JPH01275516A - Dandruff-preventive agent and hair-cosmetic - Google Patents

Abstract

PURPOSE:To provide a dandruff-preventive agent and hair-cosmetic containing uric acid, betaines or rutin and having excellent dandruff-preventing effect, stability and safety. CONSTITUTION:The objective agent contains (A) 0.001-0.5wt.% of uric acid or its derivative (e.g. uric acid salt, N-alkyl-modified uric acid or uric acid glycoside), (B) 0.001-5wt.% of betaines or their salts (e.g. lysine betaine, homaline, trigonelline or glutamic acid betaine) and (C) 0.000001-5wt.% of rutin based on total amount of the dandruff-preventive agent or hair-cosmetic. Each of the above compounds can be compounded to the dandruff-preventive agent and hair-cosmetic even in suspended state without deteriorating the activity.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to anti-dandruff agents and hair cosmetics, particularly to the improvement of substances having a dandruff-inhibiting effect.

[Prior Art] Generally, dandruff consists of sebaceous gland secretions, sweat gland secretions, peeled substances from the epidermal layer, etc., and is usually caused by hypersecretion of sebaceous glands, etc., but when the skin is infected with bacteria or yeast, dandruff The occurrence of this disease is said to be promoted pathologically. For this reason, anti-dandruff agents or hair cosmetics to which bactericidal or antibacterial agents have been added have traditionally been used to prevent dandruff.

However, some disinfectants and antibacterial agents may cause skin irritation, etc.
There are some products that have safety issues for the human body, and anti-dandruff agents and hair cosmetics that contain antibacterial agents and bactericidal agents have a so-called ecological problem, such as destroying the delicate balance of resident bacteria on the skin when used daily. From this point of view, it has been pointed out that sometimes it causes undesirable situations.

For example, zinc pyrithione (ZPT), which has traditionally been recognized as the most effective anti-dandruff drug, is also included in the category of antibacterial agents, and it is preferable to avoid using large amounts of it as much as possible. It is believed that.

Therefore, there is a widespread desire to prevent the occurrence of dandruff without the use of such antibacterial agents or bactericides, and the search for safe substances that have effective dandruff control effects and that do not require the use of antibacterial agents or bactericides. has been carried out.

Until now, substances that have anti-dandruff effects that are not based on antibacterial or bactericidal properties include alpha-tocopherol and vitamin A.
acid ester (Japanese Unexamined Patent Publication No. 51-73137) and vitamin E nicotinic acid ester (German Patent No. 230158)
No. 5 and Specification No. 2301660) have been reported.

[Problems to be solved by the invention] However, these esters of vitamin E (i.e., tocopherol) lack stability on the skin and cannot be expected to have a sustained effect in suppressing dandruff. .

Furthermore, since the vitamin E esters mentioned above are insoluble in water, they have the disadvantage of producing oily precipitates depending on the dosage form.

Additionally, there was a problem in that a large amount of surfactant was required to add the required amount of the substance.

The present invention was made in view of the problems of the prior art, and its purpose is to provide an anti-dandruff agent and hair cosmetic that are excellent in terms of anti-dandruff effect, stability, and safety. be.

To achieve the above object, the present inventors investigated the anti-dandruff effects of a wide variety of substances, and found that uric acid and its derivatives, betaines and their salts, and rutin are extremely effective in preventing dandruff. Furthermore, it was discovered that safety and stability could also be improved, and the present invention was completed.

[Means for Solving the Problems] That is, the invention according to claim 1 is an anti-dandruff agent characterized by containing one or more compounds selected from the group consisting of uric acid and derivatives thereof.

The invention according to claim 2 is a hair cosmetic composition containing one or more compounds selected from the group consisting of uric acid and its derivatives.

The invention according to claim 3 is an anti-dandruff agent characterized by containing one or more compounds selected from the group consisting of betaines and salts thereof.

The invention according to claim 4 is a hair cosmetic composition containing one or more compounds selected from the group consisting of betaines and salts thereof.

