JPS60500619A - Hair treatment agent and hair treatment method - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] Hair treatment agent and hair treatment method Technical field This invention relates to hair treatment agents such as lotions and shampoos, and hair treatment using the treatment agents. Concerning methods.

Background of the invention Recently, more and more people are complaining about hair removal. Alopecia and baldness are a phenomenon unique to men. , in the case of women, thinning hair is recognized (FF ¥, r Welter boots der Kos) Metik (k'6rterbuch der Kosmetik) J, Stuttgart, 1974, p. 147), but recently However, women tend to experience complete male hair loss or similar hair loss frequently. It has been confirmed that it has been cleared. And the cause is thought to be the use of contraceptives. However, hair cosmetics and drugs have no effect on preventing hair loss.

Human fingernails and fingernails grow throughout life, but human hair has a limited lifespan. This longevity Hair removal based on life is natural hair removal. And if the number is less than 50 per day No problem. However, due to some reason, there is a significant increase in the number of natural hair loss or abnormalities. Hair loss may be seen, but this is by no means pathological. therefore Conventional wisdom says that countermeasures against hair fall are in the field of cosmetics, not medicine.

Summary of the invention This invention makes available a hair treatment agent that has been proven to be successful through informal experiments. It is to be. Traditional hair treatment products consist of lotions and shampoos; By applying these sequentially, the effects of interaction can be obtained.

Challenges in applying this type of hair treatment agent to alopecia to prevent hair loss is almost solved by this invention.

The lotions of this invention contain active ingredients in alcohol/water or at a low fat pace. Add about 63 prix of horseradish solution concentrated 5 times, In some cases, spray-dried thymus extract is added. In addition, horseradish Alternatively, glycolic radish extract or allyl mustard oil can be used.

Other additives include vitamin B6. Aqueous solution of water-soluble vitamin F (1 ml is 1 dl of acid) a-t-copherol (dl-a-tocopherol acetate) 50 ON), d-panthenol (d-panthenol ), Cremophore> diisopropyl adipe-1-(diisopro pyl ad: pate). This shampoo is alkyl diglycol. Sodium ether sulfate (alkyl-diglycol ether sulfate) ate-sodium), l-lyacetanolamine lauryl sulfate (triacethanolamin Iaurylsulfate), Coconut Coconut fat-dimethyl a minoxide), 5 times reduced horseradish liquid. In addition, horseradish Allyl mustard oil, cremofuore, Spanish rosmarine oil (S Danish rosemary oil), isopropyl alcohol, que Contains phosphoric acid and 1-lium chloride.

Some of the above active substances have traditionally been used alone or in combination with other substances vI. There are also substances, or the desired effect is not f+. For example, lotion and It is well known to apply shampoo extracts to cover. [19724 Karl Waldmann released on April 20th ) application, publication number DE-O3i 667930. To Tagawa classification 61K 071 06:　r Neue Erkentnitzse Half Arushung (Ncue [r kenntnisse der Haarforschung) Ouitz, 19554:.

Paper by Dr. Hirschiko (Dr. 1lirsch) published on page 42 : [Pharmazeuti sches Wiirterbuch) J, Berlin, Nicol, 1 975, 5th edition, 709 pages, sub-index [Urtica Aalten ( Kurt Humins (Urtica-Arten), published in 1 llumins)'s paper, WOrterbuch dcr Kosmetik) J, Stutsgar l-, 1974, 159 pages, Rizoinde Nkus "Barbassa" (Ha arwasser)　J. Fey's paper published in J. ``Kan Baarausfaarlan 1 ~ Haarsikobun 1 ~ Aufghalde Kann Haal'ausrall und Haarsc hwund alJfQOhalIe! n　werden))'', Otztorble Karsi Fries (K) published in Munich, 1952, page 16 arl I-ries) - Sentence j The reason is that the irritability extraction for adding lotion This is because things are commercially available. In addition, this radish extract has a pH of 6 to 7. It is a brown water-soluble liquid, and the product name is EXTRAPON. (Dragoco Gelguding Land Combani Go M Beber) (DRAGOCOGerderdino & Co, Gi+bH), Day 34 50 Holzminden (German trademark no. 827971). Said The efficacy of the ingredient is only apparent when used in combination with other active ingredients.

