CH669201A5 - AT ROOM TEMPERATURES FIXED AND FREE-FLOWING BASIC COMPOSITION FOR PRINTING. - Google Patents
AT ROOM TEMPERATURES FIXED AND FREE-FLOWING BASIC COMPOSITION FOR PRINTING. Download PDFInfo
- Publication number
- CH669201A5 CH669201A5 CH1926/86A CH192686A CH669201A5 CH 669201 A5 CH669201 A5 CH 669201A5 CH 1926/86 A CH1926/86 A CH 1926/86A CH 192686 A CH192686 A CH 192686A CH 669201 A5 CH669201 A5 CH 669201A5
- Authority
- CH
- Switzerland
- Prior art keywords
- parts
- weight
- composition according
- starch
- water
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 56
- 229920002472 Starch Polymers 0.000 claims description 33
- 235000019698 starch Nutrition 0.000 claims description 29
- 239000008107 starch Substances 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 11
- 238000001746 injection moulding Methods 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 235000019871 vegetable fat Nutrition 0.000 claims description 9
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 8
- 244000061456 Solanum tuberosum Species 0.000 claims description 8
- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 8
- 235000010445 lecithin Nutrition 0.000 claims description 8
- 239000000787 lecithin Substances 0.000 claims description 8
- 229940067606 lecithin Drugs 0.000 claims description 8
- 239000004014 plasticizer Substances 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 8
- 235000019737 Animal fat Nutrition 0.000 claims description 7
- 108010010803 Gelatin Proteins 0.000 claims description 7
- 239000008273 gelatin Substances 0.000 claims description 7
- 229920000159 gelatin Polymers 0.000 claims description 7
- 235000019322 gelatine Nutrition 0.000 claims description 7
- 235000011852 gelatine desserts Nutrition 0.000 claims description 7
- 229920001592 potato starch Polymers 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 241000209140 Triticum Species 0.000 claims description 6
- 235000021307 Triticum Nutrition 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 235000014633 carbohydrates Nutrition 0.000 claims description 5
- 150000001720 carbohydrates Chemical class 0.000 claims description 5
- 239000001913 cellulose Substances 0.000 claims description 5
- 229920002678 cellulose Polymers 0.000 claims description 5
- 239000003925 fat Substances 0.000 claims description 5
- 235000019197 fats Nutrition 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 235000018102 proteins Nutrition 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 240000007594 Oryza sativa Species 0.000 claims description 4
- 235000007164 Oryza sativa Nutrition 0.000 claims description 4
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims description 4
- 240000008042 Zea mays Species 0.000 claims description 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 4
- 150000007513 acids Chemical class 0.000 claims description 4
- 239000003638 chemical reducing agent Substances 0.000 claims description 4
- 235000005822 corn Nutrition 0.000 claims description 4
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims description 4
- 235000009566 rice Nutrition 0.000 claims description 4
- 229940100445 wheat starch Drugs 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- 108010082495 Dietary Plant Proteins Proteins 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 240000003183 Manihot esculenta Species 0.000 claims description 3
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 claims description 3
- 235000010443 alginic acid Nutrition 0.000 claims description 3
- 229920000615 alginic acid Polymers 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 229920003170 water-soluble synthetic polymer Polymers 0.000 claims description 3
- 244000215068 Acacia senegal Species 0.000 claims description 2
- 235000017060 Arachis glabrata Nutrition 0.000 claims description 2
- 244000105624 Arachis hypogaea Species 0.000 claims description 2
- 235000010777 Arachis hypogaea Nutrition 0.000 claims description 2
- 235000018262 Arachis monticola Nutrition 0.000 claims description 2
- 235000007319 Avena orientalis Nutrition 0.000 claims description 2
- 244000075850 Avena orientalis Species 0.000 claims description 2
- 102000004506 Blood Proteins Human genes 0.000 claims description 2
- 108010017384 Blood Proteins Proteins 0.000 claims description 2
- 240000002791 Brassica napus Species 0.000 claims description 2
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 102000002322 Egg Proteins Human genes 0.000 claims description 2
- 108010000912 Egg Proteins Proteins 0.000 claims description 2
- 241000196324 Embryophyta Species 0.000 claims description 2
- 229920000084 Gum arabic Polymers 0.000 claims description 2
- 244000020551 Helianthus annuus Species 0.000 claims description 2
- 235000003222 Helianthus annuus Nutrition 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 241000209056 Secale Species 0.000 claims description 2
- 235000007238 Secale cereale Nutrition 0.000 claims description 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
- 125000003277 amino group Chemical group 0.000 claims description 2
- 235000021120 animal protein Nutrition 0.000 claims description 2
- 125000000129 anionic group Chemical group 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 claims description 2
- 235000012343 cottonseed oil Nutrition 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- UXELAVSYWBWGQM-UHFFFAOYSA-L disodium;2,2-diethyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCC(CC)(C([O-])=O)C(C([O-])=O)S(O)(=O)=O UXELAVSYWBWGQM-UHFFFAOYSA-L 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims description 2
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 235000020232 peanut Nutrition 0.000 claims description 2
- 125000005498 phthalate group Chemical class 0.000 claims description 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 2
- 229920002744 polyvinyl acetate phthalate Polymers 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 235000012015 potatoes Nutrition 0.000 claims description 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims description 2
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 claims description 2
- 239000001069 triethyl citrate Substances 0.000 claims description 2
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 2
- 235000013769 triethyl citrate Nutrition 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
- OWRCNXZUPFZXOS-UHFFFAOYSA-N 1,3-diphenylguanidine Chemical compound C=1C=CC=CC=1NC(=N)NC1=CC=CC=C1 OWRCNXZUPFZXOS-UHFFFAOYSA-N 0.000 claims 1
