JPS61110060A - Automatic remeasurement processing system for automatic analyzer - Google Patents

Abstract

PURPOSE:To enable efficient and quick processing for automatic remeasurement, by automatically selecting a sample for remeasurement requiring dilution to perform an automatic dilution. CONSTITUTION:When a computer 9 judges that a sample requires remeasurement by being diluted as the absorbance of samples reaches the limit value of the measuring absorbance of an analyzer at the first measurement, the sample involved is sent to the nozzle position of a sample distribution/dilution device 10 with a sample disc 2. Then, it is distributed with a nozzle of the device 10 as remeasuring sample and the nozzle stops on a dilution container 12 of a dilution disc 11 and then, lowers. After the lowering of the nozzle, the sample is discharged from the nozzle together with a dilution liquid by the device 10. The disc 11 having the remeasuring sample automatically diluted moves sequentially and then, stops at the position of a sampling nozzle 4 as an analyzer, where the remeasuring sample requiring dilution can be done efficiently and quickly by automatic selection and automatic dilution thereof.

Description

[Detailed Description of the Invention] [Field of Application of the Invention] The present invention relates to an automatic quantitative chemical analyzer, and is particularly suitable for sample measurement where the concentration of a target component in the sample to be measured is high and requires re-measurement. Concerning automatic re-measurement processing system section.

[Background of the invention]

A conventional example is shown in FIG. The cup/pull cup 1 from which the sample was taken is placed on the sample disk 2, and these sequentially move and stop while rotating. At this time, a certain amount of sample is automatically sampled from the tip of the sampling nozzle 4 by the sample separation mechanism 3. The samples are sequentially processed by stopping the movement of sample disk 2.
The sample separation mechanism 3 performs separation of a new sample. The sampling nozzle 4 is movable vertically and horizontally, and the collected sample is discharged into the reaction tank 5.
Reagents are added into the sample by the reaction reagent inlay device 6 . By adding the reagent, only the target component in the sample undergoes a reaction with the reagent.

The reaction tank 5 repeatedly rotates and stops intermittently.

During this rotation, the measuring device 7 measures the absorbance. This absorbance is calculated for one sample within a specified time.
Multiple absorbance measurements are taken. Therefore, the target component to be quantified may have a high concentration in serum as a sample to be measured by an automatic analyzer. In this case, the degree of absorption of light by the reaction liquid that has reacted with the sample and the reaction reagent is strong enough to reach or exceed the absorbance measurement limit value of the apparatus. For such samples, after the measurement is completed, a percentage alarm is displayed on the data and all information is provided to the measurer. Based on this alarm display, the measurer determines that the sample is high quality, dilutes the sample manually, and performs the measurement again. The method of manually diluting the sample and re-measuring takes a lot of time to select the samples for re-measuring, and also lacks accuracy when diluting the sample with the diluent. , lack of reliability in data.

A conventional example for obtaining reliability is shown in FIG. In this method, a diluter 8 is used to dilute the sample. According to this method, accuracy during dilution can be increased.

However, if the dilution ratio is an unspecified number, the dilution pattern must be changed for each sample. Further, it is inconvenient to manually set the diluted sample on the sample disk 2. In either method, in order to dilute a highly concentrated sample and remeasure it, it is necessary to use manual techniques or an automatic diluter.
It has the same problems as mentioned above.

[Purpose of the invention]

The purpose of the present invention is to eliminate the inconveniences of the prior art, and to automatically select samples that exceed the measurement limit of the analyzer and require dilution and re-measurement. The object of the present invention is to provide a system that can perform automatic remeasurement processing using automatic dilution.

[Summary of the invention]

The present invention uses the full reaction process photometry method, which is the photometric function of the 705 and 736 models, as a means to overcome the drawbacks of the prior art, and allows a computer to store changes in absorbance with respect to the reaction time of each sample. Based on this information, dilute the sample as described below. In addition, as a means for diluting samples, a dilution disk equipped with a dilution container and a sample preparative dilution device for automatically extracting samples for re-measurement are newly installed. With these, first 1
In the second measurement, the computer selects the information of the sample which is displayed as an alarm indicating method according to the prior art because it exceeds the measurement limit value of the analyzer and is difficult to measure. The selected sample (sample cup) is moved to the sampling position of the newly installed sample separation/dilution device by sequentially rotating the sample disk, and then stopped. Here, the sample to be remeasured is automatically collected. After separation,
The liquid is automatically diluted by being discharged together with the diluent into a dilution container provided on the dilution disk. At this time, the problem is how to determine the amount of sample to be taken and the amount of diluent to be dispensed for automatic dilution. As a solution to this problem, the amount of sample to be collected is set as the condition for the amount of sample measured at the first time. Next, regarding the amount of diluted solution to be dispensed, in the relationship between the absorbance and the reaction time memorized in the first measurement, the information on the reaction time at which the measured absorbance reached the measurement limit of the device and the actual The computer calculates the dilution ratio so that the absorbance falls within the measurement range in relation to the reaction time using the absorbance used for concentration conversion. The sample preparative dilution device is controlled based on this result. The dilution sample disk containing a new automatically diluted sample for re-measurement is moved and stopped intermittently until it stops at the lowered position of the sampling nozzle of the sample separation mechanism for the analyzer. This is a method of automatically processing re-measurement by sampling.

