JP2008125577A - Medicinal component delivery system, cup for operation and composition containing medicinal component - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cup for an operation capable of pressurizing the skin and maintaining a tightly attached state simultaneously in a medicinal component delivery system of infiltrating medicinal components into the skin, and a composition containing the medicinal component including encapsulated gold particles. <P>SOLUTION: The medicinal component delivery system for infiltrating the composition containing the medicinal component into the skin comprises a first pump (16) provided with a discharge function, a second pump (17) provided with a suction function and the cup (1) for the operation. The cup for the operation is provided with a dome-like inner cup (2) and a dome-like outer cup (3) covering the inner cup with a gap from the outer surface of the inner cup. Respective openings (2b, 3b) are positioned on the almost same surface, the internal space (2c) of the inner cup is connected through a first connection part (2d) provided on the wall part of the inner cup to the first pump, and a gap space (3c) between the inner cup and the outer cup is connected through a second connection part (3d) provided on the wall part of the outer cup to the second pump. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a medicinal ingredient delivery system for allowing a substance having medicinal ingredients to penetrate into the skin, a surgical cup used in this system, and a medicinal ingredient-containing composition.

  Conventionally, it is known that gold has a cosmetic effect on human skin. For example, skin regeneration, removal of wrinkles and stains, and the like are used for cosmetic ingredients (Patent Document 1, etc.). The surgical procedure was to sew a fine gold thread into the skin. This was obviously a medical practice and could only be performed by a doctor, and was expensive and painful and painful. Therefore, there is a demand for means for allowing gold to penetrate into the skin regardless of the surgical technique.

  For example, in order for gold particles to effectively penetrate from the surface of the skin into the interior, the gold particles must be able to pass between the cells. The cell spacing of human epithelial cells is about 250 nm, and it is said that the average particle diameter must be 70 nm or less in order to allow gold particles to pass smoothly.

  Recently, industrial production technology of gold fine particles has advanced in the fields of electronic parts and chemical catalysts. For example, in Patent Document 2, a reducing agent and an organic solvent incompatible with water are dispersed in an aqueous solution containing gold ions. A method of adding a protective colloid and stirring the resulting solution system to produce gold fine particles in an organic solvent is disclosed, and gold particles having an average particle diameter of several tens nm to several nm are obtained. Various other production methods are known, and it is not so difficult to obtain gold fine particles having an average particle diameter of 70 nm or less at present.

On the other hand, in the beauty field, conventionally, a device that applies a dome-shaped surgical cup to the skin surface to remove slimming or sebum and sucks the skin surface with a suction pump is known (Patent Document 3, etc.).
JP 2004-131484 A JP 2003-253310 A Japanese Patent No. 2651663

  As described above, gold particles having an average particle diameter of 70 nm or less are available, but cannot be penetrated into the skin simply by applying them to the skin surface. Therefore, if the suction pump of the suction device used in the cosmetic field in Patent Document 3 is replaced with a discharge pump, it is expected that there is an effect of pushing the substance applied to the skin surface into the skin.

  However, even if the dome-shaped cup is connected to the discharge pump, the inner space of the surgical cup is in a pressurized state unlike the case of the suction pump, so the surgical cup cannot be kept in close contact with the skin. There is a problem.

  Another problem is that gold particles are a foreign matter to the human body, so that they are difficult to permeate due to rejection, and even if permeated, they are difficult to settle inside the skin.

In view of the above situation, an object of the present invention is to provide a medicinal component delivery system for allowing nanometer-level gold particles to penetrate into the skin. In particular, it is an object of the present invention to provide a surgical cup capable of maintaining a close contact state with the skin while simultaneously pressing the skin with a discharge pump, and a medicinal component delivery system including such a surgical cup.
Furthermore, the present invention provides a medicinal component-containing composition containing gold particles as a medicinal component and hardly causing a rejection reaction and having high skin affinity, and medicinal component delivery for penetrating such a medicinal component-containing composition into the skin. The purpose is to provide a system.

In order to achieve the above object, the present invention provides the following configurations. The numbers in parentheses are reference numerals in the drawings showing examples to be described later, and are described for reference.
(1) The medicinal ingredient delivery system according to claim 1 is a medicinal ingredient delivery system for allowing the medicinal ingredient-containing composition applied to the surface of the skin to penetrate into the skin, and has at least a discharge function. A first pump (16), a second pump (17) having at least a suction function, and a treatment cup (1) for applying to the surface of the skin, the treatment cup having a dome shape An inner cup (2), and a dome-shaped outer cup (3) that covers the inner cup with a gap between the inner cup and the outer surface of the inner cup, each opening of the inner cup and the outer cup ( 2b, 3b) are located on substantially the same plane, and the inner space (2c) of the inner cup is connected to the first pump via a first connection part (2d) provided on the wall of the inner cup, The gap space (3c) between the inner cup and the outer cup has a second connecting portion (3d) provided on the wall of the outer cup. The second pump is connected to the second pump.