Despite extensive experiments, the mechanism of action of this novel hair treatment agent has not been fully elucidated. However, basic hypotheses can be made about the efficacy of some ingredients. did it. In other words, the efficacy of this coating liquid is similar to that of 5 times concentrated horseradish liquid (glycol). caused by the synergistic action of Japanese radish extract or allyl mustard oil) That's what I mean.

By adding thymus extract from time to time, the hair loss prevention effect is promoted and hair follicles remain. New hair growth is induced in the affected area. Newly grown hair is strong and generally Its color and luster also improve.

The main action of diisopropyl adipate is d-panthenol and cremofluor. In cooperation with Le, it promotes the delivery of thymus extract from the scalp to the hair roots. moreover , these substances make it easier to comb. In addition, diisopropyl adipate is decreases the adhesion of

Glycolic irritability extract significantly reduces sebum secretion from sebaceous glands. down.

Vitamin B6, dl-a, -tocopherol and cremophores are beneficial to hair roots. It is well known that it is effective against

The additives enhance the effects of horseradish extract, nettle extract and thymus extract let Finally, citric acid is used for the adjustment of H (approximately 5).

The foaming and cleaning effects of sodium alkyl diglycol ether sulfate are Essential for pools. In addition, triacetanolamine uralyl phate is Apart from its cleansing effect, it also effectively removes fatty acids from the scalp and triggers the scalp. It has the effect of increasing trigly ceride.

The results are consistent with horseradish concentrate, cremofuore and Spanish rosmari. This can be improved by adding fragrant oil (also effective as a fragrance).

Dimethylaminoxide in coconut oil has hair degreasing and hair softening effects, and It also has the effect of making it easier to comb.

The important thing is to use shampoo and lotion together. Both formulations Depending on the substance contained in it, it can prevent hair loss, promote new hair growth, or weaken hair. The hair is strengthened and pigment production is also initiated. And the most For best results, apply lotion to your hair twice a day (best in the morning and at night). Apply it and wash your hair with shampoo once every 2 or 3 days.

Synergistic effects and effects of the hair treatment agent (lotion and shampoo) according to the present invention Noh was first developed by Eva Tsjuleb (Department of Dermatology, University Hospital, Budapest) (see Example 1). Proven by Dr. Eva Fiiliip. At the same time, Munich Braun-Falco, head of the dermatology department at a university hospital in New York. ) also cooperated with the Institute of Medical Information Systems at the University of Munich (see Example 2). was obtained, proving its effectiveness. Furthermore, he is a former assistant to the above-mentioned Brown Fufulco. , the collaboration of the hair condition method, i.e. the trichogram IIle. Inventor Georg-Peter Heilgemeier Dr. Heilgemeir, Department of Dermatology, University Hospital Berlin-Steglitz. Dr. Orfanos, head of the department, and 11 famous skin experts It was also certified by a medical doctor. As a result of their experiments on 1800 cases, they found that It has been reported that a remarkable effect was observed in suppressing hair growth and promoting new hair growth. I'm telling you.

Of the results of the hair condition (trichogram = hair root test) from the above experiment, we are particularly interested in Experiments conducted at the University of Munich and the Institute for Medical Information Systems This is the result. According to these results, hair in the quiescent phase (hair in the process of hair loss) is 8% to 30% of the hair transitions to anagen hair, and under normal conditions, anagen hair My hair is now 80%. In addition, among the 1800 cases processed using the above method, there were some defects. No side effects (damage to the scalp or hair) were observed.

Example 1 The hair treatment agent described in claim 7 was applied to the scalp twice a day (in the morning and in the evening).