[Embodiments of the invention]

An embodiment of the automatic remeasurement processing system for an automatic analyzer according to the present invention is shown in FIG.

The present invention includes a sample cup 1, a sample disk 2, a sample separation mechanism 3, a sampling nozzle 4, a reaction tank 5, a reagent addition device 6, a measuring device 7, a data processing unit 8, a computer 9, a sample separation dilution device 10, and a sample separation device 10. It is composed of a dilution disk 11, a dilution container 12, and the like.

A sample cup 1 containing a sample is held on a sample disk 2, and a certain amount of sample is automatically collected by a sampling nozzle 4 of a sample collection mechanism 3. The sample is fed into the sample separation mechanism by the intermittent movement of the sample disk 2 that stops moving. Further, the sampling nozzle can rotate up and down, and also has the function of descending and ascending into the dilution container on the sample dilution disk. The separated sample is discharged into a reaction tank 5, and a reagent is added into the sample by a reaction reagent addition device 6.

Here, a reaction with the target component in the sample takes place. The reaction tank 6 repeats the operation of rotating and stopping intermittently. During this rotation, the absorbance is measured by the measuring device 7 each time. The absorbance measured at this time and the measurement time at that time are stored in the data processing section 8 at any time.

Here, the computer 9 independently determines whether the measured absorbance of each sample has reached the limit value of the measured absorbance of the analyzer. For a sample that has reached a limit value, diluted the sample, and is determined to require re-measurement, the sample disk 2 is operated to send the sample to the position of the sampling nozzle of the sample preparative dilution device 10. Here, a sample for re-measurement is collected at the tip of the sampling nozzle. This sampling nozzle can rotate up and down. The separated sample stops and descends on the dilution container 12 held by the sample dilution disk 11 by the operation of the sampling nozzle. After descending, the sample is discharged from the sampling nozzle together with the diluent by the sample preparative diluter [10]. Dilution sample disk 11 with automatically diluted new sample for remeasurement
While moving sequentially, it is stopped at the position of the sampling nozzle 4 for the analyzer. Here, the sample for re-measurement is collected again and quantitative analysis is performed.

The present invention automatically selects samples for re-measurement that require dilution,
By performing automatic dilution, it is possible to perform efficient and quick automatic processing, and the dilution ratio can be determined accurately, which has the effect of easily providing measurement results that are the measurement data plus the dilution ratio. be.

〔Effect of the invention〕

According to the present invention, when remeasuring a sample that requires dilution, e-dynamic sorting and automatic dilution of the sample can be performed efficiently and quickly, and the dilution accuracy can be improved. It can also be applied to the measurement of samples that require a certain level of dilution in advance, and the measurement of samples that require dilution and items that do not require dilution, such as serum immunological test items. effective.

[Brief explanation of the drawing]

1 and 2 are explanatory diagrams of conventional disaster examples, and FIG. 3 is a diagram showing an automatic remeasurement processing system for an automatic analyzer according to the present invention. 1...Sample cup, 2...Sample disk,
3... Sample separation mechanism, 4... Sampling nozzle, 5... Reaction tank, 6... Reagent addition device, 7...
Measuring device, 8... Data processing section, 9... Computer, 10... Sample preparative dilution device, 11... Sample dilution disk, 12... Dilution container.

Claims (1)

[Claims] 1. A mechanism for sequentially moving multiple sample cups, a sampling mechanism for dispensing the samples collected in the sample cups, a reagent dispensing mechanism for reacting with the target component in the sample, and measurement of these reaction solutions. In an automatic quantitative analysis system consisting of a mechanism for performing this, in order to process samples that require dilution due to their high concentration, it is equipped with an automatic processing system that can automatically select these samples, automatically dilute them, and re-measure them. An automatic remeasurement processing system for automatic analyzers characterized by: