JPS62297753A - Chromatographic device - Google Patents

Abstract

PURPOSE:To maintain an oil pressure in a circuit and to prevent the oscillation of a column during the erection thereof by connecting a crank arm and stand by a main actuator which rotates the column forward and backward at the angle smaller than 180 deg.. CONSTITUTION:The crank arm 4 and the stand 1 are connected by the main actuator 5 which rotates the column 2 forward and backward at the angle smaller than 180 deg.. The arm 4 and the column 2 are connected by an auxiliary actuator 7'. The column 2 is rotated relative to the arm 4 by the actuator 7' so that the column 2 is rotated 180 deg. forward and backward by making up the forward and backward rotation of the column 2 by the actuator 5 at the angle smaller than 180 deg.. The actuator 7' can rotate the column 2 forward and backward by a least 10 deg.C relative to the arm 4 when the actuator 5 rotates the arm 4 170 deg. forward and backward. The generation of the dead point to be generated when the column 2 is rotated 180 deg. by the actuator 5 is thus prevented by operating the actuator 5 and actuator 7' simultaneously or successively.

Description

Detailed Description of the Invention 3. Detailed Description of the Invention (Field of Industrial Application) This invention relates to a chromatography apparatus for separating target components from liquids and gases containing multiple components by chromatography on an industrial scale.

(Prior technology) The horizontal axis of the column is installed between a pair of left and right stands, the column is supported reversibly, a sprocket wheel is attached to the horizontal axis and the stand, and an endless chain is stretched between both sprocket wheels. At the same time, the stand is equipped with a worm foil on the shaft that connects the sprocket, and a worm that engages with the worm foil.The worm is manually rotated in forward and reverse directions, and the column is erected to perform the preparative separation process. It is conventionally known to open the top of the column by turning it upside down and draining the filler inside the column for replacement.

(Problems to be Solved by the Invention) In the conventional device described above, the column can swing due to the backlash between the worm and the worm wheel, and the backlash between the sprocket wheel and the endless chain, both when standing upright and when standing straight. If the column is shaken during the preparative separation process, the efficiency of the separation will deteriorate and the purity of the components to be separated will decrease.

Furthermore, it takes effort to manually flip the device from an upright position to an inverted position, and from an inverted position to an upright position.

(Means for Solving the Problem) Therefore, the present invention has a column attached to the horizontal axis of the column installed between the left and right stands, and a crank arm that can be rotated in the forward and reverse directions by degrees Celsius can be relatively rotated. The crank arm and the stand are connected by a piston-type main actuator that rotates in forward and reverse directions at an angle smaller than that of the column (1180'), and the crank arm and the column are connected by an auxiliary actuator, The auxiliary actuator rotates the column relative to the crank arm to compensate for the rotation of the column in the forward and reverse directions by an angle smaller than 180 degrees by the main actuator, thereby rotating the column 180 degrees in the forward and reverse directions.

(Function) Assuming that the main actuator rotates the crank arm 170 degrees in the forward and reverse directions, the auxiliary actuator enables the column to rotate at least 700 degrees in the forward and reverse directions relative to the crank arm. In this way, both the main actuator and the auxiliary actuator are actuated simultaneously or sequentially to reciprocate and invert the column from an upright state to an inverted state or from an inverted state to an upright state, and the column is rotated 180° with one piston or f yuator. Prevents dead points from occurring when rotating.

(Example) In the illustrated example, 1% l is the left and right stands,
Column 2 has a fixed horizontal shaft 3.3 protruding left and right from the middle of both ends, and is installed on bearings 1' and 1' provided at the upper end of the left S-right stand. It is reversibly supported between the stands.

As is well known, in order to separate target components from liquids and gases containing multiple components, a large amount of filler such as silica gel or ion exchange resin is contained in the column, depending on the purpose of separation. In the preparative separation process, the cap λ', which is equipped with a perforated plate that does not allow the filling material to pass through but allows the liquid and gas to pass through, is in an upright position with the cap λ' facing upward.

This packing material needs to be replaced with a new one at predetermined intervals or taken out for cleaning.In that case, the column must be inverted, upside down, the cap facing downwards, and the filling material must be filled from inside the column. Drain the agent and then.

Stand the column upright again, fill it with new packing material, close the cap, and restart the preparative separation process.

In order to reciprocate the column from upright to inverted and from inverted to upright, one end of the clan firmer is rotatably attached to the center of the tip of the horizontal shaft 3 of one or both of the columns, and the space between the other end and the stand is They are connected by a hydraulically actuated piston-type main actuator j that can rotate the column back and forth by, for example, 170° by expanding and contracting.

This horizontal shaft 3 is provided with a protruding piece 6 that protrudes radially from the circumferential side, and the clamp firmer is provided with two opposing pieces and Ir on both sides of the protruding piece 6, which face each other at a distance. In the example, a hydraulically actuated piston-type actuator 7' with piston ends facing each other and t I Y
Installation, mutual [one actuator 7' (or t')
, and the other actuator g' (also +st') 1
When the protruding piece 6 is extended, the actuator rF is extended and elongated.
Actuator 7' shortened with piston (or 7')
(or tl) screw, pressed against the ton end, protruding piece 6'
The horizontal shaft 3 provided with
°Let it rotate.

