JPS5910506A - Cosmetic composition - Google Patents

Abstract

PURPOSE:A cosmetic composition such as cream, shampoo, etc., preventing decomposition through oxidation and coloring in cosmetic preparation, obtained by using 1-hydroxy-2-pyridone and/or its salt, adding it to vitamin A, D, E, B6, B12 and their derivatives. CONSTITUTION:Vitamin A, D, E, B6, B12 and their derivative are blended with preferably 0.01-1wt% 1-hydroxy-2-pyridone shown by the formula (R1 is alkyl, alkenyl, cycloalkyl, bicycloalkyl, cycloalkyl-alkyl, aryl, etc.; R2 is H, alkyl, alkenyl, alkynyl, halogen, phenyl, or benzyl) to give a cosmetic composition. USE:A skin cosmetic such as nutritive cream, lipstick, toilet lotion, etc., hair cosmetic such as shampoo, rinse, tonic, liquid, hair cream, etc.

Description

[Detailed description of the invention]

The present invention applies to vitamins that are easily decomposed by oxidation such as air and ultraviolet rays, such as vitamins A, D, and E. The present invention relates to a chemical composition in which R6 and lh2 and their female conductors are stabilized. Vitamins are organic compounds that act catalytically to facilitate physiological functions such as reproduction and metabolism, and when carrying out these functions, they first accumulate in the living body, and then undergo oxidation. It is said that it combines with substances to form enzymes and participates in various reactions in living organisms. For example, vitamin A, which is often taken in stool, is
Vitamin/D is essential for maintaining the normal structure and function of mucous membranes, and has the effect of completely curing or alleviating acute skin inflammation, eczema, allergic skin disorders, psoriasis, and erythroderma. Broad vitamin E helps the absorption and utilization of vitamin A and carotenes, and when applied directly to the skin, it works on the skin vascular system, tightening the peripheral blood vessels and increasing blood flow. It has a good effect on vitamin 86, eczema, seborrheic dermatitis, hair loss,
It is said to have a preventive effect against dandruff and itching. However, these vitamins are oxidized and decomposed by nitrogen or ultraviolet rays, and become inactive, or the preparation becomes colored and the product quality is significantly impaired. , ■ Esterize vitamins and make them into raw vitamins in a fat bath. ■ Phenolic thread compounds' (tough nornohyde "coguayatilene (11 (NDGA)
HA eight gallic acid propyl blue], quinone compounds (hydroquinone, etc.), amine compounds (alkanolamines, phospholipids, etc.), organic acids (anobic acid, citric acid, tera), etc. It is possible to completely prevent oxidation. It has been found that preventive measures (■), which are only temporary prevention methods, do not have sufficient effects. teeth,
Fat-soluble vitamins are the mainstream. However, it was found that even this method could not sufficiently prevent the problem. Therefore, the inventors of the present invention have conducted intensive studies on the oxidative decomposition of vitamins and the prevention of coloration of 1ll-\.
By blending -hydroxydi-2-pyridone and/or its salt, it was possible to stabilize vitamins that are unstable to oxidation. Furthermore, it was found that the addition of phenolic compounds and organic 148K exhibits even more antioxidant effects. That is, the cosmetic composition of the present invention contains vitamins A and D. It is characterized by containing these conductors and 1-hydroxy-2-pyrido/and/or a salt thereof represented by the following general formula. 20 units [wherein RI is an alkyl group having 1 to 17 carbon atoms, an alkenyl group having 2 to 17 carbon atoms, 5 to
cycloalkyl group having 8 carbon atoms, bicycloalkyl group having 7 to 9 carbon atoms, alkyl group having 1 to 9 carbon atoms;
41 carbon atoms 't-,Nf7-chloroalkyl-alkyl group (however, /chloroalkyl residue may be substituted by an alkyl group having 1-...4 carbon atoms, aryl group, argyl group) an aralkyl group in which the alkenyl has 1 to 411.!II carbon atoms, an arylalkenyl group in which the alkenyl has 2 to 4 carbon atoms, an aryloxyalkyl or arylmercaptoalkyl group in which the alkyl each has 1 to 4 carbon atoms, benzhydryl group, phenylsulfonyl group in which alkyl has 1 to 4 carbon atoms; Alkyl group having carbon atoms, alkoxy group having 1. to 4 carbon atoms, 21.

