JPS60222060A - Die pressing and molding capsule - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to goo molded articles formed by goo pressing of low moisture materials such as starch, gelatin derivatives or hydrophilic polymers such as starch derivatives.

The present invention particularly relates to the structure and form of such a molded product,
It relates in particular to injection molded articles and in particular to capsules as described below.

In high-speed pressure molding, e.g. injection molding, the molding method is carried out at high speed so that the material to be molded exhibits the properties of a thermoplastic material during the molding process and can be quickly injected without changing the dimensions of the material. It is important that the material hardens quickly in the mold. The last mentioned property is an important factor since the precision of a large number of pressed parts must be within very narrow limits.

It has been found that the above materials can be molded into special structures and forms with high precision and dimensional stability, and in particular can be injection molded.

The present invention relates to a pressure molded article, and especially an injection molded capsule, each having a side wall, an open end and a closed end and having a joinable body part and a cap part, the capsule having (1) ) a hydrophilic polymer or a mixture of such polymers with a water content of 5 to 25% by weight (calculated for the hydrophilic polymer composition) and, when formed from gelatin, a water content of 10 to 20% by weight. (calculated for the gelatin composition) and/or (I+
) 5-25 wt.% moisture (calculated for starch composition)
(1v) the cap portion is directly placed on the open end of the body portion after the body portion is filled with the contents; die-molded as a stopper to seal the interior contents of the capsule; The locking devices are arranged opposite each other and form a separation-resistant connection after joining of said cap part and body part i? The present invention relates to a pressure-molded product, and in particular to an injection-molded capsule, characterized in that the cap portion and the body portion are processed with smaller deviations than 14S and have dimensional stability.

The characteristic (vl) of such a molded article according to H above is that the side wall portion of at least one part of the open end receives a device e in the joining area for the side wall part of the open end of the other part. and a constituting annular shoulder is formed, and both side wall portions are formed such that the outer surface at the joining area of the two portions is smooth.

A further feature of the molded product according to (V) above is that when the cap is attached to the open end of the body, the inner surface of the cap is in contact with the open end of the cylindrical side wall of the body. the inner surface of the cap and the level of the contents after filling with the contents and after closing the cap and body; This is to ensure that no air is actually trapped between them.

The molded articles prepared according to the invention have a further advantage in that they can be molded to form a unique shape so that the capsule can be clearly identified.

The invention also makes it possible to prepare molded articles on which the cap and/or the body have embossed letters. 0x) A further embodiment (X) of the present invention is to wet the joint surfaces of the cap portion and the body portion with water, thereby creating a completely liquid-tight seal between the two parts.

A preferred molded article is a two-part capsule conventionally formed from gelatin by a dip molding process. According to the invention, such capsules can still be produced from starch by molding. Such capsules are particularly useful for the precise dosing of pharmaceutical solid, cream and liquid substances, said capsules having two parts, a cap part and a body part which can be joined. Each of the capsule portions has a side wall, an open end, and a closed end.

Each capsule of the preferred molded article according to the invention is produced from starch by injection molding.

Injection molding of gelatin containing hydrophilic substances such as water is described in European Patent Application No. 1 European Patent Application No. 92,908.

Hydrophilic polymers have molecular groups in the main chain and/or side chains and can form hydrogen bridges and/or participate in hydrogen bridges with a molecular weight of about 103 to 107 Daltons (
It is a polymer with molecular mass ). In this way, the aqueous 1 coalescence is (approximately 0°C to 200°C
isothermal in water adsorption (in the temperature range up to 0)
．． It has an inflection point close to the water active point of 5. Hydrophilic polymers are distinguished from a group called hydrocolloids by their molecular dispersion properties. In order to maintain the molecular dispersion of the hydrophilic polymer, according to the working range of the present invention, if the temperature of the hydrophilic polymer is within the working range of the present invention from about 50°C to 190°C, 5 to 25 of the hydrophilic polymer
The weight fraction of water must be included.

Gelatin, one preferred hydrophilic polymer, is made from various types of gelatin, including acid- or alkali-treated bone material, acid-treated pigskin, or alkali-treated cattle hide. Gelatin of the above type has a 1.0.
000 to 2X107 Daltons or i o
, ooo to 2 x 10 Daltons, and 10
Preferably, it has a molecular weight in the range of X10' to 20X10' Daltons.

The gouy presses according to the invention are preferably made from various types of gelatin, all hydrophilic polymers containing gelatin also being combined with various additives such as those described in European Patent Application Publication No. 92,908. Plasticizers, lubricants, crosslinkers, and colorants may be included as described herein at the concentrations indicated herein. What about hydrophilic polymers? 5 inches of extenders and preferably not exceeding 60 weight factors of proteins such as sunflower protein, soybean protein, cottonseed protein, peanut protein, rapeseed oil protein, lactose, gum arabic, acrylates and methacrylates, cellulose acetyl phthalate (CAP). , hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxypropyl methylcellulose phthalate (HPMCP), hydroxymethylcellulose, polyvinylpyrroline, shellac, bentonite, polyvinyl acetate phthalate, phthalated gelatin, succinate gelatin, agar-like polysaccharides It can contain water-soluble cellulose derivatives such as.

Some of these extenders, as well as other extenders, are themselves hydrophilic polymers and can be used to make molded articles according to the invention.

These hydrophilic polymers are hydroxypropyl methylcellulose phthalate (HPMCP) 1. n-lipinyl acetate phthalate (PVAP), cellulose acetyl phthalate (CAP), acrylates and methacrylates (F!' [7DRAGIT), phthalated gelatin, succinate gelatin, crotonic acid and shellac. These polymers are preferred when enteric properties are required. These polymers preferably contain from 5 to 25% by weight water, more preferably from 15 to 22% by weight, calculated on the anhydrous polymer.

Preferred among these polymers is HPMCP.

PVAP and CAP, and particularly preferred are PVAP and CAP, most preferred are P
VAP and all of these polymers contain from 5 to 25% by weight, preferably from 15 to 22%, calculated on the composition.
Processed by injection molding with % moisture by weight.

