JPS61152621A - Liquid transparent composition for oral cavity - Google Patents

Abstract

PURPOSE:To obtain inexpensively the titled composition free from occurrence of sediment by a simple filtration operation, by blending a composition with polyoxyethylene hardened castor oil having a very small content of an adduct of 12-hydroxystearic acid with ethylene oxide. CONSTITUTION:A composition is blended with polyoxyethylene hardened castor oil having <=0.1wt%, preferably <=0.05wt% adduct of 12-hydroxystearic acid with ethylene oxide as an impurity, obtained by purifying polyoxyethylene hardened castor oil through distillation, recrystallization, etc. Occurrence of sediment is a little even if as much as about 15wt% of the hardened castor oil is added to the liquid composition for the oral cavity. Consequently, a large amount, preferably 0.5-15wt% of the hardened castor oil can be added to the composition, the hardened castor oil shows its effects efficiently, the prepared composition is also purified simply and manufacturing cost can be reduced.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to a transparent liquid oral cavity composition that does not cause crease formation.

Prior art and its problems Conventionally, various water-insoluble ingredients such as fragrances are blended into liquid transparent oral compositions such as mouthwashes.
Various surfactants are used to solubilize these components. Among these surfactants, hydrogenated ethylene and man oil are widely used because of their solubilizing power and good taste and smell. However, when polyoxyethylene hydrogenated castor oil is blended into the 11-liquid transparent oral composition, impurities in the polyoxyethylene hydrogenated castor oil become sediment and precipitate, resulting in the commercial value of the transparent liquid oral composition. There is a problem that seriously impairs the To this end, conventionally, the amount of polyoxyethylene hardening and man oil blended is less than 0.5% (wt%, same hereinafter) of the entire composition to prevent the occurrence of sores, or liquid transparent oral compositions are used. After preparing the product, a method is used in which it is left to cool and the formed sludge is removed, but the former method is difficult due to the hardening of lyoxyethylene and the small amount of man oil. However, the properties such as solubilizing power are insufficient, and it is therefore necessary to use a large amount of other surfactants to compensate for these properties, which causes problems such as impairing the taste of the oral composition. Ta. In addition, the latter method requires the above-mentioned strict purification process, is extremely time-consuming, and has problems such as an increase in manufacturing costs.

SUMMARY OF THE INVENTION In view of the above-mentioned circumstances, we conducted intensive studies on a liquid transparent oral composition that can reliably eliminate the formation of creases through simple one-time purification even when a large amount of polyoxyethylene hydrogenated castor oil is blended. As a result, the content of 12-hydroxystearic acid ethylene oxide adduct was 0.
．． It has been found that by using less than 1% polyoxyethylene hydrogenated castor oil, the above objectives are achieved.

That is, according to the studies conducted by the present inventors, it was found that the precipitate produced when I-lyoxyethylene hydrogenated castor oil is blended is mainly a 12-hydroxystearic acid ethylene oxide adduct, and therefore, 12-hydroxystearic acid Ethylene oxide adduct at 0.15-0.
The conventional polyoxyethylene hydrogenated castor oil containing 12-hydroxystearic acid ethylene oxide was refined to have a content of 12-hydroxystearic acid ethylene oxide adduct of 0.1% or less. j
? When +7 oxyethylene hydrogenated castor oil was used, even if about 15 g of this was mixed into a liquid oral composition, there was little occurrence of slag, and especially after simple filtration with an unglazed filter tube after Al11, no sludge was formed. Therefore, by incorporating a large amount of polyoxyethylene hydrogenated castor oil, the effect can be effectively exhibited, and furthermore, purification after preparation of the composition is easy, and the liquid transparent composition for oral cavity has no scum. The present invention was based on the discovery that a product can be obtained.

The present invention will be explained in more detail below.

Structure of the Invention The liquid transparent oral cavity composition of the present invention has a content of 12-hydroxystearic acid ethylene oxide adduct of 0.1.
% or less, preferably 0.05% or less, of preoxyethylene hydrogenated castor oil.

Here, the polyoxyethylene hydrogenated castor oil used in the present invention is obtained by a conventional manufacturing method and purified by distillation, recrystallization, etc., to which 12-hydroxystearic acid ethylene oxide is added as an impurity. 0.1 things
% or less, preferably 0.05- or less. That is, conventional polyoxyethylene hardened and man oil has a content of 12- and distearic acid oxide adducts in the mud, which is generally KO, 15 to 0.5%. When used, a large amount of sludge is generated, and in order to prevent this, a strict purification process is required after preparing the composition. By setting the content of 0.11 or less, the generation of sludge can be reliably prevented with a simple temporary operation after the composition is prepared, and in some cases, the formation of sludge can be prevented without such a temporary operation. It can be blended without any problem.

