JPS6183197A - ベクロメタゾン１７，２１―ジプロピオネートの新規溶媒和物、それらの製造法及び用途 - Google Patents
ベクロメタゾン１７，２１―ジプロピオネートの新規溶媒和物、それらの製造法及び用途Info
- Publication number
- JPS6183197A JPS6183197A JP60163086A JP16308685A JPS6183197A JP S6183197 A JPS6183197 A JP S6183197A JP 60163086 A JP60163086 A JP 60163086A JP 16308685 A JP16308685 A JP 16308685A JP S6183197 A JPS6183197 A JP S6183197A
- Authority
- JP
- Japan
- Prior art keywords
- beclomethasone
- dipropionate
- ether
- solvate
- isopropyl ether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 title claims 5
- 238000007614 solvation Methods 0.000 title claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 56
- 239000012453 solvate Substances 0.000 claims description 30
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 10
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 239000003960 organic solvent Substances 0.000 claims description 10
- 239000000443 aerosol Substances 0.000 claims description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 claims description 6
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 5
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 3
- 239000003380 propellant Substances 0.000 claims description 3
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 2
- 229940029284 trichlorofluoromethane Drugs 0.000 claims description 2
- 150000008282 halocarbons Chemical class 0.000 claims 2
- 239000004338 Dichlorodifluoromethane Substances 0.000 claims 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 1
- 235000019404 dichlorodifluoromethane Nutrition 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 18
- 229940092705 beclomethasone Drugs 0.000 description 18
- 239000000203 mixture Substances 0.000 description 12
- 239000013078 crystal Substances 0.000 description 9
- 238000003756 stirring Methods 0.000 description 8
- 238000001035 drying Methods 0.000 description 7
- 238000009472 formulation Methods 0.000 description 5
- 238000004817 gas chromatography Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229930195733 hydrocarbon Natural products 0.000 description 4
- 150000002430 hydrocarbons Chemical class 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- POLCUAVZOMRGSN-UHFFFAOYSA-N dipropyl ether Chemical compound CCCOCCC POLCUAVZOMRGSN-UHFFFAOYSA-N 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 235000005983 Crescentia cujete Nutrition 0.000 description 1
- 240000009087 Crescentia cujete Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT78972 | 1984-07-25 | ||
| PT7897284A PT78972A (en) | 1984-07-25 | 1984-07-25 | Preparation process of a 17,21-dipropionate beclomethasona di-isopropylic ether solution and its utilization |
| PT80796 | 1985-07-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6183197A true JPS6183197A (ja) | 1986-04-26 |
| JPH0129199B2 JPH0129199B2 (enrdf_load_stackoverflow) | 1989-06-08 |
Family
ID=20083527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60163086A Granted JPS6183197A (ja) | 1984-07-25 | 1985-07-25 | ベクロメタゾン１７，２１―ジプロピオネートの新規溶媒和物、それらの製造法及び用途 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS6183197A (enrdf_load_stackoverflow) |
| PT (1) | PT78972A (enrdf_load_stackoverflow) |
| ZA (1) | ZA855620B (enrdf_load_stackoverflow) |
-
1984
- 1984-07-25 PT PT7897284A patent/PT78972A/pt not_active IP Right Cessation
-
1985
- 1985-07-25 JP JP60163086A patent/JPS6183197A/ja active Granted
- 1985-07-25 ZA ZA855620A patent/ZA855620B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0129199B2 (enrdf_load_stackoverflow) | 1989-06-08 |
| PT78972A (en) | 1984-08-01 |
| ZA855620B (en) | 1986-03-26 |
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