JPS60243038A - 天然ビタミンｋ濃縮物の調製方法 - Google Patents
天然ビタミンｋ濃縮物の調製方法Info
- Publication number
- JPS60243038A JPS60243038A JP59098250A JP9825084A JPS60243038A JP S60243038 A JPS60243038 A JP S60243038A JP 59098250 A JP59098250 A JP 59098250A JP 9825084 A JP9825084 A JP 9825084A JP S60243038 A JPS60243038 A JP S60243038A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- vitamins
- molecular distillation
- fraction
- deodorized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940046010 vitamin k Drugs 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims description 3
- 238000000199 molecular distillation Methods 0.000 claims abstract description 31
- 239000012141 concentrate Substances 0.000 claims abstract description 26
- 229930003448 Vitamin K Natural products 0.000 claims abstract description 24
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000011712 vitamin K Substances 0.000 claims abstract description 24
- 235000019168 vitamin K Nutrition 0.000 claims abstract description 24
- 150000003721 vitamin K derivatives Chemical class 0.000 claims abstract description 24
- 239000003549 soybean oil Substances 0.000 claims abstract description 21
- 235000012424 soybean oil Nutrition 0.000 claims abstract description 21
- 229930182558 Sterol Natural products 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 15
- 235000003702 sterols Nutrition 0.000 claims abstract description 15
- 150000003432 sterols Chemical class 0.000 claims abstract description 15
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 12
- 239000008158 vegetable oil Substances 0.000 claims abstract description 12
- 238000004440 column chromatography Methods 0.000 claims abstract description 9
- 239000006227 byproduct Substances 0.000 claims abstract description 3
- 229940088594 vitamin Drugs 0.000 claims description 78
- 229930003231 vitamin Natural products 0.000 claims description 78
- 235000013343 vitamin Nutrition 0.000 claims description 78
- 239000011782 vitamin Substances 0.000 claims description 78
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 238000007670 refining Methods 0.000 claims description 7
- 229910000831 Steel Inorganic materials 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000010959 steel Substances 0.000 claims 1
- 235000013305 food Nutrition 0.000 abstract description 7
- 235000013336 milk Nutrition 0.000 abstract description 6
- 210000004080 milk Anatomy 0.000 abstract description 6
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
- 239000008267 milk Substances 0.000 abstract description 4
- 230000007935 neutral effect Effects 0.000 abstract description 4
- 239000000049 pigment Substances 0.000 abstract description 4
- 235000021588 free fatty acids Nutrition 0.000 abstract description 3
- 230000000474 nursing effect Effects 0.000 abstract description 3
- 238000000746 purification Methods 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 2
- 239000005445 natural material Substances 0.000 abstract description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 14
- 239000000126 substance Substances 0.000 description 8
- 229930003799 tocopherol Natural products 0.000 description 8
- 239000011732 tocopherol Substances 0.000 description 8
- 238000004821 distillation Methods 0.000 description 7
- 239000003240 coconut oil Substances 0.000 description 6
- 235000019864 coconut oil Nutrition 0.000 description 6
- 238000011084 recovery Methods 0.000 description 6
- 235000019149 tocopherols Nutrition 0.000 description 6
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 6
- 208000032843 Hemorrhage Diseases 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000003480 eluent Substances 0.000 description 4
- 239000003925 fat Substances 0.000 description 4
- 235000019197 fats Nutrition 0.000 description 4
- 239000000741 silica gel Substances 0.000 description 4
- 229910002027 silica gel Inorganic materials 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 3
- 230000001877 deodorizing effect Effects 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 235000013350 formula milk Nutrition 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 208000000412 Avitaminosis Diseases 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 206010021135 Hypovitaminosis Diseases 0.000 description 2
- 235000019484 Rapeseed oil Nutrition 0.000 description 2
- 235000019486 Sunflower oil Nutrition 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 235000005687 corn oil Nutrition 0.000 description 2
- 239000002285 corn oil Substances 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 239000008157 edible vegetable oil Substances 0.000 description 2
- 235000020256 human milk Nutrition 0.000 description 2
- 210000004251 human milk Anatomy 0.000 description 2
- 235000019645 odor Nutrition 0.000 description 2
- 230000009965 odorless effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- -1 soybean oil Chemical class 0.000 description 2
- 239000002600 sunflower oil Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229960001295 tocopherol Drugs 0.000 description 2
- 235000010384 tocopherol Nutrition 0.000 description 2
- 208000030401 vitamin deficiency disease Diseases 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- 206010018985 Haemorrhage intracranial Diseases 0.000 description 1
- 208000008574 Intracranial Hemorrhages Diseases 0.000 description 1
- 235000010654 Melissa officinalis Nutrition 0.000 description 1
- 244000062730 Melissa officinalis Species 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000002156 adsorbate Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 238000005377 adsorption chromatography Methods 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000010779 crude oil Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 235000002378 plant sterols Nutrition 0.000 description 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- 235000008476 powdered milk Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59098250A JPS60243038A (ja) | 1984-05-16 | 1984-05-16 | 天然ビタミンｋ濃縮物の調製方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59098250A JPS60243038A (ja) | 1984-05-16 | 1984-05-16 | 天然ビタミンｋ濃縮物の調製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60243038A true JPS60243038A (ja) | 1985-12-03 |
| JPS6317817B2 JPS6317817B2 (enExample) | 1988-04-15 |
Family
ID=14214707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59098250A Granted JPS60243038A (ja) | 1984-05-16 | 1984-05-16 | 天然ビタミンｋ濃縮物の調製方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60243038A (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003509506A (ja) * | 1999-09-22 | 2003-03-11 | ラボラトワール ファルマシアンス | アボガドのフラン脂質化合物およびポリヒドロキシル化された脂肪族アルコールを抽出する方法、該化合物に基く組成物および治療、美容並びに食品における該化合物の使用 |
| JP2004175805A (ja) * | 2002-11-27 | 2004-06-24 | Malaysian Palm Oil Board | 植物油から少量成分を抽出及び単離する方法 |
| JP2005075743A (ja) * | 2003-08-28 | 2005-03-24 | Chuu I-Fun | ダイズ種子からの揮発性画分及び組成物 |
| CN102640805A (zh) * | 2011-02-18 | 2012-08-22 | 周大捷 | 食用植物油脂脱臭、脱酸、去除苯并芘的方法 |
-
1984
- 1984-05-16 JP JP59098250A patent/JPS60243038A/ja active Granted
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003509506A (ja) * | 1999-09-22 | 2003-03-11 | ラボラトワール ファルマシアンス | アボガドのフラン脂質化合物およびポリヒドロキシル化された脂肪族アルコールを抽出する方法、該化合物に基く組成物および治療、美容並びに食品における該化合物の使用 |
| JP5021879B2 (ja) * | 1999-09-22 | 2012-09-12 | ラボラトワール エクスパンシアンス | アボガドのフラン脂質化合物およびポリヒドロキシル化された脂肪族アルコールを抽出する方法、該化合物に基く組成物および治療、美容並びに食品における該化合物の使用 |
| JP2004175805A (ja) * | 2002-11-27 | 2004-06-24 | Malaysian Palm Oil Board | 植物油から少量成分を抽出及び単離する方法 |
| JP2005075743A (ja) * | 2003-08-28 | 2005-03-24 | Chuu I-Fun | ダイズ種子からの揮発性画分及び組成物 |
| CN102640805A (zh) * | 2011-02-18 | 2012-08-22 | 周大捷 | 食用植物油脂脱臭、脱酸、去除苯并芘的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6317817B2 (enExample) | 1988-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |