JPH0455163B2 - - Google Patents

Description

Claim 1: A hair treatment agent comprising a lotion and shampoo, wherein the lotion comprises a horseradish solution of about 63 Prix concentrated 5 times with respect to an alcohol/water or low-fat base, and a glycol irritability extraction. Vitamin B 6, a water-soluble vitamin E solution prepared such that 1 ml corresponds to 500 mg of dl-a-tocopherol acetate, containing d-panthenol, cremofuore (castor oil soluble in alcohol/water) and diisopropyl adipate. However, the shampoo contains sodium alkyl diglycol ether sulfate, triacetanolamine lauryl sulfate, dimethylaminoxide of coconut oil, 5 times concentrated horseradish liquid, cremofuore (castor oil soluble in alcohol/water), Spanish rosmarin. Hair treatment agent containing oil, isopropyl alcohol, citric acid and sodium chloride. 2 In the shampoo and lotion,
The hair treatment agent according to claim 1, wherein allyl mustard oil is used in place of horseradish. 3. The hair treatment agent according to claim 1 or 2, wherein a spray-dried thymus extract is added to the lotion. 4. The hair treatment agent according to claim 3, wherein the thymus gland extract is a powder obtained by spray-drying the thymus gland of a calf as young as possible. 5. The hair treatment agent according to claim 1, wherein the base comprises ethyl alcohol/water or isopropyl alcohol/water. 6. A hair treatment composition according to claim 1, wherein the low-fat base comprises a low-fat cream or an oil-on-water emulsion or a water-on-oil emulsion. 7. A method for preparing a hair treatment lotion consisting of a lotion and a shampoo, in which 28.00 g of horseradish liquid of approximately 63 prix concentrated 5 times after removing as much fiber content as possible, and 34.00 g of a glycol-based irrigated horseradish extract 6.00 g of spray-dried thymus extract, vitamin
B62.00g, 1ml is dl-a-tocopherol acetate
Water-soluble vitamins prepared to equal 500mg
E2.00g, d-panthenol 2.00g, Cremofuore (castor oil soluble in alcohol/water) 10.00g, isopropyl alcohol 408.00g
A method consisting of mixing 32.00 g of diisopropyl azide dissolved in water and about 1000.00 g of distilled water and, after premixing the individual substances, mixing with alcohol and distilled water and filtering the mixture after about 4 weeks. . 8. A method for preparing a shampoo of a hair treatment agent consisting of a lotion and a shampoo, comprising 250.00 g of sodium alkyl diglycol ether sulfate and triacetanolamine lauryl sulfate.
541.00g, Coconut oil dimethylaminoxide 150.00
gAbout 63 fibers have been removed as much as possible and concentrated 5 times.
8.00g of Pritz horseradish liquid, Cremofuore (castor oil soluble in alcohol/water)
3.00g, spanish rosmarine oil 9.00g, isopropyl alcohol 8.00g, citric acid 10.00g,
A method consisting of mixing 10.00 g of sodium chloride and 20.00 g of distilled water. 9. Approximately 63 Prix horseradish liquid concentrated 5 times on alcohol/water or low-fat base, horseradish extract with glycol, vitamin B6, 1 ml dl-a-tocopherol acetate
A lotion containing aqueous vitamin E solution, d-panthenol, cremofuore (castor oil soluble in alcohol/water) and diisopropyl adipate, prepared to correspond to 500 mg, and sodium alkyl diglycol ether sulfate, triacetanolamine. Shampoo containing lauryl sulfate, dimethylaminoxide of coconut oil, 5x concentrated horseradish liquid, cremofuore (castor oil soluble in alcohol/water), Spanish rosmarin oil, isopropyl alcohol, citric acid and sodium chloride. A method of using a hair treatment agent consisting of rubbing the lotion into the scalp with light massage every day in the morning and evening, and washing the hair and scalp with the shampoo once every two or three days. A method of using a hair treatment agent consisting of: TECHNICAL FIELD This invention relates to hair treatment agents such as lotions and shampoos, and hair treatment methods using the treatment agents. Background of the Invention Recently, an increasing number of people are complaining of hair loss. Alopecia or baldness is a phenomenon peculiar to men, while thinning hair is observed in women (FEY).