(2) The medicinal component delivery system according to claim 2 is characterized in that, in claim 1, the first pump (16) has a suction function in addition to a discharge function.

(3) The medicinal ingredient delivery system according to claim 3 is the method according to claim 1 or 2, wherein ozone is placed in the middle of the flow path connecting the inner space (2c) of the inner cup and the first pump (16). The generator is inserted and installed.

(4) The medicinal ingredient delivery system according to claim 4 is the ultrasonic vibration module according to any one of claims 1 to 3, wherein the ultrasonic vibration surface is directed toward the opening in the internal space (2c) of the inner cup. It is characterized by having installed.

(5) The medicinal component delivery system according to claim 5 is the medicinal component delivery system according to any one of claims 1 to 4, wherein the medicinal component-containing composition includes encapsulated gold particles and a binder liquid, The gold particles having an average particle diameter of 70 nm or less and a skin-compatible outer coating film covering the gold particles are characterized in that they are formed.

(6) The medicinal component delivery system according to claim 6 is characterized in that, in claim 5, the outer covering film contains a phospholipid.

(7) The medicinal component delivery system according to claim 6 is characterized in that, in claim 5 or 6, the binder liquid contains ascorbic acid.

(8) The surgical cup according to claim 8 is a surgical cup for applying suction or pressing to the surface of the skin, comprising a dome-shaped inner cup (2), an outer surface of the inner cup, A dome-shaped outer cup (3) that covers the inner cup with a gap between the inner cup and each of the openings (2b, 3b) of the inner cup and the outer cup. A first connecting portion (2d) provided on a wall of the inner cup to connect the inner space (2c) of the inner cup to an external pump, and a gap space (3c) between the inner cup and the outer cup. And a second connection portion (3d) provided on the wall portion of the outer cup so as to be connected to another external pump.

(9) The medicinal component-containing composition according to claim 9 is a medicinal component-containing composition that is applied to the skin surface and penetrates into the skin, and includes encapsulated gold particles and a binder liquid, The encapsulated gold particles are formed of gold particles having an average particle diameter of 70 nm or less and a skin-compatible outer coating film that covers the gold particles.

(10) The medicinal component-containing composition according to claim 10 is characterized in that, in claim 9, the outer covering film contains phospholipid.

(11) The medicinal component-containing composition according to claim 11 is characterized in that, in claim 8 or 9, the binder liquid contains ascorbic acid.

(A) The medicinal component delivery system according to the present invention is a system in which a plurality of components are combined in order to allow the medicinal component-containing composition applied to the surface of the skin to penetrate into the skin. As a plurality of constituent elements, a first pump having at least a discharge function, a second pump having at least a suction function, and a surgical cup for application to the surface of the skin are provided. The treatment cup has a double structure of a dome-shaped inner cup and an outer cup, and a space is provided between the outer surface of the inner cup and the inner surface of the outer cup. Moreover, each opening of an inner cup and an outer cup is located on substantially the same surface. The inner space of the inner cup is connected to the first pump via a first connection portion provided in the wall portion of the inner cup, and a gap space between the inner cup and the outer cup is a second portion provided in the wall portion of the outer cup. It is connected with the 2nd pump via a connection part.

  Since it has such a configuration, if the discharge function of the first pump is driven, gas is sent out toward the inner space of the inner cup and discharged from its opening (corresponding to the central portion of the opening of the surgical cup). When the suction function of the second pump is driven, gas is sucked from the opening portion of the gap space between the inner cup and the outer cup (corresponding to the peripheral portion of the opening of the surgical cup). When the first pump and the second pump are driven in this manner with the treatment cup placed on the skin surface, the gap space between the inner cup and the outer cup becomes a reduced pressure state, and the surface of the skin is sucked into the gap. Close contact with the opening periphery of the space. Therefore, it is not necessary to use a band or the like for fixing the surgical cup to the skin surface. At the same time, the inner space of the inner cup is in a pressurized state and presses the surface of the skin. As a result, it is possible to achieve pressing of the skin surface at the central portion while securing a close contact state with the skin surface at the peripheral portion of the surgical cup.

