JPS62298375A - Percutaneous administration system - Google Patents
Percutaneous administration systemInfo
- Publication number
- JPS62298375A JPS62298375A JP61140238A JP14023886A JPS62298375A JP S62298375 A JPS62298375 A JP S62298375A JP 61140238 A JP61140238 A JP 61140238A JP 14023886 A JP14023886 A JP 14023886A JP S62298375 A JPS62298375 A JP S62298375A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- pressure
- administration system
- percutaneous administration
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims description 33
- 229940079593 drug Drugs 0.000 claims description 33
- 210000001519 tissue Anatomy 0.000 description 7
- 239000000853 adhesive Substances 0.000 description 6
- 230000001070 adhesive effect Effects 0.000 description 6
- 208000002193 Pain Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】 3、発明の詳細な説明 本発明は、経皮投薬を行なうシステムに関する。[Detailed description of the invention] 3. Detailed description of the invention TECHNICAL FIELD The present invention relates to systems for delivering transdermal medication.
針、カニユーレによる薬液の体内投与は、経皮投薬にお
いて効果的な方法であるが、慢性疾患患者、高齢者、衰
弱患者に対しては連続的に用いることができず、しかも
毎回受ける刺痛は、患者にとって耐えがたいものである
。Intracorporeal administration of drug solutions using needles or cannulae is an effective method for transdermal medication, but it cannot be used continuously for chronically ill, elderly, or debilitated patients, and the stinging pain experienced each time is , is intolerable to the patient.
一方、経皮投薬手段であって、体内に薬物の導入経路を
埋入せずに、皮膚表面に薬物を配置し、電気力あるいは
浸透圧を利用して薬物を導入する方法が近時注目されつ
つあるが、皮膚表面、特1こバリヤ一層の組織的解明が
未だ不充分である為、実用化には至っていない。On the other hand, transdermal medication methods, in which the drug is placed on the skin surface and uses electrical force or osmotic pressure to introduce the drug without implanting a drug introduction route into the body, have recently attracted attention. However, because the structure of the skin surface, especially the barrier layer, is still insufficiently understood, it has not been put into practical use.
上記に鑑み本発明者らは鋭意研究の結果、皮膚組織表面
上に薬物部を配置押圧することにより、汗腺及び毛穴を
通じ、体内への薬液浸透が行なわれることを知見し、本
発明に到達したものである。In view of the above, as a result of intensive research, the present inventors found that by placing and pressing a drug part on the surface of skin tissue, the drug solution permeates into the body through sweat glands and pores, and thus arrived at the present invention. It is something.
以下、本発明経皮投薬装置につき実施例を用いて詳細に
説明する。Hereinafter, the transdermal medication device of the present invention will be explained in detail using Examples.
第1図は本発明の一実施例を示す断面図であり、一体内
に接合された鍔部aDを有する筒体(13、この筒体(
1カの上部に接着されたシリコーン等からなる弾力性部
材01)及び外部から圧力を加比内部に伝達する為の栓
体03を有し、底部に配置した薬物部0・は、ゲル状あ
るいはスポンジ、海綿等の多孔質に薬剤を含浸したもの
、あるいは液状物である。薬物部+10以外は中空状体
である。FIG. 1 is a sectional view showing an embodiment of the present invention, in which a cylindrical body (13) and a cylindrical body (
It has an elastic member 01) made of silicone or the like glued to the top of the cap, and a stopper 03 for transmitting pressure from the outside to the inside.The drug part 0 arranged at the bottom has a gel-like or It is a porous material such as a sponge or sponge impregnated with a drug, or it is a liquid material. The parts other than the drug part +10 are hollow bodies.
又、筒体a3は、皮膚組織(19上に鍔部((乃の底部
に配Hしたビニルエマルジョン系の接着剤+16によっ
て密着されている。Further, the cylinder a3 is tightly adhered to the skin tissue (19) by a vinyl emulsion adhesive (16) distributed at the bottom of the flange ((()).
使用時においては、幹部0より空気等の加圧体をコンプ
レッサーにより挿入し、幹部a3を閉じる。When in use, a pressurized body such as air is inserted through the trunk 0 using a compressor, and the trunk a3 is closed.
筒体(13内部に挿入された加圧体により弾力性部材0
0は、膨張すると同時に薬物部a・及び皮膚組織09を
押圧する。The elastic member 0 is pressed by the pressure body inserted inside the cylinder (13).
0 presses the drug part a and the skin tissue 09 at the same time as it expands.
この時薬物部0・を押圧する力は、1 am2当たり約
50a+g/hである。At this time, the force for pressing the drug part 0. is approximately 50a+g/h per 1 am2.
第1の実施例はマイクロポンプ等による外部からの空気
の挿入により、薬物を皮膚組織に浸透させるものである
が、空気の注入に代わり機械的加圧手段を用いた本発明
の実施例を第2図に示す。In the first embodiment, the drug is infiltrated into the skin tissue by inserting air from the outside using a micro pump, etc. However, in the first embodiment, a mechanical pressure means is used instead of air injection. Shown in Figure 2.
