JP6055296B2 - Oral composition - Google Patents
Oral composition Download PDFInfo
- Publication number
- JP6055296B2 JP6055296B2 JP2012266282A JP2012266282A JP6055296B2 JP 6055296 B2 JP6055296 B2 JP 6055296B2 JP 2012266282 A JP2012266282 A JP 2012266282A JP 2012266282 A JP2012266282 A JP 2012266282A JP 6055296 B2 JP6055296 B2 JP 6055296B2
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- JP
- Japan
- Prior art keywords
- mass
- composition
- oral cavity
- component
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 150
- 210000000214 mouth Anatomy 0.000 claims description 86
- 150000003839 salts Chemical class 0.000 claims description 42
- 239000007788 liquid Substances 0.000 claims description 29
- 239000000551 dentifrice Substances 0.000 claims description 25
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 claims description 19
- -1 alkali metal salt Chemical class 0.000 claims description 18
- 229940005657 pyrophosphoric acid Drugs 0.000 claims description 17
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 13
- 239000000194 fatty acid Substances 0.000 claims description 13
- 229930195729 fatty acid Natural products 0.000 claims description 13
- 150000008051 alkyl sulfates Chemical class 0.000 claims description 9
- 150000001413 amino acids Chemical class 0.000 claims description 9
- 150000005846 sugar alcohols Chemical class 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 229910052783 alkali metal Inorganic materials 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 4
- 239000002736 nonionic surfactant Substances 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 235000018102 proteins Nutrition 0.000 description 61
- 102000004169 proteins and genes Human genes 0.000 description 61
- 108090000623 proteins and genes Proteins 0.000 description 61
- 230000000694 effects Effects 0.000 description 58
- 239000002253 acid Substances 0.000 description 40
- 238000004140 cleaning Methods 0.000 description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 26
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 20
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 20
- 235000019640 taste Nutrition 0.000 description 18
- 238000011156 evaluation Methods 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- 230000001629 suppression Effects 0.000 description 14
- 239000008213 purified water Substances 0.000 description 10
- 239000002689 soil Substances 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 9
- 230000002401 inhibitory effect Effects 0.000 description 9
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 9
- 125000002252 acyl group Chemical group 0.000 description 8
- 230000001680 brushing effect Effects 0.000 description 8
- 239000001506 calcium phosphate Substances 0.000 description 8
- 229960001714 calcium phosphate Drugs 0.000 description 8
- 229910000389 calcium phosphate Inorganic materials 0.000 description 8
- 235000011010 calcium phosphates Nutrition 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 239000006228 supernatant Substances 0.000 description 8
- 239000000725 suspension Substances 0.000 description 8
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 7
- 229910001424 calcium ion Inorganic materials 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 235000001014 amino acid Nutrition 0.000 description 6
- 239000011230 binding agent Substances 0.000 description 6
- 235000019658 bitter taste Nutrition 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 230000002708 enhancing effect Effects 0.000 description 6
- 239000000594 mannitol Substances 0.000 description 6
- 239000008188 pellet Substances 0.000 description 6
- 230000007505 plaque formation Effects 0.000 description 6
- 239000000600 sorbitol Substances 0.000 description 6
- 239000004386 Erythritol Substances 0.000 description 5
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 5
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 5
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 235000019414 erythritol Nutrition 0.000 description 5
- 229940009714 erythritol Drugs 0.000 description 5
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 5
- 150000004665 fatty acids Chemical class 0.000 description 5
- 235000013922 glutamic acid Nutrition 0.000 description 5
- 239000004220 glutamic acid Substances 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- AVBJHQDHVYGQLS-AWEZNQCLSA-N (2s)-2-(dodecanoylamino)pentanedioic acid Chemical compound CCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC(O)=O AVBJHQDHVYGQLS-AWEZNQCLSA-N 0.000 description 4
- MTJZWYHTZFVEGI-INIZCTEOSA-N (2s)-2-(tetradecanoylamino)pentanedioic acid Chemical compound CCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC(O)=O MTJZWYHTZFVEGI-INIZCTEOSA-N 0.000 description 4
- 102000009027 Albumins Human genes 0.000 description 4
- 108010088751 Albumins Proteins 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 239000007850 fluorescent dye Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 3
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 3
- 206010013911 Dysgeusia Diseases 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000012888 bovine serum Substances 0.000 description 3
- 235000011180 diphosphates Nutrition 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 238000005187 foaming Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000001771 impaired effect Effects 0.000 description 3
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 239000002324 mouth wash Substances 0.000 description 3
- 229940051866 mouthwash Drugs 0.000 description 3
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 235000019643 salty taste Nutrition 0.000 description 3
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 3
- 229940048086 sodium pyrophosphate Drugs 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 3
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- VCRXMSMANOGRCM-UHFFFAOYSA-N 2-(dodecanoylamino)butanedioic acid Chemical compound CCCCCCCCCCCC(=O)NC(C(O)=O)CC(O)=O VCRXMSMANOGRCM-UHFFFAOYSA-N 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 235000003704 aspartic acid Nutrition 0.000 description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000002308 calcification Effects 0.000 description 2
- 229960005069 calcium Drugs 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
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- 229940113118 carrageenan Drugs 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- ZFKJVJIDPQDDFY-UHFFFAOYSA-N fluorescamine Chemical compound C12=CC=CC=C2C(=O)OC1(C1=O)OC=C1C1=CC=CC=C1 ZFKJVJIDPQDDFY-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000010069 protein adhesion Effects 0.000 description 2
- 229940048084 pyrophosphate Drugs 0.000 description 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 229950005425 sodium myristyl sulfate Drugs 0.000 description 2
- 229940067741 sodium octyl sulfate Drugs 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 2
- NWZBFJYXRGSRGD-UHFFFAOYSA-M sodium;octadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOS([O-])(=O)=O NWZBFJYXRGSRGD-UHFFFAOYSA-M 0.000 description 2
- WFRKJMRGXGWHBM-UHFFFAOYSA-M sodium;octyl sulfate Chemical compound [Na+].CCCCCCCCOS([O-])(=O)=O WFRKJMRGXGWHBM-UHFFFAOYSA-M 0.000 description 2
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
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- 239000000230 xanthan gum Substances 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- GDFAOVXKHJXLEI-VKHMYHEASA-N N-methyl-L-alanine Chemical compound C[NH2+][C@@H](C)C([O-])=O GDFAOVXKHJXLEI-VKHMYHEASA-N 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 244000090599 Plantago psyllium Species 0.000 description 1
- 235000010451 Plantago psyllium Nutrition 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- 240000004584 Tamarindus indica Species 0.000 description 1
- 235000004298 Tamarindus indica Nutrition 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
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- 229930195712 glutamate Natural products 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
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- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
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- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 1
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- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
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- 229920001277 pectin Polymers 0.000 description 1
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- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
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- 239000000419 plant extract Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
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- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
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- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Description
本発明は、口腔用組成物に関する。 The present invention relates to an oral composition.
従来より、口腔用組成物において、配合成分の分散性を高めたり、使用感や洗浄効果の向上を図ったりする上で、発泡剤として種々の界面活性剤が用いられている。例えば、特許文献１には、かかる界面活性剤としてＮ−長鎖アシルグルタミン酸塩を配合した歯磨組成物が開示されており、特許文献２に記載の口腔用組成物では、アミノ酸系界面活性剤を配合することによって、さらにステイン形成阻害効果を得ることを試みている。 Conventionally, in the composition for oral cavity, various surfactants have been used as foaming agents in order to improve the dispersibility of the blended components and improve the feeling of use and the cleaning effect. For example, Patent Document 1 discloses a dentifrice composition containing N-long chain acyl glutamate as such a surfactant. In the oral composition described in Patent Document 2, an amino acid surfactant is used. It is trying to obtain the stain formation inhibitory effect by mix | blending.
一方、ピロリン酸塩等を配合することによって歯面への汚れの付着を防止できることも知られており、例えば、特許文献３には、アルキル硫酸塩、ピロリン酸塩等の水溶性ポリリン酸塩を１重量％以上、及びオルトリン酸塩を含有する口腔用組成物が開示されており、かかる組成物はステイン、プラーク、煙草のヤニ等の歯面の汚れに対する化学的清掃効果を高めることが記載されている。 On the other hand, it is also known that adhesion of dirt to the tooth surface can be prevented by blending pyrophosphate and the like. For example, Patent Document 3 discloses water-soluble polyphosphates such as alkyl sulfates and pyrophosphates. An oral composition containing at least 1% by weight and orthophosphate is disclosed, and it is described that such composition enhances the chemical cleaning effect against stains on tooth surfaces such as stains, plaques, tobacco spears and the like. ing.
上述したステイン、プラーク、煙草のヤニを含む、歯面に付着した種々の汚れは、歯面上に形成されたタンパク質汚れの上に、さらに細菌の共凝集や他の無機汚れの層が形成されてなる。そのため、歯面とステインやプラーク等の汚れとの間に介在するタンパク質汚れを有効に除去すれば、これらステインやプラーク等の汚れを根こそぎ除去することができ、洗浄効果を高めることが可能となる。さらに、歯面へのタンパク質汚れの付着を未然に防止できれば、歯垢形成抑制効果も大いに期待できることとなる。また、歯石形成過程の詳細については、必ずしも明らかにされているわけではないが、歯面に存在するプラークを構成する細菌、或いは粘着性デキストラン等の有機基質に、唾液や浸出液から供給されるカルシウム及びリンが付着し、これが結晶化することでプラークの石灰化現象が生じることによると考えられる。そして、この無機成分は、ハイドロキシアパタイト様の石灰化物である。
したがって、歯面へのタンパク質汚れの付着を未然に防止でき、またプラーク中に沈着したリン酸カルシウム分がハイドロキシアパタイト結晶に転移して成長するのを抑制することができれば、歯垢形成抑制効果も大いに期待できることとなる。さらに、歯牙表面からのカルシウムイオンの溶出を効果的に抑制し得る耐酸性を付与することができれば、むし歯を有効に防止することも可能となる。
Various stains attached to the tooth surface, including the stains, plaques, and cigarettes mentioned above, further form bacterial co-aggregation and other inorganic stain layers on the protein stain formed on the tooth surface. It becomes. Therefore, if protein stains intervening between the tooth surface and stains such as stains and plaques are effectively removed, the stains such as stains and plaques can be removed by uprooting, and the cleaning effect can be enhanced. . Furthermore, if the protein stain can be prevented from adhering to the tooth surface, the effect of suppressing plaque formation can be greatly expected. In addition, the details of the calculus formation process are not necessarily clarified, but calcium supplied from saliva or exudate to organic substances such as bacteria that form plaques on the tooth surface or adhesive dextran It is considered that the calcification phenomenon of plaque occurs due to the adhesion of phosphorus and crystallization. And this inorganic component is a hydroxyapatite-like calcification.
Therefore, if protein stains can be prevented from adhering to the tooth surface, and if the calcium phosphate deposited in the plaque can be inhibited from transferring to hydroxyapatite crystals and growing, the effect of plaque formation is greatly expected. It will be possible. Furthermore, if the acid resistance which can suppress effectively the elution of the calcium ion from the tooth surface can be provided, it becomes possible to effectively prevent the cavity.
一般に、口腔用組成物を用いた歯の洗浄効果を確認するにあたり、医師や歯科衛生士等の専門家による判断に委ねられる以外、使用者自身が舌等で歯面に触れた際につるつるとした感触を実感できるか否かに拠ることが多いため、こうした清掃効果を使用者が容易に実感できる口腔用組成物が好まれている。また、口腔用組成物を使用することで、むし歯に対する抵抗力を増大させることも望まれている。 In general, when checking the effect of cleaning the teeth using the composition for oral cavity, except when left to the judgment of specialists such as doctors and dental hygienists, when the user himself touches the tooth surface with the tongue etc. Therefore, oral compositions that allow the user to easily realize such a cleaning effect are preferred. Moreover, increasing the resistance with respect to a cavity by using the composition for oral cavity is also desired.
