JP2002051735A - Food product composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an antidiabetic and antiobestic food of high activity with excellent inhibition of postprandial blood glucose rise. SOLUTION: This antidiabetic and antiobestic food includes 1- deoxynojirimycin as a carbohydrate digestive enzyme-inhibitor particularly β-glucosidase inhibitor and α-amylase inhibitory protein or tannin as an α-amylase inhibitor and at least one selected from saponin, conduritol A, glumarine and dietary fiber as a glucose absorption inhibitor.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a food for preventing obesity and a food for preventing diabetes, and more particularly to a food for preventing obesity and diabetes by containing a carbohydrate digestive enzyme inhibitor and a sugar absorption inhibitor that are involved in carbohydrate digestion and absorption. Related to preventable foods.

[0002]

2. Description of the Related Art In recent years, the number of people suffering from obesity or diabetes, which is considered to be caused by overnutrition, has increased. Under these circumstances, diet, exercise, and pharmacotherapy have been proposed or implemented as methods for preventing and treating obesity and diabetes. The mechanism of the occurrence of obesity is as follows.
Glucose produced by digestion of carbohydrates in foods is absorbed into blood and blood sugar levels rise. The stimulation secretes insulin from the pancreas. Glucose taken into fat cells by the action of insulin is converted to fat. As a result, fat cells become large and fat is accumulated, resulting in obesity. Diabetes, on the other hand, is caused by a long-lasting elevated blood sugar level after a meal due to an insufficient insulin response.

[0003] Therefore, a rapid increase in blood sugar level is suppressed by inhibiting the process in which sugars in food are decomposed into glucose and absorbed. As a result, the diabetic patient is also prevented from becoming hyperglycemic, and the blood glucose level is slowly increased, so that the amount of insulin secretion is reduced, the amount of fat synthesis in fat cells is reduced, and obesity is prevented or Can be improved.

[0004] Sugar digestive enzyme inhibitors have already been used as pharmaceuticals for the treatment of diabetes. These therapeutics cannot be used in everyday food. There have been several reports on carbohydrate digestive enzyme inhibitors in natural food ingredients. For example, those that inhibit carbohydrate digestive enzymes include wheat albumin (Gastroentero).
, 111, 1313, 1996), alkaloids of the genus Mulberry (JP-A-9-140351), and sulfur-containing compounds of Euonymus (Tetrahedron Lett.,
38, 8367, 1997), and Namban Karasuuri (JP-A-10-59858).

As a natural product that inhibits sugar absorption, Gymnema sylvestre, a plant of the family Potatoes native to India, is well known (Japanese Patent Application Laid-Open No. 64-3802).
6) There are many foods using the extract on the market. In addition to Gymnema sylvesta, its genus, Gymnema inodrum (Japanese Patent Laid-Open No. 6-128161), and cod sprouts (Chem. Pharm. Bull., 42, 135)
4, 1994), and sugar beetle and dietary fiber have also been shown to have an activity of inhibiting sugar absorption.

[0006]

[Problems to be solved by the invention] Prevention of diabetes and obesity
For treatment, a low-calorie restricted diet and exercise therapy are generally used. Restricting diet often results in physical and mental distress. Therefore, a method has been devised for maintaining normal dietary contents by suppressing digestion and absorption of sugar. However, the aforementioned carbohydrate-degrading enzyme inhibitors and sugar absorption-inhibiting substances do not always have sufficient inhibitory activity, and it is difficult to take an effective intake as a daily food, and the effective intake of dietary fiber is once. It is not less than 5 g per meal, and it is not practical to use it for every meal.

[0007]

Means for Solving the Problems In order to solve the above-mentioned problems, the present inventors have studied the synergistic effect of the above-mentioned substances on the suppression of blood glucose elevation after eating a meal. As a result, they have found that the simultaneous ingestion of the carbohydrate-degrading enzyme and the sugar absorption-inhibiting substance significantly enhances the incorporation of the carbohydrate-decomposing enzyme and the sugar absorption-inhibiting substance, respectively, as a result of the present invention. That is,
The present invention is an anti-diabetic food, an anti-obesity food, and a postprandial blood sugar rise-suppressing food containing a carbohydrate digestive enzyme inhibitor and a sugar absorption inhibitor as active ingredients.