- GVIRAXRGZUXHCI-UHFFFAOYSA-N 2-acetyloxycarbonylbenzoic acid Chemical compound CC(=O)OC(=O)C1=CC=CC=C1C(O)=O GVIRAXRGZUXHCI-UHFFFAOYSA-N 0.000 claims 1
- 229920001817 Agar Polymers 0.000 claims 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 150000003890 succinate salts Chemical class 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
- 239000000843 powder Substances 0.000 description 5
- 238000007792 addition Methods 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 239000000975 dye Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229910052814 silicon oxide Inorganic materials 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 239000000654 additive Substances 0.000 description 3
- -1 edibles Substances 0.000 description 3
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 2
- 229920000945 Amylopectin Polymers 0.000 description 2
- 229920000856 Amylose Polymers 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000001023 inorganic pigment Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000000987 azo dye Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000006082 mold release agent Substances 0.000 description 1
- 239000012860 organic pigment Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229940116317 potato starch Drugs 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
- C08L3/02—Starch; Degradation products thereof, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D13/00—Finished or partly finished bakery products
- A21D13/30—Filled, to be filled or stuffed products
- A21D13/38—Filled, to be filled or stuffed products characterised by the filling composition
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/04—Apparatus specially adapted for manufacture or treatment of cocoa or cocoa products
- A23G1/20—Apparatus for moulding, cutting, or dispensing chocolate
- A23G1/22—Chocolate moulds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/02—Apparatus specially adapted for manufacture or treatment of sweetmeats or confectionery; Accessories therefor
- A23G3/0236—Shaping of liquid, paste, powder; Manufacture of moulded articles, e.g. modelling, moulding, calendering
- A23G3/0252—Apparatus in which the material is shaped at least partially in a mould, in the hollows of a surface, a drum, an endless band, or by a drop-by-drop casting or dispensing of the material on a surface, e.g. injection moulding, transfer moulding
- A23G3/0268—Moulds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Injection Moulding Of Plastics Or The Like (AREA)
- Grain Derivatives (AREA)
- General Preparation And Processing Of Foods (AREA)
- Jellies, Jams, And Syrups (AREA)
Description
BESCHREIBUNG Es ist bekannt, druckgeformte Formkörper aus natürlicher Stärke vorzugsweise mittels Spritzgiessen, herzustellen. Bevorzugt werden solche Formkörper hergestellt zum Befüllen mit Pharma-zeutika, Esswaren, Chemikalien und anderes mehr, insbesondere als pharmazeutische Kapseln, fur die dosierte Verabreichung von Medikamenten. Solche Behälter bestehen in der Regel aus einem Hauptteil und einem Verschlussteil, wobei beide Teile im verschlossenen Zustand genau ineinander passen und einen dicht verschlossenen Behälter ergeben. DESCRIPTION It is known to produce compression molded molded articles from natural starch, preferably by means of injection molding. Such molded articles are preferably produced for filling with pharmaceutical preparations, edibles, chemicals and other, in particular as pharmaceutical capsules, for the metered administration of medicaments. Such containers usually consist of a main part and a closure part, both parts of which fit exactly into one another in the closed state and result in a tightly closed container.
Die Herstellung solcher druckgeformter Behälter aus natürlicher Stärke ist aus der Europäischen Patentanmeldung Nr. 84360940.8 (Pubi. Nr 118240) bekannt. The production of such pressure-molded containers from natural starch is known from European Patent Application No. 84360940.8 (Pubi. No. 118240).
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In der industriellen Fertigung ist es nötig, die druckgeformten Gegenstände, insbesondere die sehr dünnwandigen pharmazeutischen Kapselteile mit höchster Präzision und mit hoher Geschwindigkeit herzustellen. Zudem dürfen bei der Herstellung absolut keine fehlerhaften Teile entstehen um anschliessende Kontrollen und Unterbrüche in der Abfüllmaschine praktisch auszuschalten. In industrial production, it is necessary to manufacture the pressure-molded objects, in particular the very thin-walled pharmaceutical capsule parts, with the highest precision and at high speed. In addition, absolutely no faulty parts may arise during manufacture in order to practically switch off subsequent checks and interruptions in the filling machine.
Die Bewältigung dieser Problematik der Verarbeitbarkeit hat sich als überraschend schwierig erwiesen. Bei der Herstellung von sehr dünnwandigen Teilen, beispielsweise bei Wanddicken von unter 0,5 mm, verstärken sich diese Probleme. Addressing this processability issue has been surprisingly difficult. These problems are exacerbated in the production of very thin-walled parts, for example with wall thicknesses of less than 0.5 mm.
Insbesondere ist ein sehr gutes Fliessverfahren nötig sowohl bezüglich des Ausgangspulvers (frei fliessende Stärke-Ausgangsmischung) als auch während des gesamten Spritzgiessvorganges bis hin zum flüssigen Zustand. Die Schmelze soll zur Vermeidung hoher Drücke möglichst leicht fliessen und soll bezüglich der Temperatur, der Durchmischung mit den Additiven und dem Wasser eine möglichst homogene Verteilung zeigen. In particular, a very good flow process is necessary both with regard to the starting powder (free-flowing starch-starting mixture) and also during the entire injection molding process up to the liquid state. To avoid high pressures, the melt should flow as easily as possible and should show a distribution that is as homogeneous as possible with regard to the temperature, the mixing with the additives and the water.
Weiterhin sollen die spritzgegossenen Teile eine gute Ent-formbarkeit sowie eine gute Formstabilität aufweisen, um eine Wandhaftung im Werkzeug oder Deformation beim Ausstossen zu vermeiden. Furthermore, the injection molded parts should have good demoldability and good dimensional stability in order to avoid sticking to the wall in the tool or to prevent deformation when ejecting.