  If the medicinal ingredient delivery system of the present invention is applied in a state where the medicinal ingredient-containing composition is applied to the surface of the skin, the medicinal ingredient-containing composition exerts a force toward the inside of the skin due to the pressurized state generated by the first pump. It will be permeated into the skin. Thereby, the medicinal component contained in the medicinal component-containing composition can be efficiently taken into the skin.

(B) In the above, if the first pump has a suction function in addition to the discharge function, and if the suction function of the first pump is driven, the inner space of the inner cup of the surgical cup becomes depressurized and the central portion of the opening The surface of the skin can be aspirated. By utilizing this, it is possible to remove and cleanse sebum and dirt from the surface of the skin prior to applying the medicinal component-containing composition.

(C) In the above, when the discharge function of the first pump is driven by inserting and installing an ozone generator in the middle of the flow path connecting the inner space of the inner cup and the first pump, the oil is sent to the inner cup. The gas to be used can contain ozone. Ozone is activated by sending ozone into the skin, and when the cell transitions from the quiescent state to the active state, the positive ion and the negative ion that determine the vital action potential of the cell are switched, and depolarization is activated and the blood function is activated. It recovers and can supply a lot of oxygen. As a result, cell regeneration becomes active.

(D) In the above, by placing the ultrasonic vibration module in the inner space of the inner cup with the ultrasonic vibration surface facing the opening side, when the surgical cup is placed on the skin surface, the ultrasonic vibration surface is It can be configured to hit the surface of the skin. The ultrasonic vibration has a high frequency minute amplitude that is much higher than the pressure change in the internal space caused by the first pump. If the first pump and the ultrasonic vibration module are driven at the same time, the superposition of ultrasonic vibration on the pressure change in the internal space by the first pump is applied to the skin surface.

  As a result of ultrasonic vibration, the cell temperature rises about 1 degree from the surface of the skin to a depth of 2 to 3 cm, and the fat is easily decomposed by the thermal effect. As a result, cell metabolism is increased. In the vicinity of the surface of the skin without capillaries, the lymph fluid instead of blood enters the gaps between the cells to compensate for the metabolism, but when combined with the discharge drive of the first pump, Combined with the pressing force by the first pump, the flow of lymph can be improved, and the medicinal component can reach the basal layer of the skin and be fixed. As a result, the efficacy of the medicinal component is exhibited in the basal layer of the skin.

  The superposition of the ultrasonic vibration can be performed when the first pump is in any driving state of discharge driving, suction driving, or discharging / suction repetition driving. When the first pump is combined with the suction drive, the skin surface can be effectively cleaned. A good cleaning effect is obtained by the effects of vibration and bubbles (when a cleaning agent is used) by the cavitation action by ultrasonic vibration.

(E) The above system is suitably applied to a composition containing gold particles as a medicinal component. As described above, gold particles have a cosmetic effect, but as they are, they hardly penetrate into the skin and are difficult to be fixed. By this system, the composition containing gold particles can smoothly penetrate into the skin and be fixed. A particularly suitable composition includes encapsulated gold particles and a binder solution, and the encapsulated gold particles are formed of gold particles having an average particle diameter of 70 nm or less and an outer skin coating film that covers the gold particles. ing.

  By encapsulating the gold particles with a skin-compatible outer coating, the rejection can be reduced and the skin can be easily penetrated. Such an exterior coating has the effect | action which ensures the safety | security with respect to a biological body, and contributes also to the effectiveness improvement by imitation of a biological function.

  It is preferable that the exterior coating contains phospholipid. A typical example is soybean-derived lecithin. Phospholipid is a generic term for lipids having a phosphate ester moiety in the structure. Phospholipids form a lipid bilayer by self-assembly and encapsulate nanometer-level gold particles, if present, to form lipid vesicles (liposomes). Lipid bilayers are permeable, flexible, and have fluid-like properties, making them easy to move through the skin.

  Furthermore, it is preferable that the binder liquid contains ascorbic acid. Ascorbic acid is a colorless water-soluble vitamin, so-called vitamin C. Ascorbic acid has a reducing property and thus acts as an antioxidant, and has functions such as inhibition of melanin production, promotion of collagen synthesis, and antioxidant activity. As a result, the binder liquid also contributes to the promotion of the cosmetic effect by penetrating into the skin.

(F) The surgical cup which is one of the components of the system of the present invention can be suitably used for purposes other than the delivery of medicinal ingredients. For example, the treatment cup can be kept in close contact with the surface of the skin by connecting the gap space between the inner cup and the outer cup to an external suction pump. Then, by connecting the internal space of the inner cup to an external pump having both suction / discharge functions, suction force / pressing force can be applied to the skin surface in various patterns. As a result, a massage effect on the skin is obtained.

