JP3508283B2 - Toothpaste composition - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a toothpaste composition, and more particularly, to a toothpaste composition using a more safe N-acylamino acid salt as a foaming agent. The present invention relates to an excellent toothpaste composition that does not change the taste of food. [0002] A foaming agent is added to a dentifrice composition for imparting cleaning, dispersing, emulsifying, foaming functions and the like, and a surfactant is often used as a foaming agent. [0003] The required performance of a surfactant as a foaming agent is not only detergency and foaming power, but toothpaste brushes the taste, smell and teeth of the surfactant itself for use in the mouth. The taste and smell after washing the inside of the mouth must be satisfied. Conventionally, anionic surfactants such as sodium alkylsulfate, sodium acylsarcosine and α-olefin sulfonate have been used as surfactants. In particular, sodium alkyl sulfate is excellent in performance, taste and the like, and has been widely used. However, sodium alkyl sulfate has drawbacks such as a change in taste after use, which is considered to be caused by adsorption to taste buds of the tongue and oral mucosa, and high oral mucosal irritation. In recent years, the safety of these surfactants has been a problem, and the use of surfactants having higher safety as foaming agents has been studied. One of them is N-
It has been proposed to blend a long-chain acylglutamate for toothpaste (Japanese Patent Publication No. 45-24480). N-
Long-chain acylglutamate is non-toxic, has very mild irritation to skin and mucous membranes, has good detergency, foaming power, emulsifying power, and has various characteristics such as excellent hard water resistance. And is said to be very useful as a foaming agent in toothpaste compositions. However, it has been reported that bitterness is strongly felt when a large amount of N-long-chain acylglutamic acid is contained (Japanese Patent Publication No. 58-45402). For such bitterness, JP-A-2-256608 reports that the problem of bitterness can be solved by lowering the content of higher fatty acids as impurities. However, even with this method, bitterness remains, In order to remove the fatty acid, which requires a further purification step, it becomes expensive. [0007] Under the background of the prior art described in the preceding paragraph, an object of the present invention is to improve the taste of toothpaste containing N-acylglutamate and to supply it at a low cost. is there. Here, the toothpaste is paste-like toothpaste, water toothpaste or the like. The present inventors have made intensive studies to solve the above-mentioned problems, and as a result, have adopted a magnesium salt as an N-acylglutamate and used it in a specific ratio in a toothpaste composition. It has been found that by adding the compound, the taste of toothpaste can be easily and inexpensively improved, and the present invention has been completed. That is, according to the present invention, a magnesium salt of N-acylglutamic acid is used as a foaming agent in an amount of 0.1 to 10% by weight.
An object of the present invention is to provide a dentifrice composition excellent in dentifrice taste characterized by containing. Hereinafter, the present invention will be described in detail. The magnesium N-acylglutamic acid salt, which is a characteristic component of the dentifrice composition of the present invention, is a composition in which N-acylglutamic acid: magnesium is a counter ion at a molar ratio of 2: 1 or 1: 1 or a mixture thereof. Is a mixture of There is no particular limitation on the method for producing such a magnesium N-acylglutamate. For example, N-
It can be easily obtained by a conventional method such as a method of neutralizing acylglutamic acid with magnesium hydroxide or a metathesis method of reacting an alkali metal salt of N-acylglutamic acid with magnesium sulfate or magnesium chloride. Also, by simultaneously mixing an N-acyl alkali metal salt and a magnesium salt such as magnesium sulfate and magnesium chloride in the formulation of the toothpaste composition,
tu) N-acylglutamic acid magnesium salt is also possible. The acyl group of the magnesium N-acylglutamate has 6 to 20 carbon atoms, preferably 8 to 16 carbon atoms.
Is a single or mixed fatty acid residue of saturated or unsaturated and straight or branched chain fatty acids. If the number of carbon atoms is too small, the foamability is poor, while if it is too large, the solubility is poor.