As the polyoxyethylene hydrogenated castor oil used in the present invention, one having an average number of added moles of ethylene oxide of 40 moles or more is preferably used.

Although the amount of Sf lyoxyethylene cured Himaman is not necessarily limited, it is preferably 0.5 to 5 is*, particularly 0.5 to 5 is, based on the entire composition. Since monooxyethylene hydrogenated castor oil with an ethylene oxide adduct content of 0.1% or less is used, the generation of sludge is effectively prevented even when the amount is as large as about 15%. In this case, if the amount of I-lyoxyethylene hydrogenated castor oil blended is less than 0.5, the solubilizing power of water-insoluble components may not be sufficient, and if it is more than 15, sludge may occur. .

The liquid transparent oral cavity composition of the present invention can be used as a mouthwash etc.
However, as other components of the composition of the present invention, appropriate components commonly used may be used depending on the substance, purpose of use, etc.

For example, polyhydric alcohols such as polyethylene glycol, sorbitol, glycerin, globylene glycol; /
e/4-Fragrances such as mint, essential oils such as amint, fragrance materials such as L-menthol, cardan, oilnol, anethole; su, quince sodium, stevioside,
neohesirinornohydrochalcone, glycyrrhizin,
Sweeteners such as 4-lilartin, p-methoxycinnamic aldehyde; dextranase, mutanase, sorbic acid, alexinone, β-clycyrrhetinic acid, hinokitiol, chlorhexidines, alkylglycine, alkyldiaminoethylglycine salts, allantoin, e-amitsukagulonic acid , tranexamic acid, azulene, vitamin E
One or more active ingredients such as water-soluble primary or diphosphoric acid salts, quaternary ammonium compounds such as cetylpyridinicum chloride, sodium chloride, crude drug extracts, etc. can also be blended.

In addition, in the present invention, 4! In addition to oxyethylene hydrogenated castor 7 oil, other surfactants such as sodium lauryl sulfate, catolicum dodecylbenzenesulfonate, hydrogenated coconut fatty acid monoglyceride sodium sulfate, sodium lauryl sulfoacetate, N-lauroyl dercosinic acid natrichum, N-acylglutamate,
One or more types of saccharide fatty acid esters may be blended.

The oral composition of the present invention can be prepared by dissolving the above-mentioned components in a solvent such as water or ethanol. After preparation, it can be used as a product, but it is preferable to use a filtration operation, such as pressure filtration using an unglazed filter tube, to prevent the generation of slag. This can be prevented even more reliably. In the present invention, the generation of dregs can be effectively prevented by a simple filtration operation as described above after the preparation of the composition, and the strict purification operation unlike the conventional method is not necessarily required.

Effects of the Invention The liquid transparent oral cavity composition of the present invention has a content of 12-hydroxystearic acid ethylene oxide adduct of 0.1.
-Using the following phosphoryoxyethylene hydrogenated castor oil reliably prevents the formation of sludge and sludge, and it is also possible to mix in large amounts, making the effects of phosphoryoxyethylene hydrogenated castor oil effective. In addition, since there is no need to carry out an elaborate purification process after preparing one composition, it is possible to reduce manufacturing costs and equipment investment, and as a result, the cost of the product can be lowered.

Next, an experimental example will be shown to concretely demonstrate the effects of the present invention.

[Experiment example]

Transparent liquids with the following compositions using polyoxyethylene hydrogenated castor oil (described as POE-hardened castor oil in the table) with various 12-hydroxystearate ethylene oxide (denoted as ISA-KO in the table) contents shown in Table 1. After preparing the mouthwash and performing normal filtration at room temperature, it was washed at 40°C for 1
The samples were stored for a month and the presence or absence of sludge formation was examined. Results first
Also listed in the table.

The criteria for judgment are as follows.

Judgment criteria One: No sagging occurs.

Δ: Slight creases occur, but there is no practical problem.

X: Drifting occurs.

Mouth rinse composition Dioxyethylene hydrogenated castor oil Amount shown in Table 1 Ethanol 30 qI68
5% glycerin 30 fragrance 5 saccharin natritum 0.5io
o, os Table 1 *An impurity, 12-hydroxybovine distearic acid ethylene oxide adduct, was converted into 12-hydroxystearic acid by acid decomposition of the sample, and was quantified using a gas chromatograph after death.