[7 group, /ano group or halodane may be substituted, respectively. R2 is a hydrogen atom or 1 to 4
an alkyl group having 2 to 4 carbon atoms, an alkenyl or alkynyl group each having 2 to 4 carbon atoms, a halogen, quinyl, or pennol group.
The present invention will be explained in more detail below. The vitamins used in the present invention include vitamin A and derivatives of (゛), vitamin D and its 6-conductor, vitamin E and its derivatives, vitamin 136. Examples of 812 and derivatives thereof are shown below. (1) Vitamin A and its derivatives CH20HV f/-# CHO retinal C0OH vitamin A1 acid CH20COC [13 vinegar
CO15H5+] Gurmitic acid retinal vitamin A+ Iv methyl ester, vitamin A1r・
p ether ester, vitamin A1 beak retinol ester, etc. ■Vitamin D and its derivatives vitamin D2 (ergocalcif 10-rugivitamin D3)
(Cholecalciferol) Nohydrotachysterol ■ Vitamin E and its derivatives 1 Re3 Tocopherol (Tocol) 1 R3CH3 Tocotrienol Vitamin E homologue DL-α-Tocopherol, acetic acid 1) L-α-Tocopherol, Amber d DL-α- These include tocopherol, DL-α-tocopherol cal/um succinate, and the like. Salt-limited pyridokidal, 5'-pyridoxal phosphate, pyridoxamine hydrochloride, 5'-pyridoxine benzoate, 5'
-pyridoxine caprylate, 3,4'-pyridoxy caprylate, 3,4'-pyridoxine caprylate, and the like. ■ Vitamin 812 and its derivatives include cyanocobalamin, acid IN hydroxycobalamin, conogamide, methylcobalamin, and the like. Representative examples of 1-hydroxy-2-pyridone used in the present invention are as follows.
Pyridone; l-hydroxy-4-methyl-2-pyridone
; l-hydroxy-6-methyl-2-pyridone; l-hydroxy/-4,6-dimethyl-2-pyridone; l-hydroxy-4-methyl-6'-hegetyl-2-pyridone;
1-hydroxy-4-methyl-6-(l-ethyl<methyl)-2-pyridone; 1-hydroxy-4-methyl-6
-(2,4,4-trimethylpentyl)-2-pyrido/
; l-hydroxy-4-methyl-6-unzofluor 2-
Pyridone; 1-hydroxy-4-methyl-6-gropenyl-2-pyridone; l-hydroxy-4-methyl-6-
Octenyl-2-pyrido/; 1-hydroxy-4-methyl-6-(2,2-butyl-vinyl)-2-pyridone; l-hydroxy-4-methyl-6-(cyclohexenylidene-methyl)-2 -pyridone; l-hydroxy-4
-Methyl-6-7 clohexol-2-pyrido/; 1-hydroxy-4-methyl-6-(methyl-7 clohexyl)-2-pyridone; l-hydroxy-4-methyl-6-
(2-pyrido2,2.IJhenotyl)-2-pyrido/;1-hydroxy/=4-methyl-6-(2-(nomethylcyclohexynol)-frovir)-2-pyridone;1
-hydroxy-4-methyl-6-(4-methyl-phenyl)-2-pyridone; l-hydroquino-4-methyl-6
-(3-methyl-phenyl)-2-pyridone; 1-hydroxy-4-/'-7-ru-6-(4-tert-butyl-phenyl)-2-pyridone;1-hydroxy-4-"methyl- 6-(3-methyl-4-chloro-phenyl)-2-
Pyridone;】-Hydroxy-4-methyl-6-(3,5
-cycloruphenyl)-z-g-lydone; l-hydroxy-4-methyl-6-(3-bromo-4-thaloruphenyl)-2-pyridone; 1-hydroxy-4-methyl-6-(4 -methoxysteryl)-2-pyridone; 1-
Hydroxy-4-methyl-6-(1-(4-nitrophenoxy)-butyl"-2-pyridone; 1-hydroxy-
4-Methyl-6-(4-cyanophenoxymethyl)-2
-Pyridone; l-hydroxy/-4-methyl-6'-(phenylsulfonylmethyl)-2-pyridone; 1-hydroxy-4-methyl-6-[1-(4-chlorof,nylsulfonyl)-butyl]- 2-pyridone; 1-hydroxy-4-methyl-6-47-2-pyridone; 1-hydroquine-4-methyl-6-(2,4-methylpencyl)-2-pyridone; 1-hydroxy-4- Methyl-6-
(tertiary zoterupendyl)-2-pyridone; 1-hydroxy-4-methyl-6-(2-chloro-pennol)-2
-pyridone; 1-hydroxy-4-methyl-6-(4-
Chlorbenzyl)-2-pyridone; 1-hydroxy-4
-Methyl-6-(2,5-cycloupendyl)-2-
Pyridone; 1-hydroxy-4-methyl-6-(4-bromo-benzyl)-2-pyridone; 1-hydroxy-4
-Methyl-6-(2□noquinmethyl)-2-pyridone;
1-Hydroxy-4-methyl-6-(3-methylphenoxy/-methyl)-2-pyridone; l-hydroxy/-4-
Methyl-6-(4-sec-butylphenoquine methyl)-
2-pyridone; 1-hydroxy/-4-methyl-6-(2
,4,5-trichlorf□tuximethyl)-2-pyridone; 1-hydroxy-4-methyl-6-(4-bromphenoxy-methyl)-2-pyridone: l-hydroxy-4-methyl-6-(4- 1-Hydroxy-4-methyl-6-(4-methylphenylmercagutomethyl)-2-pyridone
-pyridone; 1-hydroquine-4-methyl-6-(2-
Nuff. 1-Hydroxy-4-methyl-
6-penzhydryl-2-pyridone; 1-hydroxy-
4-Methyl-6-furyl-2=pyridone; 1-hydroquine-4-methyl-6-(furylvinyl)-2-pyridone; 1-hydroquine-4-methyl-6-styryl-2-
Pyridone; l-hydroxy-4-methyl-6-(phenylbutanoenyl)-2-pyridone; 1-hydroxy-4
-phenyl-6-mete-2-pyridone; l-hydroxy-4,6-diphenyl-2-pyridone-etc. 1-hydroxy-2-pyridone can also be used in the form of a salt. Organic bases can be used to form salts. Examples of organic bases that can be used include ethanolamine, jetanolamine, N-ethylethanolamine,
