JPS62169711A - Skin cosmetic - Google Patents

Abstract

PURPOSE:A skin cosmetic, obtained by blending vitamin D3 and/or a derivative thereof with other ingredients, having effect on prevention and improvement in all kinds of skin roughening and satisfiable from viewpoints of both safety and stability. CONSTITUTION:A skin cosmetic containing one or two or more selected from vitamin D3 (cholecalciferol) and a derivative thereof, e.g. 25- hydroxycholecalciferol, in an amount of 0.0005-0.1wt% based on the total weight. The cosmetic is effective for preventing and improving skin roughening and used in the form of toilet water, milky lotion, cream, pack, foundation etc.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application 1] The present invention relates to skin cosmetics, more specifically vitamin D3.
The present invention relates to skin cosmetics containing or a derivative thereof.

[Prior Art] In general, various raw materials, including raw materials extracted from natural products, have been blended into skin cosmetics and used to date for the purpose of preventing and improving skin roughness. ing.

For example, extracted extracts such as loofah extract and placenta extract, natural polymers such as quince, proteins such as collagen, polysaccharides such as chitin, single amino acids such as arginine, skin activators such as vitamin E, or moisturizers such as glycerin. etc. are widely used in skin cosmetics for the purpose of preventing and improving rough skin, and have continued to this day.

However, these substances that have been conventionally used to prevent and improve skin roughness are being used to prevent and improve skin roughness caused by a low amount of sebum and moisture in the facial skin, and have recently been used to prevent and improve rough skin. Papers (Development
of a 5 scientific method
rC1assification of Facia
l 5kin Types.

Hlroko Kumagai et at:X1ll
Congreso Internaciona
l de la I, F, S, C, C, vo
l.

1-19, 1984), it has no effect on preventing or improving a different type of skin roughness, one in which there is a large amount of sebum, the skin mounds and grooves are unclear, and scaling is observed. Therefore, it has the disadvantage that it cannot be expected to have a sufficient effect on normalizing a wide range of skin types.

[Problems to be Solved by the Invention] In view of these circumstances, the present inventors have developed a method that is effective in preventing and improving all kinds of skin roughness, and is also effective in terms of safety and stability. As a result of intensive research in order to obtain a substance that satisfies the needs of people, we found that when one or more selected from the group consisting of vitamin D3 and its derivatives are combined,
The present inventors have discovered that the present invention is extremely useful for preventing and improving all kinds of skin roughness, and have completed the present invention.

[Means for Solving the Problems 1] That is, the present invention provides vitamin D3 containing one or more selected from the group consisting of vitamin D3 and derivatives thereof.
It is a skin cosmetic product.

Next, the configuration of the present invention will be explained in detail.

Vitamin D3 used in the present invention is also known as cholecalciferol, and vitamin D3m conductors include 25-hydroxycholecalciferol, 1α-hydroxycholecalciferol, 5.6-trans-25-hydroxycholecalciferol, 1α-25 -Dihydroxycholecalciferol, dihydrotachysterol and the like.

These vitamin D3 or its derivatives are all white crystals and odorless. In addition, these substances are easily soluble in organic solvents such as ethanol and chloroform, slightly soluble in fatty oils, and almost insoluble in water.

The amount of vitamin D3 or its derivatives incorporated into skin cosmetics is not particularly limited, but is usually 0.000001 to 5% by weight, preferably 0.000001 to 5% by weight, based on the total amount of the cosmetics.
It is about 0.0005 to 0.1% by weight. o, oo.

If the amount is less than 0.001% by weight, the effect of preventing and improving skin roughness tends to be poor, and conversely, if the amount exceeds 5% by weight, no significant increase in the effect can be expected.

In addition, these vitamin D3 or its derivatives are 197
It was discovered almost simultaneously by DeLuca et al. and Kodicek et al.
This substance is used to improve bone cancer, bone lesions, etc.).

However, all of these uses of vitamin D3 and its derivatives are in the form of internal medicines, and no examples of external use have been observed.

In addition to the above-mentioned essential ingredients, the skin cosmetics of the present invention include common ingredients that are included in general skin cosmetics, such as oil,
Water, surfactants, humectants, lower alcohols, thickeners, chelating agents, pigments, preservatives, fragrances, and the like can be added as appropriate.

The term "skin cosmetics" as used in the present invention broadly refers to products used on the skin, such as facial cosmetics such as lotions, milky lotions, creams, and packs, and foundations.

[Example] Next, the present invention will be explained in further detail by giving experimental examples and examples. Of course, the present invention is not limited to this. The blending amount is in weight%.

Experimental example 1 Cream Phase C, as listed in Table 1, was heated and maintained at 70°C.

Phase A and phase B were added to this in sequence and pre-emulsified, then uniformly emulsified using a homomixer, and then gradually cooled to create a cream (sample NQI~
Nc+5) was prepared.

Each cream in Table 1 (sample Nα1 to NQ 4) was applied to a panel (
Sample Nα5 was applied to the right half of the face of 5 women (22 to 32 years old).
The cream was applied to the left half of the face twice a day for two consecutive months.

After the test was completed, the skin at the application sites on both the left and right sides of the face was measured using skin impedance and a replica method, and the moist feeling of the skin and the fineness and roughness of the skin texture were compared.

(Left below) Skin impedance was measured using a high-frequency resistance-capacitance measuring device devised by Masuda et al. This device consists of a main body that includes a 3.5 MH2 high frequency current generator and a resistance and capacitance detector, a 1 cm long cord, and a cylindrical electrode attached to the tip. The electrodes are concentric and consist of a center electrode with a diameter of 1 mm and an outer electrode with an inner diameter of 4 mm placed at a distance of 1.5 mm. When the electrodes are applied to the skin, high frequency waves flow through them, but the frequency is in the range of several microns. So I don't feel any discomfort from the panel. When this electrode is lightly touched on the area to be tested, the resistance rises rapidly to a certain value within one second.