The invention according to claim 5 is an anti-dandruff agent characterized by containing rutin.

The invention according to claim 6 is a hair cosmetic containing rutin.

Hereinafter, the configuration of the present invention will be explained in detail.

Examples of uric acid and its derivatives used in the present invention include uric acid, uric acid or its salts such as sodium urate, potassium urate, ammonium urate, 3-N-methyluric acid, 3-N-lauryluric acid, 7-N-butyluric acid, N-alkyl uric acid modified products such as 1-N-ethyluric acid, 9-N-lauryluric acid, 3.7-N-dimethyluric acid, 3-N-ribosyluric acid,
Examples include uric acid glycosides such as 9-N-glycodyluric acid.

These uric acid, its salts, and uric acid glycosides are also found in serum, and recently the relationship between the average survival age of mammals and serum uric acid concentration, and the relationship between cancer incidence and serum uric acid level have been studied. Although this substance is attracting attention, there are currently no examples of its application as an anti-dandruff agent or hair cosmetic.

The amount of uric acid and its derivatives added to the anti-dandruff agent or hair cosmetic is not particularly limited, but the amount is usually 0.001% to 0.5% by weight.

If it is less than 0.001% by weight, the anti-dandruff effect tends to be poor; Even if the amount exceeds 5% by weight, no significant increase in effectiveness can be expected.

Examples of the betaines used in the present invention include lysine betaine, ornithine betaine, homarin, trigonelline, alanine betaine, taurobetaine, carnitine, stachydrine, glutamic acid betaine, phenylalanine betaine, γ-butyrobetaine, betaine, and the like.

These betaines or their salts are found in seaweed, fish, and crustaceans, but their physiological significance is not necessarily clear, and there are no examples of their use as anti-dandruff agents or hair cosmetics. Not found at the moment.

The amount of betaines and their salts added to the anti-dandruff agent or hair cosmetic is not particularly limited, but is usually 0.001 to 5% by weight based on the total amount.

If it is less than 0.001% by weight, the anti-dandruff effect tends to be poor, and conversely, if it is added in excess of 5% by weight, no significant increase in the effect can be expected.

5 Main Rutin used in the present invention is obtained by extracting from plants (Japanese apricot buds, whole buckwheat plants), and is an oral drug used as a blood vessel reinforcement and cerebral hemorrhage prevention agent. It is a drug for administration. As for its medicinal effects, it has been reported that it restores the fragility and abnormal permeability of capillaries. It is also known to inhibit hyaluronidase.

The amount of rutin added to the anti-dandruff agent or hair cosmetic in the present invention is not particularly limited, but is usually 0.000001 to 5% by weight based on the total amount.

If it is less than 0.000001% by weight, the anti-dandruff effect tends to be poor, and conversely, if it is added in excess of 5% by weight, no significant increase in the effect can be expected.

Uric acid and its derivatives, or betaines and their salts of the present invention are easily soluble in water and insoluble or hardly soluble in oils and fats and organic solvents, but even in a suspended state they can be used as anti-dandruff agents or hair cosmetics. is possible and does not have any effect on the effectiveness.

Rutin is also a substance that is easily soluble in polar solvents such as water and alcohol, but even in a suspended state it can be incorporated into anti-dandruff agents or hair cosmetics without any effect on the effectiveness. .

In the present invention, the anti-dandruff agent is preferably used as a pharmaceutical, a quasi-drug, or a cosmetic.

Furthermore, hair cosmetics (including medicinal cosmetics, that is, quasi-drugs) in the present invention broadly refer to those used for the scalp or hair, such as hair tonics, scalp emulsions, hair liquids, hair shampoos, Includes hair rinse, hair cream, hair spray, etc.

Furthermore, the anti-dandruff agent or hair cosmetic of the present invention includes:
In addition to the above-mentioned essential ingredients, there are other ingredients commonly used in general medicines, quasi-drugs, and cosmetics, such as oily ingredients, ultraviolet absorbers, preservatives, humectants, surfactants, fragrances, water, alcohol, and additives. A sticky agent, a coloring agent, a drug, etc. can be added.