Many of these polymers are non-thermoplastic and it is quite surprising that they can be pressure molded according to the present invention.

The molding temperature is in the range from 50 °C to 190 °C, and the molding pressure is from 600 x 105N/m” to 3,00
0x10'N/m2) and known equipment can be used.

Preferred polymers are moldable starch compositions made from wheat, potato, rice, tapioca and the like.

Starch is about 0-100% amylose, and about 100-100% amylose.
0% amylopectin, preferably 0-70% amylose, and about 100-30% amylopectin, and most preferably potato starch and corn starch.

When the term "starch" is used in the following explanations,
The term also refers to foams, modifications or derivatives of starch as well as combinations of said foams, modifications or derivatives of starch with hydrophilic polymers which are acceptable for the intended properties, especially for capsule materials. It also includes.

Starch (when calculated on starch composition) is between 5 and 25
15 to 22, particularly preferably 17 to 2
Contains 0% water.

The starch may contain various additives such as plasticizers, lubricants, crosslinkers and/or colorants and extenders. All of these additives are the same as those mentioned above for the hydrophilic substances.

The molding temperature for starch is from 80°C to 240°C and the molding pressure is in the range from 60'0x10'N/m'' to 3.000x10'N/m2.

The mixture containing water and optionally further additives is melted at these temperatures and pressures known per se and in molding equipment known per se.

Those skilled in the art can use Gui pressure molding, i.e. profile extrusion compression molding,
Processing can be performed by vacuum forming, thermoforming, extrusion molding, or a combination of vacuum forming and polymer injection molding.

Due to the feature (1v) described above, the cap part is molded directly onto the open end of the body part as a stone/e. This method worked unexpectedly well for the above compositions and high speed molding processes, preferably injection molding and extrusion, for producing liquid-tight capsules. The body portion of the capsule can be manufactured from the materials mentioned above in any known manner.

DETAILED DESCRIPTION OF EMBODIMENT (1V) FIG. 1 shows an embodiment of a capsule that can be filled with a pharmaceutical product to be swallowed by a patient. In this embodiment, the capstone/Q1 is formed by goo molding so as to form a smooth outer surface when joined. That is, the cap stock horn ξ1 has the same outer diameter as the capsule body into which the contents 3 are filled.

FIG. 2 shows another embodiment in which grooves 4' are formed in the body 2 to ensure additional sealing of the stones/1 when the stones/1 are joined over the contents 3. It shows the aspect.

FIG. 3 shows a further embodiment in which a flat circular plate or disc 4 is inserted so as to completely shield the filling material 6. FIG.

In this embodiment, the stones are formed by goo molding so as to form a smooth outer surface when joined together. That is, the stone e 1 has the same outer diameter as the capsule body 2 into which the content 3 is filled. The force, q-plate 4 makes it possible to injection mold into closed stones at always high speeds.

The present invention also provides high-precision molded articles, especially those that are liquid-tight and prevent tampering with the filled contents.
In this application, a "locking capsule" is defined to include a filled and bonded capsule; is configured to prevent separation and disposal of the contents.

Due to limitations in prior art capsule manufacturing by prior art dip molding methods, prior art capsules do not have a positive locking device to prevent separation after filling and bonding. If a capsule like this,
A particular problem arises if a capsule containing food or medicine can be opened and its contents tampered with.

It is therefore an object of the present invention to provide a capsule constructed in such a way as to prevent tampering with its contents. The advantages of the present invention will be apparent to those skilled in the art from the following detailed description taken in conjunction with the accompanying drawings.

The capsule shown in FIG. 4 of the accompanying drawings has a cap part 1 and a body part 2. The cap part 1 has an annular protrusion 3' projecting from the inner surface of the side wall in instant contact with the open end of the body part 2. This projection 3' fits into an annular recessed groove 4' in the body part 2. The projection 3' and the groove 4' are structurally and dimensionally adapted to each other so that they fit together by a snap-in effect when the capsule parts are joined.

The projection 3' can be a continuous ring cooperating with a continuous or discontinuous groove or can be constructed by several segments or cams, and the locking device can be connected to one or more projections and The cross-sectional shape of the crab locking device may include not only a semicircular shape but also any other shape such as a triangle, a semi-ellipse or other parts of a circle or an ellipse. You should understand what you can do.

6-14 are alternative embodiments of the capsule shown in FIG. 4. In FIG. 6, the cap part 1 has a right-angled groove 5 which fits into a right-angled projection 6 of the body part 2. In FIG.

FIG. 7 shows another embodiment in which the cap part 1 has an annular conical projection 7 which fits into and is locked into a groove annular conical groove 8 of the body part 2. ing. 8th
The figure shows an alternative embodiment in which the cap part 1 has an annular triangular projection 9 which fits into and is locked into a corresponding annular triangular groove 10 of the body part 2. Ru. For better locking, the short side of the triangular protrusion 9 faces the short side of the triangular groove 1o. It has been found that the optimum locking force occurs when the short side of the triangular projection 9 is placed opposite the open end of the other part. Joining of the capsule parts is facilitated when the shortest side of the triangular projection opposite the open end of the other capsule part forms an angle of about 90° to 134° with the adjacent side wall.

FIG. 9 shows another cap part 1 having a triangular projection 9 which fits and locks into a triangular groove 10 of the body part 2. FIG.

FIG. 10 shows the corresponding annular rectangular groove 1 in the body part 2.
an annular rectangular ring 1 that is fitted and lockingly engaged with 2;
1 is shown.

FIG. 11 shows a cap part 1 having an annular projection with a triangular cross-section 13 such that the shortest side 15 of the triangle fits into and locks onto the top surface of the rectangular groove 14' of the body part 2. It shows.

FIG. 12 shows an alternative embodiment of the cap part 1, which is fitted with a triangular projection 9 shaped to mate with the triangular projection 1° of the body part 2.