しかしながら、特許文献１〜２のようにアミノ酸系界面活性剤を用いても、歯のタンパク質汚れの除去性能を得ることができず、また特許文献３のように、ポリリン酸を配合しても、タンパク質汚れの除去効果と付着防止効果とを共に十分発揮させるには至らない。また、ポリリン酸は、その配合量が増大するにつれて口腔内の洗浄後の歯の感触が低下するおそれがあるため、清掃効果を十分に実感できない可能性もある。さらに、これらの文献ではいずれも、耐酸性を高めたり、良好な低温安定性を付与したりすることに関し、何らの検討もなされていない。 However, even if an amino acid surfactant is used as in Patent Documents 1 and 2, it is not possible to obtain the removal performance of protein stains on teeth, and even if polyphosphoric acid is added as in Patent Document 3, Both the effect of removing protein stains and the effect of preventing adhesion cannot be fully exhibited. Moreover, since there exists a possibility that the touch of the tooth | gear after washing | cleaning in an oral cavity may fall as the compounding quantity increases, there exists a possibility that the cleaning effect cannot fully be realized. In addition, none of these documents discusses the improvement of acid resistance and the provision of good low-temperature stability.
したがって、本発明は、歯面に存在するタンパク質汚れを十分に除去できるとともに、タンパク質汚れの歯面への付着をも効果的に防止することができ、その清掃効果を口腔内で良好に実感することをも可能とするうえに、優れた耐酸性や良好な低温安定性を有する口腔用組成物に関する。 Therefore, the present invention can sufficiently remove protein stains present on the tooth surface, and can effectively prevent protein stains from adhering to the tooth surface, and realizes the cleaning effect well in the oral cavity. The present invention also relates to an oral composition having excellent acid resistance and good low-temperature stability.
そこで本発明者らは、種々検討したところ、Ｎ−アシルアミノ酸又はその塩及びピロリン酸又はその塩を特定の量で含有しながら、これらを特定の量比かつ特定の合計量とすることにより、タンパク質汚れの除去効果と付着防止効果とを高め、口腔内で良好な清掃効果をも実感できるとともに、優れた耐酸性や良好な低温安定性をも有する口腔用組成物が得られることを見出した。
また、本発明の口腔用組成物であれば、プラーク中に沈着したリン酸カルシウム分がハイドロキシアパタイト結晶に転移し、さらに成長してしまうのを抑制することもできるので、より優れた歯垢形成抑制効果を期待できることを見出した。
さらに、本発明の口腔用組成物であれば、優れた耐酸性をも有するため、歯牙表面からのカルシウムイオンの溶出を効果的に抑制することができるとともに、低温環境下においても良好な安定性を保持できることを見出した。
Therefore, the present inventors have conducted various studies, and while containing N-acylamino acid or a salt thereof and pyrophosphoric acid or a salt thereof in a specific amount, by setting them to a specific quantitative ratio and a specific total amount, It has been found that an oral composition having an excellent acid resistance and a good low-temperature stability can be obtained while enhancing the removal effect of protein stains and the anti-adhesion effect, realizing a good cleaning effect in the oral cavity. .
In addition, if it is the composition for oral cavity of the present invention, it is possible to suppress the calcium phosphate deposited in the plaque from being transferred to the hydroxyapatite crystal and further growing, so that it is more effective in inhibiting plaque formation. I found that I can expect.
Furthermore, since the composition for oral cavity of the present invention also has excellent acid resistance, it can effectively suppress elution of calcium ions from the tooth surface, and also has good stability in a low temperature environment. I found that I can hold.
すなわち、本発明は、次の成分（Ａ）及び（Ｂ）：
（Ａ）Ｎ−アシルアミノ酸又はその塩 ０．００５質量％以上０．３質量％以下 及び
（Ｂ）ピロリン酸又はその塩 ０．００５質量％以上０．５質量％以下
を含有し、成分（Ａ）と成分（Ｂ）の質量比（（Ｂ）／（Ａ））が０．０５以上４０以下であり、かつ成分（Ａ）と成分（Ｂ）の含有量の合計が０．０１質量％以上０．６質量％以下である口腔用組成物に関する。
That is, the present invention includes the following components (A) and (B):
(A) N-acylamino acid or salt thereof 0.005 mass% or more and 0.3 mass% or less and (B) pyrophosphoric acid or salt thereof 0.005 mass% or more and 0.5 mass% or less, and component (A ) And component (B) mass ratio ((B) / (A)) is 0.05 or more and 40 or less, and the total content of component (A) and component (B) is 0.01% by mass or more. It is related with the composition for oral cavity which is 0.6 mass% or less.
本発明の口腔用組成物は、優れた歯面のタンパク質汚れの除去効果と、歯面へのタンパク質汚れの付着抑制効果とを兼ね備えるとともに、口腔用組成物を使用した後に、歯面がつるつるとなめらかな感触となることを実感することができ、歯垢形成抑制効果を十分に期待できるとともに清掃実効感をも高めることができ、さらに優れた耐酸性や良好な低温安定性をも有する。 The composition for oral cavity of the present invention has an excellent effect of removing protein stains on the tooth surface and an effect of suppressing the adhesion of protein stains on the tooth surface, and after using the oral composition, the tooth surface is smooth. A smooth feel can be realized, a plaque formation inhibitory effect can be sufficiently expected, and a cleaning effect can be enhanced. Further, it has excellent acid resistance and good low-temperature stability.
以下、本発明について詳細に説明する。
本発明の口腔用組成物は、Ｎ−アシルアミノ酸又はその塩（Ａ）を０．００５質量％以上０．３質量％以下含有する。かかる成分（Ａ）を特定の量で含有することにより、後述する特定の量のピロリン酸又はその塩（Ｂ）との併用によって、効果的にタンパク質汚れを除去しつつその付着をも有効に抑制することができる。また、本発明の口腔用組成物を使用した後の口腔内においては、歯面が汚れのない滑らかな状態であるときに触感できる、ギシギシとした引っかかり感のないつるつるとした感触を高め、いわゆる清掃実効感を十分に高めることができる。ここで、ギシギシとした引っかかり感のないつるつるした感触とは、歯面を舌でふれたときに、摩擦を殆ど感じずに舌をすべらせることができる歯の表面がなめらかな感触をいう。
Hereinafter, the present invention will be described in detail.
The composition for oral cavity of this invention contains 0.005 mass% or more and 0.3 mass% or less of N-acylamino acid or its salt (A). By containing such a component (A) in a specific amount, it is possible to effectively suppress adhesion while effectively removing protein stains in combination with a specific amount of pyrophosphoric acid or a salt thereof (B) described later. can do. In addition, in the oral cavity after using the oral composition of the present invention, it is possible to feel when the tooth surface is in a smooth state without dirt, enhancing the feel of slippery without a squeezing feeling, so-called The cleaning effectiveness can be sufficiently enhanced. Here, the slippery touch without the squeezing feeling means a smooth feel of the tooth surface that allows the tongue to slide with almost no friction when the tooth surface is touched with the tongue.
Ｎ−アシルアミノ酸のアシル基は、優れたタンパク質汚れの除去効果と付着抑制効果とを兼ね備える観点、良好な清掃実効感をもたらす観点、及び優れた耐酸性や良好な低温安定性もたらす観点から、飽和又は不飽和の直鎖又は分岐鎖を有する脂肪酸又はそれらの混合脂肪酸を由来としたものであって、直鎖脂肪酸又は直鎖脂肪酸の混合脂肪酸を由来としたものが好ましく、炭素数６〜２２のアシル基であるのが好ましく、炭素数１０〜２０のアシル基であるのがより好ましく、炭素数１２〜１８のアシル基であるのがさらに好ましい。かかるアシル基としては、口腔用組成物の泡立ち、扱いやすさの点から、カプリロイル基、ラウロイル基、ミリストイル基、パルミトイル基、ステアロイル基、ココイル基から選ばれる１種又は２種以上が好ましく、ラウロイル基、ミリストイル基、ココイル基から選ばれる１種又は２種以上がより好ましく、ラウロイル基、ミリストイル基から選ばれる１種以上がさらに好ましい。 The acyl group of the N-acylamino acid is saturated from the viewpoint of combining excellent protein soil removal effect and adhesion suppression effect, providing good cleaning effectiveness, and providing excellent acid resistance and good low-temperature stability. Alternatively, those derived from unsaturated linear or branched fatty acids or mixed fatty acids thereof, preferably derived from linear fatty acids or mixed fatty acids of linear fatty acids, having 6 to 22 carbon atoms It is preferably an acyl group, more preferably an acyl group having 10 to 20 carbon atoms, and further preferably an acyl group having 12 to 18 carbon atoms. Such an acyl group is preferably one or more selected from a capryloyl group, a lauroyl group, a myristoyl group, a palmitoyl group, a stearoyl group, and a cocoyl group from the viewpoint of bubbling of the oral composition and ease of handling, and lauroyl. One or more selected from a group, myristoyl group, and cocoyl group are more preferable, and one or more selected from a lauroyl group and a myristoyl group are more preferable.
Ｎ−アシルアミノ酸のアミノ酸部分としては、グルタミン酸、アスパラギン酸、グリシン、アラニン、スレオニン、メチルアラニン、サルコシン、リジン、アルギニンから選ばれる１種又は２種以上が好ましい。Ｎ−アシルアミノ酸のアミノ酸部分は、成分（Ｂ）との併用によりタンパク質汚れの除去効果と汚れ付着防止の効果を向上する観点、及び優れた耐酸性や良好な低温安定性もたらす観点から、酸性アミノ酸であるのが好ましく、グルタミン酸、アスパラギン酸がより好ましく、グルタミン酸がさらに好ましい。また、これらのアミノ酸部分はＤ体、Ｌ体或いはＤ体とＬ体の混合物のいずれであってもよく、Ｌ体であるのが好ましい。 The amino acid part of the N-acylamino acid is preferably one or more selected from glutamic acid, aspartic acid, glycine, alanine, threonine, methylalanine, sarcosine, lysine and arginine. The amino acid part of the N-acylamino acid is an acidic amino acid from the viewpoint of improving the effect of removing protein stains and preventing the adhesion of stains in combination with the component (B), and providing excellent acid resistance and good low-temperature stability. Preferably, glutamic acid and aspartic acid are more preferable, and glutamic acid is more preferable. Further, these amino acid moieties may be any of D-form, L-form, or a mixture of D-form and L-form, and is preferably L-form.
Ｎ−アシルアミノ酸又はその塩（Ａ）は、１種単独で用いてもよく、２種以上組み合わせて用いてもよい。なかでも、Ｎ−アシルアミノ酸又はその塩（Ａ）としては、タンパク質汚れの除去効果と付着抑制効果、及び優れた耐酸性や良好な低温安定性もたらす観点とを向上する観点から、Ｎ−ラウロイルグルタミン酸、Ｎ−ミリストイルグルタミン酸、Ｎ−ココイルグルタミン酸、Ｎ−ラウロイルアスパラギン酸、又はこれらの塩が好ましく、Ｎ−ラウロイルグルタミン酸、Ｎ−ミリストイルグルタミン酸、又はこれらの塩がより好ましい。 N-acylamino acid or its salt (A) may be used individually by 1 type, and may be used in combination of 2 or more type. Among these, N-acylamino acid or a salt thereof (A) is N-lauroylglutamic acid from the viewpoint of improving the effect of removing protein stains and suppressing adhesion, and providing excellent acid resistance and good low-temperature stability. N-myristoyl glutamic acid, N-cocoyl glutamic acid, N-lauroyl aspartic acid, or a salt thereof is preferable, and N-lauroyl glutamic acid, N-myristoyl glutamic acid, or a salt thereof is more preferable.
Ｎ−アシルアミノ酸塩の塩としては、ナトリウム、カリウム等のアルカリ金属塩；カルシウム、マグネシウム等のアルカリ土類金属塩；アルミニウム、亜鉛等の他の無機塩；アンモニウム塩；モノエタノールアミン、ジエタノールアミン、トリエタノールアミン等の有機アミン塩；アルギニン、リジン、ヒスチジン、オルニチン等の塩基性アミノ酸塩等が挙げられる。これらは、１種単独で用いてもよく、２種以上組み合わせて用いてもよい。。なかでも、Ｎ−アシルアミノ酸塩の塩としては、香味や入手容易性の点から、アルカリ金属塩が好ましく、ナトリウム塩がより好ましい。 Examples of N-acylamino acid salts include alkali metal salts such as sodium and potassium; alkaline earth metal salts such as calcium and magnesium; other inorganic salts such as aluminum and zinc; ammonium salts; monoethanolamine, diethanolamine, tri Organic amine salts such as ethanolamine; basic amino acid salts such as arginine, lysine, histidine, ornithine and the like. These may be used alone or in combination of two or more. . Especially, as a salt of N-acyl amino acid salt, an alkali metal salt is preferable and a sodium salt is more preferable from the point of flavor or availability.