It is also possible to combine uric acid and its derivatives, betaines and their salts, or rutin.

[Action] The mechanism by which the anti-dandruff agent and hair cosmetic according to the present invention exhibits an effective anti-dandruff effect is that metabolic reactions within the scalp tissue are appropriately adjusted, and lipid peroxide, which is a factor in the occurrence of dandruff, is reduced on the scalp. This is thought to be due to the fact that uric acid and its derivatives, betaines and their salts, or rutin inhibit their formation.

[Example] Next, the present invention will be explained in more detail with reference to Examples.

Note that the present invention is not limited to this.

Moreover, the blending amount is shown in weight%.

First, the following tests were conducted to examine the effects of uric acid and its derivatives on preventing dandruff.

EXAMPLE 1 0.001% by weight of uric acid was added to a hair shampoo and the dandruff suppressing effect was measured.

That is, to 79.999 g of purified water, 15 g of lauryl sulfate triethanolamine, 5 g of coconut oil fatty acid diethanolamide, 0.001 g of uric acid, and appropriate amounts of fragrances and pigments.
The ingredients were sequentially added, heated, and then cooled to obtain a hair shampoo.

The anti-dandruff effect was measured as follows.

The target audience is men between the ages of 28 and 42 who have a relatively large amount of dandruff7.
I chose a name and did a test.

Before the start of the test, the hair was washed with a uric acid-free shampoo, and the accumulated dandruff was collected for two days after the hair washing, and the amount of protein in the collected dandruff was measured (control period).

Next, use a shampoo containing uric acid for one month.
During this period, dandruff was collected and the amount of protein was measured in the same manner as in the control period (sample period).

Compare the average dandruff protein amount for one month of the control period with the average dandruff protein amount for the last two weeks of the sample period, and if the reduction rate of dandruff is 50% or more... A: 30% or more, less than 50% In the case of... B20% or more but less than 30%...0020% or more
...I ranked it D.

The results are shown in Table 1 below.

As a result, it was found that products containing uric acid had excellent anti-dandruff effects.

Other examples are shown in Table 1 and below. All of them showed excellent effectiveness in preventing dandruff as a result of use tests similar to those described above.

Hair shampoo A hair shampoo having the following composition was prepared. The manufacturing method is similar to that of the first embodiment. .

Lauryl sulfate/Na 5. 0 Lauryl sulfate triethanolamine 5.0 Lauryl dimethylaminoacetic acid betaine 6.0 Ethylene glycol fatty acid ester 2.0 Polyethylene glycol
5.03-N-lauryl uric acid
0.05 Fragrance 0・
3 Water Residual Guide 1 Hair Rinse A hair rinse with the following composition was prepared.

The manufacturing method was a conventional method.

Dipropylene glycol 4.0 Stearyltrimethylammonium chloride 2.0 Stearyl alcohol 1.0 Polyoxyethylene (
Hydrogenated castor oil 0.5 Glycerin stearate 0.59-N-Lauryl uric acid 0.02 Water Residual group A Hair tonic ethyl alcohol 55g polyoxyethylene (8 mole addition) oleyl alcohol ether 2g and 7-N-butyluric acid 0. Appropriate amounts of Olg and fragrance were added and dissolved at room temperature to obtain an alcohol phase.

Separately, 5 g of glycerin was added and dissolved in 37.99 g of purified water. After cooling, an appropriate amount of the dye was added, and an alcohol phase was added to the aqueous phase to solubilize it to obtain a hair tonic with an anti-dandruff effect.

Tougo Inuse Hair Shampoo 52.5 g of ethyl alcohol, 20 g of polyoxypropylene butyl ether, 2 g of squalane, 13.7-dimethyluric acid 0.005 g, and an appropriate amount of fragrance were dissolved at room temperature.The alcohol phase was dissolved at room temperature, and the pigment was added to 25.495 g of purified water. A suitable amount of the above was added and stirred to obtain a hair liquid with a dandruff suppressing effect.