13 shows a corresponding annular groove 16 with a corresponding cross-sectional area of the circular segment 1 in the body part 2 which fits into and is locked into the groove; FIG. 14 shows a parallelepiped cross-section corresponding to the body part 2. 1 shows a further embodiment of a cap part 1 having an annular projection 17 with a generally parallelepiped cross-sectional area that fits into and is locked into an annular groove 18 having a surface area;

FIG. 15 shows another embodiment of the cap part 1 with one or more windows 19 formed on the cylindrical side wall near the open end and on a circular passage coaxial with the axis of the capsule. It is a mode.

The body part 2 has a corresponding number of locking cams 2o. The locking cam 20 is a protrusion formed on the cylindrical side wall near the open end of the body part 2. The cam 20
fits into the window 19 which locks into engagement when the capsule parts are joined.

Figures 16 to 20 show the locking window 19 of Figure 15.
and shows another embodiment of the cam 20. The cross-sectional area is rectangular in FIG. 16, circular in FIG. 17, triangular in FIGS. 18 and 19, and oval in FIG. 20.

No. 21 shows another embodiment of the invention in which the cap part 1 has a male thread 21 on the outer surface of the cylindrical side wall at its open end.

The male thread 21 engages with a female thread 22 on the inner surface of the cylindrical side wall at the open end of the body part 2. Another feature of this embodiment is that the body portion 1 and the cap portion 2 are joined by a smooth outer surface as indicated by J, thereby making it difficult to separate them, thereby increasing the locking properties of the capsule. It is.

FIG. 22 is an enlarged partial view of FIG. 21 showing the male thread 21, the female thread 22, and the fit and engagement with the smooth surface J of the joint area.

FIG. 23 is a variant of the embodiment of FIG. 21 in which the body part 2 has a male thread 21 on the outer surface of its open end. The male thread 21 mates with and engages the female thread 22 on the inner surface of the open end of the cap portion 1 .

FIG. 24 is an enlarged partial view of FIG. 26 showing the smooth surface J in the bonding area.

FIG. 25 shows the invention with a bayonet chimney locking device in which the cap portion 1 has an annular rectangular groove 4' adjacent the open end of the cap 1 in a direction generally parallel to the axis of the capsule. 2 shows another embodiment of the invention. The body part 2 has a triangular projection 6' on the inner surface of its open end.
have. The triangular protrusion 6' has a conical taper 6 at its front edge to enable easier insertion of the open end of the body part 2 into the interior of the cap part 1. In addition, the cap part 1 has a window 7 for mating with a protruding cam 8 formed thereon.
have.

The combination of the engagement between the groove 4' and the protrusion 3' and the engagement between the cam 8 and the window 7 provides a reliable insertion chimney locking engagement, which enhances the locking properties of this embodiment. can be increased.

FIG. 26 shows that the cap part 1 has an annular dovetail ring in the cylindrical side wall of the open end of the body part 2 for mating engagement with the dovetail groove 10 in the cylindrical side wall of the open end of the body part 2. 9 is another embodiment of the invention.

FIG. 27 shows another embodiment of the invention in which the cylindrical side wall of the open end of the cap 1 is provided with annular slits arranged symmetrically with respect to the main axis of the capsule. The slit 27 is formed in two annular wall sections 28, 29 of different lengths. The body part 2 has an upright side wall 31 whose thickness decreases towards its open end and is marked with a chi 7Q-. In the joined position shown in FIG. 27, the side wall 61 of the body part 2 is held by the bending pressure in the annular slit 27, which preferably has a tapered shape.

28, 29 and 30 show a capsule in which the cap 1 is joined to the body 2. In the joining area, a locking device such as the one designated by 17 according to the previously described embodiment is provided. One feature of the invention is that the ratio between the outer diameter (D) of the cylindrical side wall and the total length (Q) of the joined capsule can be varied. In the embodiment of the capsule shown in FIG. The ratio is 1. In Figure 30, D is more positive than L.

The advantage of having a variable ratio of D and L is that it can be modified to titrate specific requirements, especially for pharmaceutical and food applications, and the shape of the capsule can be modified to accommodate the capsule drug. Capsules, especially pharmaceutical and food capsules, can be modified so that they can be easily swallowed by children, adults and geriatric patients, who have significantly different characteristics. In this way, the form of mulch is obtained.

Figures 31, 32 and 66 show different embodiments of the invention having a cap part 1 and a body part 2 provided with a locking device such as 17 according to the previously described embodiments. FIG. 31 shows one feature of the invention that locking device 17 can be used with capsules having a smooth outer surface at joint J.

FIG. 32 shows a capsule with a body part 2 with a protruding edge at the joint J.

FIG. 36 shows a capsule having a cap part 1 with a protruding edge at the joint J.

FIG. 34 shows another embodiment of the invention. The cap portion 1 and the body portion 2 are designated by the reference numeral 17 as described above.
It has a locking device shown in . In addition, the body portion 2 has a plurality of reinforcing lips 14 formed on the inner surface of its side wall so as to project from the inner surface. Preferably, these reinforcing ribs 14 extend over the entire length of the body part 2 and are interconnected centrally at the closed end of the body part. In the construction of said ribs 14, which can be formed in triangular, rectangular or any other cross-sectional shape, the bending strength of the body part 2 is increased to such an extent that the wall thickness d can be substantially reduced. There is.

In addition, the upper end surface E of the rib 14 constitutes a locking and supporting device for the cap part 1.

The body part 2 can be manufactured by injection molding, and the ribs 14 define a flow path for the injected material.
A rapid and regular distribution of the injected material inside the injection mold is therefore easily obtained.

The ribs of FIG. 34 could alternatively be undercut on the sides of one or both portions of the capsule to improve disintegration of the capsule in the patient's gastrointestinal tract. The ribs 14 can also be molded with the outer surface of the side wall of the body portion 2 and can be formed to protrude from the outer surface.