Ｎ−アシルアミノ酸又はその塩（Ａ）の含有量は、後述する成分（Ｂ）のピロリン酸又はその塩と相まってタンパク質汚れの除去効果と付着抑制効果とを飛躍的に高める観点、清掃実効感をもたらす観点、味の観点、及び優れた耐酸性や良好な低温安定性もたらす観点から、本発明の口腔用組成物中に、０．００５質量％以上であって、好ましくは０．００７質量％以上であり、より好ましくは０．０１質量％以上である。Ｎ−アシルアミノ酸又はその塩（Ａ）の含有量は、後述する成分（Ｂ）との併用によるタンパク質汚れの除去効果と付着抑制効果を向上し、かつ苦味とえぐ味を抑制し、清掃実効感を得る観点から、本発明の口腔用組成物中に、０．３質量％以下であって、好ましくは０．２質量％以下であり、より好ましくは０．１質量％以下である。また、Ｎ−アシルアミノ酸又はその塩（Ａ）の含有量は、本発明の口腔用組成物中に、０．００５〜０．３質量％であって、好ましくは０．００７〜０．２質量％であり、より好ましくは０．０１〜０．１質量％である。 The content of the N-acylamino acid or its salt (A), in combination with the pyrophosphoric acid or its salt of the component (B) described later, enhances the effect of removing protein stains and the effect of suppressing adhesion, and has an effective cleaning effect. From the viewpoint of bringing about, the viewpoint of taste, and the viewpoint of bringing about excellent acid resistance and good low temperature stability, the composition for oral cavity of the present invention is 0.005% by mass or more, preferably 0.007% by mass or more. More preferably, the content is 0.01% by mass or more. The content of N-acylamino acid or a salt thereof (A) improves the effect of removing protein stains and suppresses adhesion due to the combined use with component (B) described below, suppresses bitterness and gummy taste, and provides an effective cleaning effect. From the viewpoint of obtaining the above, in the composition for oral cavity of the present invention, it is 0.3% by mass or less, preferably 0.2% by mass or less, and more preferably 0.1% by mass or less. Moreover, content of N-acylamino acid or its salt (A) is 0.005-0.3 mass% in the composition for oral cavity of this invention, Preferably it is 0.007-0.2 mass. %, More preferably 0.01 to 0.1% by mass.
本発明の口腔用組成物は、ピロリン酸又はその塩（Ｂ）を０．００５質量％以上０．５質量％以下含有する。かかる成分（Ｂ）を特定の量で含有することにより、上記成分（Ａ）と相まって、タンパク質汚れの除去効果と付着抑制効果とを飛躍的に高めながら、組成物を使用した後の口腔内における清掃実効感をも十分に高めることができ、加えて、優れた耐酸性や良好な低温安定性をももたらすことが可能である。ピロリン酸塩の塩としては、水への溶解性の点からナトリウム塩、カリウム塩が好ましく、これらピロリン酸又はその塩（Ｂ）を１種単独で用いてもよく、２種以上組み合わせて用いてもよい。なかでも、ピロリン酸又はその塩（Ｂ）としては、タンパク質汚れの除去効果と付着抑制効果の観点、及び優れた耐酸性や良好な低温安定性もたらす観点から、ピロリン酸ナトリウムが好ましい。 The composition for oral cavity of this invention contains 0.005 mass% or more and 0.5 mass% or less of pyrophosphoric acid or its salt (B). By containing such a component (B) in a specific amount, combined with the component (A), the effect of removing protein stains and the effect of suppressing adhesion are dramatically enhanced while the composition is used in the oral cavity. The cleaning effect can be sufficiently enhanced, and in addition, excellent acid resistance and good low-temperature stability can be provided. The salt of pyrophosphate is preferably a sodium salt or a potassium salt from the viewpoint of solubility in water. These pyrophosphoric acids or salts (B) thereof may be used alone or in combination of two or more. Also good. Especially, as a pyrophosphoric acid or its salt (B), a sodium pyrophosphate is preferable from a viewpoint of the removal effect of protein stain | pollution | contamination and an adhesion inhibitory effect, and the viewpoint which brings out the outstanding acid resistance and favorable low-temperature stability.
ピロリン酸又はその塩（Ｂ）の含有量は、上記成分（Ａ）とともにタンパク質汚れの除去効果と付着抑制効果とを相乗的に高める観点、清掃実効感をもたらす観点、及び優れた耐酸性や良好な低温安定性もたらす観点から、本発明の口腔用組成物中に、０．００５質量％以上であって、好ましくは０．０１質量％以上である。ピロリン酸又はその塩（Ｂ）の含有量は、きしみ感を抑制し清掃実効感の低下を抑制し、香味が損なわれるのを防止する点から、本発明の口腔用組成物中に、０．５質量％以下であって、好ましくは０．４質量％以下であり、より好ましくは０．１５質量％以下である。また、ピロリン酸又はその塩（Ｂ）の含有量は、本発明の口腔用組成物中に、０．００５〜０．５質量％であって、好ましくは０．０１〜０．４質量％であり、より好ましくは０．０１〜０．１５質量％である。 The content of pyrophosphoric acid or a salt thereof (B) is synergistically enhanced with the above component (A) to remove protein stains and to prevent adhesion, has a cleaning effect, and has excellent acid resistance and good From the viewpoint of providing low temperature stability, the composition for oral cavity of the present invention is 0.005% by mass or more, and preferably 0.01% by mass or more. In the composition for oral cavity of this invention, content of pyrophosphoric acid or its salt (B) suppresses a feeling of squeaking, suppresses the fall of a cleaning effective feeling, and prevents that a flavor is impaired. It is 5 mass% or less, Preferably it is 0.4 mass% or less, More preferably, it is 0.15 mass% or less. Moreover, content of pyrophosphoric acid or its salt (B) is 0.005-0.5 mass% in the composition for oral cavity of this invention, Preferably it is 0.01-0.4 mass%. Yes, more preferably 0.01 to 0.15 mass%.
上記Ｎ−アシルアミノ酸又はその塩（Ａ）の含有量とピロリン酸又はその塩（Ｂ）の含有量との合計は、タンパク質汚れの除去効果と付着抑制効果とを相乗的に高めつつ、良好な清掃実効感をもたらす観点、及び優れた耐酸性や良好な低温安定性もたらす観点から、０．０１質量％以上であって、好ましくは０．０２質量％以上である。そして成分（Ａ）と成分（Ｂ）の含有量の合計は、歯へのタンパク質汚れの除去効果と付着抑制効果を高める観点、及び清掃実効感を得る観点と味の観点から、０．６質量％以下であって、好ましくは０．４５質量％以下であり、より好ましくは０．３質量％以下であり、さらに好ましくは０．２質量％以下である。また、成分（Ａ）と成分（Ｂ）の含有量の合計は、０．０１〜０．６質量％であって、好ましくは０．０１〜０．４５質量％であり、より好ましくは０．０２〜０．３質量％であり、さらに好ましくは０．０２〜０．２質量％である。 The total of the content of the N-acylamino acid or its salt (A) and the content of pyrophosphoric acid or its salt (B) is good while synergistically enhancing the protein soil removal effect and the adhesion suppression effect. From the viewpoint of providing an effective cleaning effect and from the viewpoint of providing excellent acid resistance and good low-temperature stability, the content is 0.01% by mass or more, and preferably 0.02% by mass or more. And the sum total of content of a component (A) and a component (B) is 0.6 mass from a viewpoint of improving the removal effect and adhesion suppression effect of the protein stain | pollution | contamination to a tooth | gear, and the viewpoint of obtaining cleaning effectiveness, and taste. % Or less, preferably 0.45% by mass or less, more preferably 0.3% by mass or less, and further preferably 0.2% by mass or less. Moreover, the sum total of content of a component (A) and a component (B) is 0.01-0.6 mass%, Preferably it is 0.01-0.45 mass%, More preferably, it is 0.00. It is 02-0.3 mass%, More preferably, it is 0.02-0.2 mass%.
上記Ｎ−アシルアミノ酸又はその塩（Ａ）とピロリン酸又はその塩（Ｂ）との質量比（（Ｂ）／（Ａ））は、良好な香味を保持しつつ、タンパク質汚れの除去効果と付着抑制効果とを相乗的に高める観点、清掃実効感をもたらす観点、及び優れた耐酸性や良好な低温安定性もたらす観点から、０．０５以上であって、好ましくは０．１以上であり、４０以下であって、好ましくは１５以下であり、より好ましくは１２以下である。また、質量比（（Ｂ）／（Ａ））は、０．０５〜４０であって、好ましくは０．１〜１５であり、より好ましくは０．１〜１２である。 The mass ratio ((B) / (A)) of the N-acylamino acid or its salt (A) and pyrophosphoric acid or its salt (B) retains a good flavor and removes and removes protein stains. From the viewpoint of synergistically increasing the suppression effect, from the viewpoint of providing a cleaning effect, and from the viewpoint of providing excellent acid resistance and good low-temperature stability, it is 0.05 or more, preferably 0.1 or more. Or less, preferably 15 or less, more preferably 12 or less. Moreover, mass ratio ((B) / (A)) is 0.05-40, Preferably it is 0.1-15, More preferably, it is 0.1-12.
本発明の口腔用組成物は、上記成分（Ａ）によって泡立ちが低下するのを抑制しつつ良好な使用感を確保する観点、タンパク質汚れの付着抑制効果とタンパク質汚れの除去効果の両立の観点、また後述するように本発明の口腔用組成物が歯磨組成物である場合には、さらにアルキル硫酸塩（Ｃ）を０．５質量％以上２質量％以下含有するのが好ましい。かかるアルキル硫酸塩としては、具体的には、例えば、ラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウム、パルミチル硫酸ナトリウム、ステアリル硫酸ナトリウム、オクチル硫酸ナトリウム、カプリル硫酸ナトリウムが挙げられる。なかでも、アルキル硫酸塩（Ｃ）としては、タンパク質汚れの付着抑制効果を確保しつつタンパク質汚れの除去効果を得る観点から、ラウリル硫酸ナトリウムが好ましい。 The composition for oral cavity of the present invention has a viewpoint of securing a good feeling of use while suppressing the foaming from being lowered by the component (A), a viewpoint of coexistence of the effect of suppressing the adhesion of protein dirt and the effect of removing the protein dirt, Moreover, when the composition for oral cavity of this invention is a dentifrice composition so that it may mention later, it is preferable to contain alkyl sulfate (C) 0.5 mass% or more and 2 mass% or less further. Specific examples of the alkyl sulfate include sodium lauryl sulfate, sodium myristyl sulfate, sodium palmityl sulfate, sodium stearyl sulfate, sodium octyl sulfate, and sodium capryl sulfate. Among these, as the alkyl sulfate (C), sodium lauryl sulfate is preferable from the viewpoint of obtaining the protein soil removal effect while ensuring the protein soil adhesion inhibitory effect.
アルキル硫酸塩（Ｃ）の含有量は、良好な泡立ち、タンパク質汚れの付着抑制効果、及び良好な使用感を確保する観点から、本発明の口腔用組成物中に、好ましくは０．５質量％以上であって、より好ましくは０．８質量％以上であり、さらに好ましくは１．０質量％以上であり、好ましくは２質量％以下であって、より好ましくは１．７質量％以下であり、さらに好ましくは１．５質量％以下である。 The content of the alkyl sulfate (C) is preferably 0.5% by mass in the oral composition of the present invention, from the viewpoint of ensuring good foaming, the effect of suppressing the adhesion of protein stains, and good usability. More preferably, it is 0.8% by mass or more, more preferably 1.0% by mass or more, preferably 2% by mass or less, more preferably 1.7% by mass or less. More preferably, it is 1.5% by mass or less.
上記Ｎ−アシルアミノ酸又はその塩（Ａ）とアルキル硫酸塩（Ｃ）との質量比（（Ｃ）／（Ａ））は、良好な泡立ちを保持しつつタンパク質汚れの付着抑制効果を十分に発揮させる観点から、好ましくは５以上であり、より好ましくは１０以上であり、好ましくは２００以下であり、より好ましくは１５０以下である。また、質量比（（Ｃ）／（Ａ））は、好ましくは５〜２００であり、より好ましくは１０〜１５０である。 The mass ratio ((C) / (A)) of the N-acylamino acid or a salt thereof (A) to the alkyl sulfate (C) sufficiently exhibits the effect of suppressing the adhesion of protein stains while maintaining good foaming. From the viewpoint of making it, it is preferably 5 or more, more preferably 10 or more, preferably 200 or less, more preferably 150 or less. The mass ratio ((C) / (A)) is preferably 5 to 200, more preferably 10 to 150.