鍔部(!9を有する保持体Uの上部に位置し、外部に突
出した部分を有し、上下に動作可能な加圧体(23、駆
動手段Ql)の駆動力が、加圧体Q3の外部に突出した
部分を介して加圧体0に伝達し、加圧体(2のは保持体
Q・の内部を押圧し、薬物部+24+及び皮膚組織0に
圧力が伝達する。駆動手段Ql>は、手動電動機、圧電
体、形状記憶合金等によりて構成されている。The driving force of the pressurizing body (23, driving means Ql), which is located at the upper part of the holding body U having a flange (!9) and has an outwardly protruding portion and is movable up and down, is applied to the pressurizing body Q3. The pressure is transmitted to the pressure body 0 via the portion protruding to the outside, and the pressure body (2) presses the inside of the holding body Q, and the pressure is transmitted to the drug part +24+ and the skin tissue 0. Drive means Ql> It is composed of a manual electric motor, a piezoelectric material, a shape memory alloy, etc.
次に池の実施例を第3図に示す。保持体01)の鍔部0
)の接着部0によって密閉された保持体内部空間は、薬
物部041及び加圧体Obが充填されている。加圧体o
3はフロンガス等を充填した伸縮する球状体から成り、
生体の体温等によって膨張し、薬物部が皮膚組識口9を
押圧、薬物部0◇の薬剤が皮膚に浸透する。Next, an example of a pond is shown in FIG. Flange part 0 of holding body 01)
) The internal space of the holder sealed by the adhesive part 0 is filled with a drug part 041 and a pressurizing body Ob. Pressure body o
3 consists of an expandable spherical body filled with chlorofluorocarbon gas, etc.
The drug portion expands due to the body's body temperature, etc., presses the skin tissue opening 9, and the drug in the drug portion 0◇ penetrates into the skin.
尚、本発明経皮投薬システムにおける加圧量は、加圧部
の面積あるいは投薬する薬剤の種類によって異なるもの
であるが、好ましくは100〜10000Pa(パスカ
ル)程度の圧力を加えればよ+11゜
以上詳述の如く本発明経皮投薬システムは、皮膚表面に
配置した薬物部を少量の力によって押圧することにより
、投薬が行なわれることから、簡単な構成で安全にしか
も確実に経皮投薬が行なわれる等、効果を奏効するもの
である。The amount of pressure applied in the transdermal medication system of the present invention varies depending on the area of the pressurizing part or the type of drug to be administered, but it is preferable to apply a pressure of about 100 to 10,000 Pa (Pascal), and +11° or more. As described in detail, the transdermal medication system of the present invention administers medication by pressing the drug part placed on the skin surface with a small amount of force, and therefore can safely and reliably administer transdermal medication with a simple configuration. It is said to be effective.
次に、上述した実施例について実験例を用いて更に詳細
に説明する。Next, the above-mentioned embodiment will be explained in more detail using an experimental example.
実験例1
ポリエチレンよりなる保持体は、幹部と円形の鍔部を一
体的に構成し、シリコーン樹脂よりなる弾力性部材、水
を含浸させたスポンジからなる薬物部、及びビニルエマ
ルジシン系よりなる接着剤からなる接着部、以上の構成
要件から成る第1図に示す本発明経皮投薬システムを用
いて、ヒト上腕屈側邪に設置し、密着固定させる。Experimental Example 1 A holding body made of polyethylene has a main body and a circular flange integrally configured, an elastic member made of silicone resin, a drug part made of a sponge impregnated with water, and an adhesive made of vinyl emuldicine. Using the transdermal medication system of the present invention shown in FIG. 1, which consists of an adhesive part made of an adhesive and the above-mentioned components, it is placed on the flexor side of a human upper arm and fixed in close contact.
尚、保持体は内径が1.5(am)、外形が1.9(a
m)、高さ1.5(am)、鍔部外径が2.6(am)
、弾力性部材の厚さ0.2(cm)、薬物部の厚さ0.
5(cm)で外径が1.5(cm)であった。The holding body has an inner diameter of 1.5 (am) and an outer diameter of 1.9 (a).
m), height 1.5 (am), flange outer diameter 2.6 (am)
, the thickness of the elastic member is 0.2 (cm), and the thickness of the drug part is 0.2 (cm).
5 (cm) and the outer diameter was 1.5 (cm).
次に幹部よりマイクロポンプを用いて保持体内部に空気
を注入し、圧力が1 (c+n2)当たり70m g
/ hとなるように設定する。Next, air is injected into the holding body from the trunk using a micro pump, and the pressure is 70 m g per 1 (c + n2).
/ h.
