JPS619840B2 - - Google Patents

Info

Publication number
JPS619840B2
JPS619840B2 JP56163649A JP16364981A JPS619840B2 JP S619840 B2 JPS619840 B2 JP S619840B2 JP 56163649 A JP56163649 A JP 56163649A JP 16364981 A JP16364981 A JP 16364981A JP S619840 B2 JPS619840 B2 JP S619840B2
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP56163649A
Other versions
JPS5863399A (ja
Inventor
Takeshi Nagasawa
Katsumasa Kuroiwa
Toshuki Takabayashi
Yoshio Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitto Boseki Co Ltd
Original Assignee
Nitto Boseki Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nitto Boseki Co Ltd filed Critical Nitto Boseki Co Ltd
Priority to JP56163649A priority Critical patent/JPS5863399A/ja
Priority to DE8282304589T priority patent/DE3262797D1/de
Priority to EP82304589A priority patent/EP0077124B1/en
Priority to US06/417,377 priority patent/US4452736A/en
Publication of JPS5863399A publication Critical patent/JPS5863399A/ja
Priority to US06/579,868 priority patent/US4605614A/en
Publication of JPS619840B2 publication Critical patent/JPS619840B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP56163649A 1981-10-14 1981-10-14 新規なプラスミン測定用基質 Granted JPS5863399A (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP56163649A JPS5863399A (ja) 1981-10-14 1981-10-14 新規なプラスミン測定用基質
DE8282304589T DE3262797D1 (en) 1981-10-14 1982-09-01 Novel substrates for measuring plasmin
EP82304589A EP0077124B1 (en) 1981-10-14 1982-09-01 Novel substrates for measuring plasmin
US06/417,377 US4452736A (en) 1981-10-14 1982-09-13 Substrates for measuring plasmin
US06/579,868 US4605614A (en) 1981-10-14 1984-02-13 Method for measuring plasmin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56163649A JPS5863399A (ja) 1981-10-14 1981-10-14 新規なプラスミン測定用基質

Publications (2)

Publication Number Publication Date
JPS5863399A JPS5863399A (ja) 1983-04-15
JPS619840B2 true JPS619840B2 (ja) 1986-03-26

Family

ID=15777947

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56163649A Granted JPS5863399A (ja) 1981-10-14 1981-10-14 新規なプラスミン測定用基質

Country Status (4)

Country Link
US (2) US4452736A (ja)
EP (1) EP0077124B1 (ja)
JP (1) JPS5863399A (ja)
DE (1) DE3262797D1 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
DK201084A (da) * 1983-04-28 1984-10-29 Kimberly Clark Co Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden
JPS60241900A (ja) * 1984-05-16 1985-11-30 Nitto Boseki Co Ltd 新規な第Ｘａ因子活性測定用基質
JPS6117956A (ja) * 1984-07-04 1986-01-25 Nitto Boseki Co Ltd 新規な尿中カリクレイン測定用基質
DE3512909A1 (de) * 1985-04-11 1986-10-23 Behringwerke Ag, 3550 Marburg Verfahren zur bestimmung von plasminogenaktivatoren (pa)
JPS62126196A (ja) * 1985-11-26 1987-06-08 Nitto Boseki Co Ltd 新規なα１−アンチトリプシン測定用化合物
JPH075634B2 (ja) * 1987-10-30 1995-01-25 日東紡績株式会社 トリペプチド類及びこれを含有する抗プラスミン剤
DE3843422A1 (de) * 1988-12-23 1990-06-28 Behringwerke Ag Verfahren zur bestimmung der plasminogenaktivator-aktivitaet in alpha-2-antiplasmin-haltigen proben
US5849510A (en) * 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
US6759384B1 (en) 1994-04-26 2004-07-06 Aventis Pharmaceuticals Inc. Factor Xa inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380258B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
FR2236963B1 (ja) * 1973-07-13 1977-02-18 Cit Alcatel
CH622286A5 (ja) * 1975-06-23 1981-03-31 Pentapharm Ag
SE407571B (sv) * 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
US4056519A (en) * 1976-05-10 1977-11-01 Eli Lilly And Company Substrate for assay of plasmin
SE7801373L (sv) * 1978-02-07 1979-08-08 Kabi Ab Lett spjelkbara substrat for kvantifiering av proteaser
JPS5559149A (en) * 1978-10-30 1980-05-02 Torii Yakuhin Kk Aminoacid derivative
JPS5569549A (en) * 1978-11-16 1980-05-26 Nitto Boseki Co Ltd Novel substrate for determination of enzyme activity

Also Published As

Publication number Publication date
US4452736A (en) 1984-06-05
EP0077124A1 (en) 1983-04-20
JPS5863399A (ja) 1983-04-15
US4605614A (en) 1986-08-12
EP0077124B1 (en) 1985-03-27
DE3262797D1 (en) 1985-05-02

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