In the embodiment of the capsule shown in FIG. 35, the cap part 1 has an annular groove 22 on the inner surface of its cylindrical side wall which receives a conical part 23 of the cylindrical side wall of the body part 2.
'have. The open end of the cap part 1 rests on an annular surface 25 of a shoulder formed in the side wall of the body part 2. The joining of the cap part 1 and the body part 2 is facilitated by the closed end 23a of the body part 2 marked with a chi/e-.

In Figure 36, the third
The symbols in Figure 5 are used. The cap part 1 is the same as the cap shown in FIG. However, a slit 20' is additionally formed in the body part 2.

(As many as 1 or more slits can be formed in the circumferential direction.) The slit 20' is formed at the open end of the body part 2 to provide greater flexibility and to allow the cap part 1 to have greater flexibility. and aids and simplifies joining of the body parts 2.

FIG. 37 shows another embodiment of the invention in which the cap part 1 and the body part 2 are provided with two or more locking devices indicated by 17. In addition, the cap part 1 is provided with a slit device 20' to provide greater flexibility which aids and simplifies the joining operation of the cap part 1 and the body part 2.

FIG. 38 shows another embodiment of the invention in which the cap part 1 and the body part 2 are each provided with one or more ratchet teeth 3' on mutually opposite surfaces.

FIG. 69 is a sectional view of FIG. 38 showing the ratchet teeth 3' in mating engagement with each other.

FIG. 40 is a cross-sectional view of FIG. 68 showing the ratchet teeth 6' when they are not in mating engagement with each other.

Applying a torque to coaxially rotate one of the capsule portions about the other capsule portion may cause the teeth of one capsule portion to friction-lock engagement onto the opposing surface of the other capsule portion. .

FIG. 41 shows that the body part 2 is provided with one or more protrusions 4 in the side wall adjacent to its open end, said protrusions 4 being provided in corresponding recesses in the side wall of the cap part 1.
FIG. 3 is a side view of yet another embodiment of the present invention snap-fitted into locking engagement with the FIG.

FIG. 42 is yet another embodiment of the invention showing cap portion 1 and body portion 2 in locking engagement as indicated by numeral 3, with both cap portion 1 and body portion 2 in the joint area. It has a recessed groove 4', which groove 4' in the joining area is filled with a band 5 of sealing or joining material.

In any of the above embodiments, the body portion may have a reduced diameter at the open end to facilitate insertion during joining of the capsule portions.

FIGS. 4 to 31 and 64 to 42 also show the above (1) in which the outer surface of the molded product, particularly the outer surface of the injection-molded capsule, is formed smooth in the joint area of the cap and the body. 1 shows a highly regulated embodiment.

The invention also relates to a molded article, particularly a capsule, whose open end is closed by a coaxial cap, such that when the cap is attached to the open end of a filled body, the inner surface of the cap forms a cylindrical side wall of the body. A molded article characterized in that the molded article is arranged at the same level as or at a level closer to the level of the plane that contacts the open end of the capsule, thereby avoiding air being trapped inside the contents of the capsule. , particularly capsules.

Due to limitations in manufacturing prior art capsules by prior art dip-molding methods, prior art capsules have the following disadvantages.

- Due to the trapping of air in the spherical closed end of the cap part of the filled and closed capsule, air bubbles are created that move when the contents of the capsule are liquid.

Some capsule contents, especially cream or liquid contents, deteriorate after exposure to trapped air.

- The capsules obtained are not liquid-tight, bulky or air-tight.

- The capsules obtained are neither tamper-proof nor separable.

When a capsule is used for pharmaceutical purposes, the protruding edges disposed around the open end of the capsule are relatively sharp. Removal of the protruding edges makes the capsule easier and more attractive to swallow.

It is therefore an object of the invention to provide a capsule constructed in such a way that the disadvantages mentioned above are avoided. The capsules of the present invention are resistant to separation. Moreover, air entrapment during filling can be avoided.

Figures 43, 43a and 43b show longitudinal cross-sectional views of such an embodiment. Of course, the locking device shown in the previous figures can be used as well.

In the present invention, capsules having a unique shape can be prepared by press-molding the above-mentioned materials.

Conventional i-type pharmaceutical capsules have a cylindrical cap portion and a body portion that can be joined in the axial direction, requiring frictional engagement of the inner diameter portion of the side wall portion of the cap to the outer diameter portion of the side wall portion of the body. ing. When the cap and body are joined, the open end of the cap forms a relatively sharp protruding edge. Prior art capsules have the following main disadvantages.

Due to the manufacturing limitations of one prior art dip-molding method, prior art capsules cannot vary significantly in shape and are therefore not very malleable in shape.

- Identification of the capsule contents must be carried out by coloring and marking in different colors, i.e. only by visual means and not by visual means with tactile properties.

One prior art capsule provides only a limited number of unique shapes, which can lead to confusion in identifying different contents.

These major disadvantages are becoming even more significant as oral drug administration increases and the number of visual means for identification is limited.

Prior art capsules also have the following disadvantages.

- These capsules do not have a smooth outer surface for added ease of swallowing.

- These capsules have relatively large cavities, which result in wastage of material and loss of cage volume.

It is therefore an object of the invention to provide a capsule with a shape adapted to avoid the disadvantages and limitations mentioned above.

The advantages of the invention will become apparent to those skilled in the art upon reading the detailed description taken in conjunction with the accompanying drawings.

In the detailed description, it may be convenient to group the embodiments of the invention into the following categories.

1. Uniquely Shaped Capsules This group of uniquely shaped capsules helps avoid identification confusion and supports tactile identification of the capsule.

For convenience, the same reference numerals are used in all figures for this application.

FIG. 44 is a side view of a uniquely shaped capsule of the present invention having a cap portion 1 and a body portion 2. FIG. 45th
The figure is a top view of FIG. 43 showing the novel oval capsule.

