JPS5988409A - Hair tonic - Google Patents

Abstract

PURPOSE:To provide a hair tonic free from undesirable side effects such as the action of hormone, etc, and having excellent hair tonic effect, by using a deoxycorticosterone compound as a component. CONSTITUTION:The deoxycorticosterone compound of formula (R is H or 2-11C acyl) is compounded in a hair tonic in an amount of 0.0001-1wt%. The compound has the effect to inhibit the testosterone-5alpha-reductase activity as well as the effect to inhibit the bonding of 5alpha-dihydrotestosterone with receptor protein, and is effective to mitigate or prevent the male baldness and alopecia.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a hair nourishing agent that does not have undesirable side effects such as hormonal effects and has an excellent hair nourishing effect.Physiological symptoms such as male pattern baldness and seborrhea are caused by the It is said that this is due to increased stimulation of androgens due to excessive complaints of men, but recently it has been revealed that the main body of this androgen activity in organs such as hair roots and sebaceous glands has changed. It has become well known that 5α-dihydrotestosterone (hereinafter abbreviated as 5α-DHT) is reduced by 5α-dihydrotestosterone (hereinafter abbreviated as 5α-DHT). In other words, testosterone (
The male hormone) travels through the bloodstream to the sebaceous glands, where it is converted into the more powerful male hormone 5α-DHT by reductase in the sebaceous gland cells.This 6α-D
HT binds to intracellular receptors and acts on the nucleus to promote the proliferation of sebaceous gland cells, while HT itself exits the sebaceous gland cells and enters the bloodstream, acting on hair matrix cells and stimulating the growth of hair in the hair bulb. It is said to suppress the division of mother cells and prevent hair growth.

Therefore, it is thought that symptoms such as male pattern baldness and hair loss can be reduced or prevented by inhibiting the activity of reductase and the binding of 5α-DHT to receptor proteins; So far, a number of substances have been discovered based on this. However, even though these substances have a high inhibition rate of reductase activity, they have undesirable side effects, and their inhibition rate of binding between 5α-DHT and receptor protein is very low, so they are inferior to the actual hair growth effect. There was a drawback.

In view of the above circumstances, the present inventors have developed a method that does not have undesirable side effects such as hormonal effects, is safe, and has the effect of inhibiting both reductase activity and binding of 5α-D II T to receptor protein. As a result of intensive research in search of substances that have the same properties and in order to obtain a hair nourishing agent with excellent hair nourishing effects by blending them, it was discovered that androstenedione achieves the above object, and based on this knowledge, the present invention was developed. It was completed.

(Hereinafter in the margin) That is, the present invention is a nutritional supplement 1'1 which is a mixture of two or more types of ``species ζ'' among the ``gicicorticosterone compound'' represented by the above general formula.

Hereinafter, tj1't+J of the present invention will be described in 11.

Deoginoko used in the present invention? Reticos 70n (F, hereafter)
) O (abbreviated as S) type compounds are represented by rjij-, where 1 of the general formula is hydrogen, or where the number of carbon atoms is 2 ~
l, (1rIn addition to J chain saturation, small saturation, branching, aromatic rings, etc.
◇Specific examples include l (when is hydrogen)) OOS, I) OOS acebuto when acylno^,
+10! 'S Propione-1, I) OCS Henshade, etc., among which one or two types are blended. The blending weight is about 0.0001 to 1 ton liter%.

The base AA of the hair nourishing agent in the present invention is not particularly limited, and various types such as lotion, milky lotion, cream, etc. can be used.

In addition, the hair nourishing oil'1 according to the present invention contains dexyfludicosterone-based compounds (11) and additives commonly used in hair nourishing oils (11) such as hinogitil, cation surfactant V1. ．．
Sterilizing agents such as 1'FII, cooling agents such as menthol, 3 leave oil, squalane, high alcohols, etc., low surfactants, fragrances, oxidized l! /j +l agent, 紮ゆ(sai i! absorbent, pigment, ethanol, water'6) can be blended.

Teshi 1・IJ- used for the next Ni'F 56 Akira! This paper describes the safety test results of cosderone-based compounds.

(Target) Adult 1tr, "J") Otsu (sample) 1.
% liquid paraffin solution 2 Detexol f~: I Suderon'j 7tate 5% liquid paraffin solution 3 Liquid paraffin solution (test method) 24-hour human forearm closed test, test (judgment basis If) 廿 Strong erythema 10 Erythema 10 ii '& Kana Erythema - Negative (Results) As is clear from the above results, the demequin corticosteroid compound used in the present invention has no skin irritation at all.