Embodiments of the present invention will be described below with reference to the drawings showing examples of the present invention.
FIG. 1 is a configuration diagram schematically showing the configuration of a medicinal component delivery system according to the present invention. The main part of this system is a treatment cup 1 used on the human skin and a system drive control device 10. The system drive control device 10 is preferably configured as a unit stored in one device case, for example. The surgical cup 1 and the system drive control device 10 are connected by tube-like transfer pipes 4 and 5 capable of transferring pressurized or depressurized gas, or by an electrical connection line 21 as necessary. Is done. These gas transfer pipes 4, 5 or connection lines are all flexible, and their lengths are appropriately set in consideration of the convenience of treatment.

  The system drive control device 10 includes an electrical system unit 11 and a pump system unit 15. The pump system unit 15 includes two pumps, a first pump 16 and a second pump 17, which have a function of discharging and / or sucking gas (basically air) to the treatment cup 1. The first pump 16 has at least a discharge function, and is connected to the inner cup 2 of the treatment cup 1 described later via the first pump output portion 16 a and the first transfer pipe 4. The first pump 16 preferably further has a suction function (details will be described later). The second pump 17 has at least a suction function, and is connected to the outer cup 3 of the treatment cup 2 described later via the second pump output portion 17 a and the second transfer pipe 5.

  The type of pump of the first pump 16 and the second pump 17 is not particularly limited, but has a pressure level that does not affect the human body because it exerts a pressurizing action or a depressurizing action on human skin. It's okay. Since this system is mainly intended for cosmetic purposes (but is not limited to this), it is desirable to obtain a smooth pressure change. From this point, the bellows type is more suitable than the piston type because there is no sliding part and the air can be sucked and exhausted smoothly.

  Control of each pump of the pump system unit 15 and supply of driving power are performed by the electrical system unit 11. For pump control, starting and stopping of each pump, switching between discharge and suction, setting of pressure, adjustment of amplitude and frequency of pressure change, setting of driving time, and the like are performed.

  The control unit 13 of the electric system unit 11 includes, for example, a PIC (Peripheral Interface Controller: peripheral device connection control IC) microcomputer in which a predetermined control program is written, and an operation panel (input device for setting conditions and the like) not shown. At the same time, this system is controlled. The control of the system includes starting and stopping of the ozone generator 20 in addition to the above pump control. The power supply unit 12 generates and supplies necessary voltages and currents to each component of the system. For example, a necessary stabilized DC voltage is generated from an external AC power supply and supplied to the control unit 13. Further, pump drive power is supplied to the pump system unit 15. Further, when the ozone generator 20 is provided, an AC voltage necessary for generating ozone is output to the line 21. Although not shown, the system drive control device 10 preferably includes an appropriate display device (screen or LED element) for displaying the operating status of the system.

Preferably, the ozone generator 20 shown in FIG. 1 is inserted and installed in the middle of the flow path connecting between the internal space 2 c of the inner cup 2 and the first pump 16. Although not shown, the ozone generator 20 generates ozone (O ₃ ) by applying an alternating high voltage between two electrodes stored in the case and discharging in oxygen. The generated ozone is discharged into the internal space 2 c of the inner cup 2 together with the air discharged into the transfer pipe 4 and discharged by the first pump 16. Thereby, ozone acts on the skin surface. The action of ozone activates the oxidative effect of skin cell activity, and when the cell transitions from the quiescent state to the active state, the positive and negative ions of the vital action potential of the cell are switched, and depolarization becomes active and the blood Promote functional recovery and increase oxygen supply. As a result, the cell regeneration function is enhanced. Further, when the skin surface is cleaned before delivery of the medicinal component, it may be sterilized with ozone. Furthermore, a deodorizing and whitening effect can be obtained.

  The treatment cup 1 has a double structure including an inner cup 2 and an outer cup 3. In the illustrated example, the dome-shaped inner cup 2 includes a hemispherical dome body 2a having an internal space 2c, and is open on one side. The outer cup 3 includes a dome body 3 a substantially similar to the inner cup 2 and covers the entire inner cup 2. A gap 3c is formed by providing a predetermined gap between the outer surface of the inner cup 2 and the inner surface of the outer cup 3.

  The inner cup 2 and the outer cup 3 are preferably produced by molding plastic or glass. Although it may be made of metal, it is preferable that it is transparent because the internal situation can be visually recognized. The inner cup 2 and the outer cup 3 are made of a material having a strength that does not deform with respect to an internal pressurized state or a decompressed state by discharge or suction by the first pump 16 and the second pump 17.