FIG. 46 is a side view of another embodiment. Fig. 47 shows a capsule with a pyramid P-shaped end.
FIG. 3 is a top plan view of the figure. FIG. 48 is a side view of another embodiment showing a flat shaped capsule. Figure 49 is a top plan view of Figure 48 showing an elongated oval capsule. Figure 50 is an improved version of Figures 48 and 49 showing a modification of the oval capsule. FIG. 51 is a side view showing the cross section of FIG. 50 showing the side wall portion of the cap portion 2 which forms a perfect K1 with the side wall portion of the body portion 1 when joined. FIG. 51 also shows the smooth outer surface of the sidewall in the bonding area. The use of fully overlapping sidewalls and smooth outer surfaces at the joints makes it difficult for a tamper to grasp and attempt to separate the capsule sections. Figure 52 is a top plan view of another modification of the embodiment of Figures 48, 49, 50 and 51 showing a rectangular oval capsule;

FIG. 53 is a side view of the embodiment of FIG. 52.

Figure 54 is a top plan view of yet another embodiment showing a triangular capsule. FIG. 55 is a side view of the embodiment of FIG. 54.

FIG. 56 is a top plan view of yet another embodiment showing a star shaped capsule. FIG. 57 is a side view of the embodiment of FIG. 56.

2. Capsules shaped to match the logograms of the nine sellers This group of capsules shaped like logograms helps identify sellers. The logogram symbols of the hypothetical company are shown in Figures 58 to 61.
Shown in the figure.

FIG. 58 is a top plan view of an embodiment showing a capsule in the shape of a parallelepiped. FIG. 59 is a side view of the embodiment of FIG. 58.

FIG. 60 is a top plan view of another embodiment showing a C-shaped capsule logon. By using this new Gui molding method to produce capsules, all alphabet Capsules of numerous shapes containing letters are obtained.

FIG. 61 is a side view of the embodiment of FIG. 60.

6. Purpose shaped capsules This group of purpose shaped capsules helps to indicate the field of application. As shown in FIGS. 62 and 63, the heart shape indicates cardiac applications.

4. Capsules shaped to represent dosage forms This group of capsules representing dosage forms represents uses other than oral administration. Figures 64 and 65 show herbal capsules suitable for rectal administration. Those skilled in the art will appreciate that the embodiments described above can be used to produce capsules with a two-part hard shell in the shape of a tactile vine that is distinguishable by visually impaired patients.

5. Capsules shaped to change the volume of their contents This group of embodiments allows the volume of their contents to be changed for capsules of the same size. Figure 66 shows a spherical capsule providing the smallest possible /ξ honey cage for the largest volume of contents.

FIG. 67 is a sectional view taken along the line 24--24 of FIG. 66, also showing the separation-resistant locking device of the side walls of the body part 1 and the cap part 2 in the joining area J. 6th
FIG. 8 is a top plan view showing a circular capsule having the same diameter as the spherical capsules of FIGS. 66 and 67.

Figure 69 shows the maximum possible /Q for the smallest volume of contents.
Figure 68 is a side view showing a disc-shaped shape providing one of the capsules, and a number of capsule shapes are obtained by the new molding method, and the ratio of the volume of the contents to the cage is changed. Great flexibility is obtained when providing an encapsulated metal with a hard shell.

6. Capsules shaped to be precisely positionable on a joining machine There are various capsules that require precise positioning of the two capsule parts prior to joining, such as a screw-type or bayonet-type locking engagement. This precise positioning can be achieved by means of a positioning device on the outer surface of the capsule. 7th
Figure 0 is a side view of an embodiment of this group. 71st
The figure is a top plan view of FIG. 70 showing four possible positionings with respect to the angle of rotation of the capsule axis.

This is a major advantage compared to conventional dip-molded capsules having a circular cross-sectional area. A capsule with four possible positions for bayonet locking engagement is illustrated, for example as shown in FIG. . FIG. 71 shows a bayonet type closure which allows axial and rotational movement of the body part relative to the cap part 2. (Axial and rotational movements are indicated by dotted lines.) Those skilled in the art will appreciate that capsule shapes of the present invention may be obtained that satisfy more than one of the aforementioned groups of properties.

In yet another embodiment of the present invention, a pressure-molded product is manufactured so as to be embossed with characters or designs.

Prior art capsules are imprinted with an ink composition. This method is very complex and additionally requires a second step after capsule production. Moreover, it is difficult to stamp the closed ends of the capsule body and cap parts. The stamping according to the invention makes it possible to obtain stamped capsules without using chemical inks.

Thus, stamped capsules can be produced quite naturally. Therefore, the capsule of the present invention is engraved with characters or designs so as to avoid the above-mentioned disadvantages.

The present invention is a capsule part obtained by die molding using a mold with the desired imprinting of letters or designs (embossed or embossed).

In the present invention, manufacturing and stamping of the capsule consists of a single simple step. Moreover, during injection molding die stamping, the encapsulant material is not adversely affected as is the case in the prior art when the stamping is done by foil stamping. If foil stamping is used, the disadvantage arises that a second processing step is required. Furthermore, when stamping with foil, it is impossible to perform embossing.

FIG. 72 is a side view of an embodiment of the invention showing a capsule with body part 1 and cap part 2 joined together.

On the outside of the side wall of the cap is the seller's name CA.
Embossed 3 with the word PSUGEL is engraved on it. Such markings were not possible with prior art dip molding methods.

However, embossing can be achieved using a new molding method. FIG. 73 is a cross-sectional view of FIG. 72 taken along line 2-2.

The invention may also include a seal or adhesive bonding of the joined capsule parts to provide additional fixation to further prevent separation and tampering. Such a seal or bond also makes the capsule liquid-tight, gas-tight and prevents the ingress of moist vapor into the capsule.

To seal the gelatin, the cap and body joint surfaces are moistened with water alone or a mixture of water and a water-compatible organic solvent such as ethanol & alcohols having 1 to 4 carbon atoms. It is appropriate to moisten it with water.