[0008]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The carbohydrate digestive enzyme inhibitors used in the present invention include α-amylase inhibitors and α-glucosidase inhibitors. Examples of the α-amylase inhibitor include proteins and tannins having α-amylase inhibitory activity. The α-amylase inhibitory protein is contained in wheat, rye and the like, and tannin is contained in barley, tea, guava, banaba and the like. Examples of the α-glucosidase inhibitor include 1-deoxynojirimycin and salacinol. 1-Deoxynojirimycin is contained in mulberry leaves and the like, and salacinol is contained in Salacia reticulata and the like. In addition, carbohydrate, kidney beans, nambankarasuri and the like also contain a carbohydrate digestive enzyme inhibitor. As the carbohydrate digestive enzyme inhibitors such as α-amylase inhibitor and α-glucosidase inhibitor, powders and extracts of the above-mentioned substances containing them can be used.

[0009] The sugar absorption inhibitor of the present invention includes saponin, conduritol A, gurmarin and dietary fiber. Saponin is contained in Gymnema sylvestre, Gymnema inodrum, cod, thonburi and the like. Conduritol A and gurmarin are contained in Gymnema sylvestre and the like. Indigestible dextrin as a dietary fiber,
Galactomannan, soluble sodium alginate and the like. Dietary fiber is thought to suppress the absorption of sugar from the intestinal tract by gelling the diet. As the sugar absorption inhibitor, powders, extracts, etc. of the above substances containing these substances can be used.

[0010] The present invention provides a synergistic increase in postprandial blood glucose elevation by using a carbohydrate digestive enzyme inhibitor and a sugar absorption inhibitor in combination, and is useful for the treatment and prevention of diabetes and obesity. . In addition, the present invention has a strong carbohydrate absorption delaying action, but has little effect on the total absorption, as shown in the examples described later, and thus can be safely treated and prevented without causing nutritional disorders. .

[0011]

The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples. Preparation Example 1 500 g of dried powder of Gymnema sylvestre was extracted twice with 2 liters, and the filtrate was dried under reduced pressure to obtain a dried product. Preparation Example 2 Two liters of 30% ethanol was added to 500 g of mulberry leaf dry powder for extraction, and the filtrate was dried under reduced pressure to obtain a dried product.

Example 1 50 g of sucrose was dissolved in 100 ml of distilled water. A solution obtained by adding 120 mg of the powder obtained in Preparation Example 1 to this solution,
A powder to which 80 mg of the powder obtained in Preparation Example 2 was added and a powder to which 120 mg of the powder of Preparation Example 1 and 80 mg of the powder of Preparation Example 2 were added (hereinafter referred to as Preparation Example 3) were prepared. A control prepared by dissolving 50 g of sucrose in 100 ml of distilled water was used. This sample was subjected to a sucrose tolerance test by a healthy adult male. That is, the above-mentioned sample was orally loaded to a subject who had fasted from 9:00 pm on the day before the test, and the blood glucose level was measured over time using a simple blood glucose meter (Dexter Z; Bayer-Sankyo). The results are shown in FIG.

[0013]

[Table 1]

[0014]

As shown in FIG. 1 and Table 1, it can be confirmed that the combined use of the carbohydrate digestive enzyme inhibitor and the sugar absorption inhibitor according to the present invention synergistically enhances the postprandial blood glucose elevation inhibitory effect. Therefore, the food of the present invention is useful as an anti-diabetic and anti-obesity food.

[Brief description of the drawings]

FIG. 1 is a diagram showing the results of measuring blood sugar levels over time.

Continued on the front page F-term (reference) 4B018 MD07 MD43 MD47 ME03 4C084 AA20 MA02 MA52 NA05 ZC35 4C088 AB11 AB12 AB34 AB73 BA07 MA07 MA52 NA05 ZC35

Claims (6)

[Claims] An anti-diabetic food comprising a carbohydrate digestive enzyme inhibitor and a sugar absorption inhibitor as active ingredients. 2. An anti-obesity food comprising a carbohydrate digestive enzyme inhibitor and a sugar absorption inhibitor as active ingredients. 3. A food that suppresses postprandial blood glucose elevation, comprising a carbohydrate digestive enzyme inhibitor and a sugar absorption inhibitor as active ingredients. 4. The food according to claim 1, wherein the carbohydrate digestive enzyme inhibitor is an α-glucosidase inhibitor or an α-amylase inhibitor. 5. The food according to claim 4, wherein the α-glucosidase inhibitor is 1-deoxynojirimycin or salacinol, and the α-amylase inhibitor is an α-amylase inhibitory protein or tannin. 6. The food according to claim 1, wherein the sugar absorption inhibitor is at least one selected from the group consisting of saponin, conduritol A, gurmarin, and dietary fiber.