  FIG. 2 is a diagram showing in detail the surgical cup 1 shown in FIG. 1, wherein (A) is a front view, (B) is a longitudinal sectional view as seen from the front, and (C) is a bottom view. The opening of the inner cup 2 and the opening of the outer cup 3 are located on substantially the same plane. In use, the surgical cup 1 is applied with these openings facing the surface of the skin. A sealing material 2 e is attached to the opening peripheral edge 2 b of the inner cup 2, and a sealing material 3 e is attached to the opening peripheral edge 3 b of the outer cup 3. These sealing materials 2e and 3e are preferably elastic members and are provided to ensure good adhesion to the skin surface.

  The wall portion of the inner cup 2 is provided with a tubular first connection portion 2d that communicates with the inner space 2c and extends outward. Since the first connecting portion 2d also penetrates the wall portion of the outer cup 3, the internal space 2c and the gap space 3c do not communicate with each other. By connecting the first transfer pipe 4 shown in FIG. 1 to the end of the first connection part 2d, the internal space 2c and the first pump 16 are connected. Therefore, when the first pump 16 is driven to discharge or suction, air is sent to the internal space 2c through the first connecting portion 2d, or air is sucked from the internal space 2c. In order to make the pressure distribution in the internal space 2c as uniform as possible, it is preferable that the first connection portion 2d is provided in the vicinity of the top of the dome body 2a.

  The wall portion of the outer cup 3 is provided with a tubular second connection portion 3d that communicates with the gap space 3c and extends outward. By connecting the second transfer pipe 5 shown in FIG. 1 to the end of the second connection portion 3d, the gap space 3c and the second pump 17 are connected. Therefore, when the second pump 17 is driven for suction, air is sucked from the gap space 3c through the second connection portion 3d. In order to make the pressure distribution in the gap space 3c as uniform as possible, it is preferable that the second connection portion 3d is provided near the top of the dome body 3a.

  FIG. 3 is a cross-sectional view showing some examples of how to use the system. The treatment cup 1 is used while being applied to the surface of the subject's skin 50. At this time, the entire sealing materials 2e and 3d are allowed to contact the skin surface, and the internal space 2c and the gap space 3c are sealed.

  FIG. 3A is a cross-sectional view of the usage situation when the first pump 16 shown in FIG. 1 is driven to discharge and the second pump 17 is driven to suction. The second pump 17 is basically driven for suction during use. As a result, the gap space 3c is decompressed, and the surrounding skin surface 53 is sucked and swells. In this case, the internal space 2c is in a pressurized state by the discharge drive of the first pump 16, and the skin surface 52 in the central portion is pressed and depressed. Since the peripheral skin and the surgical cup 1 can be kept in close contact with each other by the suction of the second pump 17, even if the central skin is pressed by the discharge of the first pump 16, the surgical cup 1 is removed. Absent. In order to realize this state, the discharge pressure and the suction pressure of the first pump 16 and the second pump 17 are appropriately set. The discharge pressure of the first pump 16 may be a constant pressure or a pulsation having a predetermined amplitude and frequency. The method of use as shown in FIG. 3 (A) is useful to apply a composition containing a medicinal component to the skin surface and to penetrate the medicinal component into the skin.

  FIG. 3B is a cross-sectional view of the usage situation when the first pump 17 is driven for suction. In the illustrated example, the second pump 17 is also driven by suction, but in this case, by the suction drive of the first pump 17, the internal space 2 c is in a reduced pressure state, and the skin surface 52 in the central portion is sucked and swells. In this case, the suction drive of the second pump 17 is not necessarily required. However, in the use example in which the discharge and suction of the first pump are frequently switched during the treatment, the second pump 17 is always suction driven. It is easier to control. The method of use as shown in FIG. 3B is used to suck dust and sebum in the skin surface cleaning process. In that case, a detergent foam or the like may be applied to the surface of the skin in advance. Although not shown in FIG. 1, when sucking dust or sebum together with the cleaning agent by sucking with the first pump 16, a container or a filter for collecting them is appropriately provided, and the first pump 16 Do not disturb the suction function. Such techniques are well known.

  FIG. 3C is a cross-sectional view of the usage situation when the first pump 17 repeats the suction drive and the discharge drive. In this case, since the internal space 2c is in a pressurized state when the first pump 17 is driven to discharge, the second pump 16 is always driven for suction to make the gap space 3c in a reduced pressure state and the skin surface 53 of the surrounding portion and the treatment cup 1 The close contact state is maintained. In this use example, the skin surface 52 in the central portion repeats depression / bulging in accordance with the discharge / suction of the first pump 17. Thereby, for example, a massage effect on the skin surface can be obtained. Alternatively, there is an effect that dust, sebum and the like are easily peeled off by moving the skin in the skin surface cleaning process.