In addition, supplementally, the shampoo described in claim 8 may be used once every 2 or 3 days. I washed my hair many times. To wash your hair, apply a certain amount of shampoo evenly to your wet scalp. After lathering and leaving for 1 to 3 minutes, it was washed off with MS and dried. So After washing the hair, the hair treatment agent was repeatedly applied. Please note that you should wash your hair only once. I went.

Depending on the extent of hair loss, the duration of hair treatment was between 4 and 6 weeks. Either Also, in the early stage after the start of treatment, the current The detailed situation and medical history of the patient were investigated. The breakdown of the above situation is the degree of hair loss, from morning to night. The number of hair loss during hair removal, the degree of scalp buildup, the amount of sebum, signs of inflammation, presence of itching, etc. be. In addition, the number of hair removed per day was checked by the subject at the start of the treatment every week. covered The examiner will come to the clinic twice a week for examinations during the hair treatment period, and once a month after the hair treatment is completed. Visited the hospital once. Then, after 6 months, you will come to the hospital for a follow-up visit to check for hair regrowth and recurrence. Examined. It should be noted that the subject did not undergo any other treatment during the above period.

There were 130 subjects who received the therapeutic treatment using the Shitonbu and lotion of this invention. There were 70 men and 60 women, ranging in age from 17 to 60.

Of these subjects, 68 males and 22 females had seborrhea and no alopecia was observed. There were some that were approved and some that were not. Additionally, in 20 cases, contraceptive tablets were used. Hair loss caused by taking the drug was observed.

Furthermore, in 10 cases, hair loss due to menopause was observed, including alopecia areata and atrophic prolapse. There were 10 cases in which hair loss due to hair disease, pregnancy, etc. was observed.

Observations of each subject revealed the objective and subjective side effects of this process. Approved for use. To test the strong irritant effect of this formulation, dilute the lotion. Used without interpretation.

For this test 1, apply once to the skin of the back and leave it for 48 hours, and apply it to the same area. The test consisted of several applications of 4 to 5 applications under the same conditions, and was conducted on 20 subjects. I did it. In addition, 10 people tested the components of active extracts of plants for phototoxicity. This study was carried out on subjects. This test involves exposing the erythema area to ultraviolet light for 24 hours. That's what I mean. After 48 to 72 hours, the skin was visually inspected. .

An objective test for hair loss control effectiveness was performed on weekly hair wash days under similar precautions. Did it before. Then, the number of hair removals from 7 a.m. to 7 p.m. was counted.

Compare the results with the number of hair loss in a normal season, and compare these with the number of hair loss in the initial period. It was evaluated by

Depending on the season, the standard number of hair removals per day is between 20 and 30. hair Complete cessation or standardization of hair loss in evaluating the degree of hair treatment or regeneration.” In Table 1, the speed of hair removal is suppressed ( (1/3 or at least 172 or less) is indicated with "+".

Learn more about types of hair loss, diagnostic subdivisions, and the synergy of lotions and shampoos. Shown in Table 1.

As shown in Table 1, 80 out of 130 cases (615%) had hair loss. Complete cessation or standardization was approved. In addition, for 42 cases (323%), The inhibitory effect on hair loss was observed. No effect was observed in 8 cases (62%). In these cases, even when treated for 6 to 8 weeks, severe Hair loss phenomenon was observed. This was later confirmed, but in the eight cases above. The hair loss in 5 cases was due to alopecia areata, and the remaining 3 cases were caused by atrophic alopecia. This is due to hair disease. Therefore, no effect of this treatment was observed in either case. It's not something I wanted. In addition, in two cases where hair loss due to pregnancy was observed, 4 weeks Hair loss stopped within a short period of time. In addition, hair loss phenomenon caused by taking various contraceptive mulberry It also stopped quickly (within 4 to 6 weeks at the latest).