Then, when the main actuator S is shortened, the actuator 7' is extended, and the actuator GL is shortened, the column is erected, and if necessary, the piston of the actuator 7' is pressed against the piston of the actuator g'. Provide a screw-type stopper 9 on the stand l to receive the protruding piece 6 from below.

The piping between each actuator, 7', g', and the hydraulic source can be done, for example, as in the circuit shown in Figure 4, using a manual hydraulic pump IO'lf-operated and via an increased hydraulic accumulator//. A manual or electromagnetic directional control valve is used to switch the supply to the main actuator 5 to shorten or extend the main actuator, and when the main actuator is shortened, the actuator 7' is extended, and the actuator t'
When the main actuator is extended, the actuator 7' is shortened, and when the main actuator is extended, the actuator 7' is shortened.
' Let it expand. The main actuator 5 is a double-acting type, but is it an actuator? As shown in the figure, ', g' is a simple mechanism that supplies hydraulic pressure to the head end of the cylinder to extend the piston, and when shortening it, pushes the piston back with the restoring force of the built-in spring and drains the internal pressure oil into the pump. A moving type is fine.

When the column is erected by the forceps, the main actuator S is in the shortened state, and the piston of the actuator tactor' is extended and the protruding piece 6 is moved to the shortened state of the actuator g'.
Because the column is pressed against the piston, the column cannot be swung, so there is no loss of purity during the preparative separation process.

To invert the column in order to replace the internal packing material, the directional control valve /2 is switched and the main actuator s2 is extended. As a result of this, the piston of actuator g' simultaneously expands, and conversely, the piston of actuator g' is pressed against the piston of actuator 7', which is being shortened.

Therefore, by extension of the main actuator S, the crank arm 4
I turns 170 degrees, pushes the protruding piece 6 with actuator g' to rotate column 2 by the same amount, and at the same time, by extending actuator ν and shortening actuator 7', column column further moves 10 degrees in the same direction with respect to crank arm q. Rotate and the column is turned upside down with a total rotation of 180°.

After opening the cap 7' and discharging the filler, it is only necessary to shorten the main actuator S and shorten the extension gl of the actuator 7' for one day in order to erect the column.

In this embodiment, the main actuator 5 reciprocates the column by only 170 degrees, so the remaining 10 degrees of reciprocating rotation, which is insufficient to make the column stand upright or inverted, is covered by a pair of opposing actuators 7', in which when one extends, the other shortens. and t′, but this supplementary actuator huff′ alone is sufficient,
g' can be omitted.

That is, if actuator g' is omitted, when a column that is standing upright is turned upside down, the opposing piece g pushes the protruding piece 6 and rotates the column 1 degree by 0 degrees due to the extension of the main actuator S, and at the same time, actuator 7' moves the piston. Since it is retracted and shortened, the column rotates by its own weight for the remaining 10 degrees, pressing the protruding piece 6 against the shortened actuator 7'. In this inverted state, the column can be swung in the opposite direction; however, since no fractionation process is performed at this time and only the packing material is discharged, there is no problem in swiveling the column. When the main actuator 5 is extended to return the column to the upright state, the actuator 7' is extended to compensate for the shortfall in the main actuator, and the protruding piece 6 is pressed against the stopper 91C, thereby swinging the column back to the upright state. Movement becomes impossible.

Furthermore, the piston end of the actuator 7' is connected to the protruding piece A, and the piston end of the actuator 7' is connected to the protruding piece B, in addition to the actuator g'.

It is obvious that even the opposing piece t and the stopper 9 to which the holder is attached can be omitted.

Therefore, it should be understood that the auxiliary actuator mentioned in claim (1) above is the actuator 7'.

Incidentally, the hydraulic pump to trs is not necessarily limited to a manual type, but may be driven by a motor. Furthermore, it goes without saying that the sample supply pipe connected to the cap at the upper end of the column and the extraction pipe for fractionated components connected to the lower end can be removed when the column is inverted.

(Effects of the Invention) According to the present invention, it is possible to easily reverse the column using hydraulic pressure, and it is also possible to prevent the column from swinging when it is erected by holding the column in the hydraulic circuit.

[Brief explanation of drawings]

Fig. 1 is a schematic side view of an embodiment of the chromatography apparatus of the present invention, Fig. 2 is an enlarged side view of the main part of Fig. 1, Fig. 3 is a front view of Fig. 2, and Fig. 4 is a hydraulic circuit. l Show. In the figure, 1 indicates left and right stands, 2 indicates a column, 3 indicates a horizontal axis, DA indicates a crank arm, S indicates a main actuator, and 7' indicates an auxiliary actuator.

Claims (2)

[Claims] (1) Install the horizontal axis of the column between a pair of left and right stands,
A chromatography apparatus that reversibly supports a column includes a crank arm that is rotatably mounted relative to the horizontal axis and can rotate forward and backward with the column; and a crank arm and the stand. connect between
A piston-type main actuator that rotates the column in the forward and reverse directions at an angle smaller than 180°, and a piston-type main actuator connecting the crank arm and the column, wherein at least the main actuator rotates the column in the normal and reverse directions at an angle smaller than 180°. A chromatography apparatus comprising an auxiliary actuator that rotates a column 180° in forward and reverse directions to compensate for reverse rotation. (2) The chromatography apparatus according to claim (1), wherein the auxiliary actuator is a two-piston type actuator that opposes and pinches an overhang from the horizontal axis of the column.