FIG. 4 is a schematic cross-sectional view showing a surgical cup 1A and its connecting portion in another embodiment. Unlike the above example, the surgical cup 1A has a bell-shaped longitudinal section,
The opening is a little trumpet-shaped on the outside. As described above, the dome of the surgical cup used in the present system may have various modifications such as a hemispherical shape and a bell shape. In addition, the connection portion of the surgical cup 1A shown in FIG. 4 includes a first connection portion 2d that connects the internal space 2c to the first pump, and a second connection portion 3d that connects the gap space 3c to the second pump. It is formed of a heavy pipe. The double pipe connecting portion is connected to the double pipe hose 6 via an appropriate double pipe joint 7. The inner tube 6 a of the double tube hose 6 corresponds to the first transfer tube 4 in FIG. 1, and the outer tube 6 b corresponds to the second transfer tube 5. Thus, various forms can be taken in the connection between the surgical cup 1 and the first and second pumps.

  Next, a gold particle-containing composition that is a typical example of a medicinal ingredient-containing composition that can be effectively penetrated into the skin using the medicinal ingredient delivery system of the present invention will be described. The gold particle-containing composition includes encapsulated gold particles and a binder liquid. The encapsulated gold particles are formed of gold particles having an average particle diameter of 70 nm or less (more preferably 50 nm or less) and an outer skin coating film having skin affinity that covers the individual gold particles. Gold particles that are foreign matter to the skin are difficult to penetrate into the skin and to be fixed only by making them into nanoparticles. Therefore, by encapsulating the gold particles with a skin-compatible outer covering film and encapsulating them, the gold particles can easily penetrate into the skin without being excluded as a foreign substance, and can be fixed even after reaching the basal layer of the skin.

  It is preferable that the exterior coating contains phospholipid. Phospholipids easily form a film, and when mixed with gold particles, adsorb around gold particles to form liposomes (endoplasmic reticulum). Since the thickness of the phospholipid coating is usually about several nanometers, the size of the encapsulated gold particles is approximately the same as the size of the parent gold particles.

  As the phospholipid, for example, lecithin derived from soybean or egg is easily available. The concentration of the phospholipid is, for example, 2.5% by weight or more with respect to the binder liquid.

  The binder liquid is basically aqueous and is adjusted to have a paste-like viscosity that can be applied to the skin. It is preferable that the binder liquid contains ascorbic acid. Ascorbic acid has a reducing action and serves as an antioxidant.

  The treatment method is as follows. By kneading the gold particles and the binder liquid, the gold particles are coated with phospholipid and encapsulated to obtain a gold particle-containing composition. First, the target skin surface is sufficiently cleaned. Even in this cleaning process, dust and sebum can be removed by suctioning with the treatment cup of the present system. After the skin surface has been cleaned, the composition containing gold particles is applied to the target skin surface, covered with a surgical cup of the system, and the central portion is covered with the first pump while the surrounding portion is sucked with the second pump. By pressing, the gold particle-containing composition penetrates into the skin.

  Next, FIG. 5 is a diagram showing still another embodiment of the medicinal component delivery system of the present invention. FIG. 5A shows a cross-sectional view of the surgical cup 1B and the high-frequency transmitter 32. FIG. 5B is a cross-sectional view showing a usage state of the surgical cup 1B of FIG.

  As shown in FIG. 5 (A), the inner cup 2 and the outer cup 3 of the treatment cup 1B are the same as the embodiment shown in FIG. In the present embodiment, mounting supports 36a and 36b (a shape forming a part of the cylindrical wall) of the ultrasonic vibration module 30 hang down from the ceiling portion of the inner space of the inner cup 2, and a locking groove provided at the lower end thereof. 36a1 and 36b1 are respectively fitted with locking protrusions 35a and 35b provided on the cylindrical spring case 35 of the ultrasonic vibration module 30 to support the ultrasonic vibration module 30 in a detachable manner. Since the mounting supports 35a and 35b have moderate elasticity and can be slightly curved and deformed outward, the locking protrusions 36a1 and 36b1 can be pushed into or pulled out of the locking grooves 35a1 and 35b1. . In addition, the support system of the illustrated ultrasonic vibration module 30 is an example, and is not limited thereto, and may be a screw-in system.