The capsules are optionally heated to about 40°C to 75°C. Due to the high precision and special locking device obtained by this die pressing, heating is not absolutely necessary although it increases the sealing properties considerably and due to zero starch and numerous starch derivatives, the cap portion and It has surprisingly been found that by moistening the joints of the body parts with water at room temperature without additional heating, the capsule becomes absolutely liquid-tight and cannot be tampered with.

It is to be understood that the disclosure herein is for illustrative purposes only and that the invention includes all modifications and equivalents that fall within the scope of the claims.

Example 1 A capsule body was die-molded using an injection molding machine. The material used was 150 BLOOM B GRADE bone gelatin with 17% moisture by weight of the composition. The material was plasticized at 130°C and injected into a die at 20°C.

The capsule body was then removed from the mold, lactose was filled into the capsule and inserted into a second mold. A second mold was attached to the injection molding machine and injection molded into the open end of the filled capsule body. The same material as the body material was used. During injection molding of the stopper,
A seal is formed between the stopper and the body so that the capsule is liquid-tight and air-tight, preventing moist vapor from entering the capsule and preventing tampering.

Example 2 A capsule body was die-molded using an injection molding machine. The materials used were 10 g of moisture and a certain amount of organic plasticizer,
150 BLOO with 6% Sorbitol, 3T Glycerol (all based on weight of gelatin)
M, B GRADE bone gelatin. This material was plasticized at 130°C and injected into a die at 19°C.

After removing the capsule body from the mold, GATTFFO88F for the ethoxylated saturated glycerides of C111 to C13 is placed in the capsule body. It was filled with a creamy content, a material with the trademark LABRAF ILR, supplied by the company. Then Example 1
The steps described in were taken.

Example 3 Wheat starch containing 2α6 water was injection molded into capsule bodies at a temperature of 140° C. and a pressure of 200×10′N/α2 and injection molded into capsules under the same conditions. The cap and body had the form shown in FIG. 4. Capsules with an excellent appearance and a smooth outer surface were obtained.

Example 4 Example 3 was repeated using the configuration of FIG.

The joint surfaces of the cap part and the body part were moistened with water. Excellent sealing performance was obtained.

Example 5 Example 6 was returned 817 using the configuration of Figure 43 with the name CAPSU()KL embossed on the cap.

As a result, good results were obtained regarding air entrapment and sealing properties. The depth of the embossed characters was α03m, which was sufficient for clear reading. The same results were obtained regarding die disappearance.

[Brief explanation of drawings]