本発明の口腔用組成物は、清涼効果を高めて清掃実効感を増大させる観点から、さらに２０℃において水溶液１００ｇに対して５〜４０ｇ溶解する糖アルコール（Ｄ）を含有するのが好ましい。なお、前記水溶液は、水に糖アルコール（Ｄ）を溶解した水溶液を意味する。かかる糖アルコール（Ｄ）としては、口腔内での清涼感及び良好な香味の観点からエリスリトール、マンニトール、α−Ｄ−グルコピラノシル−１，６−ソルビトール、α−Ｄ−グルコピラノシル−１，６−マンニトール、α−Ｄ−グルコピラノシル−１，６−ソルビトールとα−Ｄ−グルコピラノシル−１，６−マンニトールの混合物である還元パラチノースから選ばれる１種又は２種以上が好ましく、適度な溶解性と味の点からエリスリトール、還元パラチノースがより好ましく、良好な清涼感の観点からエリスリトールが好ましい。 The oral composition of the present invention preferably further contains a sugar alcohol (D) that dissolves 5 to 40 g with respect to 100 g of the aqueous solution at 20 ° C. from the viewpoint of enhancing the cooling effect and increasing the cleaning effectiveness. In addition, the said aqueous solution means the aqueous solution which melt | dissolved sugar alcohol (D) in water. Examples of the sugar alcohol (D) include erythritol, mannitol, α-D-glucopyranosyl-1,6-sorbitol, α-D-glucopyranosyl-1,6-mannitol, from the viewpoint of a refreshing feeling in the oral cavity and a good flavor. One or more selected from reduced palatinose, which is a mixture of α-D-glucopyranosyl-1,6-sorbitol and α-D-glucopyranosyl-1,6-mannitol, is preferable, and from the viewpoint of moderate solubility and taste Erythritol and reduced palatinose are more preferable, and erythritol is preferable from the viewpoint of a good refreshing feeling.
成分（Ｄ）の含有量は、すっきりした清涼効果を得る観点から、本発明の口腔用組成物中に、好ましくは２０質量％以上であり、より好ましくは２５質量％以上であり、さらに好ましくは３０質量％以上であり、好ましくは６０質量％以下であり、より好ましくは５５質量％以下であり、さらに好ましくは５０質量％以下である。 The content of the component (D) is preferably 20% by mass or more, more preferably 25% by mass or more, and further preferably from the viewpoint of obtaining a refreshing refreshing effect in the composition for oral cavity of the present invention. It is 30% by mass or more, preferably 60% by mass or less, more preferably 55% by mass or less, and further preferably 50% by mass or less.
本発明の口腔用組成物は、味と使用感の観点から、さらに成分（Ｄ）以外の、２０℃において水溶液１００ｇに対して４０ｇよりも多く溶解する他の糖アルコールを含有することが好ましい。他の糖アルコールとしては、ソルビトール、キシリトールから選ばれるものが好ましく、湿潤剤としても機能するソルビトールが好ましい。成分（Ｄ）以外の糖アルコールの含有量は、使用感の点から、本発明の口腔用組成物中に１０質量％以上であることが好ましく、１５質量％以上がより好ましく、３０質量％以下が好ましい。 It is preferable that the oral composition of this invention contains the other sugar alcohol which melt | dissolves more than 40g with respect to 100g of aqueous solution in 20 degreeC other than a component (D) from a viewpoint of a taste and a usability | use_condition. As other sugar alcohols, those selected from sorbitol and xylitol are preferable, and sorbitol that also functions as a wetting agent is preferable. The content of the sugar alcohol other than the component (D) is preferably 10% by mass or more, more preferably 15% by mass or more, and more preferably 30% by mass or less in the composition for oral cavity of the present invention from the viewpoint of usability. Is preferred.
本発明の口腔用組成物の形態としては、口中に適用できるものであれば特に制限されず、練り歯磨剤や粉歯磨剤等の歯磨組成物、洗口剤や液状歯磨剤等の液体口腔用組成物として用いることができる。なかでも、良好なタンパク質汚れの除去効果と付着抑制効果の点及び良好な清掃実効感の観点から、洗口剤、液状歯磨剤から選ばれる液体口腔用組成物が好ましく、歯ブラシによる物理的な洗浄との併用によってタンパク質汚れの除去効果や付着効果を高める観点から、練歯磨剤が好ましい。 The form of the composition for oral cavity of the present invention is not particularly limited as long as it can be applied to the mouth, and is a dentifrice composition such as a toothpaste or a powder dentifrice, or a liquid oral cavity such as a mouthwash or a liquid dentifrice. It can be used as a composition. Among these, from the viewpoint of good protein stain removal effect and adhesion suppression effect and good cleaning effectiveness, a liquid oral composition selected from a mouthwash and a liquid dentifrice is preferable, and physical cleaning with a toothbrush is preferable. A toothpaste is preferred from the viewpoint of enhancing the effect of removing and adhering protein stains when used together.
本発明の口腔用組成物は、上記成分のほか、水を含有する。これにより、成分（Ａ）及び成分（Ｂ）を溶解又は分散させつつ口腔内で良好に拡散させ、タンパク質汚れの除去効果及び付着抑制効果を有効に発揮させることができる。 The oral composition of the present invention contains water in addition to the above components. Thereby, component (A) and component (B) can be favorably diffused in the oral cavity while being dissolved or dispersed, and the protein soil removal effect and adhesion suppression effect can be effectively exhibited.
例えば、本発明の口腔用組成物が歯磨組成物である場合、かかる水の含有量は、本発明の歯磨組成物１００質量％中に、好ましくは１０質量％以上であり、より好ましくは１２質量％以上であり、好ましくは６０質量％以下であり、より好ましくは５０質量％以下である。また、本発明の口腔用組成物が液体口腔用組成物である場合、かかる水の含有量は、本発明の液体口腔用組成物１００質量％中に、好ましくは５０質量％以上であり、より好ましくは７０質量％以上であり、さらに好ましくは８０質量％以上である。本発明の液体口腔用組成物１００質量％中の水の含有量は、他の成分の残部であり、好ましくは９９.９９質量％以下であり、より好ましくは９９.９８質量％以下であり、さらに好ましくは９９．９８質量％未満である。また、本発明の口腔用組成物が液体口腔用組成物であってさらにノニオン界面活性剤（Ｆ）を含有する場合、かかる水の含有量は、本発明の液体口腔用組成物１００質量％中に、好ましくは５０質量％以上であり、より好ましくは７０質量％以上であり、さらに好ましくは８０質量％以上であり、さらに好ましくは８６質量％以上であり、好ましくは９９質量％以下であり、より好ましくは９５質量％以下であり、さらに好ましくは９２質量％未満である。 For example, when the composition for oral cavity of the present invention is a dentifrice composition, the content of such water is preferably 10% by mass or more, more preferably 12% by mass in 100% by mass of the dentifrice composition of the present invention. % Or more, preferably 60% by mass or less, more preferably 50% by mass or less. Further, when the oral composition of the present invention is a liquid oral composition, the content of such water is preferably 50% by mass or more in 100% by mass of the liquid oral composition of the present invention. Preferably it is 70 mass% or more, More preferably, it is 80 mass% or more. The content of water in 100% by mass of the liquid oral composition of the present invention is the balance of the other components, preferably 99.99% by mass or less, more preferably 99.98% by mass or less, More preferably, it is less than 99.98 mass%. Further, when the oral composition of the present invention is a liquid oral composition and further contains a nonionic surfactant (F), the content of such water is in 100% by mass of the liquid oral composition of the present invention. In addition, it is preferably 50% by mass or more, more preferably 70% by mass or more, further preferably 80% by mass or more, further preferably 86% by mass or more, and preferably 99% by mass or less. More preferably, it is 95 mass% or less, More preferably, it is less than 92 mass%.
本発明の口腔用組成物が歯磨組成物である場合、その水分量は、配合した水分量及び配合した成分中の水分量から計算によって算出することもできるが、例えばカールフィッシャー水分計で測定することができる。カールフィッシャー水分計としては、例えば、微量水分測定装置（平沼産業（株））を用いることができる。この装置では、歯磨組成物を５ｇとり、無水メタノール２５ｇに懸濁させ、この懸濁液０．０２ｇを分取して水分量を測定することができる。 When the oral composition of the present invention is a dentifrice composition, its water content can be calculated from the blended moisture content and the moisture content in the blended component, but is measured, for example, with a Karl Fischer moisture meter. be able to. As the Karl Fischer moisture meter, for example, a trace moisture measuring device (Hiranuma Sangyo Co., Ltd.) can be used. In this apparatus, 5 g of the dentifrice composition can be taken and suspended in 25 g of anhydrous methanol, and 0.02 g of this suspension can be collected to measure the amount of water.
本発明の口腔用組成物が歯磨組成物である場合は、さらに粘結剤（Ｅ）を含有することが好ましい。粘結剤（Ｅ）としては、アルギン酸ナトリウム、カルボキシメチルセルロースナトリウム、カラギーナン、キサンタンガム、ポリアクリル酸ナトリウム、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ペクチン、トラガントガム、アラビアガム、グアーガム、カラヤガム、ローカストビーンガム、ジェランガム、タマリンドガム、サイリウムシードガム、ポリビニルアルコール、コンドロイチン硫酸ナトリウム及びメトキシエチレン無水マレイン酸共重合体等からなる群より選ばれる１種又は２種以上を用いることができる。なかでも、粘結剤（Ｅ）は、エーテル化度が０．７〜２．０のカルボキシメチルセルロースナトリウム、カラギーナン、キサンタンガムから選ばれる１種又は２種以上が好ましく、２種以上がより好ましい。粘結剤（Ｅ）の含有量は、本発明の口腔用組成物中に、好ましくは０．３質量％以上であり、より好ましくは０．４質量％以上であり、好ましくは２質量％以下であり、より好ましくは１．５質量％以下である。また、本発明の口腔用組成物が歯磨組成物である場合は、粘結剤（Ｅ）とともに、増粘性シリカ（ＪＩＳ Ｋ５１０１-１３-２に準ずる方法により測定される吸油量が、２００〜４００ｍＬ／１００ｇ）を１質量％以上１２質量％以下含有することが好ましい。 When the composition for oral cavity of this invention is a dentifrice composition, it is preferable to contain a binder (E) further. As binder (E), sodium alginate, sodium carboxymethylcellulose, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind One or more selected from the group consisting of gum, psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate, methoxyethylene maleic anhydride copolymer and the like can be used. Among these, the binder (E) is preferably one or more selected from sodium carboxymethylcellulose having a degree of etherification of 0.7 to 2.0, carrageenan, and xanthan gum, and more preferably two or more. The content of the binder (E) is preferably 0.3% by mass or more, more preferably 0.4% by mass or more, and preferably 2% by mass or less in the oral composition of the present invention. More preferably, it is 1.5 mass% or less. Moreover, when the composition for oral cavity of this invention is a dentifrice composition, the oil absorption amount measured by the method according to thickening silica (JIS K5101-12-2) with a binder (E) is 200-400 mL. / 100 g) is preferably contained in an amount of 1% by mass to 12% by mass.