Real 11 Enbi - Scalp emulsion 2g stearic acid 1.5g cetyl alcohol.

3 g of vaseline, 12 g of liquid paraffin, 2 g of polyoxyethylene (10 mol addition), monooleate ester, 1 g of sodium urate, and an appropriate amount of perfume were mixed and heated to 80° C. to obtain an oil phase. Separately, propylene glycol 5g1
1 g of triethanolamine and 73.4 g of purified water
The mixture was heated to 0° C., the oil phase was gradually added while stirring, and the mixture was cooled to obtain a scalp emulsion having an anti-dandruff effect.

Hair Cream Stearic acid 2g1 Stearyl alcohol 7g1 Octyldodecanol 6g1 Polyoxyethylene (10 mole addition) Cetyl ether 3g, 3-N-ribosyluric acid 0.2
g and fragrance were added thereto and heated to 80°C to obtain an oil phase.

Separately, 5g of propylene glycol and 76.8g of purified water
was heated to 80° C., the oil phase was gradually added to the aqueous phase with stirring, and the mixture was cooled to obtain a hair cream having a dandruff suppressing effect.

Inuri week 1 Hair emulsion Polyethylene glycol 1500 3.5g.

1 g of triethanolamine was dissolved in 74.999 g of purified water by heating and maintained at 70°C. Stearic acid 2.5g, cetyl alcohol 1.5g, petrolatum 5g.

Stuff 9210 g 1 polyoxyethylene (10 moles added) 2 g monooleate 1 0.001 g uric acid were dissolved by heating, and the mixture was kept at 70° C. and added to the aqueous phase. After pre-emulsification,
A hair emulsion with an anti-dandruff effect was prepared by uniformly emulsifying the product using a homomixer and slowly cooling it.

Betaines and Their Salts First, the following tests were conducted to examine the effects of betaines and their salts on preventing dandruff.

Fire Arashi Ga 1 0.02% by weight of Homarin as a betaine was added to a hair tonic and the dandruff suppressing effect was measured.

That is, 2 g of polyoxyethylene (8 mol addition) oleyl alcohol ether, 0.02 g of homarin, and an appropriate amount of fragrance were added to 55 g of ethyl alcohol, and the mixture was dissolved at room temperature to obtain an alcohol phase.

Separately, 5 g of glycerin was added and dissolved in 37.98 g of purified water. After cooling, an appropriate amount of the dye was added, and an alcohol phase was added to the aqueous phase to solubilize it to obtain a hair tonic.

The anti-dandruff effect was measured as follows.

The target audience is men between the ages of 28 and 42 who have a relatively large amount of dandruff7.
I chose a name and did a test.

Before starting the test, wash your hair with a betaine-free shampoo.
After hair washing, accumulated dandruff was collected using a hair tonic without petaine twice in the morning and evening for two days, and the amount of protein in the collected dandruff was measured (control period).

Next, a hair tonic containing homarin was used for one month, during which time dandruff was collected and the amount of protein was measured in the same manner as in the control period (sample period).

The evaluation method is based on the above Example 1 using uric acid.

The evaluation results are shown in Table 2 below.

As a result, it was found that products containing homarin had excellent anti-dandruff effects.

(The following is a margin) Other examples are shown in Table 2 and below. All of them showed excellent effectiveness in preventing dandruff as a result of use tests similar to those described above.

A hair shampoo having the following composition was prepared. The manufacturing method is similar to that of the first embodiment.

Lauryl sulfate/Na 5,0 Lauryl sulfate triethanolamine 5.0 Lauryl dimethylaminoacetic acid betaine 6.0 Ethylene glycol fatty acid ester 2.0 Polyethylene glycol
5.0 trigonelline
0.03 Fragrance 0.
3 Water Residual Fire Storm Base 1 Yu Hair Rinse A hair rinse having the following composition was prepared.

The manufacturing method was a conventional method.

