JPS62273908A - Agent for nourishing and growing hair - Google Patents

Abstract

PURPOSE:A novel agent for nourishing and growing hair, having safety and improved nourishing and growing effects on hair free from side effects, comprising an erucic acid as an active ingredient. CONSTITUTION:An agent for nourishing and growing hair, containing at least one compound selected from erucic acid (cis-13-docosenoic acid) and salts thereof acceptable as an agent for nourishing and growing hair as an active ingredient. Erucic acid sold on the market (physical constants: boiling point = 206.7 deg.C/1 mmHg; d4<55> = 0.860; nD<45> = 1.4534) is used as the erucic acid and the concentration of >=0.001% (0.001-30%) can exhibit nourishing and growing action. The active ingredient is blended with various kinds of well-known (cosmetic) bases by a conventional procedure and useful as hair cream, milky lotion, hair liquid, hair lotion, hair rinse, hair tonic, pomade, shampoo, and other cosmetics in a shape such as solution, gel, emulsion, ointment, oil, wax, spray (aerosol), etc.

Description

[Detailed Description of the Invention] 3. Detailed Description of the Invention (Field of Industrial Application) The present invention relates to a novel hair nourishing and restoring agent that has no side effects and has remarkable hair nourishing and hair growing effects.

<Conventional technology> There are many unknown aspects of the medical science related to hair loss and hair growth, and the physiological mechanisms of action of the hair nourishing ingredients used for this purpose are largely unknown.
Currently, the causes of hair loss are endocrine abnormalities and hair cycle abnormalities.

Dysfunction of the autonomic nervous system, poor blood circulation, and malnutrition.

Others (hereditary, aging, etc.) may be mentioned. Conventional hair tonic ingredients include, for example, follicle hormone (Japanese Patent Application Laid-Open No. 60-38
313), vitamin E, B2°B6.
Vitamins such as biotin and pantothenic acid, their modified amino acids (peptide substances: JP-A No. 61-7209), Φ crude drug extracts such as Oriental japonica extract, anti-inflammatory agents such as diphenhydramine hydrochloride, photosensor No. 301, hinokiol, lactic acid, etc. These include keratolytic agents, humectants such as glycerin, other scalp irritants, disinfectants, and cooling agents.

Hair nourishing and hair growth agents are used with the expectation of local efficacy by using the above-mentioned hair nourishing ingredients alone or in combination, and are used to promote hair growth, prevent dandruff, itching, and inflammation, and prevent thinning hair and hair loss. The aim is to achieve comprehensive hair nourishment and hair growth effects.

Recently, properties of substances such as testosterone-5α
-There is a tendency to focus on the reductase inhibitory effect and cell/skin activating effect and use the substance as a hair nourishing agent.

The reason why the above-mentioned testosterone-5α-reductase inhibitor is used as a hair growth agent is that -According to the theory, physiological symptoms such as male pattern baldness, coarse hair, acne vulgaris, and seborrhea are caused by metabolism. It is thought that this is due to an increase in androgenic stimulation caused by excessive accumulation of male hormone (5α-dihydrotestosterone) in the system. In other words, this male hormone (5α-dihydrotestosterone)
is thought to be produced by reducing testosterone by the action of testosterone-5α-reductase. Therefore, in various organs such as hair roots and sebaceous glands,
Testosterone-5α-reductase acts to produce and accumulate male hormones, resulting in atrophy of the hair roots and hair loss.
It is thought to induce baldness.

For example, examples of substances having testosterone-5α-reductase inhibiting properties include carboxylic acids (higher fatty acids, etc.) (described later), bicyclic fused ring compounds such as bicyclic terpenes (JP-A-59-53417; Showa 59-53418
No., JP-A-59-55813, JP-A-59-5341
No. 9, JP-A No. 59-5,5812, etc.), aromatic alcohols, aromatic carboxylic acids and their derivatives (JP-A No. 57-57, etc.)
-53401 etc.), other substances (JP-A-60-14
No. 6829.

There are related documents such as JP-A-59-59606, JP-A-59-59607, etc.).

