JPS61502956A - アドリアマイシン及びそのハロゲン化塩の調整法 - Google Patents

アドリアマイシン及びそのハロゲン化塩の調整法

Info

Publication number
JPS61502956A
JPS61502956A JP50256584A JP50256584A JPS61502956A JP S61502956 A JPS61502956 A JP S61502956A JP 50256584 A JP50256584 A JP 50256584A JP 50256584 A JP50256584 A JP 50256584A JP S61502956 A JPS61502956 A JP S61502956A
Authority
JP
Japan
Prior art keywords
alkyl
solution
product
daunomycin
adriamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP50256584A
Other languages
English (en)
Japanese (ja)
Inventor
バーリント，ヤーノス
ボルベーリ，サボルチユ
エムリ，ジユザンナ
フアゼカス，ヨージエフ
トート，ジヨルジ
Original Assignee
ビオガル　ジヨジセルジヤ−ル
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ビオガル　ジヨジセルジヤ−ル filed Critical ビオガル　ジヨジセルジヤ−ル
Publication of JPS61502956A publication Critical patent/JPS61502956A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP50256584A 1984-06-14 1984-06-14 アドリアマイシン及びそのハロゲン化塩の調整法 Pending JPS61502956A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/HU1984/000037 WO1986000073A1 (en) 1984-06-14 1984-06-14 Process for preparing adriamycine and halide salts thereof

Publications (1)

Publication Number Publication Date
JPS61502956A true JPS61502956A (ja) 1986-12-18

Family

ID=10980572

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50256584A Pending JPS61502956A (ja) 1984-06-14 1984-06-14 アドリアマイシン及びそのハロゲン化塩の調整法

Country Status (5)

Country Link
EP (1) EP0183691A1 (da)
JP (1) JPS61502956A (da)
DK (1) DK157082C (da)
FI (1) FI860683A0 (da)
WO (1) WO1986000073A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026691A (en) * 1987-03-30 1991-06-25 The Upjohn Company Combination of minoxidil and an antiinflammatory agent for treating patterned alopecia
US4997922A (en) * 1988-09-06 1991-03-05 Sanraku Incorporated Anthracycline derivatives
IT1230505B (it) * 1988-10-11 1991-10-25 Sicor Spa Procedimento per la conversione della daunorubicina in doxorubicina.
PT848009E (pt) 1996-12-16 2000-11-30 Pharmachemie Bv Processo para a preparacao de epirubicina ou seus sais de adicao de acido a partir de daunorubicina
US7388083B2 (en) 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
WO2007070820A2 (en) 2005-12-13 2007-06-21 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
IT1398273B1 (it) * 2009-05-08 2013-02-22 Antibioticos Spa Procedimento per la preparazione di 14-bromo daunomicina
IT1397234B1 (it) * 2010-01-08 2013-01-04 Antibioticos Spa Processo per la preparazione di doxorubicina.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56156300A (en) * 1980-04-26 1981-12-02 Microbial Chem Res Found Novel preparative method of anthracyclin derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL145536B (nl) * 1968-04-12 1975-04-15 Farmaceutici Italia Werkwijze voor de bereiding van een nieuw antibioticum of zijn aglycon.
GB1511680A (en) * 1975-11-18 1978-05-24 Farmaceutici Italia Daunosaminyl anthracyclinones
AT358736B (de) * 1976-12-22 1980-09-25 Erba Farmitalia Verfahren zur herstellung von neuen antitumorglycosiden

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56156300A (en) * 1980-04-26 1981-12-02 Microbial Chem Res Found Novel preparative method of anthracyclin derivative

Also Published As

Publication number Publication date
DK59486A (da) 1986-02-06
DK157082C (da) 1990-04-09
WO1986000073A1 (en) 1986-01-03
FI860683A (fi) 1986-02-14
FI860683A0 (fi) 1986-02-14
DK59486D0 (da) 1986-02-06
EP0183691A1 (en) 1986-06-11
DK157082B (da) 1989-11-06

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