JPS62114949A - Ｎ−ベンゾイル−ｄｌ−アラニンの光学分割方法 - Google Patents
Ｎ−ベンゾイル−ｄｌ−アラニンの光学分割方法Info
- Publication number
- JPS62114949A JPS62114949A JP25491685A JP25491685A JPS62114949A JP S62114949 A JPS62114949 A JP S62114949A JP 25491685 A JP25491685 A JP 25491685A JP 25491685 A JP25491685 A JP 25491685A JP S62114949 A JPS62114949 A JP S62114949A
- Authority
- JP
- Japan
- Prior art keywords
- alanine
- benzoyl
- ala
- optically active
- optical resolution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003287 optical effect Effects 0.000 title claims abstract description 12
- UAQVHNZEONHPQG-UHFFFAOYSA-N N-benzoylalanine Chemical compound OC(=O)C(C)NC(=O)C1=CC=CC=C1 UAQVHNZEONHPQG-UHFFFAOYSA-N 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 title claims description 13
- BOWUOGIPSRVRSJ-UHFFFAOYSA-N 2-aminohexano-6-lactam Chemical compound NC1CCCCNC1=O BOWUOGIPSRVRSJ-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000003795 chemical substances by application Substances 0.000 abstract description 11
- 239000002904 solvent Substances 0.000 abstract description 8
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 5
- 239000013543 active substance Substances 0.000 abstract description 4
- 229960003767 alanine Drugs 0.000 abstract description 4
- UAQVHNZEONHPQG-ZETCQYMHSA-N N-benzoyl-L-alanine Chemical compound OC(=O)[C@H](C)NC(=O)C1=CC=CC=C1 UAQVHNZEONHPQG-ZETCQYMHSA-N 0.000 abstract description 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 abstract description 2
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 description 18
- 239000013078 crystal Substances 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 235000004279 alanine Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- QMGVPVSNSZLJIA-FVWCLLPLSA-N strychnine Chemical compound O([C@H]1CC(N([C@H]2[C@H]1[C@H]1C3)C=4C5=CC=CC=4)=O)CC=C1CN1[C@@H]3[C@]25CC1 QMGVPVSNSZLJIA-FVWCLLPLSA-N 0.000 description 2
- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 description 1
- 241001279009 Strychnos toxifera Species 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229950010030 dl-alanine Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- TYRGLVWXHJRKMT-QMMMGPOBSA-N n-benzyloxycarbonyl-l-serine-betalactone Chemical compound OC(=O)[C@H](C)NC(=O)OCC1=CC=CC=C1 TYRGLVWXHJRKMT-QMMMGPOBSA-N 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229960005453 strychnine Drugs 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25491685A JPS62114949A (ja) | 1985-11-15 | 1985-11-15 | Ｎ−ベンゾイル−ｄｌ−アラニンの光学分割方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25491685A JPS62114949A (ja) | 1985-11-15 | 1985-11-15 | Ｎ−ベンゾイル−ｄｌ−アラニンの光学分割方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62114949A true JPS62114949A (ja) | 1987-05-26 |
| JPH0364496B2 JPH0364496B2 (enrdf_load_stackoverflow) | 1991-10-07 |
Family
ID=17271635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP25491685A Granted JPS62114949A (ja) | 1985-11-15 | 1985-11-15 | Ｎ−ベンゾイル−ｄｌ−アラニンの光学分割方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62114949A (enrdf_load_stackoverflow) |
-
1985
- 1985-11-15 JP JP25491685A patent/JPS62114949A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0364496B2 (enrdf_load_stackoverflow) | 1991-10-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Belokon et al. | Improved procedures for the synthesis of (S)-2-[N-(N′-benzylprolyl) amino] benzophenone (BPB) and Ni (II) complexes of Schiff's bases derived from BPB and amino acids | |
| EP0127411B1 (en) | Method of preparing alpha-l-aspartyl-l-phenylalanine methyl ester and its hydrochloride | |
| US4198524A (en) | Optically active amino acid-mandelic acid complexes | |
| Sachs et al. | Optical Rotation of Peptides. VII. α-and γ-Dipeptides of Glutamic Acid and Alanine1 | |
| EP0213785B1 (en) | Method for optical resolution of dl-cysteine and (r,s)-1-(1-naphthyl)ethylamine | |
| JPS62114949A (ja) | Ｎ−ベンゾイル−ｄｌ−アラニンの光学分割方法 | |
| JPH0689024B2 (ja) | ポリペプチド類の製造方法 | |
| US3488379A (en) | Optically active salt complexes of carnitine nitrile hydroxide and n-acryl glutamic acids and their preparation | |
| US4052372A (en) | Preparation of ε-(γ-glutamyl)-lysine | |
| EP0132373B1 (en) | A neutral amino acid complex and a method for optical resolution of a dl-amino acid | |
| JPS62114945A (ja) | Ｎ−置換−ｄｌ−フエニルアラニンの光学分割方法 | |
| US2991307A (en) | Process of resolving nu, nu-dibenzyl-dl-alpha-amino acids and products | |
| JPS606958B2 (ja) | 抗生物質の精製法 | |
| JPH0574583B2 (enrdf_load_stackoverflow) | ||
| JPS62114954A (ja) | Ｎ−ベンゾイル−ｄｌ−メチオニンの光学分割方法 | |
| Wysłouch et al. | Stereochemistry of thiazolidine ring formation from aminals and cysteine | |
| JP2505487B2 (ja) | 光学活性リジンのラセミ化法 | |
| RU2227141C2 (ru) | Способ получения соединения бензиламина | |
| JP3586710B2 (ja) | ラクトンイミン化合物及びそれらの製造方法 | |
| EP0009722B1 (en) | Optically active complex, alanine.ring-substituted mandelic acid, and the method for producing the same | |
| JP2616211B2 (ja) | 光学活性１，２―プロパンジアミンの製法 | |
| JPS62114968A (ja) | 光学活性α−アミノ−ε−カプロラクタムの製法 | |
| JPS6296454A (ja) | Ｄｌ−バリンの光学分割法 | |
| JPH0798802B2 (ja) | 光学活性インドリン―２―カルボン酸の製造法 | |
| KR850000059B1 (ko) | α-L-아스파틸-L-페닐알라닌 알킬에스테르의 제조방법 |