JPS61161239A - ｄｌ−リンゴ酸ジナトリウム水和物の製造方法 - Google Patents
ｄｌ−リンゴ酸ジナトリウム水和物の製造方法Info
- Publication number
- JPS61161239A JPS61161239A JP206185A JP206185A JPS61161239A JP S61161239 A JPS61161239 A JP S61161239A JP 206185 A JP206185 A JP 206185A JP 206185 A JP206185 A JP 206185A JP S61161239 A JPS61161239 A JP S61161239A
- Authority
- JP
- Japan
- Prior art keywords
- slurry
- malate
- water
- disodium
- monosodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- WPUMTJGUQUYPIV-UHFFFAOYSA-L sodium malate Chemical compound [Na+].[Na+].[O-]C(=O)C(O)CC([O-])=O WPUMTJGUQUYPIV-UHFFFAOYSA-L 0.000 title description 21
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 66
- 239000002002 slurry Substances 0.000 claims abstract description 49
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000007864 aqueous solution Substances 0.000 claims abstract description 19
- 238000010438 heat treatment Methods 0.000 claims abstract description 19
- DOJOZCIMYABYPO-UHFFFAOYSA-M sodium;3,4-dihydroxy-4-oxobutanoate Chemical compound [Na+].OC(=O)C(O)CC([O-])=O DOJOZCIMYABYPO-UHFFFAOYSA-M 0.000 claims abstract description 16
- 239000013078 crystal Substances 0.000 claims abstract description 14
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000006386 neutralization reaction Methods 0.000 claims abstract description 14
- 238000001704 evaporation Methods 0.000 claims abstract description 9
- 230000008020 evaporation Effects 0.000 claims abstract description 9
- 230000003472 neutralizing effect Effects 0.000 claims abstract 2
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 239000007795 chemical reaction product Substances 0.000 claims 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 abstract description 8
- 235000013373 food additive Nutrition 0.000 abstract description 2
- 239000002778 food additive Substances 0.000 abstract description 2
- 239000002245 particle Substances 0.000 abstract description 2
- 238000013019 agitation Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 230000009969 flowable effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 235000019265 sodium DL-malate Nutrition 0.000 description 20
- 238000006243 chemical reaction Methods 0.000 description 11
- 238000002425 crystallisation Methods 0.000 description 11
- 230000008025 crystallization Effects 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- 239000001630 malic acid Substances 0.000 description 8
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- 235000011090 malic acid Nutrition 0.000 description 6
- 239000012141 concentrate Substances 0.000 description 5
- 229940049920 malate Drugs 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 4
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 235000017550 sodium carbonate Nutrition 0.000 description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 description 1
- 235000014653 Carica parviflora Nutrition 0.000 description 1
- 241000243321 Cnidaria Species 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000005323 carbonate salts Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP206185A JPS61161239A (ja) | 1985-01-11 | 1985-01-11 | ｄｌ−リンゴ酸ジナトリウム水和物の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP206185A JPS61161239A (ja) | 1985-01-11 | 1985-01-11 | ｄｌ−リンゴ酸ジナトリウム水和物の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61161239A true JPS61161239A (ja) | 1986-07-21 |
| JPS6324983B2 JPS6324983B2 (https=) | 1988-05-23 |
Family
ID=11518824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP206185A Granted JPS61161239A (ja) | 1985-01-11 | 1985-01-11 | ｄｌ−リンゴ酸ジナトリウム水和物の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61161239A (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5314919A (en) * | 1987-08-28 | 1994-05-24 | The Procter & Gamble Company | Calcium supplements |
| CN103910621A (zh) * | 2013-12-30 | 2014-07-09 | 西安万隆制药股份有限公司 | 一种l-苹果酸化合物 |
| CN104592008A (zh) * | 2015-01-04 | 2015-05-06 | 安徽雪郎生物科技股份有限公司 | 一种dl-苹果酸氢钠的制备方法 |
-
1985
- 1985-01-11 JP JP206185A patent/JPS61161239A/ja active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5314919A (en) * | 1987-08-28 | 1994-05-24 | The Procter & Gamble Company | Calcium supplements |
| CN103910621A (zh) * | 2013-12-30 | 2014-07-09 | 西安万隆制药股份有限公司 | 一种l-苹果酸化合物 |
| CN104592008A (zh) * | 2015-01-04 | 2015-05-06 | 安徽雪郎生物科技股份有限公司 | 一种dl-苹果酸氢钠的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6324983B2 (https=) | 1988-05-23 |
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