JPS6117596A - ホスミドマイシンまたはその塩類の凍結乾燥粉体およびその製造法 - Google Patents
ホスミドマイシンまたはその塩類の凍結乾燥粉体およびその製造法Info
- Publication number
- JPS6117596A JPS6117596A JP13848284A JP13848284A JPS6117596A JP S6117596 A JPS6117596 A JP S6117596A JP 13848284 A JP13848284 A JP 13848284A JP 13848284 A JP13848284 A JP 13848284A JP S6117596 A JPS6117596 A JP S6117596A
- Authority
- JP
- Japan
- Prior art keywords
- freeze
- fosmidomycin
- salt
- dried powder
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 title claims abstract description 27
- GJXWDTUCERCKIX-UHFFFAOYSA-N fosmidomycin Chemical compound O=CN(O)CCCP(O)(O)=O GJXWDTUCERCKIX-UHFFFAOYSA-N 0.000 title claims abstract description 25
- 229950006501 fosmidomycin Drugs 0.000 title claims abstract description 24
- 239000000843 powder Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 12
- 229910001507 metal halide Inorganic materials 0.000 claims abstract description 10
- 150000005309 metal halides Chemical class 0.000 claims abstract description 10
- 239000011780 sodium chloride Substances 0.000 claims abstract description 6
- 238000004108 freeze drying Methods 0.000 claims abstract description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 159000000000 sodium salts Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 9
- 239000012153 distilled water Substances 0.000 abstract description 4
- 238000002347 injection Methods 0.000 abstract description 4
- 239000007924 injection Substances 0.000 abstract description 4
- 238000007710 freezing Methods 0.000 abstract description 3
- 230000008014 freezing Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940124350 antibacterial drug Drugs 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- -1 monosodium salt Chemical class 0.000 abstract 1
- 239000008176 lyophilized powder Substances 0.000 description 4
- 239000003708 ampul Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 2
- ZZPUYRHMTGOTEU-UHFFFAOYSA-M sodium;3-[formyl(hydroxy)amino]propyl-hydroxyphosphinate Chemical compound [Na+].O=CN(O)CCCP(O)([O-])=O ZZPUYRHMTGOTEU-UHFFFAOYSA-M 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13848284A JPS6117596A (ja) | 1984-07-03 | 1984-07-03 | ホスミドマイシンまたはその塩類の凍結乾燥粉体およびその製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13848284A JPS6117596A (ja) | 1984-07-03 | 1984-07-03 | ホスミドマイシンまたはその塩類の凍結乾燥粉体およびその製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6117596A true JPS6117596A (ja) | 1986-01-25 |
| JPH0443074B2 JPH0443074B2 (enrdf_load_stackoverflow) | 1992-07-15 |
Family
ID=15223108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13848284A Granted JPS6117596A (ja) | 1984-07-03 | 1984-07-03 | ホスミドマイシンまたはその塩類の凍結乾燥粉体およびその製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6117596A (enrdf_load_stackoverflow) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5377016A (en) * | 1976-12-16 | 1978-07-08 | Frosst & Co Charles E | Scaffold reflection kit utilizing triethylene tetramine hexa*methylene phosphonate |
-
1984
- 1984-07-03 JP JP13848284A patent/JPS6117596A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5377016A (en) * | 1976-12-16 | 1978-07-08 | Frosst & Co Charles E | Scaffold reflection kit utilizing triethylene tetramine hexa*methylene phosphonate |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0443074B2 (enrdf_load_stackoverflow) | 1992-07-15 |
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