Kosmetik)”, Schuttgart, 1974, 147
Page), but recently it has been confirmed that complete male hair loss or similar hair loss tends to occur frequently in women as well. The cause is thought to be the use of contraceptives, but hair cosmetics and drugs are not effective in preventing hair loss. Human fingernails and fingernails continue to grow throughout life, but human hair has a limited lifespan. Hair removal based on this lifespan is natural hair removal. And the number is 50 per day
There is no problem as long as it is within the book. However, for some reason, a significant increase in the number of natural hair loss or abnormal hair loss may be observed, but this is by no means pathological. Therefore, countermeasures against abnormal hair loss are in the field of cosmetics, not medicine. SUMMARY OF THE INVENTION The present invention is to make available a hair treatment agent that has been proven successful by informal experimentation. Conventional hair treatment agents consist of lotions and shampoos, which are applied sequentially to obtain an interactive effect.
The problems encountered in preventing hair loss by applying this type of hair treatment agent to alopecia are almost solved by the present invention. The lotion of this invention is
An alcohol/water or low-fat base with the addition of approximately 63 prix of horseradish juice concentrated 5 times as active ingredient and optionally spray-dried thymus extract. Incidentally, in place of horseradish, glycol-based Japanese radish extract or allyl mustard oil can be used. Other additives include vitamin B6, an aqueous solution of water-soluble vitamin E (1 ml is dl-a-tocopherol acetate (d1-a)
−tocopherol acetate) equivalent to 500 mg),
d-panthenol, cremopohore (castor oil soluble in alcohol/water) and diisopropyl adipate. This shampoo is sodium alkyl-diglycol ether sulfate.
sodium), triacetanolamine laurylsulfate,
Dimethylaminoxide of coconut oil (coconut fat)
dimethyl aminoxide), 5x concentrated horseradish liquid. In addition, instead of horseradish, it contains allyl mustard oil, cremofore, Spanish rosemary oil, isopropyl alcohol, citric acid, and sodium chloride. Some of the above active substances have been used alone or in combination with other substances, but the desired effects have not been achieved. For example, it is well known to apply irage extract in lotions and shampoos. [Karl Bartmann (published on April 20, 1972)
Waldmann), publication number DE-OS 1 667.
930, International Classification A61K 07/06;
Erkenntnisse der Haarforschung), Schweitz, 1955, p.
Dr. Hirsch's paper; "Pharmazeutisches WO¨rterbuch", Berlin,
New York, 1975, 5th edition, page 709, article by Curt Humins published in sub-index ``Urtica-Arten'';
Kosmetik), Schuttsgart, 1974,
Page 159, paper by H. Fey published in the sub-index ``Haarwasser'';
Haarschwund aufgehalten werden? ), Karl Fries, published in Otstorbrunn/Müchen, 1952, p. 16]
The reason is that extracts of Japanese radish for lotion addition are commercially available. This extract is a brown water-soluble liquid with a pH of 6 to 7, and is available under the trade name EXTRAPON (DRAGOCO
Gerderding & Co. GmbH), De-3450 Holzminden, German trademark no. 827971). The efficacy of said ingredients is only apparent when used in combination with other active ingredients. The mechanism of action of this new hair treatment agent has not been fully elucidated despite extensive experiments;
We were able to formulate basic hypotheses about the efficacy of some ingredients. That is, this liniment and its efficacy are produced by the synergistic action of a 5-fold concentrated horseradish solution (glycolic radish extract or allyl mustard oil). The optional addition of thymus extract promotes the anti-hair loss effect and induces new hair growth in areas where hair follicles remain. Newly grown hair is stronger and generally has better color and shine. The main action of diisopropyl adipate is d-
In collaboration with Panthenol and Cremofuore,
The goal is to promote the delivery of thymus extract from the scalp to the hair roots. Additionally, these substances improve combing. Diisopropyl adipate also reduces hair adhesion. Glycol-based Irregularis extract significantly reduces the secretion of sebum from the sebaceous glands. It is well known that vitamin B6, dl-a-tocopherol and cremophores have an effect on hair roots. Said additives enhance the effects of horseradish extract, nettle extract and thymus extract. Finally, citric acid is used for adjusting the pH (approximately 5). The foaming and cleaning effects of sodium alkyl diglycol ether sulfate are essential for shampoos. In addition to its cleansing action, triacetanolamine lauryl phate has the effect of effectively removing fatty acids from the scalp and increasing triglyceride in the scalp. This effect is enhanced by the addition of horseradish concentrate, cremo foliage and Spanish ginger rosmarin oil (which also has a flavoring effect). Dimethylaminoxide in coconut oil has hair defatting and hair softening effects, and also has the effect of making it easier to comb. The important thing is to use shampoo and lotion together. The substances contained in both formulations help prevent hair loss, promote new hair growth or strengthen weakened hair, and also initiate pigment production. And the treatment method for best results is to apply 1 lotion.