FIG. 1 is a longitudinal sectional view of one embodiment of the capsule of the present invention, FIG. 2 is a longitudinal sectional view of another embodiment, FIG. 6 is a longitudinal sectional view of yet another embodiment, and FIG. A longitudinal sectional view of the embodiment,
6 to 14 are partial sectional views showing further nine embodiments of FIG. 1, FIG. 15 is a longitudinal sectional view of another embodiment, and FIGS. 21 is a diagram showing another embodiment of the invention; FIG. 22 is an enlarged partial sectional view of the embodiment of FIG. 21; and FIG. 23 is another embodiment. Longitudinal sectional view, second
4 is an enlarged partial sectional view of the embodiment of FIG. 23, FIG. 25 is a longitudinal sectional view of another embodiment, FIG. 26 is a longitudinal sectional view of yet another embodiment, and FIG. 27 is a longitudinal sectional view of yet another embodiment. 28, 29 and 30 are longitudinal sectional views of yet another embodiment, and FIG. 31 is a longitudinal sectional view of still another embodiment, and FIG. 38 is a longitudinal cross-sectional view of another embodiment; FIG. 69 is a cross-sectional view of FIG. 38 taken along line 35--35; and FIG. 41 is a side view of yet another embodiment; FIG. 42 is a longitudinal sectional view of another embodiment; FIG. 43
Figures 43a and 43b are longitudinal sectional views of an embodiment that is resistant to separation and does not trap air during filling, and Figure 44 shows the cap portion 1 and the body portion 2. 45 is a top view of FIG. 43 showing the novel oval capsule; FIG. 46 is a side view of an alternative embodiment; FIG. 47 is a side view of the uniquely shaped capsule of the present invention having FIG. 46 is a top plan view showing a capsule tube with a pyramidal end; FIG. 48 is a side view of an alternative embodiment showing a flat shaped capsule; FIG. 49 is an elongated oval capsule. The top plan view of FIG. 48 shown in FIG.
0 is an improved version of the embodiment of FIGS. 48 and 49, showing a variant of the oval capsule, and FIG. 51 shows a cap that fully overlaps the side wall of the body part 1 when joined. a side view showing the cross section of FIG. 50 showing the side wall portion of the part;
FIG. 52 is a one-page plan view of another modification of the embodiment of FIGS. 48, 49, 50, and 51 showing a rectangular oval capsule; FIG. 56 is a one-page plan view of the embodiment of FIG. 52; 54 is a top plan view of yet another embodiment showing a triangular capsule; FIG. 55 is a side view of the capsule of FIG. 54; FIG. 56 is a still further embodiment showing a star-shaped capsule. 57 is a side view of the embodiment of FIG. 56, FIG. 58 is a top plan view of the embodiment showing the nomenclature of the parallelepiped-shaped capsule, and FIG. 59 is a top plan view of the embodiment of FIG. Fifth
8; FIG. 60 is a top plan view of another embodiment showing C-shaped capsule terminology; FIG. 61;
The figure is a side view of the implementation 5 @ of Figure 60, Figures 62 and 63 are diagrams showing a heart-shaped capsule indicating that it is used for heart 1 @, Figures 64 and 65 are rectum. Figure 66 depicting a sit-shaped capsule suitable for administration to
Figure 67 shows a spherical capsule providing the smallest possible package for the largest volume of contents; Figure 67 is a cross-section of Figure 66 taken along line 24-24; Figure 68 is a cross-sectional view of Figure 6
A top plan view showing a circular capsule having the same diameter as the spherical capsules of Figures 6 and 67; Figure 69 is a disc-shaped capsule providing one of the largest possible packages for the smallest volume of contents; The side view of FIG. 68 showing the shape of
FIG. 70 is a side view of an embodiment of the capsule in which it is necessary to precisely position all of the two capsule parts before joining, FIG.
Fig. 1 shows a plug-in closure system in which the body part can be moved axially and rotationally relative to the cap part, and Fig. 72 shows a capsule in which the body part and the cap part are joined together. ``@kai-sama side view, and Fig. 73 is a cross-sectional view taken along the line 2-2 of Fig. 72. 1...Cap, 2...Body, 3...Filling substance, 3' ...Ratchet tooth, 3''...recess, 4...
Disc, 4'... Groove, 5... Groove, 6... Projection, 7... Projection, 8... Groove, 9... Projection, 10
...Groove, 11...Ring, 12...Groove, 13...
・Triangular cross section, 14'...Groove, 14...Rip, 1
5...Short side of triangle, 16...Groove, 17...Protrusion part, 18...Groove, 19...Window part, 20...Cam,
20'...Slit, 21...Male thread, 22...
・Female thread, 22'...groove, 23...conical part,
25... Annular surface of shoulder portion, 27... Slit, 28.
29°: annular wall portion, 31: side wall portion, D: outer diameter of side wall portion, L: total length of joint capsule, J: joint region. Patent ratio m person Warner Rampart Konno Zony FI
G, 1 FIG, 2 FHGB FIG, If FIG, 9 FIG, 12 FIG, 13 FIG2+ FIG 22 FIG 23 FIG 24 FIG, 25 FIG, 26 FIG, 27 FIG, 28 FIG, 29 FIG, 30 FIG 3 1 FIG, 32 FIG 33 FIG 34 FIG, 35 FIG 36 FIG, 37 FIG 38 FIG, 39 FIG, 40 FIG, 41 FIG, 42 - FIG, 42a FIG, 42b z 2 FIG 43 FIG, 44 FIG 45 FIG, 47 F IG, 48 FIG, 49 FIG, 50 FIG, 51 lG52 IG53 FIG55 FIG56 FIG, 58 FIG 57 FIG, 59 FIG 60 FIG 61 FIG, 62 FIG, 63 FIG, 64 FIG, 65 FIG, 66 FIG, 67 Continuation priority on page 1 claim [companion] ] December 2, 1
S) [phase] 557306 [phase] 198 p December 2nd [
Phase] United States (US) [Stock] 557,500 @ 198* 1
February 2 @ United States (US) @ 557502 ■ 198 Pancreas August 17 [phase] United States (US) ■ 616 ω Procedural amendment (method) April 11, 1985 Commissioner of the Patent Office Manabu Shiga 1 , Indication of the case 1982 Patent Application No. 218801 2 Name of the invention Gui Pressure Molded Capsule 3 Relationship to the case by the person making the amendment Patent applicant name '7--1--Lambert Compagnie 4, Rev. Agent 5, date of amendment order: January 9, 1985 (shipment date: January 29, 1985)
) Contents of the amendment 1) The column for the brief explanation of the drawings in the specification will be amended as shown in the attached sheet. 2) Submit an engraving of the drawing (with changes to the content) as shown in the attached sheet. (However, in order to make the drawings continuous, the drawing numbers "Figure 6-73" have been corrected to "Figure 5-72".) Above 4, a brief explanation of the drawings. 1 is a longitudinal sectional view of one embodiment of the capsule of the present invention, FIG. 2 is a longitudinal sectional view of another embodiment, FIG. 3 is a longitudinal sectional view of yet another embodiment, and FIG. 4 is a longitudinal sectional view of a first embodiment. A longitudinal cross-sectional view of the embodiment,
5 to 13 are partial sectional views showing nine further embodiments of FIG. 1, FIG. 14 is a longitudinal sectional view of another embodiment, and FIGS. 20 is a partial sectional view showing another embodiment of the invention; FIG. 21 is an enlarged partial sectional view of the embodiment of FIG. 20; FIG. 22 is a partial sectional view of another embodiment of the invention. Longitudinal sectional view, 2nd
6 is an enlarged partial sectional view of the embodiment of FIG. 22, FIG. 24 is a longitudinal sectional view of another embodiment, FIG. 25 is a longitudinal sectional view of yet another embodiment, and FIG. 26 is a further embodiment. FIGS. 27, 28 and 29 are longitudinal sectional views of yet another embodiment; FIGS. 30 to 36 are longitudinal sectional views of yet another embodiment; FIG. 37 is a longitudinal sectional view of yet another embodiment; 68 is a cross-sectional view taken along the line 55-55 in FIG. 37; FIG. 39 is a longitudinal sectional view of another embodiment; FIG. FIG. 40 is a side view of a further embodiment, FIG. 41 is a longitudinal sectional view of another embodiment, FIGS. 42, 42a and 42a. Figure 42b is a longitudinal cross-sectional view of an embodiment that is resistant to separation and does not trap air during filling; Figure 43 shows the unique shape of the invention having a cap portion 1 and a body portion 2; 44 is a top view of FIG. 42 showing the new oval capsule; FIG. 45 is a side view of an alternative embodiment; and FIG. 46 is a pyramid-shaped end. FIG. 47 is a side view of another embodiment showing a flat shaped capsule; FIG. 48 is a top plan view of FIG. 47 showing an elongated oval capsule. Plan view,
FIG. 49 is a modification of the embodiment of FIGS. 47 and 48, showing a variant of the oval capsule; FIG. 50 shows a cap portion that completely overlaps the side wall of the body part 1 when joined; Figure 49 is a cross-sectional side view showing the side wall of the capsule, and Figure 51 is a side view showing the side wall of the capsule.
7, 48, 49 and 50; FIG. 52 is a side view of the embodiment of FIG. 51; FIG. 53 shows a triangular capsule. 54 is a side view of the capsule of FIG. 56; FIG. 55 is a top plan view of a further embodiment showing a star-shaped capsule; FIG. 56 is a top plan view of the capsule of FIG. 55; FIG. 57 is a side view of the embodiment of FIG.
57 is a side view of the embodiment of FIG. 57; FIG. 59 is a top plan view of another embodiment showing C-shaped capsule terminology; FIG. 60 is a side view of the embodiment of FIG. 59; Figures 61 and 62 depict heart-shaped capsules indicating cardiac use; Figures 63 and 64 depict herbal capsules suitable for rectal administration; Figure 65 shows a spherical capsule providing the smallest possible package for the largest volume of contents, Figure 66
The figures are a sectional view taken along the line 24-24 of Fig. 65, Fig. 67 is a top plan view showing a circular capsule having the same diameter as the spherical capsules of Figs. 65 and 66, and Fig. 68 is The side view of Figure 67 showing the disc-shaped configuration providing one of the largest possible packages for the smallest volume of contents, Figure 69 accurately positioning the two capsule parts prior to joining. FIG. 70 is a side view of an embodiment of the capsule which is highly recommended; FIG. 72 is a side view of an embodiment of the present invention showing a capsule with a body portion and a cap portion joined together, and FIG. 72 is a sectional view taken along line 2--2 of FIG. 71. DESCRIPTION OF SYMBOLS 1... Cap, 2... Body, 6... Filling material, 3'... Ratchet tooth, 6N... Recessed part, 4...
Disc, 41... Groove, 5... Groove, 6... Projection, 7... Projection, 8... Groove, 9... Projection, 10
...Groove, 11...S/G, 12...Groove, 13...
・Triangular cross section, 14'...groove, 14...rib, 1
5...Short side of triangle, 16...Groove, 17...Protrusion part, 18...Groove, 19...Window part, 20...Cam,
20'... Surin F121... Male thread, 22...
・Female thread, 221...groove, 23...conical part,
25... Annular surface of the shoulder, 27... Surin), 28.
29...Annular wall part, 31...9I11 wall part, leaf/
Outer diameter of side wall, L...Total length of joint capsule, J...
junction area.