By the way, as mentioned above, there is a literature that shows that certain carboxylic acids (higher fatty acids, etc.) have testosterone-5α-reductase inhibiting properties and cell activating properties, and the latter has a synergistic effect with cell activating and water retention effects. It is assumed that the effect is to prevent hair removal and hair removal.

Examples of the higher fatty acids having testosterone-5α-reductase inhibiting properties include oleic acid (18 carbon atoms
) (JP-A-59-152308), n-capric acid (
carbon number 10), n-caprylic acid (carbon number 8).

Lauric acid (12 carbon atoms), myristic acid (14 carbon atoms)
), palmitic acid (16 carbon atoms), stearic acid (18 carbon atoms) (six types of fatty acids: JP-A-59-172410
), lylunic acid (18 carbon atoms), parinaric acid (18 carbon atoms), petroselic acid (18 carbon atoms), palmitoleic acid (16 carbon atoms) (these four types of fatty acids: JP-A-59-1
72411) etc. In addition, fatty acids with an odd number of carbon atoms and their derivatives (JP-A-61-5007, JP-A-61-5014) and branched fatty acids and their derivatives (JP-A-61-5014) have the cell/skin activating properties. -7205) etc. In addition, as aromatic carboxylic acids and the like having enzyme inhibiting properties, cinnamic acid and its derivatives are also used.
7-53401).

As described above, the reason why there is a wide range and variety of substances that are said to have the testosterone-5α-reductase inhibitory property and/or the hair-growth/hair-growth effect is due to the enzyme activity of the testosterone-5α-reductase and the hair-growth/hair-growth effect. The specificity of physiological activity related to hair growth etc. is thought to be due to the correlation with the molecular structure of the chemical substance. Therefore, even if the compounds are similar or homologous, such as higher fatty acids with the same number of carbon atoms, their isomers (positional isomers, structural isomers, geometric isomers) will affect the presence or absence of the enzymatic activity and physiological activity and their potency. Therefore, it is extremely difficult to predict or predict the presence or absence of the characteristics related to the enzyme activity and physiological activity. There are significant differences between the sexes, and the current situation is that it is impossible to tell without directly measuring and searching for the hair-growth and hair-growth effects of each substance.

-Thus, there are a wide variety of substances that have hair-nourishing and hair-growth effects, and these conventional hair-nourishing and hair-growth agents (particularly hormones) have side effects and do not necessarily have sufficient hair-nourishing and hair-growth effects. , the development of new hair nourishing and hair growth agents is desired.

<Problems to be Solved by the Invention> This invention is intended to meet the above-mentioned demands, and is intended to search for and find out the hair-nourishing and hair-growth effects of various fatty acids and their salts.
As a result of the test, erucic acid (erecic ac
The present invention was completed based on the discovery that id) and its salts have excellent hair-nurturing and hair-growth effects, and thereby provides a hair-nurturing and hair-growth agent that is safe without side effects and has remarkable hair-nurturing and hair-growth effects. The purpose is to

Means for Solving the Problems In order to achieve the above object, the present invention uses erucic acid as an active ingredient of a hair nourishing agent.
, IUPAC: cis-13-tocosenoic acid = cis-1
3-docosenoic acid) (hereinafter simply referred to as "erucic acid") or/and a salt of erucic acid as an active ingredient.

The erucic acid used in this invention is commercially available erucic acid (physical constants: boiling point = 206.7°C/lmmHg, d4 = 0.8
60.

n45=1.4534) is used. In addition, the identity of erucic acid and its purity can be confirmed by measuring the physical properties of commercially available erucic acid.

By the way, the existence of erucic acid in nature is found in rapeseed (
Rapeseed), Wa
llflower) and astragalus (Nastu
Brassicaceae (Cruciferae) (Cr
uciferae) and Tropidae (Trop
It is present in the fatty oils of seeds of plants belonging to the family Aeolaceae), and is included as glycerides in, for example, rapeseed oil, mustard seed oil, grape kernel oil, and the like. Therefore, erucic acid can be obtained by using a crude product obtained by hydrolyzing the oil with alkali or acid using a known method (Dor6e method: J, Che
m.