Überraschenderweise lassen sich die Probleme lösen, wenn man: Surprisingly, the problems can be solved by:
1. eine bei Raumtemperatur feste und frei fliessende Stärke-Ausgangsmischung verwendet, die unter den Verarbeitungsbedingungen einen Formling mit praktisch amorpher Wandstruktur ergibt, 1. uses a starch mixture which is solid and free-flowing at room temperature and which, under the processing conditions, gives a molding with a practically amorphous wall structure,
2. die Viskosität der Schmelze bei 90-240° C und besonders 140-190° C zwischen 2500 und 50 Pas ( = Pascal x Sekunde), vorzugsweise 2000 und 50 Pas, insbesondere 1500-50 Pas liegt, und 2. the viscosity of the melt at 90-240 ° C and especially 140-190 ° C between 2500 and 50 Pas (= Pascal x second), preferably 2000 and 50 Pas, in particular 1500-50 Pas, and
3. der Glasübergangspunkt der in geschlossenem Raum auf 140-190°C erwärmten Mischung bei mindestens 25°C, vorzugsweise bei mindestens 46 °C und insbesondere bei etwa 65 °C liegt. Diese Bedingungen werden mit der im weiteren definierten Zusammensetzung erreicht. 3. the glass transition point of the mixture heated to 140-190 ° C. in an enclosed space is at least 25 ° C., preferably at least 46 ° C. and in particular approximately 65 ° C. These conditions are achieved with the composition defined below.
Die im weiteren angegebene Zusammensetzung erlaubt es, Spritzgussmaschinen im kontinuierlichen 24-Stunden-Betrieb zu fahren unter weitgehender Ausschaltung von Fehlerquellen bzw. der oben genannten Nachteile. The composition specified below enables injection molding machines to be operated in continuous 24-hour operation, largely eliminating sources of error or the disadvantages mentioned above.
Die vorliegende Erfindung betrifft in diesem Sinne eine für das Druckformen brauchbare bei Raumtemperaturen feste und frei fliessende Basiszusammensetzung, dadurch gekennzeichnet, dass diese enthält: In this sense, the present invention relates to a base composition which is solid and free-flowing at room temperatures and is suitable for printing, characterized in that it contains:
Menge a) Amount a)
mindestens eine chemisch at least one chemically
72-89,58 Gewichtsteile nicht-modifizierte Stärke 72-89.58 parts by weight of unmodified starch
b) b)
mindestens einen at least one
0-5 Gewichtsteile 0-5 parts by weight
Viskositätsverminderer Viscosity reducer
c) c)
mindestens einen at least one
0-5 Gewichtsteile 0-5 parts by weight
Dissolutionsbeschleuniger Dissolution accelerator
d) d)
mindestens ein at least one
0,02-1 Gewichtsteile 0.02-1 parts by weight
Texturierungsmittel Texturing agent
e) e)
Wasser water
10-22 Gewichtsteile wobei (i) die Komponenten (b) und (c) zusammen immer mindestens 0,4 Gewichtsteile und höchstens 5 Gewichtsteile und (ii) die Summe der Komponenten (a), (b), (c), (d) und (e) 100 Gewichtsteile ergeben. 10-22 parts by weight where (i) components (b) and (c) together always at least 0.4 parts by weight and at most 5 parts by weight and (ii) the sum of components (a), (b), (c), (d ) and (e) give 100 parts by weight.
Diese Basiszusammensetzung, welche insbesondere für das Spritzgiessen brauchbar ist, kann weitere Komponenten enthalten, wie dies weiter unten beschrieben ist. Teile bedeuten immer Gewichtsteile. Die oben bzw. in Anspruch 1 angegebenen oberen Grenzen sind technisch bedingt. This basic composition, which is particularly useful for injection molding, can contain further components, as described below. Parts always mean parts by weight. The upper limits specified above or in claim 1 are due to technical reasons.
Unter chemisch unmodifizierter Stärke ist das natürlich vorkommende pflanzliche Kohlenhydrat zu verstehen, welches zur Hauptsache aus Amylose und Amylopektin besteht. Diese Stärke wird beispielsweise aus Kartoffeln, Reis, Tapioca, Mais, Roggen, Hafer, Weizen und anderen Pflanzen gewonnen. Ebenso ist unter diesem Begriff Stärke mit modifizierter physikalischer Struktur zu verstehen, wie gekochte Stärke und hoch-wasserlösliche Stärke. Solche Stärke oder ein Gemisch solcher Stärken lassen sich in der angegebenen Zusammensetzung unter Druck und erhöhter Temperatur zu kompakten Formkörpern verarbeiten. Chemically unmodified starch is understood to mean the naturally occurring vegetable carbohydrate, which mainly consists of amylose and amylopectin. This starch is obtained from potatoes, rice, tapioca, corn, rye, oats, wheat and other plants, for example. This term also means starch with a modified physical structure, such as cooked starch and highly water-soluble starch. Such starch or a mixture of such starches can be processed into compact moldings in the stated composition under pressure and elevated temperature.
Bevorzugt ist der Anteil an physikalisch veränderter Stärke an der natürlichen Stärke nicht höher als 50%, vorzugsweise nicht höher als 20%. Bevorzugt ist die natürliche Stärke. The proportion of physically modified starch in natural starch is preferably not higher than 50%, preferably not higher than 20%. Natural starch is preferred.
Die Stärke (a) ist in der Basiszusammensetzung vorzugsweise in einer Menge von 72-89,58 Teilen, vorzugsweise 75-85 Teilen und vorzugsweise etwa 79-83 Teilen vorhanden, bezogen auf 100 Teile dieser Zusammensetzung. The starch (a) is preferably present in the base composition in an amount of 72-89.58 parts, preferably 75-85 parts and preferably about 79-83 parts, based on 100 parts of this composition.
Die Stärke hat vorzugsweise einen Gehalt an Amylose von 0-70% und Amylopektin von 100-30%. Bevorzugt ist Kartoffelstärke. The starch preferably has an amylose content of 0-70% and amylopectin of 100-30%. Potato starch is preferred.
