JPS6176416A - 活性型ビタミンｄ↓３誘導体のカプセル剤用組成物 - Google Patents
活性型ビタミンｄ↓３誘導体のカプセル剤用組成物Info
- Publication number
- JPS6176416A JPS6176416A JP19808484A JP19808484A JPS6176416A JP S6176416 A JPS6176416 A JP S6176416A JP 19808484 A JP19808484 A JP 19808484A JP 19808484 A JP19808484 A JP 19808484A JP S6176416 A JPS6176416 A JP S6176416A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- capsules
- composition
- derivatives
- encapsulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 19
- 150000003704 vitamin D3 derivatives Chemical class 0.000 title claims abstract description 9
- 238000005538 encapsulation Methods 0.000 title description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000002775 capsule Substances 0.000 claims abstract description 16
- 229930003427 Vitamin E Chemical class 0.000 claims abstract description 10
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Chemical class CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000011709 vitamin E Chemical class 0.000 claims abstract description 10
- 229940046009 vitamin E Drugs 0.000 claims abstract description 10
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 6
- 239000007901 soft capsule Substances 0.000 abstract description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 235000001968 nicotinic acid Nutrition 0.000 abstract 1
- 239000011664 nicotinic acid Substances 0.000 abstract 1
- 125000005472 straight-chain saturated fatty acid group Chemical group 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
- 239000007902 hard capsule Substances 0.000 description 10
- 239000007788 liquid Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 5
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 description 5
- 229960002535 alfacalcidol Drugs 0.000 description 4
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 3
- 150000003710 vitamin D derivatives Chemical class 0.000 description 3
- 235000005282 vitamin D3 Nutrition 0.000 description 3
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 3
- 239000011647 vitamin D3 Substances 0.000 description 3
- 229940021056 vitamin d3 Drugs 0.000 description 3
- 208000020084 Bone disease Diseases 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 229930003316 Vitamin D Natural products 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229940042585 tocopherol acetate Drugs 0.000 description 2
- 235000019166 vitamin D Nutrition 0.000 description 2
- 239000011710 vitamin D Substances 0.000 description 2
- 229940046008 vitamin d Drugs 0.000 description 2
- JWUBBDSIWDLEOM-UHFFFAOYSA-N 25-Hydroxycholecalciferol Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CCC1=C JWUBBDSIWDLEOM-UHFFFAOYSA-N 0.000 description 1
- 239000003872 25-hydroxy-cholecalciferol Substances 0.000 description 1
- 235000021318 Calcifediol Nutrition 0.000 description 1
- 208000013038 Hypocalcemia Diseases 0.000 description 1
- 208000000038 Hypoparathyroidism Diseases 0.000 description 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 description 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- JWUBBDSIWDLEOM-DTOXIADCSA-N calcidiol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C JWUBBDSIWDLEOM-DTOXIADCSA-N 0.000 description 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000000705 hypocalcaemia Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 150000003398 sorbic acids Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19808484A JPS6176416A (ja) | 1984-09-20 | 1984-09-20 | 活性型ビタミンｄ↓３誘導体のカプセル剤用組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19808484A JPS6176416A (ja) | 1984-09-20 | 1984-09-20 | 活性型ビタミンｄ↓３誘導体のカプセル剤用組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3361432A Division JPH0774149B2 (ja) | 1991-12-27 | 1991-12-27 | 硬ゼラチンカプセル |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6176416A true JPS6176416A (ja) | 1986-04-18 |
| JPH0437803B2 JPH0437803B2 (enrdf_load_stackoverflow) | 1992-06-22 |
Family
ID=16385243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19808484A Granted JPS6176416A (ja) | 1984-09-20 | 1984-09-20 | 活性型ビタミンｄ↓３誘導体のカプセル剤用組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6176416A (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61168357A (ja) * | 1984-10-25 | 1986-07-30 | ワ−ナ−・ランバ−ト・カンパニ− | カプセルを密封する方法 |
| JPH01146821A (ja) * | 1987-10-26 | 1989-06-08 | Eli Lilly & Co | ペルゴリド化合物の安定化 |
