, or a mixture of these in any proportion, but the L-form is preferred from the viewpoint of biocompatibility.

The high-purity N-long-chain acylglutamic acid thus obtained is added to the dentifrice composition in the form of an alkali metal salt such as sodium acid or potassium salt or in the form of a salt of a basic amino acid such as lysine. In addition, the foaming property, safety, and the like that should be originally provided are not impaired.

N-long-chain acylglutamic acid salts include those having 8 carbon atoms.
A water-soluble salt of glutamic acid N-substituted with up to 20 saturated or unsaturated acyl groups is used. Examples of the acyl group include caprinoyl, lauroyl, tridecanoyl, 2-methyllauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, isostearyl, oleoyl and the like. It may be a mixture of coconut oil fatty acid residues, palm oil fatty acid residues, hardened beef fatty acid residues, or a mixed fatty acid residue of coconut oil and hardened beef tallow.

In the present invention, the higher fatty acid to be removed from the N-long-chain acylglutamic acid is an unreacted higher fatty acid in the acylation reaction, and includes not only a free form but also a salt form.

The dentifrice composition generally comprises dibasic calcium phosphate dihydrate and anhydride, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, silicic anhydride,
Abrasives such as hydrated silicic acid, aluminosilicate, alumina, aluminum hydroxide, etc., thickeners such as glycerin, sorbite, propylene glycol, polyethylene glycol, etc .; Binders, sweeteners such as sodium saccharin, glycyrrhizin salts, stevioside, neohesperidin dihydrochalcone, paramethoxycinnamic aldehyde, perillartin, aspartame, and flavors such as menthol, carvone, and anethole are used. Fluorides such as tin oxide and sodium fluoride, fungicides such as chlorhexazine salts, phosphate compound builders such as sodium phosphate, dex Ranaze, enzymes such as amylase,
Active ingredients such as anti-inflammatory agents such as ε-aminocaproic acid, tranexamic acid, and allantoinate, and gingival conserving agents such as sodium chloride are appropriately used.

In the case of a paste-like dentifrice composition, it can be produced by kneading these components with an appropriate amount of water. In the case of water dentifrice, these components can be manufactured by stirring and mixing an appropriate amount of water and / or alcohol. As alcohol,
Ethanol is preferred. The mixing ratio of the foaming agent, abrasive, thickener, sweetener, bactericide, builder, anti-inflammatory agent, gingival conserving agent, and the like in the dentifrice composition of the present invention is not particularly limited, and conventionally known paste-like pastes can be used. It may be the same as that of a dentifrice composition (toothpaste) or a water dentifrice.

The taste of the paste-like dentifrice composition was improved by adding 0.1 to 5.0% by weight of an N-long chain acylglutamate having a higher fatty acid content of 1.0% or less as the foaming agent of the present invention. In the case of water dentifrice, the taste of the dentifrice composition can be improved by adding 0.05 to 10% by weight of high-purity N-long-chain acylglutamic acid. However, since the degree of taste and flavor varies greatly among individuals, it is impossible to add various taste components based on the dentifrice composition of the present invention. The above-mentioned sweeteners, flavors and the like can be used as these taste components. In particular, aspartame is weakly acidic and stable, and it is effective to mix it with a weakly acidic dentifrice composition for the purpose of imparting sweetness.

As the foaming agent, in addition to the N-long-chain acylglutamate used in the present invention, commonly used surfactants such as sodium lauryl sulfate and sodium lauroyl sarcosine can be used at all.

Next, examples will be shown to specifically describe the features of the present invention.

Example 1 A paste-like dentifrice was prepared according to the formulation shown in Table 1 according to a conventional method.

For comparison, a paste-like dentifrice was prepared using N-lauroyl-L-glutamate (sodium salt) having a different lauric acid content in accordance with the formulation of Example 1, and a toothpaste was prepared by a panel of 10 experts when using the dentifrice. Was subjected to a taste test. Table 2 shows the results.

However, the scores in the table mean 3: have a dusty taste, 2: have a slightly dusty taste, and 1: do not have a dusty taste.

As is clear from Table 2, the dentifrice composition of the present invention having a lauric acid content of 1.0% by weight or less in N-lauroyl-L-glutamate hardly feels unpleasant taste.

Examples 2 to 6 As shown in Table 4, various N with different higher fatty acid contents
-A paste-like dentifrice was prepared using long-chain acyl-L-glutamate based on the formulation in Table 3 below, and a taste test was performed.

In the taste test, the same expert panel as in Example 1 was used to perform a taste test of orange juice after brushing the teeth. The results are shown in Table 4.

However, the scores in the table mean 5: extremely change in flavor, 4: considerably change in flavor, 3: slightly change in flavor, 2: almost no change in flavor, 1: no change in flavor.

Dibasic calcium phosphate dihydrate 40.0 Carboxymethylcellulose 1.0 Glycerin 10.0 From the results shown in Table 4, the paste-like dentifrice of the present invention in which the higher fatty acid content in N-long-chain acyl-L-glutamate is 1.0% by weight or less is used. It is clear that the taste of the orange juice after doing so hardly changes.

Example 7 Using high purity N-lauroyl-L-glutamate (the content of lauric acid is 0.2% by weight) and aspartame as a sweetener, a slightly acidic solution (pH 6.
8) A paste-like toothpaste was prepared and a taste test was performed.

The taste test was performed by an expert panel as in Example 1.
A taste test of the orange juice during brushing and after use was performed.

As a result, no change in dustiness and taste of orange juice was felt.

Example 8 A paste dentifrice was prepared according to the formulation shown in Table 6 using high-purity N-lauroyl-L-glutamate (the content of lauric acid was 0.2% by weight) and sodium chloride, and a taste test was conducted.

The taste test was performed by an expert panel as in Example 1.
A taste test of the orange juice during brushing and after use was performed.

As a result, no change in dustiness and taste of orange juice was felt.

Example 9 A paste-like dentifrice was prepared according to the formulation shown in Table 7 using high-purity N-lauroyl-L-glutamate (the content of lauric acid was 0.2% by weight) and sodium chloride, and a taste test was conducted.

The taste test was performed by an expert panel as in Example 1.
A taste test of the orange juice during brushing and after use was performed.

As a result, no change in dustiness and taste of orange juice was felt.

Example 10 A water dentifrice was prepared according to the composition shown in Table 8 below.

[Effects of the Invention] According to the present invention, a paste-like dentifrice composition in which the "dustiness" and the "juice effect" excellent in taste are improved and various taste components according to personal preference can be added can be obtained. Could be developed.

──────────────────────────────────────────────────続 き Continuation of the front page (72) Inventor Koichiro Nagata 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa Prefecture Ajinomoto Co., Inc. Kawasaki Plant (56) References JP-A-58-45402 (JP, B2) No. 45-24480 (JP, B1) (58) Fields investigated (Int. Cl. ⁶ , DB name) A61K 7/16-7/28

Claims (4)

(57) [Claims] 1. A dentifrice composition containing 5.0 to 0.1% by weight of an N-long-chain acylglutamate, wherein the content of a higher fatty acid in the N-long-chain acylglutamate is N-long-chain acylglutamate. 1.0% by weight or less of the higher fatty acid in the dentifrice composition.
% Dentifrice composition. 2. The dentifrice composition according to claim 1, wherein the dentifrice composition is a paste dentifrice. 3. The dentifrice composition according to claim 1, wherein the dentifrice composition is water dentifrice. 4. The dentifrice composition according to claim 1, wherein the N-long-chain acylglutamate is N-long-chain-L-acylglutamate.