Glutamic acid may be optically active or racemic,
The natural L-form is preferred. [0014] In the case of magnesium N-acylglutamate which is a characteristic component of the present invention, the free fatty acid which is an unreacted impurity derived from the synthesis of N-acylglutamic acid is contained in the magnesium salt by about 3%. However, although the bitterness depends on the specific case, it can be cited as one of the merits of the present invention that the bitterness is acceptable. The amount of the magnesium N-acylglutamate in the dentifrice composition of the present invention is as follows:
Although it depends on the purpose of the product and the type of the acyl group, it is 0.1 to 10% by weight as described above. More specifically, in the case of a paste-like toothpaste, the content is 0.1 to 10% by weight, preferably 0.1 to 5% by weight, and more preferably 0.3 to 3% by weight. 0.1% by weight of N-acylglutamic acid magnesium salt
If it is less than 1, the foaming property is undesirably reduced. If it exceeds 5% by weight, the appropriate softness required for the paste-like toothpaste may be lost, and if it exceeds 10% by weight, it is not preferable. The same applies to the case of water toothpaste in which the amount is 0.1 to 10% by weight. However, in the case of a formulation to be applied directly into the oral cavity, it is preferable to mix 0.1 to 5 wt%. If the amount is more than this, a dilution type formulation is used, preferably 1 to 10% by weight,
In actual use, dilute about 10-fold. If the amount is less than 0.1% by weight, flavor separation may occur, which is not preferable. On the other hand, if it exceeds 10% by weight, it becomes difficult to design a formulation for water toothpaste, which is not preferable. Now, toothpaste compositions generally contain, in addition to the foaming agents described above, usually dibasic calcium phosphate dihydrate and anhydride, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, silicic anhydride, Abrasives such as hydrated silicic acid, aluminosilicate, alumina and aluminum hydroxide; viscous agents such as glycerin, sorbite, propylene glycol and polyethylene glycol;
Binders such as carboxymethylcellulose, carrageenan, sodium alginate, veegum, hydroxyethylcellulose, polyvinyl alcohol, etc .; Fragrances such as carvone and anethole are used. Further, fluorides such as sodium monofluorophosphate, tin fluoride and sodium fluoride, bactericides such as fluorhexazine salts, phosphate compound builders such as sodium phosphate, Enzymes such as tranase and amylase,
Active ingredients (raw materials) such as anti-inflammatory agents such as ε-aminocaproic acid, tranexamic acid, and allantoinate, and gingival astringents such as sodium chloride are appropriately used. The dentifrice composition of the present invention also has N as a foaming agent. Except for using a predetermined amount of magnesium acylglutamate, it is needless to say that these materials can be used for the preparation. EXAMPLES Hereinafter, the present invention will be described specifically with reference to examples, but the present invention is not limited to the examples.
All percentages in the examples are based on weight. Examples 1-4 and Comparative Examples 1-3 Paste toothpastes having the compositions shown in Table 1 below were prepared according to a conventional method. [Table 1] The N-acyl-L-glutamate in the paste-like toothpaste is as shown in Table 2 below. [Table 2] The toothpaste prepared was subjected to a taste test of orange juice during and after use by a panel of 10 experts. Specifically, about 1.0 g of the prepared toothpaste was taken with a toothbrush, brushed for about 1 minute, and the taste when the mouth was rinsed with tap water was evaluated (during use). After rinsing, orange juice was drunk and the taste was evaluated (after use). In addition, the foamability was also examined. The results (average score) are also shown in Table 2 above. However, the scores shown in the table were based on the criteria shown in Table 3 below. [Table 3] As can be seen from Table 2, the dentifrice composition of the present invention using N-lauroyl-L-glutamic acid magnesium salt or the like showed little bitterness during use and no change in flavor after use. On the other hand, those of Comparative Examples 1 and 2 felt bitter and changed the flavor of the orange juice after use, and it is understood that those of the present invention are superior. In Comparative Example 3, the scores during and after use are excellent, but the foamability is poor, and it is understood that the product of the present invention is excellent. Examples 5 to 9: The N-acyl-L-glutamate in the paste-like toothpaste composition shown in Table 1 above was replaced with the N-acyl-L-glutamic acid salt of Examples 5 to 9 shown in Table 4 below. A taste test of orange juice during and after toothpaste was performed by a professional panel of ten persons in the same manner as described above, using magnesium glutamate as a salt. The results are also shown in Table 4. [Table 4] As can be seen from Table 4 above, N-acyl-L-glutamic acid: magnesium is 1: 1 to 2: 1.
In (molar ratio), there was no change in bitterness and flavor both during and after use. Examples 10 to 12: N-acyl-L-glutamate in the paste-like dentifrice composition shown in Table 1 was converted to four N-acyl-L-glutamic acids having different free fatty acid contents.
Magnesium glutamic acid salt (N-lauroyl-L
-Glutamic acid: magnesium = 1: 1 (molar ratio))
A taste test of orange juice during and after toothpaste use was performed by a panel of 10 professionals as described above. The results are shown in Table 5 below. [Table 5] According to Table 5, 3% of free fatty acid is contained as an impurity.
It can be seen that N-acyl glutamate may be accompanied to some extent. Example 13 A paste-like toothpaste having the composition shown in Table 6 below was prepared and evaluated by a professional paneler in the same manner as described above. [Table 6] The composition shown above was in use (rating 1.
Both the taste-related performances after 1) and after use (rating 1.2) were excellent. Example 14 A paste-like toothpaste having the composition shown in Table 7 below was prepared and evaluated by a specialized panelist. [Table 7] The composition shown above was prepared as in Example 6
Both the taste performance during use (rating 1.2) and after use (rating 1.2) were excellent. Example 15 A toothpaste having the composition shown in Table 8 below was prepared and evaluated by a specialized panelist. [Table 8] The composition shown above was prepared as in Example 7
Both the taste performance during use (rating 1.1) and after use (rating 1.1) were excellent. According to the present invention, a toothpaste composition which has good taste during and after use and can be suitably used as an oral composition for paste-like toothpaste, water toothpaste, and the like can be easily and inexpensively provided. It was about to be.

Claims (1)

(57) Patent Claims: 1. A N- acylglutamate magnesium salt as a foaming agent, dentifrice composition characterized in that it contains 0.1 to 10 wt%.