The hair loss phenomenon of the subjects disappeared in 18 cases and was minimized in 1 case. It was. This treatment was also found to be effective for menopausal hair loss, and the hair loss phenomenon was excluded in 10 cases. (within 4 to 6 weeks).

(continued on next page) Of the 90 subjects (68 men, 22 women) with seborrheic alopecia, 50 cases (55.6% ), hair loss stopped, and in 40 cases (444%), hair loss stopped over time. decreased sharply. In cases where this treatment was applied, no hair loss suppression phenomenon was observed. Although there were no cases of negative effects, 32 cases required an 8-week treatment period before the effects appeared. It took a while.

In most cases, the duration of treatment was determined by the degree of hair loss before treatment. Ma In addition, cases of recurrence were determined in the same way. Table 2 shows these relationships.

The number of hair loss per day, or the degree of hair loss if less than 100 (32 cases), is 1 00 to less than 200 hairs (61 cases), the degree of hair loss is "medium", 200 or more hairs The degree of hair loss was ``strong'' when there were less than 300 hairs (29 cases), and 12 cases when there were more than 300 hairs (8 cases). The degree of hair loss in the case of In 93 cases with fewer than 200 tubes, treatment over 4 to 6 weeks resulted in significant improvement. I got good results.

Among these 93 cases, hair loss stopped in some cases 3 weeks after the start of treatment. moreover In these cases, hair loss has stopped (not hair regrowth has been observed). There are some things. In addition, hair that has been recognized to have regenerated should be treated after 6 weeks. It appeared only in those cases.

(continued on next page) As shown in Table 2, if there is more than 200 hairs removed per day, 4 weeks If the treatment in between is sufficient to stop hair loss, in cases of severe seborrheic hair loss) , treatment continued for 8 weeks. In this case, some of the Vitamin B6 and pantothenic acid (trade name: Bepanthen) Treatment with ) was also conducted.

Recurrence was observed in 30 of the subjects who underwent hair treatment. 1 of these 0 cases relapsed within 3 months after treatment, and the remaining 20 cases occurred within 6 months. Recurrence was observed. However, for both subjects, hair loss after recurrence The rate is always low compared to the hair loss rate before treatment. Therefore, when reprocessing, the initial Hair loss can be halted by treatment for a shorter period of time (within 3 to 4 weeks). did it.

There is a correlation between the degree of hair loss and the likelihood of recurrence. This is a “strong hair removal treatment”. The recurrence rate is 48% for those with severe disease, 23% for moderate disease, and 23% for moderate disease. This is clear from the fact that there is no recurrence in the case of ``.

In seborrheic alopecia, in addition to the effect of stopping hair loss, other effects were also observed. Zunawa In both cases, the occurrence of scalp plaque accompanied by itching is eliminated, and severe seborrhea is alleviated. It became normal. Also, in some cases, the quality of the regrown hair and the Changes were also observed. Nine cases were reported, mainly in the early stages of seborrheic alopecia. It was recognized that: In other words, in addition to strengthening the existing hair, it also strengthens the existing hair. Areas of weakened or downy hair and the boundaries between these areas and areas of normal hair. New hair growth was observed in the area. Simultaneously with hair growth and strengthening In some cases, the color of the downy hair became darker.

At the same time as the test using this example, we also conducted a test using another example (Example 2). It was.

Example 2 This example applies to the hair treatment agent described in claims 8 and 9. Performed using a treatment agent containing thymus extract as described in Sections 3 and 4. Ta.

Forty-eight subjects (39 men and 9 women) with androgenetic alopecia were tested. processing period The period should be at least 12 weeks if possible, and other hair treatment products (internal and external) should not be used during this period. °) was not used explicitly. In addition, claim paragraph 1 may be modified as shown below. Applied. In other words, apply lotion to the scalp twice a day (morning and evening) while gently massaging the scalp. Apply the solution. Wash your hair with shampoo once every 2 to 4 days. In addition, this hair wash Rub the shampoo into your scalp while gently massaging your scalp, and after a few minutes, wash it off with lukewarm water. It is done by flowing.