Apply it to your hair twice a day (preferably in the morning and at night) and wash your hair with shampoo once every 2 or 3 days. The synergistic action and efficacy of the hair treatment agent (lotion and shampoo) according to the present invention were first demonstrated by Eva and Dr.
Proven by Dr. Eva Fu¨lo¨p. At the same time, Braun Falco, head of the dermatology department at the University Hospital in Milunchen,
Dr. Falco also demonstrated this efficacy with the cooperation of the Institute of Medical Information Systems at Milunchen University (see Example 2). In addition, Georg Peter Heilgemeier, a former assistant to Braun-Falco and co-inventor of the hair condition method, or trichogramme.
Peter Heilgemeir), Dr. Orfanos, head of the dermatology department at the University Hospital Berlin-Schutegritz, and 11 other eminent dermatologists. They conducted experiments on 1,800 cases and reported that it was significantly effective in suppressing hair loss and promoting new hair growth. Among the results of the hair condition (trichogram = hair test) from the above experiments, the results of experiments conducted at Myuncheng University and the Institute of Medical Information Systems are particularly noteworthy. According to this result, 8 of the hairs in the growth stationary phase (hairs in the process of hair loss)
% to 30% of hair transitions to anagen hair,
Under normal conditions, 80% of the hair was in the growth phase. Of the 1,800 cases treated with the above method, no adverse side effects (damage to the scalp or hair) were observed. Example 1 The hair treatment agent described in claim 7 was applied to the scalp twice a day (in the morning and in the evening). In addition, the hair was additionally washed once every two or three days with the shampoo described in claim 8. To wash the hair, a certain amount of shampoo was evenly applied to the wet scalp, lathered, left for 1 to 3 minutes, rinsed with warm water, and dried. After washing the hair, a hair treatment agent was repeatedly applied. Note that the hair was washed only once each time. Depending on the degree of hair loss, the duration of hair treatment is 4
The duration was between 1 week and 6 weeks. In each case, at an early stage after the start of treatment, the detailed current situation and residential history were investigated according to the treatment status of the scalp. The details of the above conditions include the degree of hair loss, the number of hair removals from morning to night, the degree of scalp buildup, the amount of sebum, signs of inflammation, and the presence or absence of itching sensation. In addition, the number of hair removals per day was checked by the test subjects themselves every week at the start of the treatment. Subjects visited the clinic twice a week for examination during the hair treatment period, and once a month after the hair treatment was completed. After 6 months, the patients visited the hospital to check for hair regeneration and recurrence. Note that during the above period, the subjects did not receive any other treatment. There were 130 subjects who underwent therapeutic treatment with shampoo and lotion of this invention, of whom 70 were male and 60 female, and their ages ranged from 17 to 60. Of these subjects, 68 men and 22 women had seborrhea, and some had alopecia and some did not. In 20 cases, hair loss was caused by taking contraceptive tablets.
Furthermore, 10 cases had hair loss due to menopause, and 10 cases had hair loss due to alopecia areata, atrophic alopecia, pregnancy, etc. Observations of each subject revealed spectatorial and subjective side effects caused by this treatment.
To test the strong irritant effect of this formulation, the lotion was used undiluted. This test
The test consisted of one application applied to the skin of the back and left for 48 hours, and several applications applied 4 to 5 times to the same area under the same conditions, on 20 subjects. Additionally, a test for phototoxicity of the components of the active extract of the plant was carried out on 10 subjects. This test involves exposing the erythematous area to ultraviolet light for 24 hours. The skin was then visually inspected after 48 to 72 hours. Objective tests for anti-hair loss effects were carried out every week before hair wash day under similar precautions.