N-Methyl-jetanolamine, triethanolamine, noethylaminoethanol, 2-amino-2-methyl-n-zoronoyanor, dimethylaminonoro, mother nol, 2-amino-2-mealnoronodendiol, triinonolo・Zonolamine, ethylenenoamine, hexamethylene diamine, morpholine, hyherinone, / chlorhexylamine, tributylamine, dodecylamine,
N,N-dimethyl-dodecylamine, sudearylamine, oleylamine, pennolamine, dipenzolamine, N-ethylpencylamine, trimethylstearylamine, N-menaloomorpholine, N-methylpiperazone,
4-Methyl 7-chlorohexylamine, N-hydroxyethylmorpholine is added. In addition to organic amine salts, alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as magnesium salts and calcium salts, and ammonium salts are also available]
It can be used frequently. The amount of l-hydroxy-2-pyridone or its salt explained above varies depending on the type and amount of vitamin, but is generally 0.001 to 510, preferably o,
ot-i% by weight. In the hair cosmetic of the present invention, it is possible to incorporate other optional ingredients such as gold, as long as they do not affect the effect of the present invention. Such optional ingredients include the following substances. Hydrocarbon complexes such as liquid e-rafin, petrolatum, solid paraffin, squalane and olefin oligomers: isoglobil myristate, innolovir palmitate, stearyl stearate, octyldodecyl myristate, octyldodecyl oleate and 2-ethyl Esters such as hexanoic acid triglylide; higher alcohols such as cetanol, stearyl alcohol, behenyl alcohol, and hexyldecanol; glyceryl monostearate, norbitan mono and lumitate, polyoxyethylene cetyl ether, holoxyethylene stearate, and polyoxyetherene solpicone mono (7) Emulsifiers; Cellulose derivatives such as methyl cellulose, hydroxyethyl cellulose, hydroxyl cellulose and cationized cellulose; Thickeners such as natural molecules; ethylene glycol, fluoropylene gellicol, 1 , 3-butylene glycol, glycerin, and sorbitol; and other small amounts of ingredients such as solvents, disinfectants, and fragrances. The cosmetic composition of the present invention can be used in skin cosmetics such as nutritional creams, lipsticks, and lotions, and hair cosmetics such as shampoos, conditioners, tonics, hair creams, etc. , a detailed description of the invention. Before that, we will explain the evaluation test method. Coloration degree Samples of each building were placed in a transparent container and irradiated with ultraviolet rays for 24 hours using a carbon arc device, and then judged with the naked eye.Judgment criteria ○...Discolored odor with almost no discernible degree of coloring The odor of the sample treated above was scratched and compared with the sample before irradiation (standard sample). Slightly light... almost no odor In the following test examples, the blending amount is indicated by weight.Test Example 1 A composition of 9 cypresses shown in the table below was manufactured by Kaim and its performance was evaluated. The results are shown in the same table.As is clear from the table, it is more stable against ultraviolet rays when 1-hydroxy-2-pyridone is added, but it is not effective when the amount added is less than o, o o i wt%. When wj% is less than 5 and it exceeds 5, a bad odor will occur.Test Example 2 A nutritional cream 1aI4 having the composition shown in F was prepared and tested for its ultraviolet stability. The degree of heat and odor were good. 0 Microtalis 2 phosphorus wax 1.0 Minoru 3.02 Norin
Rough-in to 2.0 fluid
20.0 Norbitane Sesquiolate 4. Of robylene glycol 8. f+vitamin A
0.11-hydroxy-2
-Pyridone -0.01 fragrance
0.3 Purified water
Remaining Test Example 3 A lotion having the following composition was prepared and its ultraviolet stability was tested. This lotion had good coloring and odor after 24 hours of ultraviolet irradiation. Ingredients 0 weight glycerin
5.0 oleyl alcohol
0.2 polyoquinoethylene (Eo20) stearyl ether 2゜ethanol, g
, 10.0 colors
Suitable silk-vitamin D
0.05 vitamin E
0.31-hydroxy/-2-pyritono 0
1 fragrance o
, i Remaining purified water

