JPS6119273B2 - - Google Patents
Info
- Publication number
- JPS6119273B2 JPS6119273B2 JP49138945A JP13894574A JPS6119273B2 JP S6119273 B2 JPS6119273 B2 JP S6119273B2 JP 49138945 A JP49138945 A JP 49138945A JP 13894574 A JP13894574 A JP 13894574A JP S6119273 B2 JPS6119273 B2 JP S6119273B2
- Authority
- JP
- Japan
- Prior art keywords
- wounds
- wound
- cleaning
- infection
- ethylene oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004140 cleaning Methods 0.000 claims description 34
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 20
- 229920001577 copolymer Polymers 0.000 claims description 16
- 239000012530 fluid Substances 0.000 claims description 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 229920001400 block copolymer Polymers 0.000 claims description 6
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical group CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 2
- 206010052428 Wound Diseases 0.000 description 79
- 208000027418 Wounds and injury Diseases 0.000 description 79
- 229920005862 polyol Polymers 0.000 description 28
- 150000003077 polyols Chemical class 0.000 description 28
- 239000000243 solution Substances 0.000 description 27
- 208000015181 infectious disease Diseases 0.000 description 25
- 229920001983 poloxamer Polymers 0.000 description 17
- 238000011282 treatment Methods 0.000 description 17
- 239000004094 surface-active agent Substances 0.000 description 12
- 229940064804 betadine Drugs 0.000 description 11
- 239000003599 detergent Substances 0.000 description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 239000000645 desinfectant Substances 0.000 description 9
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 7
- 230000028709 inflammatory response Effects 0.000 description 7
- 239000011630 iodine Substances 0.000 description 7
- 229910052740 iodine Inorganic materials 0.000 description 7
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 230000002421 anti-septic effect Effects 0.000 description 5
- 239000012459 cleaning agent Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- -1 poly(propylene) chains Polymers 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000009931 harmful effect Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000700198 Cavia Species 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 238000000692 Student's t-test Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229940112493 phisohex Drugs 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- QDHHCQZDFGDHMP-UHFFFAOYSA-N Chloramine Chemical class ClN QDHHCQZDFGDHMP-UHFFFAOYSA-N 0.000 description 1
- 241001340526 Chrysoclista linneella Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 208000026137 Soft tissue injury Diseases 0.000 description 1
- 241000201788 Staphylococcus aureus subsp. aureus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 230000003816 axenic effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229940035535 iodophors Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/722—Ethers of polyoxyalkylene glycols having mixed oxyalkylene groups; Polyalkoxylated fatty alcohols or polyalkoxylated alkylaryl alcohols with mixed oxyalkylele groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/460,451 US3997458A (en) | 1974-04-12 | 1974-04-12 | Method of cleansing contaminated wounds and surgical scrub solutions for same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS50132119A JPS50132119A (US20100056889A1-20100304-C00004.png) | 1975-10-20 |
| JPS6119273B2 true JPS6119273B2 (US20100056889A1-20100304-C00004.png) | 1986-05-16 |
Family
ID=23828764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP49138945A Expired JPS6119273B2 (US20100056889A1-20100304-C00004.png) | 1974-04-12 | 1974-12-05 |