The scalp felt by the test subjects Nayama et al. before the start of treatment, 4 weeks and 12 weeks after the start of treatment Itching, pain, and intensity of hair removal were checked. In usage, processing 7) Symptoms after treatment (seborrhea, scalp plaque, hair loss, etc.) ) were evaluated by the same inspector. One item that was briefly examined was the degree of coloration of the hair. Ma In addition, at the start of treatment, 4 weeks after the start of treatment, and 12 weeks after the start of treatment, the front part of the head, The root pattern was determined for the rear and sides.

Brown F. is a modification of the method by Van Scott. Following the method of Braun-Falco, the hair growth direction and flatness are determined. By rapidly pulling in rows, 50 to 70 hair strands are pulled out at the same time. It was. In addition, the method of Van Scotto mentioned above is similar to that of Scotto E.J. .

Reinertson, R, P, Steinuller, R. “Hair root growth and tissue changes in human scalp after phosphorus treatment”, G.I.Invest. Gumatology = (J, Invest, Derm).

29.197-204.1957. Also, Brown Fal Ko's method is based on (1) Brown, Fufulco, and Oh's "Normal Pathological Hair Growth 'The dynamics of (^rch, K11n, exp, Derm, ), 227.419-452. 1966 (2) Brown Falco O, Neussi↑l- Zeher (Fi "On the influence of hair washing on hair root pattern" by Scher, Ch. Archiv Klinish Expedition Gumatology, 226, 136-143.1966 (3) Braun Fufurko O, Larsner B. [Removal Techniques for Normal Pathological Hair Root Patterns] by (Ra5sner, B.) On the Effects of Art”, Arkhiv Klinish Expeditions Gu Matology, 223,501-'508゜1965 (4) Brown Falco ・“Chronic Diffusion Against Women” by Oh, Zaun, H. About the Essence of Sexual Hair Removal”, Alheif Clinic Expeditions Darts 1-logy, 215, 165-180. ing. A special hair removal clamp is used to remove the hair clumps.

To avoid the development of hair root shrinkage, the hair is stored in a Petri dish immediately after hair removal.

Note that the inside of this bedding dish is humidified with cotton soaked in water. collected samples must be processed as soon as possible. Part of the sample hair close to the hair root is placed between two struts in saline and the remaining portion is discarded. and, Individual hair roots are classified into various types using a 31x binocular microscope. and, The type of each hair root by filling in its absolute number and the trichoridigram i.e. The percentage of hair root condition is calculated. For other characteristics of individual hair follicle types, see the text above. It is described in the presentation. In this invention, the hair roots can be of the malnutrition type, pseudotrophic type, or It was classified into vegetative type and vegetative stationary type.

In this test, a period of 7 days is required between the last hair wash and hair removal. This is particularly noteworthy. Unfortunately this confirms for all examples Although the number of hairs with pseudonutritional disorders has increased, the number of hairs with pseudonutritional disorders has increased due to the time of last hair washing or hair removal. Assuming that it is due to too late, the false nutritional deficiency in all tests Some hair roots can be regarded as vegetative hair roots.

Hair growth is improved by treatment with the treatment agent of this invention. This means that It is indicated by an increase in the growth type of hair that falls into the follicle pattern. Along with this, raw The proportion of long resting type hair inevitably decreases, and in this example, the proportion of hair of the malnutrition type decreases. The proportion of hair is close to 0%. The test samples were from three areas of the scalp: the frontal region; Obtained from parietal and occipital regions. Among the treated groups, one group The effect was compared over time (at the start of treatment, after one month, and after one month had passed). 3 months have elapsed), and the normal state (the proportion of hair in the growth period is approximately 80% condition) was also questioned.

A total of 46 available examples were subjected to statistical evaluation. Of these, the above 3 Sixteen cases had data available for one of the two time points, the first two There were 25 cases with data available for the time point.