本発明の口腔用組成物が歯磨組成物である場合は、本発明の効果を阻害しない範囲でさらに研磨剤を含有することができる。研磨剤としては、例えばリン酸カルシウム、リン酸水素カルシウム、炭酸カルシウム、水酸化アルミニウム、ケイ酸アルミニウム、ケイ酸ジルコニウム、研磨性シリカ（ＪＩＳ Ｋ５１０１−１３−２に準ずる方法により測定される吸油量が、５０〜１５０ｍＬ／１００ｇ）等が挙げられる。研磨剤は、ＲＤＡ値（Radioactive Dentine Abrasion values、ＩＳＯ１１６０９研磨性の試験方法 付随書Ａにより測定される値）が２０〜２５０のものが一般に用いられる。本発明の口腔用組成物は、高いタンパク質汚れの除去効果と付着抑制効果に加え、優れた清掃実効感をもたらすことから、研磨剤の含有量を低減しても優れた効果を発揮することができる。研磨剤の含有量は、本発明の口腔用組成物中に、好ましくは１質量％以上であり、好ましくは２０質量％以下であり、より好ましくは１０質量％以下である。 When the composition for oral cavity of the present invention is a dentifrice composition, an abrasive can be further contained as long as the effects of the present invention are not impaired. As the abrasive, for example, calcium phosphate, calcium hydrogen phosphate, calcium carbonate, aluminum hydroxide, aluminum silicate, zirconium silicate, abrasive silica (oil absorption measured by a method according to JIS K5101-13-3 is 50 -150mL / 100g) etc. are mentioned. As the abrasive, one having an RDA value (Radioactive Dentine Abrasion values, a value measured by ISO 11609 abrasive test method appendix A) of 20 to 250 is generally used. The composition for oral cavity of the present invention brings about excellent cleaning effectiveness in addition to the high protein soil removal effect and adhesion suppression effect, and therefore can exhibit excellent effects even if the content of the abrasive is reduced. it can. The content of the abrasive is preferably 1% by mass or more, preferably 20% by mass or less, and more preferably 10% by mass or less in the composition for oral cavity of the present invention.
本発明の口腔用組成物は、さらにノニオン界面活性剤（Ｆ）を含有することが好ましい。かかる成分（Ｆ）を含有することにより、耐酸性を高めて歯牙表面からのカルシウムイオンの溶出を有用に抑制することができるとともに、良好な低温安定性を付与することができる。また、プラーク中に沈殿したリン酸カルシウム分がハイドロキシアパタイトに付着するのを有効に抑制することもできる。成分（Ｆ）としては、グリセリン脂肪酸エステル、ショ糖脂肪酸エステル、平均付加モル数が６０未満、好ましくは平均付加モル数が４０以下のポリオキシエチレン硬化ヒマシ油が挙げられる。これらは１種単独で用いてもよく、２種組み合わせて用いてもよい。なかでも、有効に耐酸性を高め、リン酸カルシウムの付着を抑制する観点、及び低温安定性を効果的に付与する観点から、グリセリン脂肪酸エステル、ショ糖脂肪酸エステルが好ましい。成分（Ｆ）の含有量は、耐酸性を高め、リン酸カルシウムの付着を抑制する観点、及び低温安定性を付与する観点から、本発明の口腔用組成物中に、好ましくは０．０１質量％以上であり、より好ましくは０．０５質量％以上であり、さらに好ましくは０．１質量％以上である。成分（Ｆ）の含有量は、味・使用感の観点から、本発明の口腔用組成物中に、好ましくは２質量％以下であり、より好ましくは１質量％以下であり、さらに好ましくは０．８質量％以下である。 The oral composition of the present invention preferably further contains a nonionic surfactant (F). By containing such a component (F), the acid resistance can be enhanced to effectively suppress the elution of calcium ions from the tooth surface, and good low temperature stability can be imparted. Moreover, it can also suppress effectively that the calcium-phosphate component precipitated in the plaque adheres to hydroxyapatite. Examples of the component (F) include glycerin fatty acid ester, sucrose fatty acid ester, and polyoxyethylene hydrogenated castor oil having an average added mole number of less than 60, preferably an average added mole number of 40 or less. These may be used individually by 1 type and may be used in combination of 2 types. Among these, glycerin fatty acid ester and sucrose fatty acid ester are preferable from the viewpoint of effectively increasing acid resistance, suppressing adhesion of calcium phosphate, and effectively imparting low temperature stability. The content of the component (F) is preferably 0.01% by mass or more in the oral composition of the present invention from the viewpoint of enhancing acid resistance, suppressing adhesion of calcium phosphate, and imparting low temperature stability. More preferably, it is 0.05 mass% or more, More preferably, it is 0.1 mass% or more. The content of the component (F) is preferably 2% by mass or less, more preferably 1% by mass or less, and still more preferably 0 in the composition for oral cavity of the present invention from the viewpoint of taste and feeling of use. 0.8 mass% or less.
本発明の口腔用組成物は、さらに、本発明の効果を阻害しない範囲で、フッ化スズ、フッ化ナトリウム、フッ化アンモニウム等のフッ素イオン供給化合物、モノフルオロリン酸ナトリウム等のフッ化物のほか、乳酸アルミニウム、リン酸カルシウム、ヒドロキシアパタイト、アルギニン-炭酸カルシウム等の象牙質知覚過敏用成分；グリセリン、ポリエチレングリコール、プロピレングリコール等の湿潤剤；甘味剤；香料；ｐＨ調整剤；カチオン性殺菌剤等の殺菌剤；抗炎症剤；防腐剤；植物抽出物；その他有効成分等を含有することができる。 The composition for oral cavity of the present invention further includes a fluoride ion supply compound such as tin fluoride, sodium fluoride and ammonium fluoride, and a fluoride such as sodium monofluorophosphate as long as the effects of the present invention are not impaired. , Aluminum lactate, calcium phosphate, hydroxyapatite, arginine-calcium carbonate and other dentin hypersensitivity ingredients; glycerin, polyethylene glycol, propylene glycol and other moisturizers; sweeteners; fragrances; pH adjusters; An agent; an anti-inflammatory agent; an antiseptic; a plant extract; and other active ingredients.
上述した実施態様に関し、本発明はさらに以下の口腔用組成物を開示する。
［１］次の成分（Ａ）及び（Ｂ）：
（Ａ）Ｎ−アシルアミノ酸又はその塩 ０．００５質量％以上０．３質量％以下 及び
（Ｂ）ピロリン酸又はその塩 ０．００５質量％以上０．５質量％以下
を含有し、成分（Ａ）と成分（Ｂ）の質量比（（Ｂ）／（Ａ））が０．０５以上４０以下であり、かつ成分（Ａ）と成分（Ｂ）の含有量の合計が０．０１質量％以上０．６質量％以下である口腔用組成物。
［２］成分（Ａ）と成分（Ｂ）の質量比（（Ｂ）／（Ａ））は、０．０５以上であって、好ましくは０．１以上であり、４０以下であって、好ましくは１５以下であり、より好ましくは１２以下である上記［１］の口腔用組成物。
［３］成分（Ａ）と成分（Ｂ）の含有量の合計は、０．０１質量％以上であって、好ましくは０．０２質量％以上であり、０．６質量％以下であって、好ましくは０．４５質量％以下であり、より好ましくは０．３質量％以下である上記［１］又は［２］の口腔用組成物。
This invention discloses the following oral compositions further regarding the embodiment mentioned above.
[1] The following components (A) and (B):
(A) N-acylamino acid or salt thereof 0.005 mass% or more and 0.3 mass% or less and (B) pyrophosphoric acid or salt thereof 0.005 mass% or more and 0.5 mass% or less, and component (A ) And component (B) mass ratio ((B) / (A)) is 0.05 or more and 40 or less, and the total content of component (A) and component (B) is 0.01% by mass or more. The composition for oral cavity which is 0.6 mass% or less.
[2] The mass ratio ((B) / (A)) of the component (A) to the component (B) is 0.05 or more, preferably 0.1 or more, and 40 or less, preferably The composition for oral cavity according to the above [1], which is 15 or less, more preferably 12 or less.
[3] The total content of the component (A) and the component (B) is 0.01% by mass or more, preferably 0.02% by mass or more, and 0.6% by mass or less, The composition for oral cavity according to the above [1] or [2], which is preferably 0.45% by mass or less, more preferably 0.3% by mass or less.
［４］成分（Ａ）の含有量は、０．００５質量％以上であって、好ましくは０．００７質量％以上であり、より好ましくは０．０１質量％以上であり、０．３質量％以下であって、好ましくは０．２質量％以下であり、より好ましくは０．１質量％以下である上記［１］〜［３］のいずれか１記載の口腔用組成物。
［５］成分（Ａ）は、炭素数６〜２２のアシル基を有し、より好ましくは炭素数１０〜２０のアシル基を有し、さらに好ましくは炭素数１２〜１８のアシル基を有する上記［１］〜［４］のいずれか１記載の口腔用組成物。
［６］成分（Ａ）は、Ｎ−アシル酸性アミノ酸又はその塩である上記［１］〜［５］のいずれか１記載の口腔用組成物。
［７］成分（Ａ）は、Ｎ−ラウロイルグルタミン酸、Ｎ−ミリストイルグルタミン酸、Ｎ−ココイルグルタミン酸、Ｎ−ラウロイルアスパラギン酸及びこれらの塩から選ばれる１種又は２種以上であり、より好ましくはＮ−ラウロイルグルタミン酸、Ｎ−ミリストイルグルタミン酸及びこれらの塩から選ばれる１種又は２種以上である上記［１］〜［６］のいずれか１記載の口腔用組成物。
[4] The content of component (A) is 0.005% by mass or more, preferably 0.007% by mass or more, more preferably 0.01% by mass or more, and 0.3% by mass. The composition for oral cavity according to any one of [1] to [3] above, which is preferably 0.2% by mass or less, more preferably 0.1% by mass or less.
[5] Component (A) has an acyl group having 6 to 22 carbon atoms, more preferably has an acyl group having 10 to 20 carbon atoms, and more preferably has an acyl group having 12 to 18 carbon atoms. The composition for oral cavity according to any one of [1] to [4].
[6] The composition for oral cavity according to any one of the above [1] to [5], wherein the component (A) is an N-acyl acidic amino acid or a salt thereof.
[7] Component (A) is one or more selected from N-lauroyl glutamic acid, N-myristoyl glutamic acid, N-cocoyl glutamic acid, N-lauroyl aspartic acid and salts thereof, and more preferably N- The composition for oral cavity according to any one of [1] to [6] above, which is one or more selected from lauroylglutamic acid, N-myristoylglutamic acid, and salts thereof.
［８］成分（Ｂ）の含有量は、０．００５質量％以上であって、好ましくは０．０１質量％以上であり、０．５質量％以下であって、好ましくは０．４質量％以下であり、より好ましくは０．１５質量％以下である上記［１］〜［７］のいずれか１記載の口腔用組成物。
［９］成分（Ｂ）は、ピロリン酸又はそのアルカリ金属塩であり、より好ましくはピロリン酸ナトリウムである上記［１］〜［８］のいずれか１記載の口腔用組成物。
[8] The content of component (B) is 0.005% by mass or more, preferably 0.01% by mass or more, and 0.5% by mass or less, preferably 0.4% by mass. The composition for oral cavity according to any one of [1] to [7] above, more preferably 0.15% by mass or less.
[9] The composition for oral cavity according to any one of [1] to [8], wherein component (B) is pyrophosphoric acid or an alkali metal salt thereof, more preferably sodium pyrophosphate.
［１０］さらにアルキル硫酸塩（Ｃ）を含有する上記［１］〜［９］のいずれか１記載の口腔用組成物。
［１１］アルキル硫酸塩は、ラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウム、パルミチル硫酸ナトリウム、ステアリル硫酸ナトリウム、オクチル硫酸ナトリウム及びカプリル硫酸ナトリウムから選ばれる１種又は２種以上であり、より好ましくはラウリル硫酸ナトリウムである上記［１０］の口腔用組成物。
［１２］成分（Ｃ）の含有量は、０．５質量％以上であって、より好ましくは０．８質量％以上であり、さらに好ましくは１．０質量％以上であり、２質量％以下であって、より好ましくは１．７質量％以下であり、さらに好ましくは１．５質量％以下である上記［１０］又は［１１］の口腔用組成物。
［１３］成分（Ａ）と成分（Ｃ）との質量比（（Ｃ）／（Ａ））は、５以上であり、より好ましくは１０以上であり、２００以下であり、より好ましくは１５０以下である上記［１０］〜［１２］のいずれか１記載の口腔用組成物。
[10] The composition for oral cavity according to any one of [1] to [9], further containing an alkyl sulfate (C).
[11] The alkyl sulfate is one or more selected from sodium lauryl sulfate, sodium myristyl sulfate, sodium palmityl sulfate, sodium stearyl sulfate, sodium octyl sulfate and sodium capryl sulfate, more preferably sodium lauryl sulfate. A composition for oral cavity according to [10] above.
[12] The content of component (C) is 0.5% by mass or more, more preferably 0.8% by mass or more, still more preferably 1.0% by mass or more, and 2% by mass or less. The composition for oral cavity according to the above [10] or [11], which is more preferably 1.7% by mass or less, and further preferably 1.5% by mass or less.