The reciprocal of this resistance is the conductance (Conduct-a
nce), and its unit is μΩ. This conductance is almost proportional to the water content on the skin surface, and the higher the water content of the skin, the better the moist feeling of the skin, so we decided to evaluate the moist feeling of the skin by increasing the conductance. .

Table 2 compares the conductance in the skin impedance on the face of the panel using the Na2 cream with the facial area of the panel using the floor 5 cream.

1α-25-dihydroxycholecalciferol 10
- The conductance of the application site (right face) of the panel using the cream containing 4% by weight is significantly higher than that of the application site of the panel using the above drug-free cream (Na5). I understand.

This shows that the cream that gave the skin a more moisturized feel was Na 2 according to the above.

The conductance of all panels was measured in the same manner.

Compare the conductance of the right face of the panel using the cream containing 1α-25-dihydroxycholecalciferol and the conductance of the left face using the Na5 cream, and if the conductance on the right side increases by 70% or more, it is considered to be significantly effective. The results are shown in Table 3.The results are shown in Table 3.The results are shown in Table 3.

Table 3 On the other hand, the fineness of the skin texture was observed using the replica method.

A silicone rubber was brought into close contact with the skin to take a surface image of the skin, and then engineered boxy resin was poured into the silicone rubber to obtain an inverted image. A surface roughness tester was operated on the surface of this inverted image to examine the skin condition. It was determined that the greater the undulations of the skin surface, the finer the skin texture.

In the same way, replica images of the faces of all panels were taken and the left and right sides of the face were compared. If the right side of the face had clearly larger undulations, it was determined that there was an effect, and if there was no obvious difference, it was determined that there was no effect. The results are summarized in Table 3.

It was found that 1α-25-dihydroxycholecalciferol added to the cream had an excellent effect on improving the moist feeling, fine texture, and texture of the skin in approximately proportion to the concentration added.

Examples of the present invention are shown below.

Example 1 8 g of 95% ethyl alcohol and 0 polyvinylpyrrolidone
．． 0.5g, oleyl alcohol 0.1g, polyoxyethylene monooleate 1.2g, 1α-hydroxycholecalciferol 0.001g1 fragrance 0.2g1 paraoxybenzoic acid methyl ester 0.1g1 a small amount of antioxidant, a small amount of pigment mixed and dissolved. did. Add this to 5g of glycerin
Example 2 A lotion with the effect of improving rough skin was obtained by stirring and adding the following ingredients to a solution dissolved in 85.349 g of purified water. Example 2: Cetyl alcohol 1.2 g, Sufu 99210 g 1 Vaseline 2 gs 5.6-trans-25- Hydroxycholecalciferol 0.1g 1 paraoxybenzoic acid ethyl ester 0.2g, glycerin monostearate 1g
1 Ig of polyoxyethylene (20 mol addition) monostearate, 1 g of polyoxyethylene (20 mol addition) monooleate, and 0.1 g of fragrance were heated and mixed and dissolved at 70°C,
Similarly, dipropylene glycol 5gs polyethylene glycol 15002g, triethanolamine 0.2
g1 76.2 g of purified water was heated and dissolved at 75°C. Both were mixed and emulsified, and the emulsified particles were prepared using a homogenizer and cooled to obtain a W2O type emulsion having an effect on improving rough skin.

Example 3 Dipropylene glycol 5g 1 triethanolamine 0
．． 5g of powder coloring, 10g of powder coloring, 0.1g of fragrance, 0.2g of paraoxybenzoic acid ethyl ester, a small amount of antioxidant, and 60.699995g of purified water were mixed, uniformly dispersed, and heated to 75°C. Stearic acid 1.2g into this
, cetyl alcohol 0.3g, liquid paraffin 20g1
Polyoxyethylene oleate ester 2g, 25-
A mixture of 0.000001 g of hydroxycholecalciphenol was mixed and melted and kept at 75° C. to perform reaction emulsification, and the mixture was stirred while cooling to obtain a foundation having an effect of preventing rough skin.

Example 4 8 g of 95% ethyl alcohol, 5 g of 1.3-butylene glycol, 1.5 g of polyoxyethylene (20 mol addition) monooleate, 0.0005 g of cholecalciferol
1 paraoxybenzoic acid ethyl ester 0.2gs fragrance 0
．． 1g of pigment is mixed and dissolved, 10g of polyvinyl alcohol, 20001g of polyethylene glycol, and 74.1995g of purified water are mixed and dissolved at 80℃, and the mixture is stirred and added, and the mixture is cooled to room temperature to create a dry film-type pack that has the effect of preventing rough skin. I got it.

Example 5 5 g of 95% ethyl alcohol, 1.2 g of polyoxyethylene sorbitan monooleate, 0 sodium alginate
．． 1g, sodium chondroitin sulfate 0.2g, hyaluronic acid 0.1g, vitamin E acetate 0.1g, glycyrrhizic acid monoammonium salt 0.1g1, paraoxybenzoic acid methyl ester 0.1g1, 25-hydroxycholecalciferol 0.00005g1, and an appropriate amount of pigment. Mix this with 5g of glycerin and 88.09g of purified water.
995g was mixed and added to the mixture with stirring to obtain a beauty serum having an effect of preventing rough skin.

Claims (1)

[Claims] A skin cosmetic containing one or more selected from the group consisting of vitamin D_3 and its derivatives.