| US7635675B2 (en) | 2003-08-13 | 2009-12-22 | Biocon Limited | Micro-particle fatty acid salt solid dosage formulations for therapeutic agents |
| JP2015108026A (ja) * | 2015-03-10 | 2015-06-11 | 杏林製薬株式会社 | イミダフェナシン含有口腔内速崩錠 |
| JP2016117768A (ja) * | 2016-03-24 | 2016-06-30 | 杏林製薬株式会社 | イミダフェナシン含有口腔内速崩錠 |
| JP2017082012A (ja) * | 2017-02-14 | 2017-05-18 | 杏林製薬株式会社 | イミダフェナシン含有口腔内速崩錠 |
| JP2017088618A (ja) * | 2017-02-14 | 2017-05-25 | 杏林製薬株式会社 | イミダフェナシン含有口腔内速崩錠 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5312414A (en) * | 1976-07-21 | 1978-02-03 | Chugai Pharmaceut Co Ltd | Production of preparation containing stable 1alpha-hydroxyvitamines d |
| JPS5740461A (en) * | 1980-08-25 | 1982-03-06 | Teijin Ltd | Novel activated vitamin d3 derivative composition |
| JPS5740414A (en) * | 1980-08-25 | 1982-03-06 | Teijin Ltd | Novel active type vitamin d3 derivative composition |
| JPS5740415A (en) * | 1980-08-25 | 1982-03-06 | Teijin Ltd | Novel active type vitamin d3 derivative composition |
-
1984
- 1984-09-20 JP JP19808484A patent/JPS6176416A/ja active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5312414A (en) * | 1976-07-21 | 1978-02-03 | Chugai Pharmaceut Co Ltd | Production of preparation containing stable 1alpha-hydroxyvitamines d |
| JPS5740461A (en) * | 1980-08-25 | 1982-03-06 | Teijin Ltd | Novel activated vitamin d3 derivative composition |
| JPS5740414A (en) * | 1980-08-25 | 1982-03-06 | Teijin Ltd | Novel active type vitamin d3 derivative composition |
| JPS5740415A (en) * | 1980-08-25 | 1982-03-06 | Teijin Ltd | Novel active type vitamin d3 derivative composition |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61168357A (ja) * | 1984-10-25 | 1986-07-30 | ワ−ナ−・ランバ−ト・カンパニ− | カプセルを密封する方法 |
| JPH01146821A (ja) * | 1987-10-26 | 1989-06-08 | Eli Lilly & Co | ペルゴリド化合物の安定化 |
| US7635675B2 (en) | 2003-08-13 | 2009-12-22 | Biocon Limited | Micro-particle fatty acid salt solid dosage formulations for therapeutic agents |
| JP2015108026A (ja) * | 2015-03-10 | 2015-06-11 | 杏林製薬株式会社 | イミダフェナシン含有口腔内速崩錠 |
| JP2016117768A (ja) * | 2016-03-24 | 2016-06-30 | 杏林製薬株式会社 | イミダフェナシン含有口腔内速崩錠 |
| JP2017082012A (ja) * | 2017-02-14 | 2017-05-18 | 杏林製薬株式会社 | イミダフェナシン含有口腔内速崩錠 |
| JP2017088618A (ja) * | 2017-02-14 | 2017-05-25 | 杏林製薬株式会社 | イミダフェナシン含有口腔内速崩錠 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0437803B2 (enrdf_load_stackoverflow) | 1992-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1547588B1 (en) | Soft capsule preparation | |
| US4656027A (en) | Pharmaceutical mixture | |
| DE3688114D1 (de) | Inklusionskomplexe von 7-isopropoxy-isoflavon mit cyclodextrinen, verfahren zu deren herstellung und diese inklusionskomplexe enthaltende pharmazeutische praeparate. | |
| KR950007859A (ko) | 경구 투여용 라파마이신 제형 | |
| DK164259C (da) | Farmaceutisk formulering til langsom frigivelse af den aktive bestanddel og fremgangsmaade til fremstilling af en saadan formulering | |
| KR940021054A (ko) | 캡슐형 유비데카레논 경구 제제 | |
| HUT67661A (en) | New pyrazine derivatives, their preparation and pharmaceutical compositions containing them | |
| CZ287558B6 (en) | Pharmaceutical preparation | |
| JPS6176416A (ja) | 活性型ビタミンｄ↓３誘導体のカプセル剤用組成物 | |
| ATE14884T1 (de) | S-adenosinylmethionine-derivate, verfahren zu ihrer herstellung und die pharmazeutischen zusammensetzungen welche als aktive substanz diese derivate enthalten. | |
| MXPA04008151A (es) | Capsulas de envoltura dura que contienen ibuprofeno. | |
| JPH04288016A (ja) | 活性型ビタミンｄ３類軟カプセル剤の製造方法 | |
| ATE13488T1 (de) | Gallium-chlorid, ein neues antikrebsmittel. | |
| JPS63166824A (ja) | 軟カプセル剤 | |
| US3421282A (en) | Method for obtaining capsules having oily drugs closed therein | |
| JPS61189219A (ja) | 安定な活性型ビタミンｄ↓３類含有製剤 | |
| ATE1442T1 (de) | Pharmazeutisches mittel, enthaltend all-e- oder 13-z-7,8-dehydro-retinsaeure und verfahren zu seiner herstellung. | |
| US3360434A (en) | Method for reducing blood pressure with phenylalanine derivatives | |
| US4948591A (en) | Soft capsular preparation of sodium picosulfate | |
| HU228857B1 (en) | Stable formulation containing fumagillin | |
| JPS646214A (en) | Remedy for ulcerative colonopathy | |
| JPS60218318A (ja) | 軟カプセル充填用組成物 | |
| GB2142534A (en) | Stabilization of compositions with anionic surfactant | |
| JPH0446122A (ja) | 活性型ビタミンｄ↓３類含有製剤 | |
| RU2154473C2 (ru) | Фармацевтическая композиция и способ профилактики или лечения осложнений сахарного диабета (варианты) |