[13] The mass ratio ((C) / (A)) between the component (A) and the component (C) is 5 or more, more preferably 10 or more, and 200 or less, more preferably 150 or less. The composition for oral cavity according to any one of the above [10] to [12].
［１４］さらに２０℃において水溶液１００ｇに対して５〜４０ｇ溶解する糖アルコール（Ｄ）を含有する上記［１］〜［１３］のいずれか１記載の口腔用組成物。
［１５］成分（Ｄ）は、エリスリトール、マンニトール、α−Ｄ−グルコピラノシル−１，６−ソルビトール、α−Ｄ−グルコピラノシル−１，６−マンニトール、α−Ｄ−グルコピラノシル−１，６−ソルビトールとα−Ｄ−グルコピラノシル−１，６−マンニトールの混合物である還元パラチノースから選ばれる１種又は２種以上であり、より好ましくはエリスリトールである上記［１４］の口腔用組成物。
［１６］成分（Ｄ）の含有量は、２０質量％以上６０質量％以下であり、より好ましくは２５質量％以上５５質量％以下であり、さらに好ましくは３０質量％以上５０質量％以下である上記［１４］又は［１５］の口腔用組成物。
［１７］さらに成分（Ｄ）以外の他の糖アルコールを含有する上記［１］〜［１６］いずれか１記載の口腔用組成物。
[14] The composition for oral cavity according to any one of [1] to [13], further containing a sugar alcohol (D) that dissolves 5 to 40 g with respect to 100 g of the aqueous solution at 20 ° C.
[15] Component (D) is erythritol, mannitol, α-D-glucopyranosyl-1,6-sorbitol, α-D-glucopyranosyl-1,6-mannitol, α-D-glucopyranosyl-1,6-sorbitol and α -The composition for oral cavity of said [14] which is 1 type (s) or 2 or more types chosen from the reduced palatinose which is a mixture of -D-glucopyranosyl-1, 6-mannitol, More preferably, it is erythritol.
[16] The content of component (D) is 20% by mass or more and 60% by mass or less, more preferably 25% by mass or more and 55% by mass or less, and further preferably 30% by mass or more and 50% by mass or less. The composition for oral cavity according to the above [14] or [15].
[17] The composition for oral cavity according to any one of the above [1] to [16], further containing a sugar alcohol other than the component (D).
［１８］歯磨組成物である場合における水の含有量は、１０質量％以上６０質量％以下であり、より好ましくは１２質量％以上５０質量％以下であり、液体口腔用組成物である場合における水の含有量は、５０質量％以上９９.９９質量％以下であり、より好ましくは７０質量％以上９９.９８質量％以下である上記［１］〜［１７］のいずれか１記載の口腔用組成物。
［１９］さらに研磨剤を１質量％以上２０質量％、より好ましくは１質量％以上１０質量％以下含有する上記［１］〜［１８］のいずれか１記載の口腔用組成物。
［２０］さらに粘結剤（Ｅ）を含有する上記［１］〜［１９］のいずれか１記載の口腔用組成物。
［２１］成分（Ｅ）の含有量は、０．３質量％以上であり、好ましくは０．４質量％以上であり、２質量％以下であり、好ましくは１．５質量％以下である上記［２０］記載の口腔用組成物。
[18] The content of water in the case of a dentifrice composition is 10% by mass or more and 60% by mass or less, more preferably 12% by mass or more and 50% by mass or less, and in the case of a liquid oral composition. Water content is 50 mass% or more and 99.99 mass% or less, More preferably, it is 70 mass% or more and 99.98 mass% or less, It is for oral cavity any one of said [1]-[17]. Composition.
[19] The composition for oral cavity according to any one of [1] to [18], further containing an abrasive in an amount of 1% by mass to 20% by mass, more preferably 1% by mass to 10% by mass.
[20] The composition for oral cavity according to any one of [1] to [19], further containing a binder (E).
[21] The content of component (E) is 0.3% by mass or more, preferably 0.4% by mass or more, 2% by mass or less, and preferably 1.5% by mass or less. [20] The composition for oral cavity according to [20].
［２２］さらに（Ｆ）ノニオン界面活性剤を含有する上記［１］〜［２１］のいずれか１記載の口腔用組成物。
［２３］成分（Ｆ）が、グリセリン脂肪酸エステル及びショ糖脂肪酸エステルから選ばれる１種又は２種である上記［２２］記載の口腔用組成物。
［２４］成分（Ｆ）の含有量は、０．０１質量％以上であり、好ましくは０．０５質量％以上であり、より好ましくは０．１質量％以上であり、２質量％以下であり、好ましくは１質量％以下であり、より好ましくは０．８質量％以下である上記［２２］又は［２３］記載の口腔用組成物。
［２５］歯磨組成物である上記［１］〜［２１］の口腔用組成物。
［２６］液体口腔用組成物である上記［２２］〜［２４］の口腔用組成物。
[22] The composition for oral cavity according to any one of [1] to [21], further comprising (F) a nonionic surfactant.
[23] The composition for oral cavity according to the above [22], wherein the component (F) is one or two selected from glycerin fatty acid ester and sucrose fatty acid ester.
[24] The content of component (F) is 0.01% by mass or more, preferably 0.05% by mass or more, more preferably 0.1% by mass or more, and 2% by mass or less. The composition for oral cavity according to the above [22] or [23], which is preferably 1% by mass or less, more preferably 0.8% by mass or less.
[25] The composition for oral cavity according to the above [1] to [21], which is a dentifrice composition.
[26] The oral composition of [22] to [24], which is a liquid oral composition.
以下、本発明について、実施例に基づき具体的に説明する。なお、表中に特に示さない限り、各成分の含有量は質量％を示す。 Hereinafter, the present invention will be specifically described based on examples. In addition, unless otherwise indicated in a table | surface, content of each component shows the mass%.
［実施例１〜８、比較例１〜２］
表１に示す処方にしたがい、ｐＨ７に調整した液体口腔用組成物を調製し、下記方法にしたがって、タンパク質汚れの除去効果、タンパク質汚れの付着抑制効果及び洗浄性を評価した。
なお、表１に示す各液体口腔用組成物は、全量１００質量％となるように調製した。
[Examples 1-8, Comparative Examples 1-2]
According to the formulation shown in Table 1, a liquid oral composition adjusted to pH 7 was prepared, and the protein soil removal effect, protein soil adhesion inhibitory effect and detergency were evaluated according to the following methods.
In addition, each liquid oral cavity composition shown in Table 1 was prepared so that it might become 100 mass% of total quantity.
《タンパク質汚れの除去効果の評価試験》
ヒドロキシアパタイト（ＨＡｐ）粉（ＨＡＰ-２００ 太平化学産業（株））５０ｍｇを精製水５ｍｌと混合した懸濁液を製造した。次に、懸濁液にアルブミン（ウシ血清由来 和光純薬（株）ｐＨ５．２）１５ｍｇを加えて振動させながら９０分間おいた。なお、振動は、振盪機（ＣＵＴＥ ＭＩＸＥＲ ＣＭ―１０００（ＥＹＥＲＡ東京理化器械（株）））を用いて行った。
<Evaluation test of protein stain removal effect>
A suspension in which 50 mg of hydroxyapatite (HAp) powder (HAP-200 Taihei Chemical Industrial Co., Ltd.) was mixed with 5 ml of purified water was produced. Next, 15 mg of albumin (bovine serum-derived Wako Pure Chemical Industries, Ltd. pH 5.2) was added to the suspension and allowed to stand for 90 minutes while shaking. The vibration was performed using a shaker (CUTE MIXER CM-1000 (EYERA Tokyo Rika Kikai Co., Ltd.)).
その後、ＨＡｐを懸濁液ごと遠心分離機（３０００ｒｍｐ、５分）にかけた後に上澄み液を吸引除去し、洗浄（精製水５ｍＬを加えて再度遠心分離した後に上澄み液を吸引除去する）を２回繰り返した。洗浄後のＨＡｐと精製水５ｍＬを混合し、懸濁液を製造し、懸濁液から７５μＬずつ取り出し、再度遠心分離機にかけた後に上澄み液を吸引除去して各液体口腔用組成物の評価のためのＨＡｐを準備した。これらの洗浄後のＨＡｐに、各液体口腔用組成物１ｍＬを加え、２分間攪拌した。次いで、遠心分離機にかけた後に上澄み液を誘引除去し、前述と同様にして精製水３００ｍＬによる洗浄を行った。洗浄後のＨＡｐに１Ｎ塩酸 １００μＬ、リン酸バッファー（０．１ｍｏｌ ｐＨ８．４）１ｍＬを加えて攪拌した溶液から、４００μＬを取り出し、蛍光色素溶液（フルオレスカミン ０．３ｍｇ／ｍＬ アセトン溶液）１５０μＬを加えて混合した。この蛍光色素液を混合した混合溶液から、さらに２００μＬを取り出して暗所に３０分間静置した。なお、静置を含み、試験は全て室温（２０℃）で行った。 Then, after the HAp is put together with the suspension in a centrifuge (3000 rpm, 5 minutes), the supernatant is removed by aspiration, and washed (5 mL of purified water is added and centrifuged again, and the supernatant is removed by aspiration) twice. Repeated. The washed HAp and purified water (5 mL) are mixed to produce a suspension, 75 μL is taken out from the suspension, centrifuged again, and the supernatant is removed by suction to evaluate each liquid oral composition. HAp was prepared for. 1 mL of each liquid oral composition was added to these washed HAp and stirred for 2 minutes. Next, after centrifuging, the supernatant was attracted and removed, and washed with 300 mL of purified water in the same manner as described above. 400 μL is taken out from the solution obtained by adding 100 μL of 1N hydrochloric acid and 1 mL of phosphate buffer (0.1 mol pH 8.4) to the washed HAp, and adding 150 μL of a fluorescent dye solution (fluorescamine 0.3 mg / mL acetone solution). Added and mixed. A further 200 μL was taken out from the mixed solution mixed with the fluorescent dye solution and allowed to stand in the dark for 30 minutes. All tests were conducted at room temperature (20 ° C.), including standing.
次に、ＨＡｐに残存するタンパク質の量（タンパク質残存量）を、蛍光を測定することにより求めた。蛍光の測定には、マイクロプレート蛍光光度計 Ｇｅｍｉｎｉ ＥＭ（モレキュラーデバイス(株)）を用い、励起光波長３６０ｎｍにて蛍光波長４８０ｎｍの測定を行った。各濃度のアルブミンのリン酸バッファー液（リン酸バッファー０．１ｍｏｌ、ｐＨ８．４）の蛍光の測定結果を元に検量線を作製し、蛍光の測定結果からタンパク質残存量へ換算した。 Next, the amount of protein remaining in HAp (protein residual amount) was determined by measuring fluorescence. For measurement of fluorescence, a microplate fluorometer Gemini EM (Molecular Device Co., Ltd.) was used, and a fluorescence wavelength of 480 nm was measured at an excitation light wavelength of 360 nm. A calibration curve was prepared based on the fluorescence measurement results of the phosphate buffer solution of each concentration of albumin (phosphate buffer 0.1 mol, pH 8.4), and converted to the protein residual amount from the fluorescence measurement results.
上述の評価試験において、液体口腔用組成物を精製水とした以外は、同様にしてタンパク質残存量を求め、この値を１００として、各液体口腔用組成物について求めたタンパク質残存量から、タンパク質除去率（％）を算出した。結果を表１に示すとともに、実施例１及び比較例１〜２の結果を図１に示す。 In the above evaluation test, except that the liquid oral composition was purified water, the amount of remaining protein was determined in the same manner, and this value was taken as 100, and the protein removal was performed from the amount of remaining protein determined for each liquid oral composition. The rate (%) was calculated. While showing a result in Table 1, the result of Example 1 and Comparative Examples 1-2 is shown in FIG.