Als Viskositätsverminderer (b) sind beispielsweise tierische und pflanzliche Fette einzeln oder im Gemisch, insbesondere solche hydrierte Fette geeignet, vorzugsweise solche die bei Raumtemperatur fest sind. Vorzugsweise haben diese einen Schmelzpunkt von über 50° C. Diese Fette sind in der Regel Tryglyceride mit einem Anteil von CI4-, CI6- und C18-Säuren, beispielsweise Ci8 (etwa 65%), C16 (etwa 30%), C14 (etwa 5%). Suitable viscosity reducers (b) are, for example, animal and vegetable fats, individually or in a mixture, in particular hydrogenated fats, preferably those which are solid at room temperature. These preferably have a melting point of above 50 ° C. These fats are generally tryglycerides with a proportion of CI4, CI6 and C18 acids, for example Ci8 (approximately 65%), C16 (approximately 30%), C14 (approximately 5%).
Die angewandte Menge ist vorzugsweise 0-5 Teile, vorzugsweise 0-3 Teile, vorzugsweise 0,8-1,2 Teile bezogen auf 100 Teile der Basiszusammensetzung. The amount used is preferably 0-5 parts, preferably 0-3 parts, preferably 0.8-1.2 parts based on 100 parts of the base composition.
Diese Viskositätsverminderer wirken gleichzeitig als Weichmacher, Schmiermittel und Formtrennmittel, so dass sich die Zugabe solcher spezieller Mittel erübrigt. These viscosity reducers also act as plasticizers, lubricants and mold release agents, so that the addition of such special agents is unnecessary.
Als Dissolutionsbeschleuniger (c) bevorzugt sind feste Mono-und Diglyceride, vorzugsweise langkettiger Säuren vorzugsweise von C14-, Ci6-, Cis-Fettsäuren, und Phosphatide, insbesondere Lecithin. Bevorzugte Zugaben sind 0-5 Teile, vorzugsweise 0,1-2 Teile, vorzugsweise 0,2-1 Teil, solcher einzelner Verbindungen oder ein Gemisch solcher Verbindungen bezogen auf 100 Teile der Basiszusammensetzung. Solid mono- and diglycerides, preferably long-chain acids, preferably of C14-, Ci6-, cis-fatty acids, and phosphatides, in particular lecithin, are preferred as dissolution accelerators (c). Preferred additions are 0-5 parts, preferably 0.1-2 parts, preferably 0.2-1 part, of such individual compounds or a mixture of such compounds based on 100 parts of the base composition.
Die Summe der Komponenten (b) und (c) beträgt immer mindestens 0,4 Teile und vorzugsweise 1-2,2 Teile bezogen auf 100 Teile der Basiszusammensetzung. The sum of components (b) and (c) is always at least 0.4 part and preferably 1-2.2 parts based on 100 parts of the base composition.
Das Texturierungsmittel (d) ist Utandioxid oder Siliziumoxid oder ein Gemisch dieser Verbindungen. Es wurde gefunden, dass solche Verbindungen ein freies Fliessen des Ausgangsmaterials als Pulver bei Raumtemperatur gewährleisten und im weiteren während des Verarbeitungsprozesses verhindern, dass sich im Trichter und an der Schnecke Brücken bilden, die das Einziehen des Ausgangsmaterials auf die Schnecke behindern. Durch die Zugabe dieser Verbindungen wird erreicht, dass die Dosierung von Zyklus zu Zyklus konstant gleichmässig und gleich schnell erfolgt. The texturing agent (d) is utan dioxide or silicon oxide or a mixture of these compounds. It has been found that such compounds ensure that the starting material flows freely as a powder at room temperature and further prevent bridges which prevent the starting material from being drawn onto the screw during the processing process in the funnel and on the screw. The addition of these compounds ensures that the dosage from cycle to cycle is constant and constant.
Es ist somit nicht nötig, das Ausgangsmaterial zu granulieren oder sonstwie vorzubehandeln. It is therefore not necessary to granulate or otherwise pretreat the starting material.
Die Menge des Texturierungsmittels ist vorzugsweise 0,02-1 Teile, bezogen auf 100 Teile der Basiszusammensetzung. Für Titandioxid liegt die optimale Zugabemenge bei etwa 0,25 Teilen und für Siliziumoxid bei etwa 0,1 Teilen (bezogen auf 100 Teile der Basiszusammensetzung) je nach Basiszusammensetzung. Natürlich kann auch mehr Titanoxid oder Siliziumoxid zugegeben werden. Allerdings wirkt der Überschuss dann nur als Füllmittel und kann auch die Eigenschaften des Produktes negativ beeinflussen. The amount of the texturing agent is preferably 0.02-1 part based on 100 parts of the base composition. The optimum addition amount for titanium dioxide is about 0.25 part and for silicon oxide about 0.1 part (based on 100 parts of the base composition) depending on the base composition. Of course, more titanium oxide or silicon oxide can also be added. However, the excess then only acts as a filler and can also negatively affect the properties of the product.
Das Wasser (e) ist anwesend in einer Menge von 10-22 Teilen, vorzugsweise 10-20 Teilen, vorzugsweise 15-19 Teilen bezogen auf 100 Teile der Basiszusammensetzung, dabei insbesondere für dünnwandige Gegenstände die bevorzugten Bereiche gelten. The water (s) is present in an amount of 10-22 parts, preferably 10-20 parts, preferably 15-19 parts, based on 100 parts of the base composition, the preferred ranges especially for thin-walled objects.
Die Verfahrensbedingungen sind abhängig vor allem von der The process conditions depend primarily on the
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669 201 669 201
4 4th
verwendeten Stärke, der Komponenten (b) bis (e) und der gegebenenfalls zusätzlich anwesenden weiter unten genannten Additive. starch used, components (b) to (e) and any additives additionally mentioned below.