Country Status (7)
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4147782A (en) * | 1976-06-24 | 1979-04-03 | William H. Rorer, Inc. | Pharmaceutical detergent composition |
| US4491576A (en) | 1979-01-17 | 1985-01-01 | Block Drug Company, Inc. | Polyoxyethylene derivatives as antipruritic ectoparasiticide |
| US4326977A (en) * | 1980-11-10 | 1982-04-27 | Basf Wyandotte Corporation | Liquid antiseptic cleaners with improved foaming properties |
| US4544495A (en) | 1981-08-10 | 1985-10-01 | Basf Wyandotte Corporation | High foaming liquid shampoo composition |
| US4704102A (en) * | 1982-09-30 | 1987-11-03 | Geneco Inc. | Method of eliminating intra abdominal infections |
| DE3312431A1 (de) * | 1983-04-07 | 1984-10-11 | B. Braun Melsungen Ag, 3508 Melsungen | Pvp-iod-wundpuder mit synergistisch wirkender pudergrundlage |
| NL8301389A (nl) | 1983-04-20 | 1984-11-16 | Chem Y | Nieuwe vloeibare jodoforen. |
| US4879109A (en) * | 1986-05-15 | 1989-11-07 | Emory University | Method for treating burns |
| US5071649A (en) * | 1986-05-15 | 1991-12-10 | Emory University | Method of preventing blockage in catheters |
| US5041288A (en) * | 1986-05-15 | 1991-08-20 | Emory University | Method of treating tissue damaged by reperfusion injury |
| US5078995A (en) * | 1986-05-15 | 1992-01-07 | Emory University | Fibrionolytic composition |
| US5047236A (en) * | 1986-05-15 | 1991-09-10 | Emory University | Method of treating stroke |
| US5250294A (en) * | 1986-05-15 | 1993-10-05 | Emory University | Improved perfusion medium for transplantation of organs |
| US5648071A (en) * | 1986-05-15 | 1997-07-15 | Emory University | Method of treating tumors |
| US5064643A (en) * | 1986-05-15 | 1991-11-12 | Emory University | Method for treating sickle cell disease |
| US5089260A (en) * | 1986-05-15 | 1992-02-18 | Emory University | Method of treating ischemic tissue |
| US5039520A (en) * | 1986-05-15 | 1991-08-13 | Emory University | Plasma extender |
| US5030448A (en) * | 1986-05-15 | 1991-07-09 | Emory University | Method of delivering drugs to damaged or diseased tissue |
| US5240701A (en) * | 1986-05-15 | 1993-08-31 | Emory University | Method of performing angioplasty procedures |
| US5028599A (en) * | 1986-05-15 | 1991-07-02 | Emory University | Method of treating mycardial damage |
| US5811088A (en) * | 1987-02-20 | 1998-09-22 | Emory University | Antiinfective compounds and methods of use |
| IE63315B1 (en) * | 1989-04-24 | 1995-04-05 | Becton Dickinson Co | Radiation sterilizable antimicrobial ointment and process to manufacture |
| NZ236229A (en) * | 1989-12-05 | 1993-02-25 | Calgon Corp | Compositions comprising ethylene oxide/propylene oxide block copolymers: use in treating wounds |
| AU647484B2 (en) * | 1990-04-26 | 1994-03-24 | Cytrx Corporation | Composition and method for topical treatment of damaged or diseased tissue |
| US6933286B2 (en) | 1991-03-19 | 2005-08-23 | R. Martin Emanuele | Therapeutic delivery compositions and methods of use thereof |
| USRE38558E1 (en) | 1991-03-19 | 2004-07-20 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| US7202225B1 (en) | 1993-10-15 | 2007-04-10 | Emanuele R Martin | Therapeutic delivery compositions and methods of use thereof |
| AU662146B2 (en) | 1991-03-19 | 1995-08-24 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| US5696298A (en) * | 1991-03-19 | 1997-12-09 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| WO1993000100A2 (en) * | 1991-06-24 | 1993-01-07 | Carrington Laboratories, Inc. | Wound cleanser |
| US5622649A (en) * | 1991-06-27 | 1997-04-22 | Emory University | Multiple emulsions and methods of preparation |
