JPS61212512A - Hair tonic - Google Patents

Abstract

PURPOSE:To provide a safe and excellent hair tonic compound containing melatonin. CONSTITUTION:The objective hair tonic can be produced by compounding 0.0001-5wt%, preferably 0.001-1wt% melatonin (a pale yellowish white crystalline powder obtained as a component secreted from conarium), and if necessary, various additives (e.g. disinfectant such as hinokitiol, cationic surfactant, etc., refreshing agent such as menthol, etc., oil such as olive oil, squalane, etc., perfume, antioxidant, UV absorber, dye, ethanol, water, etc.). It is expected that the falling-off of hair can be decreased or prevented by antagonizing testosterone or 5alpha-DHT (a male hormone) or inhibiting the bonding of the hormones with receptor protein, and melatonin exhibits the antagonistic effect.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention provides a hair nourishment that is safe and has an excellent hair nourishing effect by incorporating melatonin.

[Prior Art] Physiological symptoms such as male-pattern baldness and seborrhea are said to be due to increased stimulation of androgenic hormones based on excessive accumulation of male hormones. The main body of this androgenic hormone activity in organs such as hair roots and sebaceous glands is 5α-dihydrotestosterone (hereinafter referred to as 5α-DHT), which is produced by reducing testosterone by testosterone-5α-reductase (hereinafter referred to as T-5α-R) in these target organs. ) is becoming well known.

That is, testosterone produced by the tsubamaru and adrenal glands is transferred to the bloodstream and converted into 5α-DHT, a more powerful male hormone, by T-5α-R in the cells of the sebaceous glands and hair follicles. This 5α-DHT binds to intracellular receptors and acts on the nucleus to promote cell proliferation in sebaceous gland cells, while acting on hair matrix cells to suppress the division of hair matrix cells in the hair bulb, resulting in hair growth. is considered to be a hindrance.

[Problems to be solved by the invention] Symptoms such as male pattern baldness and hair loss can be reduced or prevented by antagonizing testosterone or 5α-DHT or inhibiting its binding to receptor proteins. Based on this viewpoint, several substances have been discovered so far. However, these substances have disadvantages in that they have undesirable side effects or are inferior in substantial hair growth effects.

On the other hand, melatonin was developed in the late 1950s by Lerne
It was discovered as a component secreted by the pineal gland by the group of Dr. As a function of melatonin,
It acts on the hypothalamus and is said to suppress the biosynthesis and secretion of gonadotropin-releasing factors, and melatonin is also said to suppress various hormones. . The present inventors focused on the antihormonal effect of melatonin, and determined that testosterone or 5α-DH in sebaceous gland cells or hair matrix cells.
As a result of extensive research into the effect on T, we discovered that melatonin has a direct antagonistic effect on testosterone and 5α-DHT locally. We have now completed the hair dye.

[Means for Solving the Problems] That is, the present invention is a hair nourishment characterized by containing melatonin.

Hereinafter, the configuration of the present invention will be explained in detail.

Melatonin used in the present invention
) has the chemical name N-acetyl 5-methox
It is called ytrypta-n+ine and is a pale yellowish white crystalline powder.

The blending amount of melatonin is o, oooi in the hair nourishment of the present invention.
It is desirable to set it to 5 weight%, preferably o,ooi to 1 weight%.

In addition to melatonin, the hair care product of the present invention includes additives commonly used in hair care products, such as bactericidal agents such as hinokitiol and cationic surfactants, cooling agents such as menthol, oils such as olive oil, squalane, and higher alcohols, In addition, surfactants, fragrances, antioxidants, ultraviolet absorbers, pigments, ethanol, water, etc. can be added.

Next, melatonin receptor protein and 5α used in the present invention
-Competitive antagonism with DHT will be explained using comparative examples.

Competitive antagonism between receptor protein and 5α-DHT Ta
Kayasu et al.'s method (Arch, Dermatol
, Res.

264, 50-51.1979), the amount of binding between the receptor protein and 5α-DHT was measured. The sample concentration used in the experiment was 10-6 molar. Competitive competitive inhibition rate was calculated from the obtained data using the following formula. The results are shown in Table 1.