Je höher der Wassergehalt umso niedriger können die Temperaturen und Drucke im Spritzgussverfahren gewählt werden. Je niedriger der Wassergehalt umso höher sind die zu wählenden Drucke und Temperaturen. Die Wahl der geeigneten Drucke und Temperaturen ist einfach und kann von jedem Fachmann ohne weiteres durchgeführt werden. Die Drucke liegen für dickwandige Gegenstände im Bereich von 300 x 105 N/m2 bis 3000 x 105 N/m2 und für dünnwandige etwa im Bereich 600 x 105 N/m2 bis 3000 x 105 N/m2 vorzugsweise 900 x 105—15Ö0 x 105 N/m2. Die Arbeitstemperaturen liegen vorwiegend im Bereich von 80-240°C, vorzugsweise bei 130-210°C und insbesondere bei 150-190° C. The higher the water content, the lower the temperatures and pressures can be selected in the injection molding process. The lower the water content, the higher the pressures and temperatures to be selected. The selection of the suitable pressures and temperatures is simple and can be carried out easily by any person skilled in the art. For thick-walled objects, the prints are preferably in the range from 300 x 105 N / m2 to 3000 x 105 N / m2 and for thin-walled objects in the range from 600 x 105 N / m2 to 3000 x 105 N / m2 preferably 900 x 105-1510 x 105 N / m2. The working temperatures are mainly in the range of 80-240 ° C, preferably 130-210 ° C and especially 150-190 ° C.
An sich bekannte Apparate, wie z.B. Spritzgussmaschinen, können verwendet werden. Apparatus known per se, e.g. Injection molding machines can be used.
Bezogen auf den gleichen Wassergehalt lässt sich Kartoffelstärke leichter, d.h. bei niedrigeren Druck- und Temperaturbedingungen verarbeiten als Weizenstärke. Der Schwierigkeitsgrad wächst in der Reihenfolge Kartoffelstärke, Weizenstärke, Maisstärke, Reisstärke. Bevorzugt ist Kartoffelstärke und Weizenstärke, insbesondere Kartoffelstärke. In relation to the same water content, potato starch is easier, i.e. Process at lower pressure and temperature conditions than wheat starch. The level of difficulty increases in the order of potato starch, wheat starch, corn starch, rice starch. Potato starch and wheat starch, in particular potato starch, are preferred.
Die oben genannte Stärke kann ganz oder teilweise ersetzt sein durch wasserlösliche Derivate der Cellulose, wie z.B. Hydroxyäthylcellulose, Hydroxypropylcellulose, Hydroxypropyl-methylcellulose; durch andere wasserlösliche Carbohydrate, wie z.B. Agar-Agar; tierische Proteine, wie z.B. Gelatine; pflanzliche Proteine wie Sonnenblumen-, Baumwollsamen-, Erdnuss-, Rapssamenproteine; Blutproteine, Eiproteine; acylierte Derivate der vorgenannten Proteine; im weiteren auch durch Alginate; Lactose; Gummi Arabicum; wasserlösliche synthetische Polymere wie an sich bekannte anionische oder kationische Polyaciylate; Polyvi-nylpyrrolidone und/oder Vmylacetat. The above-mentioned starch can be replaced in whole or in part by water-soluble derivatives of cellulose, e.g. Hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose; by other water-soluble carbohydrates, e.g. Agar Agar; animal proteins such as Gelatin; vegetable proteins such as sunflower, cottonseed, peanut, rapeseed proteins; Blood proteins, egg proteins; acylated derivatives of the aforementioned proteins; furthermore also by alginates; Lactose; Gum arabic; water-soluble synthetic polymers such as anionic or cationic polyacylates known per se; Polyvinyl pyrrolidones and / or vinyl acetate.
Im weiteren kann die Stärke auch ganz oder teilweise ersetzt sein durch Verbindungen mit enterischen Eigenschaften d.h. solche Polymere, die sich in wässrigen Medien mit leicht basischem pH-Wert auflösen, wie z.B. Hydroxypropylmethylcellulosephtha-lat (HMPCP), Polyvinylacetatphthalat (PVAP), Celluloseace-tylphthalat (CAP), kationisch modifizierte Aciylate und Methaciy-late z.B. mit einer tertiären oder quaternären Aminogruppe, wie die gegebenenfalls quarternierte Diäthylaminoäthylgruppierung; Gelatine-phthalate und/oder Gelatine-succinate. Bevorzugt ist Gelatine. Furthermore, the starch can also be completely or partially replaced by compounds with enteric properties, i.e. such polymers that dissolve in aqueous media with a slightly basic pH, e.g. Hydroxypropylmethylcellulose phthalate (HMPCP), polyvinyl acetate phthalate (PVAP), cellulose peace tylphthalate (CAP), cationically modified acylates and methacrylate e.g. with a tertiary or quaternary amino group, such as the optionally quaternized diethylaminoethyl group; Gelatin phthalates and / or gelatin succinate. Gelatin is preferred.
Vorzugsweise ist die Stärke zu höchstens 20% durch ein oder ein Gemisch dieser genannten wasserlöslichen Derivate und/oder Verbindungen mit enterischen Eigenschaften ersetzt, vorzugsweise durch nicht mehr als etwa durch 3-10%. The starch is preferably replaced by at most 20% by one or a mixture of these water-soluble derivatives and / or compounds having enteric properties, preferably by not more than about 3-10%.
Der oben erwähnten Basiszusammensetzung können zusätzlich auch Weichmacher zugesetzt werden in einer Menge von vorzugsweise 0,5-10 Teilen, insbesondere 0,5-5 Teile, bezogen auf die angegebenen 100 Teile. Dabei müssen die Ausgangsmateria-5 lien mit allenfalls flüssigen Zusätzen solange gemischt werden, bis diese vollständig absorbiert sind und eine feste rieselfahige Mischung entsteht. Ein Überschuss bzw. ein Zusammenkleben der einzelnen Gemischkörner muss vermieden werden. Solche Weichmacher sind beispielsweise Polyalkylenoxide, wie Polyäthy-io lenglykole, Polypropylenglykole, Polyäthylen-propylenglykole; niedrigmolekulare organische Weichmacher wie Glycerin, Glyce-rinmono-, -di- und -triacetat; Propylenglykol, Sorbitol, Natrium-diäthylsulfosuccinat, Triäthylcitrat, Tributylcitrat. Plasticizers can also be added to the above-mentioned base composition in an amount of preferably 0.5-10 parts, in particular 0.5-5 parts, based on the 100 parts indicated. The starting materials must be mixed with any liquid additives until they are completely absorbed and a solid, free-flowing mixture is formed. Excess or sticking together of the individual mixture grains must be avoided. Such plasticizers are, for example, polyalkylene oxides, such as polyethylene glycols, polypropylene glycols, polyethylene propylene glycols; low molecular weight organic plasticizers such as glycerin, glycerol mono-, di- and triacetate; Propylene glycol, sorbitol, sodium diethyl sulfosuccinate, triethyl citrate, tributyl citrate.