FIGS. 1 to 3 show the test results for the frontal region, occipital region, and temporal region, respectively.

These results are based on Dr. Brown-Fufruco's analysis of the frontal, temporal, and occipital regions. Based on the hair follicle examination of hair roots, Gu. W. Van Eimeren of the Institute for Academic Information Systems It was conducted by Dr. En) and M. Zund (M, 5und).

In each figure, A, B, and C indicate the slope before treatment, after one month, and after three months, respectively. . Here, we will discuss hair growth in each region of the scalp (frontal, temporal, and occipital). The proportion of hair is expressed by its frequency. In this figure, the proportion of hair in the growth phase is The results show not only a high standard value for the proportion of cases, but also a significant decrease in the number of cases during the treatment period. Ta.

Before treatment, we examined the presence or absence of seborrhea, and found that 12 cases had severe seborrhea, and 6 cases had Moderate seborrhea was observed in 1 patient and mild seborrhea in 4 patients. Then, after starting the process 4 After a week, the same examiner examined the degree of seborrhea and found that it was severe, moderate, and severe. Mild seborrhea occurred in 4, 8, and 8 cases, respectively.

Furthermore, when a similar test was conducted after 12 weeks, severe and moderate seborrhea were detected. There were 4 cases of each, and 6 cases of mild seborrhea. Also, as pityriasis simplex The occurrence of the head plate was severe in 6 cases, moderate in 6 cases, and weak in 6 cases. There were 2 cases. After 4 weeks, severe and moderate head plate development were respectively There were 3 cases and 5 cases of weak severity. Furthermore, after 12 weeks, the intensity of There were no cases of plate formation, and there were 5 cases each of moderate and weak cases.

In order to evaluate the degree of hair loss, Hamilton subdivided male hair loss. Ta. This is according to Hamilton, J.B. [Hair removal pattern, type and extent], Anne of the New York Academy. Me of Science (Ann, of the New York Acad) emy of 5science), 53.

708.1951 and Heilgmeier G.P. ``Results of the hair root condition method'' by IR, G., P.), Ina Agral D. Sertazione (doctoral dissertation), Minchen, 1975. process Examples include 17 times ■ type distribution, 13 times TV type distribution, 4 times V type distribution, and 2 times A ■-type distribution and one ■-type distribution were observed. Nine cases were diagnosed with androgenetic alopecia ( The distribution pattern of the female type was typical of the female type. during the 3-month observation period. In all cases, no change was observed in the distribution pattern of hair loss.

One of the subjects had severe hair loss on the top of his head after 12 weeks of treatment. Coloring was observed. However, based on the results of this test, hair coloring may also occur. It is unclear to what extent these changes are due to extrinsic changes or to what extent they are due to the effects of this treatment agent. Ru.

No significant n1 effects due to treatment application were observed.

One of the test subjects was diagnosed with worsening hair loss based on his own judgment, so he was not treated. Treatment was discontinued 3 weeks after the start of treatment, and another subject stopped treatment 4 weeks after the start of treatment due to scalp inflammation. It was canceled in between. However, in all cases, clinical control tests may not be able to determine objective symptoms. No condition was recognized. In other instances, during the treatment period, treatment No cosmetic disturbances or irritating effects were observed on the hair-bearing scalp areas.

This hair treatment agent was used in 48 subjects (39 males, 9 females) with androgenetic alopecia. The effect of up to 12 weeks of treatment on hair growth was examined. In that case, scalp disease, Subjective symptoms such as itching and fever in the scalp area where hair grows are determined based on the test subject's opinion. Decided. According to the subject's opinion, the intensity of hair loss was reduced.

It should be noted that almost all of the subjects were satisfied with the effectiveness of this treatment agent. That's true.