Then, the number of hair removed from 7 a.m. to 7 p.m. was counted. The results were evaluated by comparing the number of hair removals during a normal season and by comparing these with the number of hair removals at the initial stage. It depends on the season, but the standard number of hair removals per day is
There are 20 to 30 pieces. In evaluating the degree of hair treatment or regeneration, complete cessation or standardization of hair loss is indicated by "++". In Table 1, "+" indicates that the rate of hair removal was suppressed (1/3 or at least 1/2 or less) compared to before the start of treatment. Types of hair loss, diagnostic subdivisions, and synergistic effects of lotion and shampoo are shown in Table 1. As shown in Table 1, complete cessation or standardization of hair loss was observed in 80 out of 130 cases (61.5%). Furthermore, in 42 cases (32.3%), a hair loss inhibiting effect was observed. No effect was observed in 8 cases (6.2%), and severe hair loss was observed in these cases even when treated for 6 to 8 weeks. This was later confirmed, but the above 8.
The hair loss in 5 of the cases was due to alopecia areata, and the remaining 3 cases were due to atrophic alopecia. Therefore, in all cases, the effect of this treatment was not observed. Furthermore, in the two cases where hair loss due to pregnancy was observed, the hair loss phenomenon stopped within 4 weeks. Furthermore, the hair loss phenomenon caused by taking various contraceptives also stopped quickly (within 4 to 6 weeks at the latest). The hair loss phenomenon of the subjects disappeared in 18 cases;
In one case, it was minimized. This treatment was also found to be effective in regenerative hair loss, and in 10 cases, the hair loss phenomenon gradually normalized (within 4 to 6 weeks).

[Table] Of the 90 subjects with seborrheic hair loss (68 men, 22 women), hair loss stopped in 50 cases (55.6%), and hair loss stopped in 40 cases (44.4%). It decreased rapidly over time. Among the cases in which this treatment was applied, there were no cases in which hair loss suppression phenomenon was not observed, but in 32 cases, it took a treatment period of 8 weeks before the effect appeared. In most cases, the duration of treatment was determined by the degree of hair loss before treatment. In addition, cases of recurrence were determined in the same manner. Table 2 shows these relationships. If the number of hair loss per day is less than 100 (32 cases), the degree of hair loss is "weak", if it is 100 or more and less than 200 (61 cases), the degree of hair loss is "medium", and if there are 200 or more hairs, the degree of hair loss is "medium".
If there are fewer than 300 hairs (29 cases), the degree of hair loss is “strong”;
The degree of hair loss in cases of 300 or more hairs (8 cases) is classified as “strongest”
And so. Out of the 130 cases, 93 cases with fewer than 200 hairs removed per day showed very good results with treatment over a period of 4 to 6 weeks. these
In some of the 93 cases, hair loss stopped three weeks after treatment began. Furthermore, in these examples,
In some cases, not only hair loss stopped, but also hair regrowth. Note that hair regeneration was observed only in those treated for 6 weeks.

[Table] As shown in Table 2, when 200 or more hairs were removed per day, the 4-week treatment was not able to sufficiently stop the hair loss. For some of these cases (for example, cases of severe seborrheic alopecia), treatment was continued for 8 weeks. In this case, some patients were also treated with vitamin B6 and pantothenic acid (trade name Bepanthen).30 of the subjects who underwent hair treatment showed regrowth. Of these, 10 cases relapsed within three months after treatment, and the remaining 20 cases relapsed within 3 months.
Recurrence was observed within a month. However, for all subjects, the hair loss rate after recurrence is always lower than the hair loss rate before treatment. Therefore, when reprocessing, the period of time (3 to 4
Hair loss could be stopped by treatment (within 1 week). There is a correlation between the degree of hair loss and the likelihood of recurrence. This means that the recurrence rate for "severe" cases of hair loss is 48%, and for "moderate" cases, the recurrence rate is 23%.
