JPS61167622A - Diabetes-controlling agent - Google Patents

Abstract

PURPOSE:To use cell wall component of beer yeast as a diabetes-controlling agent containing a large amount of food fiber. CONSTITUTION:It has ben found that the cell wall of beer yeast is rich in vitamins and minerals, contains 25% crude protein and 50.4% food fiber such as glucan, mannan, etc., and is effective as a fiber diet for controlling diabetes. The beeryeast cell wall is obtained by contacting fresh beer yeast produced by Asahi Beer Co, with a sodium hydroxide solution of 10pH for 50sec to remove the bitter taste, washing with water, letting stand at 50-70 deg.C for >=2hr to effect the autodigestion, and extracting and removing the solubilized component with water. The obtained powder is tableted to a tablet of 243.75mg weight. Daily administration of 30 tablets of the beer yeast corresponds to about 3.5g of food fiber. Improvement in GTT, in renal function such as lowering of HbA value, and hyperlipemia accompanied by diabetes has been confirmed.

Description

[Detailed description of the invention] Brewer's yeast contains proteins, vitamins (BIB, B vitamins such as nicotinic acid, pantothenic acid, and provitamin B), minerals (P, Fe, Mg
Since it contains many medicinal ingredients such as nucleic acid-related substances such as RNA, etc.), it has been used for a long time for the prevention and treatment of a wide range of diseases, as well as for promoting metabolic function and fortifying nutrition. However, surplus brewer's yeast produced by brewer's yeast has a bitter taste derived from hops, and the cytoplasm has strong autolytic properties, so raw yeast is washed by contacting it with an alkaline aqueous solution with a pH of 9 to 11 for a short time to remove bitterness. After removing bitterness, the essential step is to dry it to lose its self-digestion properties. This rapid drying prevents autolysis of the cytoplasm, as it was thought that many of the useful components of yeast exist within the cell chambers, to prevent useful components from decreasing due to decomposition due to autolysis. There is nothing wrong with this way of thinking. However, it is a fact that little consideration has been given to the composition and pharmacological effects of cell wall components, which make up half of the yeast components.

On the other hand, it has been discovered that dietary fiber is useful for controlling diabetes, and fiber has come to be used as a diabetes control food, but many of the known fibers lack nutrients or are unbalanced. There was hardly anything that was satisfactory in this respect.

The present inventors discovered that the cell wall fraction of brewer's yeast contains 50.4% dietary fiber and arrived at the present invention.

(Left below) General components of beer yeast cell wall fraction (analysis example) Loss on drying
10.9% ignition residue
1.5% Total nitrogen 4.0% Crude protein (N x 6.25) 25.0% Thiamine salt 10 μg/g > Riboflavin
10 μg/g > total phosphorus 0
．． 4% Total reducing sugar 49.5%・Glycogen 2469%・Glucan
14.8%*Umbrella Mannan 1
3.9% Kasakafumi glycose equivalent (by Somogyi method after hydrochloric acid digestion) - By Anthrone method after separation After studying the effects on blood insulin and lipids, we found that the effect was greater than expected.The beer yeast cell wall used in the present invention was fresh beer yeast provided by Asahi Beer Co., Ltd. The bitterness was removed by contacting with a caustic soda solution adjusted to The composition of the powder is based on the analysis value described above, and the powder is
Lock 243.75. It is made into tablets.

The composition of this tablet is as described above, and it is thought that it is rich in vitamins and minerals, and crude protein, glucan, mannan, etc., which account for 25% of the tablet, constitute vegetable fiber, which accounts for 50.4% as mentioned above. Therefore, if you take 30 tablets a day, you will be ingesting 3.5g of dietary fiber. Based on this premise, 30 tablets per day were administered to 2 patients with type 1 diabetes and 6 patients with type 2 diabetes for 2 weeks to 1 month, and GTT, HbA, blood IR concentration, and CPR1 were administered before and after meals.
A clinical experiment was conducted to examine serum cholesterol and triglyceride levels. The effects of administering the beer yeast cell wall tablets at this time were as shown in the table below.

Effect of beer yeast wall tablets on diabetic patients 8 from the previous table
Improvement in GTT was observed in 5 of the cases, and improvement in renal function control, such as a reduction in HbA levels, was required. Of the two patients undergoing insulin treatment, one case no longer required insulin, and the other case's insulin usage was halved.

Regarding blood IRI values, in 4 cases I
RI value was suppressed. However, there were also cases where insulin secretion increased when GTT improved. Regarding blood lipids, two cases showed suppression of cholesterol and neutral fat. This effect is illustrated by the treatment results for a 43 year old male patient in the following table.

Medicinal efficacy of tablets according to the present invention Height: 169 am Weight: Before administration: 77 kg After administration: 77 kg Blood sugar diurnal fluctuations Blood lipids In the clinical example described above, ingestion of 30 brewer's yeast tablets per day means intake of about 3.5 g of dietary fiber in addition to meals. That means you did it. However, none of the eight patients mentioned above complained of abdominal fullness or gas generation after taking the drug. Furthermore, improvement in hyperlipidemia associated with diabetes was observed by administration of the tablets of the present invention.

Claims (1)

[Claims] 1. Diabetes control agent whose main ingredient is beer yeast cell wall component.