| JPH05112794A (ja) * | 1991-10-23 | 1993-05-07 | Sodick Co Ltd | 不燃性放電加工液 |
| US5470568A (en) * | 1992-02-13 | 1995-11-28 | Arch Development Corporation | Methods and compositions of a polymer (poloxamer) for cell repair |
| US5605687A (en) * | 1992-05-15 | 1997-02-25 | Arch Development Corporation | Methods and compositions of a polymer (poloxamer) for repair of electrical injury |
| MX9305535A (es) * | 1992-09-18 | 1994-03-31 | West Agro Inc | Composiciones y concentrados germicidas a base de yodo-detergente, acuosos y estables. |
| US5616348A (en) * | 1992-09-18 | 1997-04-01 | West Agro, Inc. | Germicidal detergent-iodine compositions including polyvinyl pyrrolidone and compatible nonionic surfactant complexors |
| US5292525A (en) * | 1992-10-14 | 1994-03-08 | Merck & Co., Inc. | Method and composition for removing an alginate from a cutaneous substrate |
| US5762917A (en) * | 1994-09-27 | 1998-06-09 | Virotex Corporation | Method and composition for cleansing wounds with minimal cytotoxicity for minimal scarring |
| US5733884A (en) | 1995-11-07 | 1998-03-31 | Nestec Ltd. | Enteral formulation designed for optimized wound healing |
| US5709852A (en) * | 1995-12-05 | 1998-01-20 | Basf Corporation | Ethylene oxide/propylene oxide/ethylene oxide (EO/PO/EO) triblock copolymer carrier blends |
| US5919830A (en) * | 1998-04-30 | 1999-07-06 | Gopalkrishnan; Sridhar | Stable non-aqueous blends for personal care compositions |
| JP4881515B2 (ja) * | 2001-06-29 | 2012-02-22 | ホシザキ電機株式会社 | 生体の損傷部位の清浄化方法 |
| AU2003262769A1 (en) * | 2002-08-20 | 2004-03-11 | Pinnell, Doren M | Methods for treating fungal infections |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2739922A (en) * | 1952-03-13 | 1956-03-27 | Herman A Shelanski | Mixtures of polymeric n-vinyl pyrrolidone and halogens |
| US3326806A (en) * | 1964-08-10 | 1967-06-20 | Huntington Lab Inc | Novel germicidal scrub solutions |
| US3367877A (en) * | 1965-02-03 | 1968-02-06 | West Laboratories Inc | Detergent-hydriodic acid compositions |
| US3539520A (en) * | 1967-07-12 | 1970-11-10 | West Laboratories Inc | Compositions comprising quaternary ammonium germicides and nonionic surfactants |
| US3624224A (en) * | 1969-12-22 | 1971-11-30 | Schering Corp | Novel first aid products |
| GB1338003A (en) * | 1971-06-18 | 1973-11-21 | Ici Ltd | Cleaning compositions |
| US3728449A (en) * | 1972-05-01 | 1973-04-17 | West Laboratories Inc | Germicidal iodine compositions for application to skin tissue including teats of milk animals |
-
1974
- 1974-04-12 US US05/460,451 patent/US3997458A/en not_active Expired - Lifetime
- 1974-11-12 CA CA213,668A patent/CA1028954A/en not_active Expired
- 1974-12-05 JP JP49138945A patent/JPS6119273B2/ja not_active Expired
- 1974-12-06 IT IT13081/74A patent/IT1028550B/it active
-
1975
- 1975-02-04 AU AU77883/75A patent/AU503627B2/en not_active Expired
- 1975-04-10 DE DE2515600A patent/DE2515600C2/de not_active Expired
- 1975-04-11 FR FR7511425A patent/FR2267112B1/fr not_active Expired
-
1977
- 1977-08-04 US US05821963 patent/USRE29909F1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US3997458A (en) | 1976-12-14 |
| USRE29909E (en) | 1979-02-13 |
| IT1028550B (it) | 1979-02-10 |
| FR2267112A1 (US20100056889A1-20100304-C00004.png) | 1975-11-07 |
| JPS50132119A (US20100056889A1-20100304-C00004.png) | 1975-10-20 |
| USRE29909F1 (en) | 1989-03-21 |
| FR2267112B1 (US20100056889A1-20100304-C00004.png) | 1978-11-10 |
| AU503627B2 (en) | 1979-09-13 |
| CA1028954A (en) | 1978-04-04 |
| DE2515600C2 (de) | 1982-09-16 |
| AU7788375A (en) | 1976-08-05 |
| DE2515600A1 (de) | 1975-10-23 |
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