《タンパク質汚れの付着抑制効果の評価試験》
ヒドロキシアパタイト（ＨＡｐ）粉（ＨＡＰ-２００ 太平化学産業（株））５０ｍｇを精製水５ｍｌと混合した懸濁液を製造した。次に、このＨＡｐ懸濁液を７５μＬずつ取り出し、遠心分離機（３０００ｒｐｍ、５分）にかけた後に上澄み液を吸引除去して各液体口腔用組成物の評価用のＨＡｐを準備した。これらの洗浄後のＨＡｐに液体口腔用組成物１ｍＬを加え、２分間攪拌した後、前述と同様に精製水３００ｍＬによる洗浄を２回行った。次にアルブミン水溶液（ウシ血清由来 和光純薬（株）ｐＨ５．２、３ｍｇ／ｍＬ）７５μＬを加え、前述と同様にして振動させながら９０分間おいた。次に、遠心分離機（３０００ｒｍｐ、５分）にかけた後に上澄み液を吸引除去し、前述と同様に精製水３００ｍＬによる洗浄を２回行った。洗浄後のＨＡｐに１Ｎ塩酸 １００μＬ、リン酸バッファー（０．１ｍｏｌ ｐＨ８．４）１ｍＬを加えて攪拌した後、４００μＬを取り出し、蛍光色素溶液（フルオレスカミン ０．３ｍｇ／ｍＬ アセトン溶液）１５０μＬを混合した。この蛍光色素溶液を混合した溶液から、さらに２００μＬを取り出して暗所に３０分間静置した。静置後、ＨＡｐに付着したタンパク質の量（タンパク質付着量）を、前述と同様の蛍光測定により求めた。
<Evaluation test of protein dirt adhesion suppression effect>
A suspension in which 50 mg of hydroxyapatite (HAp) powder (HAP-200 Taihei Chemical Industrial Co., Ltd.) was mixed with 5 ml of purified water was produced. Next, 75 μL of this HAp suspension was taken out and subjected to a centrifuge (3000 rpm, 5 minutes), and then the supernatant was removed by suction to prepare HAp for evaluation of each liquid oral composition. 1 mL of the liquid oral composition was added to these washed HAp and stirred for 2 minutes, followed by washing with 300 mL of purified water twice as described above. Next, 75 μL of an albumin aqueous solution (bovine serum-derived Wako Pure Chemical Industries, Ltd., pH 5.2, 3 mg / mL) was added, and the mixture was allowed to stand for 90 minutes while vibrating as described above. Next, after centrifuging (3000 rpm, 5 minutes), the supernatant was removed by suction and washed with 300 mL of purified water twice as described above. After adding 1 mL of 1N hydrochloric acid and 1 mL of phosphate buffer (0.1 mol pH 8.4) to the washed HAp and stirring, 400 μL is taken out and mixed with 150 μL of fluorescent dye solution (fluorescamine 0.3 mg / mL acetone solution) did. A further 200 μL was taken out from the solution mixed with the fluorescent dye solution and allowed to stand in the dark for 30 minutes. After standing, the amount of protein adhering to HAp (protein adhesion amount) was determined by fluorescence measurement as described above.
上述のタンパク質汚れ付着抑制効果の評価試験において、液体口腔用組成物を精製水とした以外は、同様にしてタンパク質付着量を求め、この値を１００として、各液体口腔用組成物について求めたタンパク質残存量からタンパク質汚れ抑制率（％）を算出した。結果を表１に示すとともに、実施例１及び比較例１、２の結果を図２に示す。 In the above-described evaluation test of the protein dirt adhesion inhibitory effect, the amount of protein adhesion was determined in the same manner except that the liquid oral composition was purified water, and this value was taken as 100 to determine the protein determined for each liquid oral composition. The protein stain inhibition rate (%) was calculated from the remaining amount. The results are shown in Table 1, and the results of Example 1 and Comparative Examples 1 and 2 are shown in FIG.
表１及び図１の結果より、成分（Ａ）のみを０．０１質量％含有する比較例２にはタンパク質汚れの除去効果がないものの、成分（Ｂ）のみを０．０１質量％含有する比較例１で示されるタンパク質汚れ除去率に対して、成分（Ｂ）０．０１質量％と成分（Ａ）０．０１質量％を併用する実施例１は、約２倍ものタンパク質汚れ除去率を示しており、タンパク質汚れ付着抑制率も飛躍的に向上していることが確認できる。 From the results of Table 1 and FIG. 1, although Comparative Example 2 containing only 0.01% by mass of component (A) does not have the effect of removing protein stains, a comparison containing only 0.01% by mass of component (B) Example 1 that uses 0.01% by mass of component (B) and 0.01% by mass of component (A) with respect to the protein soil removal rate shown in Example 1 shows a protein soil removal rate of about twice as much. It can be confirmed that the protein dirt adhesion inhibition rate is also dramatically improved.
これらの結果より、本発明の口腔用組成物は、上記特定の量の成分（Ａ）及び成分（Ｂ）を、特定の質量比及び特定の合計量で含有すれば、成分（Ａ）又は成分（Ｂ）を単独で用いる場合に比べ、高いタンパク質汚れの除去効果及び付着抑制効果を発揮する、優れた洗浄性を有し、これら成分（Ａ）及び成分（Ｂ）の併用に拠る効果を十分に発揮できることが容易にわかる。 From these results, if the composition for oral cavity of the present invention contains the specific amount of component (A) and component (B) in a specific mass ratio and a specific total amount, component (A) or component Compared with the case where (B) is used alone, it exhibits excellent detergency that exhibits a high protein stain removal effect and adhesion suppression effect, and has sufficient effects due to the combined use of these components (A) and (B). It is easy to see that
［実施例９〜１７、比較例３〜６］
表２に示す処方の歯磨組成物を調製し、下記方法にしたがって、使用後の歯面の感触の評価、及び味の評価を行った。
結果を表２〜３に示す。
[Examples 9 to 17, Comparative Examples 3 to 6]
A dentifrice composition having the formulation shown in Table 2 was prepared, and the feel of the tooth surface after use and the taste were evaluated according to the following methods.
The results are shown in Tables 2-3.
《使用後の歯面の感触》
得られた歯磨組成物１ｇを歯ブラシにとって２分間歯をブラッシングした後、口腔内を水で数回すすぎ、その後の歯面を舌で触ったときの感触を下記基準にしたがって評価した。評価は専門パネラー２名で行い、協議による評価結果を表２に示す。
ＡＡ：歯面がなめらかな感触であり、清掃実効感が高い。
Ａ ：歯面がややきしむが、清掃実効感はある。
Ｂ ：歯面がなめらかでなく、清掃実効感に乏しい。
Ｃ ：歯面がギシギシする（歯面に摩擦を強く感じる）
<Feeling of tooth surface after use>
After brushing the teeth for 2 minutes using 1 g of the obtained dentifrice composition as a toothbrush, the inside of the oral cavity was rinsed several times with water, and the feeling when the subsequent tooth surface was touched with the tongue was evaluated according to the following criteria. The evaluation is conducted by two expert panelists, and the results of the discussion are shown in Table 2.
AA: The tooth surface is smooth and the cleaning effect is high.
A: The tooth surface is slightly creased, but there is a sense of cleaning effectiveness.
B: The tooth surface is not smooth and the cleaning effectiveness is poor.
C: The tooth surface is distorted (the tooth surface feels friction strongly)
《味》
得られた歯磨組成物１ｇを歯ブラシにとって２分間歯をブラッシングした後、口腔内を水で数回すすいだ。ブラッシング中の味及び水で数回すすいだ後味を下記基準にしたがって評価した。評価は専門パネラー２名で行い、協議による評価結果を表２に示す。
ＡＡ：苦味、えぐ味、及び塩味は感じられない。
Ａ ：極めて僅かに苦味、えぐ味、または塩味を感じる。
Ｂ ：僅かに苦味、えぐ味、または塩味を感じる。
Ｃ ：苦味、塩味及びえぐ味を感じる。
ＣＣ：極めて強い苦味またはえぐ味を感じる。
"taste"
After 1 g of the obtained dentifrice composition was brushed with a toothbrush for 2 minutes, the oral cavity was rinsed several times with water. The taste during brushing and the aftertaste after rinsing several times with water were evaluated according to the following criteria. The evaluation is conducted by two expert panelists, and the results of the discussion are shown in Table 2.
AA: Bitterness, gummy taste, and salty taste are not felt.
A: Very slightly bitter, pungent or salty.
B: Slightly bitter, pungent or salty.
C: A bitter taste, a salty taste and a bitter taste are felt.
CC: A very strong bitter or pungent taste is felt.
表２の結果より、本発明の成分（Ａ）及び成分（Ｂ）の含有量であれば、ブラッシング後（洗浄後）の歯面の感触がなめらかで清掃実効感も高いことが認められる。一方、比較例３、４のように成分（Ｂ）ピロリン酸ナトリウムの含有量が多い場合には、歯磨後の歯面がなめらかではなく、舌でふれたときに摩擦のある感触があるため清掃実効感に欠けることが認められる。さらに、比較例３、４は、含有量の多い成分（Ｂ）と成分（Ａ）を併用しているため、味についても苦味、えぐ味、塩味が感じられ、特に比較例４は極めてこれらの異味が強かった。 From the results shown in Table 2, it can be seen that if the contents of the component (A) and the component (B) of the present invention are used, the feel of the tooth surface after brushing (after cleaning) is smooth and the cleaning effectiveness is high. On the other hand, when the content of component (B) sodium pyrophosphate is large as in Comparative Examples 3 and 4, the tooth surface after brushing is not smooth, and there is a frictional feel when touched with the tongue, so cleaning is performed. It is recognized that there is a lack of effectiveness. Furthermore, since Comparative Examples 3 and 4 use both the component (B) and the component (A) having a high content, bitterness, gummy taste, and salty taste are also felt with respect to the taste. The taste was strong.
［比較例７〜８（実施例１１との対比）］
表３に示す処方の歯磨組成物を調製し、下記方法にしたがって、３名のパネラーについてタンパク質汚れ付着抑制率の評価を行った。実施例１１を含め、評価結果を表３に示す。
《人でのタンパク質汚れの付着抑制率の評価》
１）予め歯科衛生士により、プラークがゼロになるまで歯をブラッシングした。
２）得られた歯磨組成物１ｇを歯ブラシにとって、歯科衛生士が２分間歯をブラッシングした。
３）その後、歯磨き、ブラッシング、洗口液による洗浄を行なうことなく、２４時間、通常の生活を送った。
４）２４時間後に、歯に付着した歯垢量を測定した。歯垢量の測定部位は１名につき上下左右４本ずつの１６歯であって（１番、４番、６番、７番の歯）、測定箇所は図３に示すように歯間に位置する４箇所（測定箇所：Ｘ）と、平滑面に位置する６箇所（測定箇所：Ｙ）の合計１０箇所とした。歯垢量は、各測定箇所について図３に示すように、歯に歯垢が付着している領域の歯肉からの高さによって定量した。各歯磨組成物の歯垢量は３名のパネラーの合計量とした。
５）なお、プラークがゼロになるまでの歯のブラッシングを行うのみで歯磨組成物によるブラッシングを行っていない場合の歯垢量を１００として、各歯磨組成物について求めた歯垢量との差を減少分（タンパク質汚れ付着抑制量）とし、タンパク質汚れ付着抑制率（％）を算出した。
[Comparative Examples 7 to 8 (Comparison with Example 11)]
A dentifrice composition having the formulation shown in Table 3 was prepared, and the protein stain adhesion inhibition rate was evaluated for three panelists according to the following method. The evaluation results including Example 11 are shown in Table 3.
<Evaluation of protein stain adhesion inhibition rate by humans>
1) The teeth were brushed by a dental hygienist in advance until the plaque became zero.
2) A dental hygienist brushed the teeth for 2 minutes using 1 g of the obtained dentifrice composition as a toothbrush.
3) Afterwards, he / she lived a normal life for 24 hours without brushing his teeth, brushing or washing with mouthwash.
4) After 24 hours, the amount of plaque adhering to the teeth was measured. There are 16 teeth for measuring plaque amount, 4 teeth, 4 teeth, 4 teeth, 6 teeth, and 7 teeth, and the measurement points are located between the teeth as shown in FIG. 4 places (measurement places: X) and 6 places (measurement places: Y) located on a smooth surface were used. As shown in FIG. 3, the amount of plaque was quantified by the height from the gingiva in the area where the plaque adhered to the teeth, as shown in FIG. 3. The plaque amount of each dentifrice composition was the total amount of three panelists.
5) Note that the difference from the amount of plaque obtained for each dentifrice composition is defined as 100, where the amount of plaque when only brushing teeth until the plaque is zero and not brushing with the dentifrice composition is 100. The decrease rate (%) of protein stain adhesion was calculated as the decrease (protein stain adhesion suppression amount).
