JPS6129463B2 - - Google Patents
Info
- Publication number
- JPS6129463B2 JPS6129463B2 JP52117777A JP11777777A JPS6129463B2 JP S6129463 B2 JPS6129463 B2 JP S6129463B2 JP 52117777 A JP52117777 A JP 52117777A JP 11777777 A JP11777777 A JP 11777777A JP S6129463 B2 JPS6129463 B2 JP S6129463B2
- Authority
- JP
- Japan
- Prior art keywords
- rotavirus
- suspension
- subunits
- subunit
- inner capsid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 241000702670 Rotavirus Species 0.000 claims description 35
- 210000000234 capsid Anatomy 0.000 claims description 18
- 239000000725 suspension Substances 0.000 claims description 15
- 241000700605 Viruses Species 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 11
- 210000003608 fece Anatomy 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- 241000124008 Mammalia Species 0.000 claims description 7
- 238000005119 centrifugation Methods 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 230000002550 fecal effect Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000004365 Protease Substances 0.000 claims description 3
- 102000004142 Trypsin Human genes 0.000 claims description 3
- 108090000631 Trypsin Proteins 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012588 trypsin Substances 0.000 claims description 3
- 108090000526 Papain Proteins 0.000 claims description 2
- 239000007853 buffer solution Substances 0.000 claims description 2
- 229940055729 papain Drugs 0.000 claims description 2
- 235000019834 papain Nutrition 0.000 claims description 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 235000019419 proteases Nutrition 0.000 claims 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 claims 1
- 239000012141 concentrate Substances 0.000 description 17
- 210000002966 serum Anatomy 0.000 description 16
- 238000012360 testing method Methods 0.000 description 13
- 239000000499 gel Substances 0.000 description 10
- 208000005577 Gastroenteritis Diseases 0.000 description 9
- 239000000427 antigen Substances 0.000 description 8
- 102000036639 antigens Human genes 0.000 description 8
- 108091007433 antigens Proteins 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 230000000295 complement effect Effects 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 238000003745 diagnosis Methods 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 244000309466 calf Species 0.000 description 4
- 230000000951 immunodiffusion Effects 0.000 description 4
- 238000000386 microscopy Methods 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 241000700198 Cavia Species 0.000 description 3
- 206010067470 Rotavirus infection Diseases 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 230000035931 haemagglutination Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000000405 serological effect Effects 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 239000007975 buffered saline Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000031504 Asymptomatic Infections Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000702244 Orthoreovirus Species 0.000 description 1
- 241000702263 Reovirus sp. Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229960002319 barbital Drugs 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000012817 gel-diffusion technique Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 238000005497 microtitration Methods 0.000 description 1
- 238000002439 negative-stain electron microscopy Methods 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB40608/76A GB1539221A (en) | 1976-09-30 | 1976-09-30 | Viral preparations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5344625A JPS5344625A (en) | 1978-04-21 |
| JPS6129463B2 true JPS6129463B2 (enrdf_load_html_response) | 1986-07-07 |
Family
ID=10415735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11777777A Granted JPS5344625A (en) | 1976-09-30 | 1977-09-30 | Rota virus inner cafsid subbunit formulation |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5344625A (enrdf_load_html_response) |
| BE (1) | BE859289A (enrdf_load_html_response) |
| CH (1) | CH633825A5 (enrdf_load_html_response) |
| DE (1) | DE2744174A1 (enrdf_load_html_response) |
| DK (1) | DK433277A (enrdf_load_html_response) |
| FR (1) | FR2366360A1 (enrdf_load_html_response) |
| GB (1) | GB1539221A (enrdf_load_html_response) |
| NL (1) | NL7710729A (enrdf_load_html_response) |
| SE (1) | SE445392B (enrdf_load_html_response) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE445466B (sv) * | 1977-12-01 | 1986-06-23 | Wellcome Found | Sett att foroka rotavirus in vitro |
| JPS6237259A (ja) * | 1985-08-12 | 1987-02-18 | Honda Motor Co Ltd | 車両用アンチロツク制御装置の作動確認装置 |
-
1976
- 1976-09-30 GB GB40608/76A patent/GB1539221A/en not_active Expired
-
1977
- 1977-09-30 JP JP11777777A patent/JPS5344625A/ja active Granted
- 1977-09-30 SE SE7710955A patent/SE445392B/xx not_active IP Right Cessation
- 1977-09-30 CH CH1199277A patent/CH633825A5/de not_active IP Right Cessation
- 1977-09-30 NL NL7710729A patent/NL7710729A/xx not_active Application Discontinuation
- 1977-09-30 DK DK433277A patent/DK433277A/da not_active Application Discontinuation
- 1977-09-30 BE BE181387A patent/BE859289A/xx not_active IP Right Cessation
- 1977-09-30 FR FR7729433A patent/FR2366360A1/fr active Granted
- 1977-09-30 DE DE19772744174 patent/DE2744174A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| BE859289A (fr) | 1978-03-30 |
| SE445392B (sv) | 1986-06-16 |
| GB1539221A (en) | 1979-01-31 |
| FR2366360B1 (enrdf_load_html_response) | 1983-12-16 |
| SE7710955L (sv) | 1978-03-31 |
| FR2366360A1 (fr) | 1978-04-28 |
| JPS5344625A (en) | 1978-04-21 |
| CH633825A5 (en) | 1982-12-31 |
| DK433277A (da) | 1978-03-31 |
| NL7710729A (nl) | 1978-04-03 |
| DE2744174A1 (de) | 1978-04-27 |
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