  An ultrasonic vibration body 31 is provided at the tip of the ultrasonic vibration module 30, and an ultrasonic vibrator 31 a that is a piezoelectric element is disposed inside the ultrasonic vibration body 31. The ultrasonic vibration generated by the ultrasonic vibrator 31 a is emitted from the lower surface of the ultrasonic vibrator 31. A plurality of protrusion-like spacers 32 are provided on the lower surface of the ultrasonic vibrator 31, and this forms a space between the lower surface of the ultrasonic vibrator 31 and the skin surface, and in that space. This is because the same pressure as that of the internal space 2c is applied.

  The ultrasonic transducer 31a, which is a piezoelectric element, generates ultrasonic waves by applying an appropriate high-frequency voltage (for example, 1 MHz). Accordingly, a line 37 for supplying a high-frequency voltage to both end electrodes of the ultrasonic transducer 31a passes through the walls of the inner cup 2 and the outer cup 3 (however, the sealed state of each space is ensured), and the external The high frequency oscillator 38 is connected. For example, the high-frequency oscillator 38 may be stored in the system drive control device 10 illustrated in FIG. 1.

  Further, the movable support rod 33 extends upward from the upper surface of the ultrasonic vibrator 31, and the upper end of the movable support rod 33 is supported by the spring case 35. A spring 34 is disposed in the spring case 35 so that the movable support rod 33 passes therethrough. The spring 34 urges the movable support rod 33 downward. The lower surface of the ultrasonic vibrator 31 is set so as to protrude from the opening surface when the treatment cup 1B is not used.

  In the use state of FIG. 5B, the ultrasonic vibration body 31 is pushed upward by pressing the treatment cup 1B against the skin surface, and the movable support rod 33 compresses it against the spring 34, The ultrasonic vibrator 31 moves upward. At this time, since the ultrasonic vibrating body 31 presses the skin surface by the elastic force of the compressed spring 34, the ultrasonic vibrating body 31 adheres to the skin. The pressure control (see white arrows) of the inner cup 2 and the outer cup 3 during the treatment is performed in the same manner as in the above-described embodiment. In this embodiment, the effect of ultrasonic waves is further added.

  By using ultrasonic vibration in combination, the encapsulated gold particles can be more effectively delivered to the basal layer of the skin. Due to the effect of ultrasound, the temperature of the cell rises about 1 degree to a depth of 2 to 3 cm of the skin, and the thermal effect causes the fat to be easily decomposed and the cellular metabolism of the cell becomes active. In the vicinity of the surface of the skin where there are almost no capillaries, lymph instead of blood enters the interstices between the cells to compensate for the metabolic function. As a result, the encapsulated gold particles are facilitated to reach the base layer.

  Also, it is effective to use ultrasonic vibration in combination when sucking the internal space 2c. For example, when the skin surface is cleaned, the cleaning effect is enhanced by the effect of vibration and foam of the cleaning agent due to the cavitation action.

  Finally, FIG. 6 is a graph showing several examples of pressure control methods for the internal space (center portion) and the gap space (surrounding portion) of the surgical cup of the present system described above. The horizontal axis represents time, the positive direction on the vertical axis represents the suction force (depressurized state), and the negative direction represents the pressing force (pressurized state).

  In FIG. 6A, the first pump is driven to discharge and the second pump is driven to suck, and no ultrasonic vibration is generated. The second pump maintains suction between the surgical cup and the skin surface by maintaining suction at a constant pressure. The first pump controls the discharge pressure so that the pressing force has a constant amplitude and a constant frequency (for example, about 200 times per minute).

  In FIG. 6B, the first pump and the second pump are controlled in the same manner as in FIG. 6A to generate ultrasonic vibrations. The ultrasonic vibration has a much smaller amplitude and a much higher frequency (for example, 1 MHz) than the pressure change of the first pump. Therefore, as shown in the figure, fine ultrasonic vibration is superimposed on the pulsation of the pressure change of the first pump.

  In FIG. 6C, both the first pump and the second pump are driven for suction. The second pump maintains the suction at a constant pressure, and the first pump controls the suction pressure with a constant amplitude and a constant frequency.

  In FIG. 6D, the second pump is continuously sucked at a constant pressure, and the first pump is controlled to repeat suction and discharge at a constant amplitude and a constant frequency.

  The configuration and control method of the medicinal component delivery system according to the present invention have been described above. However, as long as the principle of the system is followed, the configuration and control method may have various modifications. Those variations are also included in the scope of the present invention. The present system and its surgical cup are particularly suitable as a medicinal ingredient delivery system for delivering encapsulated gold particles to the skin base, but can also be used to deliver other medicinal ingredients into the skin. In addition, it can be used in combination with treatment for delivering medicinal ingredients or alone, for cleaning the skin surface or for massaging.