Die Summe der Gewichtsteile von Wasser und Weichmacher 15 soll vorzugsweise die angegebenen Maximalgehalte für Wasser nicht übersteigen. Bevorzugt beträgt also die Summe von Wasser und Weichmacher 10-22, vorzugsweise 10-20 und vorzugsweise 15-19 Teile bezogen auf 100 Teile der Basiszusammensetzung. The sum of the parts by weight of water and plasticizer 15 should preferably not exceed the stated maximum water contents. The sum of water and plasticizer is therefore preferably 10-22, preferably 10-20 and preferably 15-19 parts, based on 100 parts of the base composition.
Die Mischung kann auch gefärbt sein. Geeignete Farbstoffe 20 sind beispielsweise bekannte AzofarbstofFe oder organische oder anorganische Pigmente, oder natürlich vorkommende Farbstoffe. Bevorzugt sind anorganische Pigmente, wie die an sich bekannten Oxide des Eisens oder des Titans in einer Konzentration von 0,001-10%, vorzugsweise 0,5-5%, bezogen auf das Gewicht aller 25 die Behälterwand bildenden Komponenten. The mixture can also be colored. Suitable dyes 20 are, for example, known azo dyes or organic or inorganic pigments, or naturally occurring dyes. Inorganic pigments, such as the oxides of iron or titanium known per se, are preferred in a concentration of 0.001-10%, preferably 0.5-5%, based on the weight of all 25 components forming the container wall.
Die folgenden Beispiele erläutern die Erfindung: The following examples illustrate the invention:
Beispiel 1 example 1
Eine Zusammensetzung bestehend aus 81 Teilen natürlicher 3o Kartoffelstärke, einem Teil des hydrierten Triglycerides enthaltend die Fettsäuren C^Q^C^ im Verhältnis von 65:31:4 Gewichtsprozent, 0,7 Teile Lecithin, 0,3 Teile Titandioxid und 17 Teile Wasser wird in einem Pulververmischer während 10 Minuten gemischt. Man erhält danach ein frei fliessendes Pulver. Dieses 35 Pulver wird in den Trichter einer Spritzgussmaschine gefüllt und bei einer Temperatur von 180°C und einem Druck von 1500 bar in ein Spritzgusswerkzeug für Kapselhaupt- und Verschlussteile, dessen Formwandtemperatur bei 40° C liegt, gespritzt. Nach dem Abkühlen und Entformen erhält man einen formstabilen Kapsel-40 haupt- oder Verschlussteil, der sich ohne weiteres auf einer Abfüllmaschine verarbeiten lässt. A composition consisting of 81 parts of natural 3o potato starch, part of the hydrogenated triglyceride containing the fatty acids C ^ Q ^ C ^ in a ratio of 65: 31: 4 percent by weight, 0.7 parts of lecithin, 0.3 parts of titanium dioxide and 17 parts of water mixed in a powder mixer for 10 minutes. A free-flowing powder is then obtained. This 35 powder is filled into the hopper of an injection molding machine and injected at a temperature of 180 ° C and a pressure of 1500 bar into an injection molding tool for capsule main and closure parts, the mold wall temperature of which is 40 ° C. After cooling and demolding, a dimensionally stable capsule-40 main or closure part is obtained, which can be easily processed on a filling machine.
Mit dieser Mischung lässt sich die Spritzgussmaschine ohne weiteres im 24-Stunden-Betrieb fahren, ohne dass Unterbrüche an der Maschine oder Fehler an den Kapselteilen feststellbar sind. With this mixture, the injection molding machine can easily be operated in 24-hour operation without interruptions on the machine or errors in the capsule parts being detectable.
Analoge Resultate erhält man bei der Verwendung der folgenden Zusammensetzungen gemäss Tabelle 1 : Analogous results are obtained when using the following compositions according to Table 1:
45 45
669 201 669 201
Tabelle 1 Table 1
Nr. No.
