CN85103166A - The shape of improved capsule - Google Patents
The shape of improved capsule Download PDFInfo
- Publication number
- CN85103166A CN85103166A CN85103166.8A CN85103166A CN85103166A CN 85103166 A CN85103166 A CN 85103166A CN 85103166 A CN85103166 A CN 85103166A CN 85103166 A CN85103166 A CN 85103166A
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- China
- Prior art keywords
- cap
- shell capsule
- hard
- capsule
- thrusts
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- 239000002775 capsule Substances 0.000 title claims description 52
- 239000007887 hard shell capsule Substances 0.000 claims abstract description 30
- 230000000694 effects Effects 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 229920000159 gelatin Polymers 0.000 claims description 12
- 235000019322 gelatine Nutrition 0.000 claims description 12
- 108010010803 Gelatin Proteins 0.000 claims description 11
- 239000008273 gelatin Substances 0.000 claims description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 9
- 239000006260 foam Substances 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000002537 cosmetic Substances 0.000 claims description 4
- 239000000975 dye Substances 0.000 claims description 4
- 239000003337 fertilizer Substances 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 4
- 235000013599 spices Nutrition 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 3
- 230000000295 complement effect Effects 0.000 claims description 3
- 239000008393 encapsulating agent Substances 0.000 claims description 3
- 238000005470 impregnation Methods 0.000 claims description 3
- 238000001746 injection moulding Methods 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 229920000881 Modified starch Polymers 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000013270 controlled release Methods 0.000 claims description 2
- 238000000354 decomposition reaction Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 235000019426 modified starch Nutrition 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 238000009792 diffusion process Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000008878 coupling Effects 0.000 abstract description 5
- 238000010168 coupling process Methods 0.000 abstract description 5
- 238000005859 coupling reaction Methods 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 2
- -1 seed Substances 0.000 description 2
- 0 C1C2=*C1*C2 Chemical compound C1C2=*C1*C2 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4883—Capsule finishing, e.g. dyeing, aromatising, polishing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
Abstract
Hard-shell capsule has columniform, but the coaxial cap of socket and body portion all have sidewall, open end and a closing end, cap is connected with the body coupling, a ring uplift thing is arranged on the inner wall surface of cap portion, or a kind of structure that plays the bulge effect arranged, and the open end from this bulge to cap portion, be furnished with every a determining deviation and make cap and body just in time be fixed on the device of coaxial position.
Description
The present invention is the relevant shape of improving capsule, particularly improves the shape of hard-shell capsule, but this hard-shell capsule have columniform socket, coaxial cap and housing parts to be to constitute the container of storage (as medicine) usefulness.
A kind of duricrust gelatine capsule of introducing in the US Patent 3508678 is to mate around the groove of housing and protuberance device that the cap inwall extends internally by one to contact and sealed.This capsule also has two meshing devices that separate to reach pre-locked state.
Though the quality of these capsules is fine, because the speed of high speed loading operation increases and press speed increases, can make capsule processing coarse, even closed fully capsule also can be thrown off phenomenon.The objective of the invention is to reduce the loss of capsule, when increasing operating speed, improve the safe reliability of charging, and make printing quality better.
(can reach the result that wants as the height that increases by two thrusts that exist in the capsule) is seemingly rational to increase friction force so that cap and body are fixed together, and still, has now found that this can reduce the quality of capsule.
Unexpected discovery: if the cap of capsule has a ring uplift thing or a kind of structure (being preferably the structure of a plurality of bulges) that plays the effect of ring uplift thing is arranged, and from this bulge, open end to cap portion, is furnished with anchor fitting every a determining deviation, so that cap and housing just in time are fixed on coaxial position, such capsule can satisfy these requirements.This means that two annulus that occur in the level cross-sectionn at cap and any height of housing lap place all have identical common center point, the situation that therefore departs from circle or ovalisation can reduce to minimum.Surprisingly: known capsule can not satisfy this condition, even when cap is connected with housing parts is coaxial, also can leave the space so that cap and housing move freely, thereby can not be in just in time coaxial position (shown in figure A-A).
