JPS6158195B2 - - Google Patents
Info
- Publication number
- JPS6158195B2 JPS6158195B2 JP58057700A JP5770083A JPS6158195B2 JP S6158195 B2 JPS6158195 B2 JP S6158195B2 JP 58057700 A JP58057700 A JP 58057700A JP 5770083 A JP5770083 A JP 5770083A JP S6158195 B2 JPS6158195 B2 JP S6158195B2
- Authority
- JP
- Japan
- Prior art keywords
- antithrombotic
- present
- mucopolysaccharide
- plasma
- glow discharge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000463 material Substances 0.000 claims description 49
- 230000002785 anti-thrombosis Effects 0.000 claims description 37
- 239000003146 anticoagulant agent Substances 0.000 claims description 24
- 239000004677 Nylon Substances 0.000 claims description 19
- 229920001778 nylon Polymers 0.000 claims description 19
- 238000011282 treatment Methods 0.000 claims description 18
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 15
- 208000028659 discharge Diseases 0.000 claims description 15
- -1 polyethylene Polymers 0.000 claims description 10
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 229920000728 polyester Polymers 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- 239000004814 polyurethane Substances 0.000 claims description 4
- 229920002379 silicone rubber Polymers 0.000 claims description 3
- 239000004945 silicone rubber Substances 0.000 claims description 3
- 229920003225 polyurethane elastomer Polymers 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 description 15
- 238000000034 method Methods 0.000 description 11
- 239000002861 polymer material Substances 0.000 description 9
- 102000008186 Collagen Human genes 0.000 description 8
- 108010035532 Collagen Proteins 0.000 description 8
- 229920001436 collagen Polymers 0.000 description 8
- 238000001228 spectrum Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 6
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 5
- 102000009027 Albumins Human genes 0.000 description 5
- 108010088751 Albumins Proteins 0.000 description 5
- 229920001287 Chondroitin sulfate Polymers 0.000 description 5
- 102000008946 Fibrinogen Human genes 0.000 description 5
- 108010049003 Fibrinogen Proteins 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 229940059329 chondroitin sulfate Drugs 0.000 description 5
- 208000007536 Thrombosis Diseases 0.000 description 4
- 229920005601 base polymer Polymers 0.000 description 4
- 229940012952 fibrinogen Drugs 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 229920000669 heparin Polymers 0.000 description 3
- 229960002897 heparin Drugs 0.000 description 3
- 239000012567 medical material Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 230000010287 polarization Effects 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000002473 artificial blood Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229940045110 chitosan Drugs 0.000 description 1
- KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004623 platelet-rich plasma Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001302 tertiary amino group Chemical group 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
- Materials For Medical Uses (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58057700A JPS59183762A (ja) | 1983-03-31 | 1983-03-31 | 新規な抗血栓性材料 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58057700A JPS59183762A (ja) | 1983-03-31 | 1983-03-31 | 新規な抗血栓性材料 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59183762A JPS59183762A (ja) | 1984-10-18 |
| JPS6158195B2 true JPS6158195B2 (enrdf_load_stackoverflow) | 1986-12-10 |
Family
ID=13063205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58057700A Granted JPS59183762A (ja) | 1983-03-31 | 1983-03-31 | 新規な抗血栓性材料 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59183762A (enrdf_load_stackoverflow) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4500676A (en) * | 1983-12-15 | 1985-02-19 | Biomatrix, Inc. | Hyaluronate modified polymeric articles |
| HU219815B (hu) * | 1995-02-07 | 2001-08-28 | Fidia Advanced Biopolymers S.R.L. | Eljárás tárgyak hialuronsavval, hialuronsavszármazékokkal és félszintetikus polimerekkel történő bevonására |
| JP3504548B2 (ja) * | 1999-11-08 | 2004-03-08 | 朝日インテック株式会社 | 潤滑性ガイディングカテーテル |
| CN102247810B (zh) * | 2011-04-26 | 2013-01-30 | 浙江大学 | 一种壳聚糖表面修饰的方法及其应用 |
-
1983
- 1983-03-31 JP JP58057700A patent/JPS59183762A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59183762A (ja) | 1984-10-18 |
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