Inhibition rate (%) - (C-t/C) As is clear from 1, melatonin has a higher relationship with receptor protein and 5α compared to the conventionally known ethinyl estradiol.
It has a large binding inhibiting effect due to competitive antagonism with -DHT, and can be said to be a substance that achieves the object of the present invention. Therefore, it was expected that the hair growth agent of the present invention containing melatonin would have a greater hair growth effect.

[Example] Next, the present invention will be explained in more detail by giving examples. The present invention is not limited thereby.

Hair growth effect measurement method Judgment was made based on the change in the number of strands of hair removed when washing the hair before and after using the hair tonic.

There were 10 subjects in each of the four groups of Examples 1 to 3 and Comparative Example 1. The measurement period was 4 months.
The first two months are a period of no hair growth, and the latter two months are a period of hair growth, during which you wash your hair every two days.
Hairs were collected once a week and their number was counted. The number of hairs pulled out for each period is summarized by data on the number of hairs pulled out for a total of 8 times during the 2 months without hair tonic application, and data on the number of hairs pulled out for a total of 8 times during the 2 months when hair tonics were applied, for each period. , average value + α
It was expressed as the number of hairs pulled per session. The unit is a book. The effectiveness was determined based on the difference between the average values for each period as shown below.

However, the number of hairs pulled was reduced by more than 70, indicating a significant effect.

+: The number of hair-pulled trees decreased by 40 or more, and a considerable effect was recognized.

±: The number of hairs removed was reduced by 10 or more, indicating that it was somewhat effective.

: The reduction in the number of hairs pulled was less than 10, so it cannot be said that there is an effect.

(Margin below) (Manufacturing method) Melatonin, ethinyl estradiol, and 40 mole adduct of hydrogenated castor oil EO were added to 95% ethanol, stirred and dissolved, and then ion-exchanged water was added and mixed to obtain a hair nourishing agent.

(The following is a blank space) As is clear from these results, it can be said that the hair nourishing material according to the present invention containing melatonin has a superior hair nourishing effect compared to the hair nourishing material containing conventionally known ethinyl estradiol.

[Example 4] Polyoxyethylene (8 mol) in 55.0 g of hair nourishing ethanol
Oleyl alcohol ether 2.0g, melatonin 0.
After adding 0.05 g of hinokitiol and 0.05 g of hinokitiol and dissolving the perfume and dye, 42.45 g of ion-exchanged water was added and solubilized to obtain a hair nourishing material.

[Example 5] Melatonin 0.5g, polyoxyethylene (60 mol)
Hydrogenated castor oil2. Og, glycerin 10.0 g, dipropylene glycol 10.0 g and 1.3-butylene glycol5. Og and 5.0 g of polyethylene glycol 1500 are heated and dissolved at 60° C. (Part A). Cetyl isooctanoate 10.0g.

5.0 g of squalane, 2.0 g of petrolatum, and 2.0 g of propylparaben are heated and dissolved at 60°C (Part B).

8. Add 30.0 g of a 1% aqueous solution of carboxyvinyl polymer and 0.03 g of sodium hexametaphosphate to ion-exchanged water.
Dissolve in 35g (0 parts). Part A and Part B are mixed at 60°C and treated with a homomixer to form a gel. Gradually add 0.5 g of ion-exchanged water to this and disperse with a homomixer. Next, add 0 parts to this, and finally add 0.12 parts of caustic potash.
An aqueous solution prepared by dissolving 5.0 g of ion-exchanged water was added and emulsified using a homomixer to obtain a 0/- emulsion type hair nourishing material.

[Example 6] Liquid paraffin 5.0g, cetostearyl alcohol 5.5g, petrolatum 5.5g, glyceryl monostearate 3. Og, polyoxyethylene (20 mol) 2-
3.0 g of octyl dodecyl ether, 0.05 g of vitamin E acetate, 0.3 g of propylparaben, and 0.05 g of fragrance are heated and dissolved and mixed. Add to this 0.5 g of melatonin, 7.0 g of glycerin, and 20 g of dipropylene glycol. A heated and dissolved mixture of Og, 5.0 g of polyethylene glycol 4000, 0.005 g of sodium hexametaphosphate, and 45.095 g of ion-exchanged water was added and emulsified with a homomixer to obtain a cream-like hair nourishment.

Claims (1)

[Claims] Hair nourishing agent characterized by containing melatonin