From the results in Table 1, it was confirmed that the occurrence of sludge can be prevented by using polyoxyethylene hydrogenated castor oil containing 0.1 t or less of 12-human mixistearic acid ethylene oxide adduct. .

Examples are shown below.

[Example 1] 85% glycerin 30 thiethanol 30 polyoxyether/hardened castor oil 10 (H8A-EO content 0.02%) Sodium saccharin 0.2 Alkyldiaminoethylglycine salt 0.1 Flavor
5. Water The remainder is diluted 100 times before use.

[Example 2] 85 tiglycerin 30 isoglobil alcohol 30 tyglycerin ethylene hydrogenated castor oil 8 (H8A-IO content 0.0
4%) Sodium lauryl sulfate 2s, carinnatrichum 0,2 alkyldiaminoethylglycine t3[0,1 fragrance
5 100.0% This should be diluted 100 times before use [Example 3] 85% glycerin 20q6 ethanol
20 Polyoxyethylene hydrogenated castor oil 12 (1iSA-[0 content 0.0
2%) Sodium saccharin 0.2 Chlorhexinone glucone-110.05 Flavor
3 Use 100.0q diluted 100 times.

[Example 4] 851% 51% glycerin 20 tinglobil alcohol 20-lioxyethylene hydrogenated castor oil 10 (H8A-EO content 0.03 t) Sodium N-lauroyl sarcosinate 2 Sacchulin sodium 0.2
Chlorhexidine glutamate liquid 0.05 fragrance
3 100.0ch This is used after being diluted 10'O times.

[Example 5] 85 tiglycerin 10% ethanol 10 polyoxyethylene hydrogenated castor oil 5 (H8A-go content 0.
04%) Stevioside 0.5 Chlorhexisone Glucone) Solution 0.05% Bovine Extract
0.1 Fragrance 2 100.0 This is diluted 50 times and used @ [Example 6] 85% glycerin 10% isoglopyl alcohol 10I lyoxyethylene hydrogenated castor oil 5 (H8A-EO content 0
．． 04 Ch) Sodium quince 0.1 Glycyrrhizin 0.2 Tranegisamic acid
0.5 fragrance 1
・5 100.0% This should be diluted 50 times before use.

[Example 7] 85 tiglycerin 10 thiethanol 8I lyoxyethylene hydrogenated castor oil 3 (H8A-EO content 0.03 t) Sodium lauryl sulfate 2 Glycyrrhizin 0.3 Tranesamic acid
0.5 fragrance 1.
5 100.0chi This is diluted 50 times and used.

[Example 8] 85 Tiglycerin 10 Thiisoglobyl alcohol 8 Proxyethylene hydrogenated castor oil 3 (ISA-[0 content 0
．． 02 Ch) Sodium N-lauroyl sarcosinate 2 Sodium saccharin 0.1 β-Glycyrrhetinic acid 0.2 Flavor
2 [Example 9] 85% glycerin 5 Cetanol
8 Polyoxyethylene hydrogenated castor oil 5 (USA-EO content o, oz
%) Stevioside 0.2 Sodium chloride 3 Flavor 1 Water Remaining 100, Ots This is used after diluting it 10 times.

[Example 10] 85% glycerin 5 Thiisoglobyl alcohol 8 Polyoxyethylene hydrogenated castor oil 5 (ISA-IO content 1O, 05%) Glycyrrhite 10.2 Vitamin E1 Fragrance 1 100.01 This was diluted 10 times. and use it.

(Example 11) 85% glycerin 5 cetanol
2 polyoxyethylene hardening and man oil 3 (ISA-KO containing 1o, os
h) Stevioside 0.2 Dextranase 10000 u/g fragrance
1 100.0% This is diluted 10 times before use.

[Example 12] 85 Chronic glycerin 5 Tiinoglobil alcohol 2 Polyoxyethylene hydrogenated castor oil 3 (ISA-EO content 0,
04 Ch) Saccharin Natrichum 0.1 Dextranase 10000 u/g Chlorhegysidine Gluco $-) ff 0.0
5 Fragrance 0.5 100.0 This is used after being diluted 10 times.

Claims (1)

[Scope of Claims] A transparent liquid composition for the oral cavity, characterized in that it contains polyoxyethylene hydrogenated castor oil containing 1,12-hydroxystearic acid ethylene oxide adduct at a content of 0.1% by weight or less. thing. 2. The composition according to claim 1, wherein the amount of polyoxyethylene hydrogenated castor oil is 0.5 to 15% by weight of the entire composition.