And it is clear from the fact that it does not recur in "weak" cases. In seborrheic alopecia, in addition to the effect of stopping hair loss, other effects were also observed. In other words, in both cases, the occurrence of scalp plaque accompanied by itching is eliminated,
The severe seborrhea also eased and returned to normal. In some cases, changes were also observed in the quality and quantity of regenerated hair. This was mainly in the early stages of seborrheic alopecia, but the following were observed in nine cases. That is, in addition to the strengthening effect on existing hair, new hair growth was observed in weakened hair or downy hair areas and in the boundary area between this area and normal hair areas. moreover,
Concomitant with hair growth and strengthening, in some cases the downy hair darkened. At the same time as the test according to this example, a test according to another example (Example 2) was also conducted. Example 2 This example uses a hair treatment agent described in claims 8 and 9 to which the thymus extract described in claims 3 and 4 is added. I did it. Forty-eight subjects (39 men and 9 women) with androgenetic alopecia were tested. Whenever possible, the treatment period was 12 weeks or longer, and no other hair treatment agents (internal or external) were used during this period. Further, the first claim has been applied as shown below.
That is, apply lotion to the scalp twice a day (morning and evening) while gently massaging the scalp. Wash your hair with shampoo once every 2 to 4 days. This hair washing is performed by rubbing the shampoo into the scalp while gently massaging the hair, and washing it off with lukewarm water after a few minutes. Before the start of the treatment, and 4 weeks and 12 weeks after the start of the treatment, the test subjects themselves were checked for scalp itching, pain, and intensity of hair loss. On the other hand, the same examiner evaluated the symptoms before the start of the treatment, during the treatment period and after the end of the treatment (such as seborrhea, scalp plaque and hair loss situation). A further item examined was the degree of coloration of the hair. In addition, the patterns of hair roots were determined on the front, back, and sides of the head at the start of the treatment, 4 weeks after the start of the treatment, and 12 weeks after the start of the treatment. Braun-Falco is a modification of Van Scott's method.
Fifty to seventy hair strands were simultaneously plucked out by rapidly pulling parallel to the direction of hair growth, according to the method of . In addition, the above fan
Scott's method was developed by Scot, E. J. A., Huang, Reinertson, R. P., and Steinuller, R. "Hair root growth in human scalp after amethopterin treatment. "Organizational Change"
J.Invest Dermalology (J.Invest.
Drem), 29, 197-204, 1957. In addition, Brown-Falco's method is based on (1) ``Dynamics of normal pathological hair growth'' by Brown-Falco, O., Arch.
Klin.exp.Drem), 227, 419-452, 1966 (2) "On the influence of hair washing on the hair root pattern" by Brown, Falco, O. and Fischer, Ch.・Dermatology,
226, 136-143, 1966 (3) "On the influence of hair removal techniques on the normal pathological root pattern" by Braun Falco, O. and Rassner, B., Arkhif Clinic.
Expedites Dermatology, 223,
501-508, 1965 (4) Brown Falco O.
Zaun, H., ``On the Essence of Chronic Diffuse Hair Loss in Women'', Dermatology, 215, 165-180, 1962. There is. A special hair removal clamp is used to remove the hair clumps. To avoid the development of hair root shrinkage, the hair is stored in a Petri dish immediately after hair removal. Note that the inside of this Petri dish is humidified with cotton soaked in water. It is necessary to process the collected samples as quickly as possible. The part of the sample hair close to the hair root is placed between two struts in saline, and the remaining part is discarded. Individual hair roots are then classified into various types using a 31x binocular microscope. Then, by entering the absolute number, the type of each hair root and the trichorizogram, that is, the ratio of the state of the hair root, are calculated. Further characteristics of individual hair root types are described in the above references. In this invention, the hair roots can be of the malnutrition type, pseudotrophic type, or
It was classified into vegetative type and vegetative stationary type. It is particularly noteworthy that this test requires a period of 7 days between the last hair wash and hair removal. Unfortunately, this has not been confirmed for all cases, but assuming that the increase in pseudotrophic hairs is due to the last hair wash or hair being pulled too late, it is possible to A malnourished hair root can be considered a vegetative hair root. By treatment with the treatment agent of the invention, hair growth is improved, as indicated by an increase in the growth type of hair in the hair root pattern. Correspondingly, the percentage of growth-static type hair inevitably decreases, and in this example, the percentage of nutritionally impaired type hair is close to 0%. Test samples were obtained from three areas of the scalp: frontal, parietal and occipital. Of the treated groups, 1
Only the group was tested, and the effect could only be determined by comparison over time (at the beginning of treatment, after 1 month and after 3 months), and the effect was determined only by comparison over time (at the beginning of treatment, after 1 month and after 3 months) Approximately 80% of the conditions) were also required. A total of 46 available cases were subjected to statistical evaluation. Of these, 16 cases had data available for all three time points.