表３の結果より、Ｎ−アシルアミノ酸又はその塩及びピロリン酸又はその塩を特定の量で含有しながら、これらを特定の量比かつ特定の合計量とする本発明の口腔用組成物（歯磨組成物）は、ヒトの口腔内に適用した場合においても、良好な歯垢形成抑制効果が認められた。 From the results in Table 3, the composition for oral cavity of the present invention (dentifrice) containing N-acylamino acid or a salt thereof and pyrophosphoric acid or a salt thereof in a specific amount and a specific amount ratio and a specific total amount. When the composition was applied to the human oral cavity, a good plaque formation inhibitory effect was observed.
［実施例１８〜２４、比較例９〜１２］
表４に示す処方の液体口腔用組成物を調製し、下記方法にしたがって、各評価を行った。
結果を表４に示す。
[Examples 18 to 24, Comparative Examples 9 to 12]
The liquid oral composition of the prescription shown in Table 4 was prepared, and each evaluation was performed according to the following method.
The results are shown in Table 4.
《使用後の歯面の感触》
得られた液体口腔用組成物１０ｍＬで口腔内を２０秒間含嗽し、吐き出した直後の歯面を舌で触ったときの感触を下記基準に従って、評価した。評価は専門パネラー２名で行い、協議による評価結果を表４に示す。
ＡＡ：歯面がなめらかな感触であり、清掃実効感が高い。
Ａ ：歯面がややきしむが、清掃実効感はある。
Ｂ ：歯面がなめらかでなく、清掃実効感に乏しい。
Ｃ ：歯面がギシギシする（歯面に摩擦を強く感じる）。
<Feeling of tooth surface after use>
The mouth of the oral cavity was rubbed with 10 mL of the obtained liquid oral composition for 20 seconds, and the feel when the tooth surface immediately after vomiting was touched with the tongue was evaluated according to the following criteria. The evaluation is conducted by two expert panelists, and the results of the discussion are shown in Table 4.
AA: The tooth surface is smooth and the cleaning effect is high.
A: The tooth surface is slightly creased, but there is a sense of cleaning effectiveness.
B: The tooth surface is not smooth and the cleaning effectiveness is poor.
C: The tooth surface is distorted (the tooth surface feels friction strongly).
《味》
得られた液体口腔用組成物で口腔内を２０秒間含嗽し、吐き出した。含嗽中の味、及び吐き出した直後の後味を下記基準に従って、評価した。評価は専門パネラー２名で行い、協議による評価結果を表４に示す。
ＡＡ：異味を感じない。
Ａ ：ほとんど異味を感じない。
Ｂ ：わずかに異味を感じる。
Ｃ ：異味を感じる。
"taste"
The resulting oral cavity composition was moistened for 20 seconds and exhaled. The taste during moistening and the aftertaste immediately after spitting were evaluated according to the following criteria. The evaluation is conducted by two expert panelists, and the results of the discussion are shown in Table 4.
AA: I don't feel nasty.
A: Almost no nasty taste.
B: Slightly different taste.
C: A nasty taste is felt.
《低温保存安定性》
得られた液体口腔用組成物を透明ＰＥＴ容器に入れ、５℃で１週間保存し、液の性状を下記に示す判定基準にて評価した。
ＡＡ：透明である。
Ａ ：やや透明である。
Ｂ ：沈殿が生じるが、室温に戻せば透明。
Ｃ ：沈殿が生じ、白濁した。
なお、本発明において口腔用組成物が透明であるとは、着色の有無にかかわらず、外観上にごりや沈殿物がなく、波長５５０ｎｍの光の透過率（セル長１０ｍｍ）で９０％以上であることを言う。
<Low temperature storage stability>
The obtained liquid oral composition was placed in a transparent PET container and stored at 5 ° C. for 1 week, and the properties of the liquid were evaluated according to the following criteria.
AA: Transparent.
A: Slightly transparent.
B: Precipitation occurs, but clears when returned to room temperature.
C: Precipitation occurred and it became cloudy.
In the present invention, the composition for oral cavity is transparent, regardless of the presence or absence of coloration, there is no dust or precipitate on the appearance, and the light transmittance at a wavelength of 550 nm (cell length 10 mm) is 90% or more. Say that.
《リン酸カルシウム付着物抑制試験》
１３．１ｍＭのＣａＣｌ2溶液を９．１ｍＬ取り、精製水で７０ｍＬにしたのち、アルブミン（牛血清由来 和光純薬（株））を０．１８g溶解させ、溶液を調整した。その溶液を攪拌しながら ４０ｍＭ のＫ2ＨＰＯ4溶液を１０ｍＬ添加し、最終濃度（Ｃａ濃度１．５ｍＭ、Ｐ濃度５ｍＭ）とした。その溶液に対して鏡面研磨処理を行ったヒドロキシアパタイトペレット（ペンタックスリコーイメージング（株））を３０分間浸漬した。鏡面研磨とは研磨紙４０μｍ, １２μｍ, ３μｍの３種類のラッピングフィルム（住友スリーエム製）を粗い方から細かい順に水を含ませて研磨したものである。溶液からペレットを取り出し、得られた液体口腔用組成物に３分間浸漬したのちに、さらに新しく調製した最終濃度（Ｃａ濃度１．５ｍＭ、Ｐ濃度５ｍＭ）の溶液に浸漬した。このサイクル試験を１０回繰り返し行った。その後ペレットを取りだし、ペレット表面に付着している沈着物の様子を走査型電子顕微鏡により観察し、沈着物の付着抑制効果を下記に示す判定基準により判定した。
Ａ ：付着物がなかった。
Ｂ ：ペレット表面にやや付着物が見られた。
Ｃ ：ペレット表面全体に一様に付着物が見られた。
《Calcium phosphate adhesion suppression test》
After taking 9.1 mL of 13.1 mM CaCl 2 solution and making it 70 mL with purified water, 0.18 g of albumin (bovine serum-derived Wako Pure Chemical Industries, Ltd.) was dissolved to prepare a solution. While stirring the solution, 10 mL of 40 mM K 2 HPO 4 solution was added to obtain final concentrations (Ca concentration 1.5 mM, P concentration 5 mM). Hydroxyapatite pellets (Pentax Ricoh Imaging Co., Ltd.) that had been mirror-polished to the solution were immersed for 30 minutes. Mirror polishing is a polishing process in which three types of lapping films (manufactured by Sumitomo 3M) of abrasive paper 40 μm, 12 μm, and 3 μm are added with water in order from the roughest to the smallest. The pellets were taken out from the solution, immersed in the obtained liquid oral composition for 3 minutes, and then immersed in a solution having a final concentration (Ca concentration 1.5 mM, P concentration 5 mM) prepared newly. This cycle test was repeated 10 times. Thereafter, the pellets were taken out, the state of deposits adhering to the pellet surface was observed with a scanning electron microscope, and the adhesion suppression effect of the deposits was determined according to the following criteria.
A: There was no deposit.
B: Some deposits were seen on the pellet surface.
C: Deposits were uniformly observed on the entire pellet surface.
《耐酸性の評価》
ヒドロキシアパタイト粉（（株）大平化学製）０．５ｇに対して、得られた液体口腔用組成物１０ｍＬを１０分間作用させた後、遠沈し、上澄みを取り除いた。残部の粉体を水で洗浄した後、０．１Ｍの乳酸５ｍＬを加え、５分間反応させた。その後、上澄みを取り出し、ＣａテストワコーＥ（和光純薬（株））を用いて溶出したカルシウムイオン濃度を測定し、下記に示す判断基準にて評価した。
Ａ ：カルシウムイオン濃度が1.5Ｍ未満であった。
Ｂ ：カルシウムイオン濃度が1.5Ｍ以上〜2Ｍ未満
Ｃ ：カルシウムイオン濃度が２Ｍ以上であった。
<Evaluation of acid resistance>
10 mL of the obtained liquid oral composition was allowed to act on 0.5 g of hydroxyapatite powder (manufactured by Ohira Chemical Co., Ltd.) for 10 minutes, and then centrifuged and the supernatant was removed. After the remaining powder was washed with water, 5 mL of 0.1 M lactic acid was added and reacted for 5 minutes. Thereafter, the supernatant was taken out, and the calcium ion concentration eluted using Ca Test Wako E (Wako Pure Chemical Industries, Ltd.) was measured and evaluated according to the following criteria.
A: The calcium ion concentration was less than 1.5M.
B: The calcium ion concentration was 1.5M or more and less than 2M. C: The calcium ion concentration was 2M or more.
表４の結果より、Ｎ−アシルアミノ酸又はその塩及びピロリン酸又はその塩を特定の量で含有しながら、これらを特定の量比かつ特定の合計量とする本発明の口腔用組成物（液体口腔用組成物）は、ヒトの口腔内に適用した場合においても、使用後に良好な感触を得ることができるだけでなく、優れた歯垢形成抑制効果を発揮し、低温環境下でも優れた保存安定性を有するとともに耐酸性にも優れることがわかる。 From the results of Table 4, the composition for oral cavity of the present invention (liquid) containing N-acylamino acid or a salt thereof and pyrophosphoric acid or a salt thereof in a specific amount and having a specific amount ratio and a specific total amount. Even when applied to the oral cavity of humans, the composition for oral cavity not only provides a good feel after use, but also exhibits an excellent plaque formation inhibitory effect and excellent storage stability even in a low-temperature environment It can be seen that it has excellent properties and acid resistance.
以上のように、本発明の口腔用組成物は、タンパク質汚れの除去効果と付着抑制効果とを相乗的に高めながら、良好な清掃実効感をもたらすとともに、良好な後味を保持し、歯垢形成抑制にも大いに寄与できることがわかる。また、低温保存安定性や耐酸性にも優れていることがわかる。 As described above, the composition for oral cavity of the present invention synergistically enhances the effect of removing protein stains and suppresses adhesion while providing a good cleaning effect and maintaining a good aftertaste to form plaque. It can be seen that it can greatly contribute to suppression. Moreover, it turns out that it is excellent also in low-temperature storage stability and acid resistance.
Claims (11)
（Ａ）Ｎ−アシル酸性アミノ酸又はその塩 ０．００５質量％以上０．３質量％以下 及び
（Ｂ）ピロリン酸又はその塩 ０．００５質量％以上０．５質量％以下
を含有し、成分（Ａ）と成分（Ｂ）の質量比（（Ｂ）／（Ａ））が０．１以上４０以下
であり、かつ成分（Ａ）と成分（Ｂ）の含有量の合計が０．０１質量％以上０．６質量％以下である口腔用組成物。 The following components (A) and (B):
(A) N-acyl acidic amino acid or its salt 0.005 mass% or more and 0.3 mass% or less and (B) Pyrophosphoric acid or its salt 0.005 mass% or more and 0.5 mass% or less, The mass ratio of (A) to component (B) ((B) / (A)) is 0.1 or more and 40 or less, and the total content of component (A) and component (B) is 0.01% by mass. The composition for oral cavity which is 0.6 mass% or less.
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| JP2012266282A JP6055296B2 (en) | 2012-06-08 | 2012-12-05 | Oral composition |
| RU2014153494A RU2663700C2 (en) | 2012-06-08 | 2013-06-07 | Oral care composition |
| EP13800196.1A EP2859881B1 (en) | 2012-06-08 | 2013-06-07 | Oral composition |
| US14/400,644 US9211241B2 (en) | 2012-06-08 | 2013-06-07 | Oral composition |
| TW102120458A TWI630919B (en) | 2012-06-08 | 2013-06-07 | Oral composition |
| PCT/JP2013/065786 WO2013183748A1 (en) | 2012-06-08 | 2013-06-07 | Oral composition |
| CN201380030180.1A CN104363886B (en) | 2012-06-08 | 2013-06-07 | Oral composition |
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| JPH085773B2 (en) * | 1986-09-02 | 1996-01-24 | ライオン株式会社 | Oral composition |
| JP2845245B2 (en) * | 1988-10-20 | 1999-01-13 | 味の素株式会社 | Toothpaste composition |
| JPH0912438A (en) * | 1995-06-28 | 1997-01-14 | Lion Corp | Composition for oral cavity |
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| JP2008143824A (en) * | 2006-12-08 | 2008-06-26 | Lion Corp | Dentifrice composition |
| JP2010143843A (en) * | 2008-12-18 | 2010-07-01 | Lion Corp | Liquid composition for oral cavity |
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