JPS6124510A - Composition for preventing drying - Google Patents

Abstract

PURPOSE:A drying preventing composition capable of preventing nasal cavity, oral cavity and pharyngeal mucosa from being dried for a long time, obtained by adding a humectant of a polyhydric alcohol, etc. and a surface active agent which is water-soluble at a normal temperature to water in a specific ratio and concentration. CONSTITUTION:(A) One or more humectants selected from polyhydric alcohols, amino acids, polypeptides, saccharides and inorganic salts and (B) a surface active agent such as preferably suger ester, polyoxyethylent higher fatty acid sorbitan ester, polyoxyethylene-polyoxypropylene copolymer, etc. in a ratio of the component A:B of 100:1-2:1, preferably 50:1-3:1 are dissolved in water in such a way that the concentration of the component A is 0.1-20wt%, preferably 1-10wt%, and the concentration of the component B is 0.01-5wt%, preferably 0.05-1wt%, to give the titled composition capable of preventing drying of throat for a long period and suppressing extremely snoring sound.

Description

DETAILED DESCRIPTION OF THE INVENTION [Technical Field] The present invention relates to a composition for preventing dryness of the mucous membranes of the nasal cavity, oral cavity, and pharynx.

[Background technology]

In recent years, as air-conditioning equipment has been installed in ordinary houses and automobiles, people living there often complain of dry throats, making them more susceptible to catching colds and hurting their throats. or,
Feeling of dry throat as a result of excessive exercise or excessive drinking is a common experience.

These dry throats are caused by the dryness of the oral and pharyngeal mucous membranes, but in such cases, increasing the humidity in the room,
Throat with water? I have been dealing with it by moisturizing it and temporarily stopping my dry throat.

Furthermore, many people are troubled by snoring during sleep, and it is said that the cause of high snoring is often due to dryness of the mucous membranes of the nasal cavity and pharynx.

Conventionally, in the cosmetics field, moisturizing lotions, moisturizing creams, etc. have been used to prevent skin from drying out and keep the skin always moisturized, but there is still no known method to prevent mucous membranes in the human body from drying out. Not yet.

[Disclosure of the invention]

The present inventors have conducted extensive research on preventing dryness of the mucous membranes of the nasal cavity, oral cavity, and pharynx in order to prevent the aforementioned dry throat and reduce the volume of snoring during sleep, and as a result, they have obtained the composition of the present invention.

The present inventors dissolved 0.1% to 20% of a moisturizer known in the cosmetics field in water, injected or dropped it through the nostrils, or swished it into the oral cavity and gargled it. oral cavity,
Although we have investigated ways to prevent dryness of the pharyngeal mucosa, we have not been able to obtain sufficient effects on dry throat or snoring during sleep.

Moreover, even if there was an effect, it was extremely temporary.

Therefore, we investigated compositions in which vegetable oils, animal oils, fatty acids, and esters were emulsified and dispersed in water together with various surfactants in addition to moisturizers, but none of these were effective. This resulted in a feeling of discomfort in the oral cavity.

However, when a composition containing a moisturizer and a surfactant that is water-soluble at room temperature dissolved in water at a specific concentration and blending ratio was injected or dripped into the nostrils or swished into the mouth and gargled, something surprising happened. I learned that it can prevent a dry throat for a long time and greatly reduce the volume of snoring during sleep.

The reason for this is presumed to be that the surfactant has the effect of uniformly diffusing and spreading the moisturizing agent on the mucous membranes of the nasal cavity, throat, and pharynx and retaining it for a long period of time.

In this way, we have completed the composition of the present invention, which is used to prevent dryness of the mucous membranes of the nasal cavity, oral cavity, and pharynx for a long period of time, which has not yet been known.

[Embodiment]

In the composition of the present invention, one or more types of humectants and one or more types of surfactants that are water-soluble at room temperature are blended in water.

The moisturizers used in the present invention are polyhydric alcohols, amino acids, polypeptides, sugars, and inorganic salts. Polyhydric alcohols include polyethylene glycol and glycerin, and amino acids include oxyproline and pyrrolidone carbon. Acids are polypeptides, soluble collagen is polypeptides, and sugars are chondroitin sulfate and sodium sulfate.
Hyaluronic acid is preferred, and the inorganic salts include sodium chloride and magnesylanochloride. The concentration of humectants in the composition according to the invention is between 0.1 and 20% by weight, preferably between 1 and 10% by weight.