It is the block diagram which showed typically the structure of the medicinal component delivery system by this invention. It is a figure which shows the surgical cup shown in FIG. 1 in detail, (A) is a front view, (B) is the longitudinal cross-sectional view seen from the front, (C) is a bottom view. (A)-(C) are sectional drawings which show some examples of the usage method of this system. It is a schematic sectional drawing which shows the treatment cup 1A and its connection part in another Example. It is a figure which shows another embodiment of the medicinal component delivery system of this invention. (A) shows a sectional view of the surgical cup 1B and the high-frequency transmitter 32. FIG. (B) is sectional drawing which shows the use condition of the treatment cup 1B of (A). (A)-(D) are the graphs which showed some examples of the pressure control method of the internal space (center part) and gap | interval space (surrounding part) of the treatment cup of the above-mentioned system.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1, 1A, 1B Treatment cup 2 Inner cup 2a Cup wall part 2b Opening peripheral part 2c Internal space 2d 1st connection part 2e Sealing material 3 Outer cup 3a Cup wall part 3b Opening peripheral part 3c Gap space 3d 2nd connection part 3e Sealing material 4 1st transfer pipe 5 2nd transfer pipe 6 Double pipe hose 7 Joint for double pipe 10 System drive control device 14 Output terminal 16 1st pump 16a 1st pump output port 17 2nd pump 17a 2nd pump output port 20 Ozone generator 21 Voltage supply line 31 Ultrasonic vibration module 32 Ultrasonic vibration body 33 Spacer 34 Movable support rod 35 Spring 36 Spring case 38 High frequency oscillator 50, 52, 53 Skin

Claims (11)

A medicinal ingredient delivery system for allowing a medicinal ingredient-containing composition applied to the surface of the skin to penetrate into the skin,
A first pump (16) having at least a discharge function; a second pump (17) having at least a suction function; and a surgical cup (1) for applying to the surface of the skin;
The surgical cup comprises a dome-shaped inner cup (2) and a dome-shaped outer cup (3) that covers the inner cup by providing a gap between the outer surface of the inner cup,
The openings (2b, 3b) of the inner cup and the outer cup are located on substantially the same plane, and the inner space (2c) of the inner cup is a first connecting portion (2d) provided on the wall of the inner cup. ) And the gap space (3c) between the inner cup and the outer cup is connected to the second pump via a second connection part (3d) provided on the wall of the outer cup. A medicinal ingredient delivery system characterized by being connected to a pump.   The medicinal component delivery system according to claim 1, wherein the first pump (16) has a suction function in addition to a discharge function.   The medicinal ingredient delivery according to claim 1 or 2, wherein an ozone generator is inserted and installed in a flow path connecting the internal space (2c) of the inner cup and the first pump (16). system.   The medicinal component delivery system according to any one of claims 1 to 3, wherein an ultrasonic vibration module is installed in the internal space (2c) of the inner cup with the ultrasonic vibration surface facing the opening.   The medicinal component-containing composition includes encapsulated gold particles and a binder liquid, and the encapsulated gold particles are composed of gold particles having an average particle diameter of 70 nm or less and an outer skin coating film that covers the gold particles. The medicinal component delivery system according to any one of claims 1 to 4, which is formed.   The medicinal component delivery system according to claim 5, wherein the outer coating contains a phospholipid.   The medicinal component delivery system according to claim 5 or 6, wherein the binder liquid contains ascorbic acid. A surgical cup for applying suction or pressure to the surface of the skin,
A dome-shaped inner cup (2) and a dome-shaped outer cup (3) that covers the inner cup by providing a gap between the outer surface of the inner cup, each of the inner cup and the outer cup The openings (2b, 3b) are located on substantially the same plane,
A first connection portion (2d) provided on a wall of the inner cup to connect the inner space (2c) of the inner cup to an external pump;
And a second connecting portion (3d) provided on a wall portion of the outer cup to connect a gap space (3c) between the inner cup and the outer cup to another external pump. Surgery cup. A composition containing a medicinal component that is applied to the surface of the skin and penetrates into the skin,
The encapsulated gold particles include an encapsulated gold particle and a binder liquid, and the encapsulated gold particle is formed of a gold particle having an average particle diameter of 70 nm or less and a skin-compatible outer coating film that covers the gold particle. Medicinal component-containing composition.   10. The medicinal component-containing composition according to claim 9, wherein the outer covering film contains a phospholipid.   The said binder liquid contains ascorbic acid, The medicinal component containing composition of Claim 9 or 10 characterized by the above-mentioned.

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