Stärke Strength
Komponente b) Component b)
Komponente c) Component c)
Komponente d) Component d)
Wasser Andere Water other
Art Art
% %
Art Art
% Art % Art
% %
Art Art
% %
% %
Art Art
% %
1 1
Kartoffel potato
75,00 75.00
hydriertes Pflanzenfett hydrogenated vegetable fat
1,25 Lecithin 1.25 lecithin
1,5 1.5
TI02 TI02
0,25 0.25
22,0 22.0
- -
- -
2 2nd
Kartoffel potato
80,00 80.00
hydriertes Pflanzenfett hydrogenated vegetable fat
1,0 Lecithin 1.0 lecithin
0,9 0.9
Ti02 Ti02
0,1 0.1
18,0 18.0
— -
— -
3 3rd
Kartoffel potato
88,6 88.6
hydriertes Pflanzenfett hydrogenated vegetable fat
0,8 Lecithin 0.8 lecithin
0,5 0.5
Si02 Si02
0,1 0.1
10,0 10.0
— -
— -
4 4th
Weizen wheat
78,0 78.0
hydriertes Pflanzenfett hydrogenated vegetable fat
- Monoglycerid, C18 - monoglyceride, C18
5,0 5.0
SÌO2 SÌO2
3,04 3.04
19,0 19.0
Farbstoff dye
0,96 0.96
5 5
Weizen wheat
79,0 79.0
hydriertes Pflanzenfett hydrogenated vegetable fat
2,05 - 2.05 -
— -
Ti02/Si02 1:1 Ti02 / Si02 1: 1
0,95 0.95
18,0 18.0
— -
— -
6 6
Weizen wheat
85,0 85.0
hydriertes Tierfett hydrogenated animal fat
2,8 - 2.8 -
- -
T1O2 T1O2
0,20 0.20
12,0 12.0
- -
- -
7 7
Mais Corn
75,0 75.0
hydriertes Herfett hydrogenated fats
4,80 Monoglycerid, C]g 4.80 monoglyceride, C] g
0,2 0.2
Ti02 Ti02
0,15 0.15
17,0 17.0
gekochte Stärke cooked starch
2,85 2.85
8 8th
Mais Corn
78,0 78.0
hydriertes Tierfett hydrogenated animal fat
3,0 Monoglycerid, Q8 3.0 monoglyceride, Q8
1,0 1.0
Ti02 Ti02
0,05 0.05
14,0 14.0
gekochte Stärke cooked starch
3,95 3.95
9 9
Reis rice
79,0 79.0
- -
- Monoglycerid, Q8 - monoglyceride, Q8
2,0 2.0
Si02 Si02
1,0 1.0
17,5 17.5
Farbstoff dye
0,5 0.5
10 10th
Reis rice
80,25 80.25
hydriertes Tierfett hydrogenated animal fat
0,9 Diglyceride CI8, CI6 0.9 diglycerides CI8, CI6
0,6 0.6
Si02 Si02
0,25 0.25
15,0 15.0
Glycerin Glycerin
3 3rd
11 11
Tapioca Tapioca
75,2 75.2
hydriertes Tierfett hydrogenated animal fat
0,9 Diglyceride C18 C16 0.9 diglycerides C18 C16
0,6 0.6
Si02 Si02
0,3 0.3
21,0 21.0
HMPCP HMPCP
2 2nd
12 12
Kartoffel potato
73,96 73.96
hydriertes Tierfett hydrogenated animal fat
2,0 Diglyceride Ci8, Ci6 2.0 diglycerides Ci8, Ci6
2,0 2.0
SiOz SiOz
0,04 0.04
17,0 17.0
PEG 1000 PEG 1000
5 5
13 13
Kartoffel potato
75,25 75.25
hydriertes Tierfett hydrogenated animal fat
1,5 Diglyceride Q8, Ci6 1.5 diglycerides Q8, Ci6
1,0 1.0
TI02 TI02
0,25 0.25
18,0 18.0
PEG 4000 PEG 4000
4 4th
14 14
Kartoffel potato
75,25 75.25
Pflanzenfett Vegetable fat
1,5 Lecithin 1.5 lecithin
1,0 1.0
Ti02 Ti02
0,25 0.25
18,0 18.0
Sorbitol Sorbitol
4 4th
15 15
Weizen wheat
60,00 60.00
Pflanzenfett Vegetable fat
1,5 Lecithin. 1.5 lecithin.
1,2 1.2
TiQ2 TiQ2
0,25 0.25
17,0 17.0
Polyaayl-säure Polyaylic acid
20,05 20.05
G G
Claims (19)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1926/86A CH669201A5 (en) | 1986-05-05 | 1986-05-05 | AT ROOM TEMPERATURES FIXED AND FREE-FLOWING BASIC COMPOSITION FOR PRINTING. |
| DE3712029A DE3712029C2 (en) | 1986-05-05 | 1987-04-09 | Compression molded bodies |
| FR878705189A FR2598148B1 (en) | 1986-05-05 | 1987-04-13 | STARCH-BASED FORMULATIONS. |
| BE8700407A BE1000461A3 (en) | 1986-05-05 | 1987-04-15 | Formulations starch. |
| IT47862/87A IT1205824B (en) | 1986-05-05 | 1987-04-16 | FORMULATION BASED ON STARCH, SUITABLE FOR TREATMENT UNDER PRESSURE |
| JP62106517A JPH07711B2 (en) | 1986-05-05 | 1987-05-01 | Starch-based compound |
| GB8710422A GB2190093B (en) | 1986-05-05 | 1987-05-01 | A starch based formulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1926/86A CH669201A5 (en) | 1986-05-05 | 1986-05-05 | AT ROOM TEMPERATURES FIXED AND FREE-FLOWING BASIC COMPOSITION FOR PRINTING. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH669201A5 true CH669201A5 (en) | 1989-02-28 |
Family
ID=4221825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1926/86A CH669201A5 (en) | 1986-05-05 | 1986-05-05 | AT ROOM TEMPERATURES FIXED AND FREE-FLOWING BASIC COMPOSITION FOR PRINTING. |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPH07711B2 (en) |
| BE (1) | BE1000461A3 (en) |
| CH (1) | CH669201A5 (en) |
| DE (1) | DE3712029C2 (en) |
| FR (1) | FR2598148B1 (en) |
| GB (1) | GB2190093B (en) |
| IT (1) | IT1205824B (en) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2205323B (en) * | 1987-03-09 | 1991-01-30 | Warner Lambert Co | Destructurized starch and process for making same |
| GB2208651B (en) * | 1987-08-18 | 1991-05-08 | Warner Lambert Co | Shaped articles made from pre-processed starch |
| JPH0718474B2 (en) * | 1987-12-25 | 1995-03-06 | 日産自動車株式会社 | Transmission belt |
| GB2214918B (en) † | 1988-02-03 | 1992-10-07 | Warner Lambert Co | Polymeric materials made from starch and at least one synthetic thermoplastic polymeric material |
| US5095054A (en) * | 1988-02-03 | 1992-03-10 | Warner-Lambert Company | Polymer compositions containing destructurized starch |
| BE1002635A6 (en) * | 1988-12-09 | 1991-04-16 | Amylum Nv | METHOD FOR MANUFACTURING A mixture of starch and polyvinyl alcohol AND THUS MANUFACTURED MIXTURE. |