Soc, 1942. 477) That is, ijI can be produced by fractional precipitation using a solvent fractionation method and a recrystallization method. Similarly, prepared erucic acid is verified by measuring physical properties to confirm the identity of erucic acid and its purity.

This erucic acid is 0.001% or more (0,001 to 30
%), it is recognized that it produces hair nourishing and hair growth effects. This test method for the hair-growth effect of erucic acid involves shaving the hair from the back of a domestic rabbit (10 weeks 1) and applying a diluted solution of erucic acid at a predetermined concentration (example of solvent:
99.5% ethanol) is repeatedly applied over a certain period of time, and the elongated hair is measured.

In addition, erucic acid is not toxic or irritating to the skin (based on the punch test method, etc.), and has no side effects like hormones.

The hair nourishing agent of the present invention contains erucic acid or at least one salt selected from the group of salts of erucic acid and metals that are acceptable as a hair nourishing agent.
Manufactured. The above-mentioned acceptable salt may be any salt that is generally acceptable as a hair nourishing agent, such as an ammonium salt or a salt with an alkali metal such as a lithium salt, a sodium salt, or a potassium salt, or a calcium salt or a strontium salt.

Salts with alkaline earth metals such as barium salts and other salts can be used.

The amount of erucic acid or/and its salt in the hair nourishing/growth agent of the present invention is not particularly limited as it can be varied depending on the form of use. In principle, it is sufficient that it is present in an effective amount, but generally the content (single or combined amount) is 0.001 to ( 30) ffi amount%, preferably 0.01 to 15 ffi amount% (even 0.1 to 1
(optimally 0% by weight) can exhibit hair nourishing and hair growth effects.

In addition, the hair nourishing/hair growth agent of the present invention is prepared by blending at least one kind selected from the above-mentioned erucic acid and its salts into various known (cosmetic) bases, etc. in a conventional manner, such as hair cream, milky lotion, etc. hair liquid.

It can be used in hair lotions, hair rinses, hair tonics, pomades, shampoos and other cosmetics. The cosmetics may be in the form of a solution or a sol.

Gels, emulsions, ointments, oils, waxes.

It can be used in various forms such as spray (aerosol). In addition, should the above-mentioned erucic acid be added?

Whether or not to incorporate the various salts thereof is determined depending on the form and form of the final product as a hair nourishing/growth agent.

For example, erucic acid is added to shampoos, hair creams, etc., and erucic acid salts (such as sodium salts) are added to hair lotions.

Furthermore, it goes without saying that the hair nourishing and restoring agent of the present invention can be used in combination with other known hair nourishing and restoring agents, and can exhibit excellent synergistic effects. In addition, the hair growth agent of this invention includes various surfactants and solvents.

Since it is stable against various other additives such as pigments, fragrances, preservatives, antioxidants, and humectants, it can also be used in combination with these various additives.

<Example> Next, a description will be given based on a specific example.

(1) Preparation of erucic acid: The erucic acid used in this invention is commercially available erucic acid (physical constant:
Boiling point -206.7℃/lmmHg, d4=0.8
60, no-1,4534).

(2) Test method for hair nourishing and hair growth effects of erucic acid.

The hair on the back of a male rabbit (10 weeks 1) was shaved, and 1 ml of the erucic acid 0.2% ethanol solution (solvent: 99.5% ethanol) was applied to this area once a day. Measure the length of the elongated hair on each day. As a control, 1 ml of 99.5% ethanol containing no erucic acid was similarly applied to a comparatively close control position on the back once a day, and the length of the elongated hair on the 6th day was similarly measured. do.

The test results are shown in Table 1. In the table, A = average Shinshi standard deviation of hair on the control side (+nm) A' = average Shinshi standard deviation of hair on the test side (mn+) B = (average value of hair on the test side) - (hair on the control side ) (fflIll) *=means the average of the respective average values of the control side and the test side, respectively. All units are mn+.