Dipropylene glycol 4.0 Stearyltrimethylammonium chloride 2.0 Stearyl alcohol 1. 0 Polyoxyethylene (60 mol addition) Hydrogenated castor oil 0. 5 Glycerin stearate 0.5 Taurobetaine
0.5 water 1 s. hair tonic ethyl alcohol 2 g of polyoxyethylene (8 moles added) oleyl alcohol ether, 0.2 g of lysine betaine, and an appropriate amount of fragrance were added and dissolved at room temperature to obtain an alcohol phase. . Separately, 5 g of glycerin was added and dissolved in 37.8 g of purified water. After cooling, an appropriate amount of the dye was added, and an alcohol phase was added to the aqueous phase to solubilize it to obtain a hair tonic with an anti-dandruff effect.

Dog plate week 11 Hair liquid Add 20 g of polyoxypropylene butyl ether, 2 g of squalane, 0.05 g of ornithine betaine, and an appropriate amount of fragrance to 52.5 g of hair liquid ethyl alcohol, dissolve at room temperature, and add an appropriate amount of coloring matter to 25.45 g of purified water. A hair liquid having a dandruff suppressing effect was obtained by adding the following ingredients and stirring.

Kwagoka 11 Scalp emulsion 2g stearic acid 1.5g cetyl alcohol.

Vaseline 3g1 Liquid paraffin 12g1 Polyoxyethylene (10 mole addition) monooleate ester 2g17
- Mix 0.08 g of petitrobetaine and an appropriate amount of fragrance.
It was heated to 0°C to obtain an oil phase. Separately, propylene glycol 5
g1 Triethanolamine Ig and purified water 73.4
2 g was heated to 80° C., the oil phase was gradually added while stirring, and the mixture was cooled to obtain a scalp milky lotion having an anti-dandruff effect.

χ Plate 1j Hair Cream Stearic acid 2g1 Stearyl alcohol 7g1 Octyldodecanol 6g1 Polyoxyethylene (10 mol addition) Cetyl ether 3g1 Carnitine 0.05g and an appropriate amount of fragrance were added and heated to 80°C to obtain an oil phase. Separately, add 5 g of propylene glycol and 76.95 g of purified water to 80 g.
The oil phase was gradually added to the aqueous phase while stirring, and the mixture was cooled to obtain a hair cream having a dandruff suppressing effect.

Mi 1111” - hair emulsion Polyethylene glycol 1500 3.5g.

1 g of triethanolamine was dissolved in 74.49 g of purified water by heating and maintained at 70°C. Stearic acid 2.5g, cetyl alcohol 1.5g, petrolatum 5g.

Stuff 9210g 1 polyoxyethylene (10 mol addition) monooleic acid ester 2g 1 Stachydrine 0. Ol
g was dissolved by heating and added to the aqueous phase while keeping the temperature at 70°C. After preliminary emulsification, the mixture was uniformly emulsified using a homomixer and slowly cooled to prepare a hair emulsion with anti-dandruff effect.

First, in order to investigate the effect of rutin on preventing dandruff, the following test was conducted.

0,0002% by weight of Oran Weekjo Niltin was blended into a hair tonic and the dandruff suppressing effect was measured.

The method for preparing the hair tonic and measuring the anti-dandruff effect was in accordance with Example 9 above.

The evaluation results are shown in Table 3 below.

As a result, it was found that products containing rutin had excellent anti-dandruff effects.

(The following is a margin) Other examples are shown in Table 3 and below. All of them showed excellent effectiveness in preventing dandruff as a result of use tests similar to those described above.

Hi-Saraga 11 Hair Shampoo A hair shampoo having the following composition was prepared. The manufacturing method is similar to that of the first embodiment.

Lauryl sulfate/Na 5.0 Lauryl sulfate triethanolamine 5.0 Lauryl dimethylaminoacetic acid betaine 6.0 Ethylene glycol fatty acid ester 2.0 Polyethylene glycol
5.0 Rutin 0
．． 003 Fragrance 0.3
Water Residue Container Dish 11 Hair Rinse A hair rinse having the following composition was prepared.

The manufacturing method was a conventional method.