| US5043196A (en) * | 1989-05-17 | 1991-08-27 | National Starch And Chemical Investment Holding Corporation | Biodegradable shaped products and the method of preparation thereof |
| US5035930A (en) * | 1988-12-30 | 1991-07-30 | National Starch And Chemical Investment Holding Corporation | Biodegradable shaped products and the method of preparation thereof |
| IL93620A0 (en) * | 1989-03-09 | 1990-12-23 | Butterfly Srl | Biodegradable articles based on starch and process for producing them |
| IT1233599B (en) * | 1989-05-30 | 1992-04-06 | Butterfly Srl | POLYMERIC COMPOSITIONS FOR THE PRODUCTION OF BIODEGRADABLE PLASTIC ITEMS AND PROCEDURES FOR THEIR PREPARATION |
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| US5409973A (en) * | 1989-08-07 | 1995-04-25 | Butterfly S.R.L. | Polymer composition including destructured starch and an ethylene copolymer |
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| IT1242722B (en) * | 1990-08-09 | 1994-05-17 | Butterfly Srl | LAYERED STARCH FILM AND LOW PERMEABILITY AND PROCEDURE FOR ITS PRODUCTION. |
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| NL9100590A (en) * | 1991-04-05 | 1992-11-02 | Limburg Prod Centrale | METHOD FOR MANUFACTURING AN ENVIRONMENTALLY FRIENDLY PACKAGING |
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| US5412005A (en) * | 1991-05-03 | 1995-05-02 | Novamont S.P.A. | Biodegradable polymeric compositions based on starch and thermoplastic polymers |
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| JP4064476B2 (en) * | 1996-03-29 | 2008-03-19 | エラワン ファーマスーティカル リサーチ アンドラボラトリー カンパニー リミテッド | Spherical agglomerated starch with silicon dioxide |
| US6159516A (en) * | 1999-01-08 | 2000-12-12 | Tfh Publication, Inc. | Method of molding edible starch |
| US6210709B1 (en) * | 1999-03-24 | 2001-04-03 | Elementis Specialties, Inc. | Flexible gelatin free encapsulation material useful for pharmaceuticals, paint balls and other formulations |
| ATE291420T1 (en) * | 1999-11-19 | 2005-04-15 | Swiss Caps Rechte & Lizenzen | METHOD FOR PRODUCING A MOLDED BODY CONTAINING STARCH, HOMOGENIZED MASS CONTAINING STARCH AND DEVICE FOR PRODUCING A SOFT CAPSULE |
| EP1258242A1 (en) * | 2001-05-15 | 2002-11-20 | Swiss Caps Rechte und Lizenzen AG | Process of manufacturing shaped bodies, in particular soft capsules |
| TWI366442B (en) | 2003-07-30 | 2012-06-21 | Novartis Ag | Palatable ductile chewable veterinary composition |
| WO2006082842A1 (en) * | 2005-02-03 | 2006-08-10 | Qualicaps Co., Ltd. | Hard capsule having improved solubility |
| EP2115008B1 (en) | 2007-03-01 | 2019-09-18 | De Staat der Nederlanden, vert. door de Minister van Volksgezondheid, Welzijn en Sport, namens de Minister, Projectdirectie ALT, het INTRAVACC | Biodegradable material based on opened starch |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1605150A (en) * | 1968-12-31 | 1973-03-16 | ||
| GB1333966A (en) * | 1970-12-05 | 1973-10-17 | Hayashibara Co | Gelatin-containing shaped bodies |
| JPS5015494B1 (en) * | 1971-02-15 | 1975-06-05 | ||
| US4076846A (en) * | 1974-11-22 | 1978-02-28 | Sumitomo Bakelite Company Limited | Protein-starch binary molding composition and shaped articles obtained therefor |
| GB1592062A (en) * | 1977-02-18 | 1981-07-01 | Coloroll Ltd | Biodegradable composition |
| GB1600496A (en) * | 1977-09-16 | 1981-10-14 | Coloroll Ltd | Plasticsbased composition |
| GR78492B (en) * | 1982-03-26 | 1984-09-27 | Warner Lambert Co | |
| BG46154A3 (en) * | 1983-02-18 | 1989-10-16 | Warner-Lambert Company Llc | Method for preparing of capsules |
| US4576284A (en) * | 1983-12-02 | 1986-03-18 | Warner-Lambert Company | Closing of filled capsules |
| CH664938A5 (en) * | 1983-10-20 | 1988-04-15 | Warner Lambert Co | PRINTED ARTICLES. |
| CH661878A5 (en) * | 1983-11-04 | 1987-08-31 | Warner Lambert Co | CAPSULE DOSING FORMS. |
-
1986
- 1986-05-05 CH CH1926/86A patent/CH669201A5/en not_active IP Right Cessation
-
1987
- 1987-04-09 DE DE3712029A patent/DE3712029C2/en not_active Expired - Lifetime
- 1987-04-13 FR FR878705189A patent/FR2598148B1/en not_active Expired - Lifetime
- 1987-04-15 BE BE8700407A patent/BE1000461A3/en not_active IP Right Cessation
- 1987-04-16 IT IT47862/87A patent/IT1205824B/en active
- 1987-05-01 GB GB8710422A patent/GB2190093B/en not_active Expired - Lifetime
- 1987-05-01 JP JP62106517A patent/JPH07711B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2598148B1 (en) | 1991-10-31 |
| IT1205824B (en) | 1989-03-31 |
| FR2598148A1 (en) | 1987-11-06 |
| GB2190093B (en) | 1990-08-22 |
| DE3712029A1 (en) | 1987-11-12 |
| JPS6310644A (en) | 1988-01-18 |
| BE1000461A3 (en) | 1988-12-13 |
| IT8747862A0 (en) | 1987-04-16 |
| GB2190093A (en) | 1987-11-11 |
| GB8710422D0 (en) | 1987-06-03 |
| DE3712029C2 (en) | 1994-09-15 |
| JPH07711B2 (en) | 1995-01-11 |
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Legal Events
| Date | Code | Title | Description |
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| PL | Patent ceased |