Considering the hair growth mechanism, it is possible to improve hair growth ability by treatment agents for promoting hair growth. Improvement occurs as follows. In other words, the period of quiescence in the hair cycle disappears. artificially prolonging the growth period due to Occurs due to the end of the term. As a result, the number of hairs in the quiescent period in the hair root pattern is reduced. The proportion of hair in the growth phase will increase slightly.

Effect of treatment agent on the proportion of hair in the growth period 1. After 3 months of hair treatment, male It is clear that it is effective for sexual hair loss symptoms and hair growth, but It would be necessary to conduct tests and back it up statistically.

FIG, IA FIG, IB F,lG,IC international search report A, NIJEX To T) i2 INTERNAT 0NAL 5EARCH REPORT ON TERNATIONAL APP CATION No. PCT/EP 83100057 (SA +755) CH-A-17925 4None

Claims (9)

[Claims] (1) A hair treatment agent consisting of a lotion and a shampoo, wherein the lotion Approximately 63 Brix concentrated 5 times over alcohol/water or low fat base (Prix) Horseradish liquid, Glycol extract, Vitamin B6 ．． Water prepared so that 1d corresponds to 500 μl of former-a-1-co-circumferol acetate Soluble vitamin E solution, d-panthenol, cremofore (for alcohol/water) containing soluble castor oil) and diisopropyl adibate, Sodium alkyl diglycol ether sulfate, triacetanolamine Lauritus sulfate, coconut oil dimethylaminoxide, 5x concentrated horseradish liquid , cremofuore (alcone oil, isopropyl alcohol, citric acid and salts) A hair treatment agent characterized by containing sodium chloride. (2) In the shampoo and lotion, instead of horseradish, The hair treatment agent according to claim 1, characterized in that mustard oil is used. (3) A spray-dried thymus extract is added to the lotion. The hair treatment agent according to claim 1 or 2, characterized in that: (4) The thymus extract is a powder obtained by spray-drying the thymus of a calf as young as possible. The hair treatment agent according to claim 3, characterized in that: (5) The base is ethyl alcohol/water or isopropyl alcohol/water The hair treatment agent according to claim 1, characterized in that it comprises the following. (6) the low-fat base is a low-fat cream or an emulsion of oil in water; or an emulsion of water to oil. The hair treatment agent described. (7) Horseradish with approximately 63 brix concentrated 5 times by removing as much fiber as possible A solution of liquid 28.009 and glycol extract 34.009 is also available. For the dispersion, 6.00 g of spray-dried thymus extract, vitamin [362 ,00 fl, 1 m is equivalent to 11 dl-a-)-co-negative ferol 50011 g of vinegar. Water-soluble vitamin E prepared as follows: 2.00 fi, d-panthenol 2.0 0 fl, Cremofore (castor oil soluble in alcohol/water) 10. 009, diisopropyl dissolved in 408.00 g of isopropyl alcohol 32.00 g of ajidai-to and about 1000.00 g of distilled water are mixed, and , the individual substances are premixed and then mixed with alcohol and distilled water, and the mixture is Claims 1 to 6, characterized in that the compound is filtered after about 4 weeks. A method for preparing a hair treatment agent according to any one of the above. (8) Sodium alkyl diglycol ether sulfate 250.00g, triacetate Tanolamine lauryl sulfate-1~541.00! ? , coconut oil dimethyla Minoxide 150.00 (about 6 times concentrated by removing Il content as much as possible) 3 Brix Horseradish Liquid 8009, Cremofore (for alcohol/water) soluble castor oil) 3. (1 (l　g, Spanicsicorosmarine oil 9.00 q, isopropyl alcohol 8003, citric acid io,'oo g. Characterized by mixing sodium chloride 10.0G 7 and distilled water 20.009 Any one of claims 1 to 6 which describes the shampoo of the hair treatment agent according to claim 1 How to prepare poo. (9) Gently massage lotion into the scalp every morning and evening. Wash your hair and scalp with shampoo once every 2 or 3 days. The hair treatment according to any one of claims 1 to 6, characterized in that: How to use physical chemicals. Tsumugi