(Hereinafter referred to as 1-1) Next, the present invention will be explained in more detail by giving examples. The present invention is not limited thereby. The blending amount is in weight%.

The test method will be explained in the Examples.◇ Hair growth effect measurement method Judgment was made based on the change in the number of strands of hair removed during hair washing before and after using the hair growth agent. There were 10 subjects in each of the four groups of Examples 1 to 3 and Comparative Example 1. The measurement period was 4 months, with the first 2 months being a period of no application of hair tonic, and the latter 2 months being a period of applying hair tonic. They were collected and counted. The number of hairs pulled out for each period is shown as data for a total of 8 hairs pulled out for 2 months without hair tonic application, and 818 hairs pulled out for 2 months with hair tonic applied. The effectiveness was determined based on the difference between the average values for each period as shown below.

廿：The number of hairs pulled was reduced by more than 70, indicating a significant effect.

The number of brushed trees was reduced by more than the number of open trees, indicating a considerable effect.

±: The number of hairs removed was reduced by 10 or more, indicating that it was somewhat effective.

1: The number of hairs removed was less than 10, and it could not be said to be effective.

(hereinafter -° margin) Example 1 Hair nourishing agent (Kosho type) (Tsukuda I) 95% ethanol 80 Deoxycorticosterone 10 Hinokitiol 00] Biotin
0.01 hardened castor NI+ (E
O) 40 mol (J additive 0.5 purified water
J848 fragrance, pigment
Appropriate 1. ) (Manufacturing method) Ethanol, xycorticosterone, and hinokichi kari.
Add 40 moles of alcohol, vinegar, hydrogenated human oil (1!:o), additives, fragrances, and pigments, stir to dissolve J'1,
Next, purified water was added and mixed to create a transparent liquid hair growth agent.Example 2 Hair growth agent (lotion) (city)
10
．． 0 Propylene Glycol 50 Oleyl Alcohol 0.31 Nopolyoxyethylene 1 Rubitan Esthes Monolaurate (2DEf1.) 1
．． 0 polyoxyethylene lauryl ether (2:1En) 10
95% ethanol 10.0 deoxycorticosterone propionate O,0CI
01 Deoxycortyphsterone 0.05
Purified Water '16499 Fragrance, Pigment, Preservative (Production Method) Add glycerin and propylene glycol to purified water and dissolve at room temperature. On the other hand, add and dissolve the remaining ingredients in ethanol, add 1 part of the above-mentioned purified water to solubilize it, adjust the color, pass through the water, and obtain a hair nourishing agent.
(Left below) Example 3
Hair nourishing agent (emulsion type) Fragrance, pigment, preservative Appropriate amount (manufacturing method) Heat each of the above ingredients (A) and (B) to 80'C, mix and emulsify both ingredients at the same temperature, and bring to room temperature while stirring. It was cooled and a hair nourishing agent was obtained.

(Results) Example 1 No body Buddha No application period Hair tonic application period Effect 1
214±46 161±45
+2361±35 241±36 -1
-)3473±29 365±34++4193±
46 145±310'5174±51121±4
4+ 6 368±25 268±29
-H-7151±41 135±
34 ±8 411±39
309±36 ++9315±41
251±35+ 10 425±50 314±32
+10 Example 2 Panel sintering Non-application period Hair tonic application period Effect 1
415±54 301±46
++2365±36 345±38 -1+
3241±41209±31+ 4352±29 261±25 -H-546
1±37 351±38 ++
()Non-application period Hair tonic application period Effect 6 254±21 21
3±59 4-7194±18 171
±31 ±8 168±24
141±19 +9295±4423
9±24+ 10 345±48 231±36
+10 Examples Penel boil Non-application period Hair tonic application period Effect 1
545±35 461±39
++2375±41296±25tan3. 416±29 321±3
6 ++4218±36361±41+ 5 198±25 171±21
+6356±46241±23 7256±29' 201±35+ 8 195±25 171±21
+9265±41245±29+ 10 312±39 209±3
As is clear from the results of the effect test of 1 ++ or more, the hair nourishment according to the present invention containing the D+ and osJ compounds has excellent effects.

Example 4 Hair nourishing agent (cream type) Fragrance, pigment, preservative Appropriate amount (manufacturing method) Dissolve (4) uniformly at 70-75 C, add ω) prepared in advance and stir to obtain. The emulsion was cooled to obtain a hair nourishing agent.

Patent applicant Shiseido Co., Ltd.

Claims (1)

[Scope of Claims] A hair nourishing treatment r't 0 (
I-1 mi all white)