Claims (1)

Claims: 1) A pressed molded article, and in particular an injection molded capsule, each having a side wall, an open end and a closed end and having a joinable body part and a cap part, comprising: 10 if the shaped article is formed from (1) a hydrophilic polymer or a mixture of such polymers having a moisture content of 5 to 25% by weight (calculated on the hydrophilic polymer composition) and gelatin; ~200-20% by weight gelatin composition) and/or (1) 5-2
The body part was filled with the contents (produced by II + 1 Guy pressing and θV for capsules) from a starch or starch composition with 5% by weight moisture (calculated on the starch composition). (v) said cap portion is then molded directly onto the open end of said body portion with a stopper to seal the interior contents of the capsule; at least one locking device in a side wall region adjacent to the section, said locking devices facing each other and forming a separation-resistant connection after joining of said camping section and body section; A pressure-molded product, in particular an injection-molded turnip, characterized in that the cap part and the body part are machined with a deviation as small as 1 inch and have dimensional stability. cell. 2) characterized in that the capsules are produced by injection molding starch or a starch composition having a water content of 5 to 25% by weight, preferably 17 to 20% by weight, calculated on the starch composition; A capsule according to claim 1. 3) Capsules according to claim 1 or 2, characterized in that the starch is wheat, potato, rice or tapioca starch or a mixture thereof. 4) The capsules are calculated from 10 to 100% based on the gelatin composition.
Claim 1, characterized in that it is produced by injection molding gelatin having a water content of 20% by weight.
Capsules as described in Section. 5) Claims 1 to 4, characterized in that the starch and/''! bamboo gelatin composition contains one or more plasticizers, extenders, lubricants and/or colorants. 6) for receiving and configuring a stopper device in the joint region of at least one part of the open end of the other part for a side wall of the open end of the other part; It has a side wall portion forming an annular shoulder, and both side wall portions are formed in such a shape that the outer surface of the joining area of the two portions, that is, the body portion and the cap portion is smooth. The capsule according to any one of claims 1 to 5. 7) When the cap part is attached to the open end of the body part, the inner surface of the cap part is attached to the body part. located at substantially the same level as, or even lower than, the level of the horizontal plane tangent to the open end of the cylindrical side wall of the cylindrical side wall of the cylindrical side wall of the cylindrical side wall of the cylindrical side wall of Claims 1 to 6, characterized in that no air is subsequently trapped between the inner surface of the cap part and the level of the contents. 8) the cap portion being coaxial with the open end of the body portion by having a circular disc circumferentially engaging an annular peripheral portion of the open end of the body portion; 8. A capsule according to claim 7, characterized in that it is a joined circular disc. 9) The cap part is an annular disc disposed at a circumferential edge opposite the open end of the body part. Capsule according to claim 7, characterized in that the capsule has a recess, and a side wall of the body part fits into and projects into the recess. 10) The capsule of the cap part and the body part Any one of claims 1 to 5, 1, characterized in that each capsule is molded so as to be joined to a unique shape so that the capsule can be identified by touch. The capsule according to claim 10. 11) The capsule according to claim 10, characterized in that each part of the capsule is formed into a shape that conforms to a symbol representing the name of the pengu. 12 ) A capsule according to claim 10, characterized in that it has a shape adapted to the field of application. 13) Characters and/or designs are embossed on at least one of the cap part and the body part, Claim 1 characterized in that bamboo-press erasing printing is performed.
The capsule according to any one of items 1 to 12. 14) The capsule according to any one of claims 1 to 5 and claim 10, characterized in that it has a shape representing the mode of administration. 15) The capsule according to any one of claims 1 to 5 and claim 10, which has a shape that allows the volume of the contents to be changed. 16) Capsules according to any one of claims 1 to 5, characterized in that they have a shape that allows them to be placed accurately on a filling machine. 17) The capsule according to any one of claims 1 to 5, which is in the form of a tablet. 18) The liquid-tight seal of the cap part and the body part is obtained by wetting the joint surfaces with water or a mixture of water and a water-compatible organic solvent. 18. The capsule according to any one of items 1 to 17.