Claims (1)

[Scope of Claims] A cosmetic characterized by containing vitamins A, D, E, R6,812 and derivatives thereof, and l-hydroxy-2-pyridone and/or a salt thereof represented by the following general formula. composition. 2H In the formula, R1 is an alkyl group having 1 to 17 carbon atoms, an alkenyl group having 2 to 17 carbon atoms, 57
cycloalkyl group having 8 carbon atoms, bicycloalkyl group having 7 to 9 carbon atoms, alkyl group having 1 to 9 carbon atoms;
a cycloalkyl-alkyl group having 4 carbon atoms (however, the cycloalkyl residue may be substituted by an alkyl group having 1 to 4 carbon atoms), an aryl group having 1 to 4 alkyl atoms; aralkyl radicals having carbon atoms, arylalkenyl radicals in which alkenyl has 2 to 4 carbon atoms, aryloxyalkyl radicals in which alkyl each has 1 to 4 carbon atoms or 'arylmercaptoalkyl radicals, benzhydryl radicals, alkyl radicals having 1 to 4 carbon atoms; ~
F with 4 carbon atoms, nylsulfonylalkyl represents a furylalkenyl group with carbon atoms, and the above-mentioned aryl residues represent an alkyl group with 1 to 4 carbon atoms, a furyl group with 1 to 4 carbon atoms; Each may be substituted with an alkoxy group, a nitro group, an ano group, or a...roken. R2 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl or alkynyl group each having 2 to 4 carbon atoms, a phenyl group, or a benzyl group. ]