There were 25 cases with data available for the first two time points. FIGS. 1 to 3 show the test results for the frontal region, occipital region, and temporal region, respectively. The results were based on a follicular examination of hair follicles in the frontal, temporal and occipital regions by Dr. Brown Falco and by W. van Eimelen of the Institute for Medical Information Systems at G.S.F. It was conducted by Dr. Van Eimeren and M. Sund. A in each figure,
B and C indicate the frequency before treatment, after one month, and after three months, respectively. Here, the proportion of hair in the growth phase in each region of the scalp (frontal, temporal, and occipital) is expressed as a frequency. This figure shows not only a high standard value for the proportion of hair in the anagen phase, but also a significant decrease in cases during the treatment period. Before treatment, we checked for the presence of seborrhea and found that
Seborrhea was severe in 12 cases, moderate in 6 cases, and mild in 4 cases. and,
Four weeks after the start of treatment, the same examiner examined the degree of seborrhea, and found that 4, 8, and 8 cases had severe, moderate, and weak seborrhea, respectively. Furthermore, when similar tests were conducted after 12 weeks, there were 4 cases each of severe and moderate seborrhea, and 6 cases of weak seborrhea. In addition, the occurrence of scalp plaque as pityriasis simplex is 6 times more severe.
For example, 6 cases are moderate and 2 cases are weak.
It was an example. After 4 weeks, there were 3 cases each of severe and moderate scalp plaque, and 5 cases of mild scale. Furthermore, after 12 weeks,
There were no cases of severe scalp plaque, and there were 5 cases each of moderate and mild cases. To evaluate the degree of hair loss, a subdivision of male hair loss was performed by Hamilton. This is based on "Hair Loss Patterns, Their Types and Extents" by Hamilton, J.B., Ann. of the New York Academy of Science.
Sciece) 53, 708, 1951 and Heilgemeir, G.P., ``On the results of the hair root condition method'', Inaaglar Deitssertatzion (doctoral thesis), Müchen,
Shown in 1975. Some of the processing examples include 17 times type distribution, 13 times type distribution, 4 times type distribution, 2 times type distribution,
A two-time type distribution and a one-time type distribution were observed. In nine cases, the distribution pattern of androgenetic alopecia (female pattern) was typical of the female pattern. During the 3-month observation period, no change in the distribution pattern of hair loss was observed in any case. In one of the subjects, coloration was observed in the hair on the top of the head where hair loss was severe after 12 weeks of treatment. However, based on the course of this test, the extent of hair coloration or extrinsic changes can be determined.
It is unclear whether this processing agent is expensive or not. No serious side effects caused by the treatment agent application were observed. One of the subjects discontinued the treatment 3 weeks after starting the treatment due to self-judgment that the hair loss phenomenon had worsened, and another subject discontinued the treatment 4 weeks after starting the treatment due to scalp inflammation. Canceled. but,
In all cases, no objective symptoms were observed by clinical control tests. In other cases, during the treatment period, no cosmetic disturbances or irritation effects due to the application of the treatment agent were observed on the hair-bearing scalp areas. The effect of treatment with this hair treatment agent for up to 12 weeks on hair growth was examined in 48 subjects (39 males and 9 females) with androgenetic alopecia. In that case,
Subjective symptoms such as scalp pain and itching in the scalp area where hair grows were determined based on the opinions of the subjects. According to the subject's opinion, the intensity of hair loss was reduced. It should be noted that almost all of the subjects were satisfied with the effects of this treatment agent. Considering the hair growth mechanism, improvement of hair growth ability by a treatment agent for promoting hair growth occurs in the following manner. In other words, artificial extension of the growth period by eliminating the growth quiescent period of the hair cycle;
Alternatively, it may occur due to premature termination of the period of growth quiescence due to the production of follicles. As a result, the number of hairs in the quiescent period in the hair root pattern decreases, and the proportion of hairs in the anagen period increases. The effect of treatment agents on the proportion of hair in the growth period is
It is clear that 3 months of treatment is effective on hair growth due to male alopecia, but further tests are needed to provide statistical support.