The surfactants that are water-soluble at room temperature used in the present invention include sugar ester, soybean phospholipid, polyoxyethylene lauryl ether, polyoxyethylene higher alcohol ether, polyoxyethylene higher fatty acid ester, polyoxyethylene higher fatty acid sorbitan ester, Polyoxyethylene higher fatty acid sorbitol, polyoxyethylene-
Polyoxypropylene copolymer, polyoxyethylene
Polyoxypropylene copolymer + fatty acid, polyoxyethylene-added fatty acid glyceride, phosphoric acid ester, amphoteric surfactant, polyoxyethylene cholesterol, but preferably sugar ester, polyoxyethylene higher fatty acid sorbitan ester, polyoxyethylene −
Polyoxypropylene copolymer, polyoxyethylene-added fatty acid glyceride. The concentration of the surfactant which is water-soluble at room temperature in the composition according to the invention is between 01 and 5% by weight, preferably between 0.05 and 1% by weight.

The ratio of the humectant to the surfactant which is water-soluble at room temperature in the composition of the present invention is 100:1 to 2:1 by weight, preferably 50:1 to 3:1.

Although the water used in the present invention is not particularly limited,
Preferably, city water is desalinated by ion exchange to have an electrical resistivity of 1 μσ or less, and then sterilized using a sterilizing lamp or a sterilizing filter.

The method of using the composition of the present invention is not particularly limited, but it is preferably injected or dropped through the nostrils, or swished into the mouth or gargled.

The composition of the present invention may contain preservatives for long-term storage, and water-soluble polymer compounds for ease of use and improvement of the feeling of use.

EXAMPLES The present invention will be explained in more detail with reference to Examples below. The percentages in the examples are by weight.

Example 1 Three drops of the following composition were dropped into the nostrils of person A, who suffers from snoring, 5 minutes before going to bed, and the volume was measured using a continuous volume recorder and when no drops were applied. A comparison was made.

The results are shown in Table 1.

Composition/I61 Composition/r62 Composition layer 3 Composition/16.4 Composition/I65 Composition layer 6 Composition 47 Composition layer 8 Composition/l69 1 Polyoxyethylene-added fatty acids Table 1 Volume measurement results -1 Example 2 The following ■ from the nostrils of four people A, B, C, and D who suffer from snoring.
Measurements were carried out in the same manner as in Example 1 using the three compositions (■■). The results are shown in Table 2.

Composition■ Polyoxyethylene higher fatty acid sorbitan ester 0.3% sodium chloride 0.9% magnesium chloride 0.1% glycerin
0.5% purified water
Residual acid compound - Sugar ester 05% sodium chloride, 1% polyethylene glycol 0.5% purified water
Residual group acid ■ Polyoxyethylene-added fatty acid glyceride
0.1% glycerin 0.8% hyaluronic acid o, i% purified water
Remainder Table 2 Sound volume measurement results-2 Example 6 Three people A, B, and C gargled with water in a heated room with a temperature of 24°C and a humidity of 30%, and gargled with the following composition.
E, F Three people were made to do light exercise to promote dry throat, and the time until they complained of dry throat was measured. The results are shown in Table 6.

Composition Table 3 Results of dry throat [Effects of the invention] The anti-drying composition of the present invention can prevent dryness of the nasal cavity, oral cavity, and pharyngeal mucosa for a long period of time with a simple usage method, and can also prevent dryness during sleep. It can significantly reduce the volume of snoring.

Claims (1)

[Claims] 1. One or more humectants selected from polyhydric alcohols, amino acids, polypeptides, sugars, or inorganic salts and a surfactant that is water-soluble at room temperature in a ratio of 100:1 by weight.
An anti-drying composition formed by blending the moisturizing agent and surfactant in water in a ratio of ~2:1 and with concentrations of 0.1 to 20% by weight and 0.01 to 5% by weight, respectively. thing.