加圧直後の皮膚表面から、弾力性部材の頂点部までの距
離を測定し、1時間後加圧直後と同様に匪離を測定した
。The distance from the skin surface to the apex of the elastic member immediately after pressurization was measured, and 1 hour later, the separation was measured in the same manner as immediately after pressurization.
結果、1時間後の距離は、加圧直後の距離に比べ、約1
0%の減少が、あった。As a result, the distance after 1 hour was approximately 1 compared to the distance immediately after pressurization.
There was a 0% decrease.
第1図及び第2図及び第3図は、本発明経皮投薬システ
ムの一実施例を示す断面図である。
(11)・・・・・・・・・・・・・・・・・・・弾力
性部材、<21)・・・・・・・・・・・・・・・・・
・・駆動手段、03・・・・・・・・・・・・・・・・
・・・筒体、 +23.(13・・・・・・・・・
・・・加圧体、03・・・・・・・・・・・・・・・・
・・・幹部、 co、at>・・・・・・・・・・
・・保持体、+I t) 、口■・・・・・・・・・・
・・接着剤、+ILC3,O9・・・・・皮膚組織、(
1の、Q金、ao・・・・・薬物部、(17) 、 Q
!it 、 07)−−−・−鍔部。
特許出願人 株式会社アドバンス開発研究所第1図
第2図
競
第3図
N競1, 2, and 3 are cross-sectional views showing one embodiment of the transdermal medication system of the present invention. (11)・・・・・・・・・・・・・・・Elastic member, <21)・・・・・・・・・・・・・・・
・・Drive means, 03・・・・・・・・・・・・・・
...Cylinder body, +23. (13......
・・・Pressure body, 03・・・・・・・・・・・・・・・
・・・executive, co, at>・・・・・・・・・・・・
・・Holding body, +I t) , mouth ■・・・・・・・・・・
...Adhesive, +ILC3, O9...Skin tissue, (
1, Q money, ao... drug department, (17), Q
! it, 07) ---・- Tsuba. Patent applicant Advance Development Institute Co., Ltd. Figure 1 Figure 2 Competition Figure 3 N Competition
Claims (1)
とする経皮投薬システム。A transdermal medication system comprising a medicinal solution and a pressing means for pressing the medicinal solution.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61140238A JP2757984B2 (en) | 1986-06-18 | 1986-06-18 | Transdermal medication system |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61140238A JP2757984B2 (en) | 1986-06-18 | 1986-06-18 | Transdermal medication system |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS62298375A true JPS62298375A (en) | 1987-12-25 |
JP2757984B2 JP2757984B2 (en) | 1998-05-25 |
Family
ID=15264121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP61140238A Expired - Lifetime JP2757984B2 (en) | 1986-06-18 | 1986-06-18 | Transdermal medication system |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2757984B2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003321350A (en) * | 2002-02-28 | 2003-11-11 | Lintec Corp | Percutaneously absorbable preparation and method for percutaneously absorbing drug using the same |
JP2008125577A (en) * | 2006-11-17 | 2008-06-05 | Eisuke Imanaga | Medicinal component delivery system, cup for operation and composition containing medicinal component |
JP2010522604A (en) * | 2007-03-29 | 2010-07-08 | キユーポラ・メデイカル・リミテツド | Apparatus and system for skin treatment |
US7858112B2 (en) | 2002-02-28 | 2010-12-28 | Lintec Corporation | Percutaneous absorption system and percutaneous absorption method |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59131367A (en) * | 1982-10-12 | 1984-07-28 | ラボラトワ−ル・フルニエ・エス・エ− | Apparatus for subcataneously administering active component |
JPS59155267A (en) * | 1983-02-23 | 1984-09-04 | 帝国製薬株式会社 | Capsule pad adhering agent for subcateneous absorption |
-
1986
- 1986-06-18 JP JP61140238A patent/JP2757984B2/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59131367A (en) * | 1982-10-12 | 1984-07-28 | ラボラトワ−ル・フルニエ・エス・エ− | Apparatus for subcataneously administering active component |
JPS59155267A (en) * | 1983-02-23 | 1984-09-04 | 帝国製薬株式会社 | Capsule pad adhering agent for subcateneous absorption |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003321350A (en) * | 2002-02-28 | 2003-11-11 | Lintec Corp | Percutaneously absorbable preparation and method for percutaneously absorbing drug using the same |
US7858112B2 (en) | 2002-02-28 | 2010-12-28 | Lintec Corporation | Percutaneous absorption system and percutaneous absorption method |
JP2008125577A (en) * | 2006-11-17 | 2008-06-05 | Eisuke Imanaga | Medicinal component delivery system, cup for operation and composition containing medicinal component |
JP2010522604A (en) * | 2007-03-29 | 2010-07-08 | キユーポラ・メデイカル・リミテツド | Apparatus and system for skin treatment |
Also Published As
Publication number | Publication date |
---|---|
JP2757984B2 (en) | 1998-05-25 |
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