Table 1 Results of hair growth and hair growth effect test of erucic acid
(Unit: w) [Margin below this page] (3) Shampoo formulation example [Ingredients] [Content/weight%] Sodium polyoxyethylene alkyl ether sulfate (E, 02 mol) ・−・・−・−−− ---One--
−・−・・−・−・・ 15. Coconut oil fatty acid jetanolamide・−・ 5. Glycerin −・−−−−・−
・−−−−−−−−−−−・−・−・−−−−−1−−
---
−・0.2・Fragrances and preservatives−・−・−−−−−
−−−−−−−−−−・−−−−−−・−・Amount/Ion exchange water −1−−−−−−−−−−−−・−・・The whole is set as 100 .

(4) Hair cream prescription example [Ingredients] [Content/MW%] Liquid paraffin
−−−−−−−−−・・−20・Solid paraffin−・−
−−−−−−1−−−・−・−・−−m−−−−−
-・-3・Polyoxyethylene cetyl ether (E, 0 15 mol) ・・・−・−・・−・−1−−
−−−−・・−−−−1−・−・2. Sorbitan sesquioleate −・・−・−・・−Toerucic acid ・
・−・−−１−−−−−・−・−・・・−・・・−・−
・−−−−−−−−・・・−0,5・Potassium hydroxide
−・・−・−−−−−１−−・−−−１−・−・−・−
・－・・・・ 0. Toglycerin-1------
−−−−・・−・−−−−−−−−−−−−−−−−−
−−−・−・3・Fragrances and preservatives・−−−−−・−
−1−−−−・−−1−−・−・−−−−・Appropriate amount・Ion exchange water～−−−−−−−−−−・・−・−・The whole is set as 100.

(5) Prescription example of Hair Loshishin [Ingredients] [Content/Weight%]・9
5% ethanol--1-----・・------1--
−−・−−−−−−−・−−−1−・−20・Glycerin−−−−−−−−−−−−−−−−
−・−−−−−−−−−−−・・−・3・Polyoxyethylene sorbitan monolaurate (8,020 mol>−−−−−−−−
−−−・Sodium toerucate−・−・−・・−・−
・−・−・−−−１−−・ 0.5・Fragrances and preservatives−・・−・・−−−−−−−１・−・−・−・−・−・
Appropriate amount・Ion exchange water・−・−・・−・−・−・・
The whole number is 100.

(6) Prescription example of Heartonic [Ingredients] [Content/Weight%]・9
5% ethanol---------・・−・−・−------
−−−−−−−−−・−−−−−−60・Polyoxyethylene hydrogenated castor oil (E, 0 60 mol) −−−−−−−−
−・0.5・Glycerin−・−・−1−−−−・−・
−−−−−−−−−−−−−−−・−・−−−−−−−
--・3・Erucic acid・−・−・−・−−−111−−−
−−・・・−１−−−・−・−・・・−・−・−・ 0
．． 1.Fragrances and pigments・−・−・−・−−−−−・−−
----------------------Amount of ion-exchanged water----------------The entire amount is 100.

(7) Pomade prescription example [Ingredients] [Content/Mi1%]/
Mokurooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo!!!
−−−−−−・−−−−−−−1−−−−・−・
...13.Castor oil--------1・--・・--
−−−１−−・−・・−・・−−−−−−m−−−−・
85.8 Erucic acid------------
１－－－－・−・・・・・−−−−−−−−−・−−−
−−−−1・Fragrance・−・−・・−−1−−−−−−−
−・−・−・・−・−・−・−−−−−−・・−・−・
0.2 <Actions and Effects of the Invention> The hair nourishing and hair growing agent according to the present invention is safe and has an excellent hair nourishing and hair growing effect that achieves the purpose of the invention due to the excellent hair nourishing and hair growing effect of erucic acid. special

Claims (1)

[Claims] (1) A hair nourishing agent containing as an active ingredient at least one compound selected from the group consisting of erucic acid and salts of erucic acid that are acceptable as hair nourishing agents.