Dipropylene glycol 4. 0 Stearyltrimethylammonium chloride 2.0 Stearyl alcohol 1.0 Polyoxyethylene (
60 mole addition) Hydrogenated castor oil 0.5 Glycerin stearate 0. 5 Rutin
0.0005 water Residue: 55 g of atonic ethyl alcohol, 2 g of polyoxyethylene (8 moles added), oleyl alcohol ether, and 0.00 rutin.
00001 g and an appropriate amount of fragrance were added and dissolved at room temperature to obtain an alcohol phase. Separately, 5 g of glycerin was added and dissolved in 3.7.99999 g of purified water. After cooling, an appropriate amount of the dye was added, and an alcohol phase was added to the aqueous phase to solubilize it to obtain a hair tonic with an anti-dandruff effect.

Hair liquid ethyl alcohol 52.5g, polyoxypropylene butyl ether 20g1 squalane 2g1 rutin O.00
25.4995 g of purified water and an appropriate amount of pigment were added to an alcohol phase in which an appropriate amount of 0.05 g and fragrance were added and dissolved at room temperature, and the mixture was stirred to obtain a hair liquid having a dandruff suppressing effect.

Scalp emulsion 2g stearic acid 1.5g cetyl alcohol.

3 g of petrolatum, 12 g of liquid paraffin, 1 g of polyoxyethylene (10 mol addition), monooleate Lg, 0008 g of rutin O, and an appropriate amount of perfume were mixed and heated to 80° C. to obtain an oil phase. Separately, 5 g of propylene glycol, 1 g of triethanolamine, and 73.4992 g of purified water.
was heated to 80° C., the oil phase was gradually added while stirring, and the mixture was cooled to obtain a scalp emulsion having an anti-dandruff effect.

11 Hair cream stearic acid 2g1 stearyl alcohol 7g1 octyldodecanol 6g1 polyoxyethylene (10 mol addition) cetyl ether 3g1 rutin 0.02g and an appropriate amount of fragrance were added and heated to 80°C to obtain an oil phase. Separately, 5 g of propylene glycol and 76.98 g of purified water were heated to 80° C., and the oil phase was gradually added to the aqueous phase with stirring, and the mixture was cooled to obtain a hair cream having a dandruff suppressing effect.

Husband's Week 24 Hair Emulsion Polyethylene glycol 1500 3.5g.

1 g of triethanolamine was dissolved in 74.4999 g of purified water by heating and maintained at 70°C. 2.5g stearic acid, 1.5g cetyl alcohol, 5g petrolatum, 11 squalane
0 g of polyoxyethylene (10 mol addition) monooleic acid ester 2 g and 10001 g of rutin O were dissolved by heating, and the mixture was kept at 70° C. and added to the aqueous phase. After preliminary emulsification, the mixture was uniformly emulsified using a homomixer and slowly cooled to prepare a hair emulsion with anti-dandruff effect.

[Effects of the Invention] Since the present invention is configured as described above, it produces the effects described below.

According to the anti-dandruff agent or hair cosmetic according to claim 1 or 2, since it contains uric acid and its derivatives, it is safe and stable and has an excellent anti-dandruff effect.

According to the anti-dandruff agent or hair cosmetic according to claim 3 or 4, since it contains betaines and their salts, it is safe and stable, and has an excellent anti-dandruff effect.

According to the anti-dandruff agent or hair cosmetic according to claim 5 or 6, since it contains rutin, it has good safety and stability, and has an excellent anti-dandruff effect even when the amount is extremely small. ing.

Claims (6)

[Claims] (1) An anti-dandruff agent characterized by containing one or more compounds selected from the group consisting of uric acid and its derivatives. (2) A hair cosmetic containing one or more compounds selected from the group consisting of uric acid and its derivatives. (3) An anti-dandruff agent containing one or more compounds selected from the group consisting of betaines and their salts. (4) A hair cosmetic containing one or more compounds selected from the group consisting of betaines and their salts. (5) An anti-dandruff agent characterized by containing rutin. (6) A hair cosmetic characterized by containing rutin.