Specifically, the present invention is relevant with hard-shell capsule, this hard-shell capsule is columniform, but the coaxial cap of socket and housing parts, cap and body all have a sidewall, an open end and a closing end, cap matches each other with body and is connected, it is characterized by: a ring uplift thing is arranged on the inner wall surface of cap portion or a kind of structure (being preferably the structure of uplift sector and/or thrust) that plays the effect of ring uplift thing is arranged, and to cap portion open end, being furnished with every a determining deviation is enough to make cap and body just in time to be fixed on the device of coaxial position from this bulge or this structure.
That the closing end of cap and body can be is hemispheric, conical, steeple shape, flat or other Any shape.Be preferably semisphere, particularly for the capsule of dip forming.The ring uplift thing of cap portion is preferably circumferential, and can be interruption.The structure that plays the bulge effect can be the uplift sector of many thrusts or some circumferential arrangement.If the cap long enough, then also have an additional ring uplift thing or play the structure of ring uplift thing effect in cap portion.
The cross-sectional plane of bulge can be annular arrangement or triangle or polygon, yet, the shape of bulge cross-sectional plane there are not strict regulations, its shape depends on the manufacture method of cap portion.
The device that makes cap and housing just in time be fixed on coaxial position should not be close to above-mentioned ring uplift thing, and at interval sufficiently long distance so that this anchor fitting really shows its effect.This anchor fitting can be a ring uplift thing, and the structure of a kind of a plurality of bulges and/or a plurality of thrusts is so that cap and housing just in time are fixed on coaxial position.
Proved that best structure is the structure of many thrusts, these thrusts are arranged with form of annular rings, preferably arrange with symmetric form, and adjacent thrust distance to each other preferably all equates.This structure is minimum to be two thrusts, is preferably three thrusts, so that the mobile of cap and body (not at coaxial position) reduces to minimum.
The height of selected thrust so that the open end of the open end of cap portion and body link together; These thrusts contact with the lateral wall of body, produce a very little pressure at contact point.Preferably arrange 3-10 in cap portion) 4,5,6,7,8,9, or 10) individual thrust, it is better to arrange 6,7,8,9 or 10 thrusts, and it is best to arrange 6 or 8 thrusts.These thrusts can have different shape (with regard to cross-sectional plane, diameter, height etc.), and these shapes are known.Preferably the shape of these thrusts is all identical, particularly highly equal.Also can use a ring uplift thing, this ring uplift thing can be selected form of discontinuity.
Above-mentioned ring uplift thing and make cap and distance that body just in time is fixed between the device of coaxial position is important, the ring uplift thing preferably is positioned at the top of cap, near the closing end of cap, the device that makes cap and body just in time be fixed on coaxial position is not answered near the bulge the adjacent cap closing end.Certainly, the actual length of this distance depends on the cap portion size of capsule.
Ring uplift thing or the structure that plays the bulge effect preferably are positioned at the top of cap, near the closing end of cap, being positioned at the long 50%(of cap calculates by the length overall of cap) locate better, preferably be positioned at the long 33%-45%(of cap and calculate by the length overall of cap), near the closing end place of cap.
The device that makes cap and body just in time be fixed on coaxial position preferably is positioned at the long 50%-95% place of cap (count from the top of cap until cap open end), be positioned at (the 55%-80% place especially, 50%-85% place of cap length overall, count open end by the closing end top of cap until cap) better, the 65%-75%(that preferably is positioned at the cap length overall is counted by the closing end top of cap, until the open end of cap).For two thrusts, its position is preferably in the long scope of above-mentioned 65%-75% cap.
Top bulge and make cap and body just in time is fixed on distance between the device of coaxial position more preferably greater than 2 millimeters, better greater than 2.5 millimeters.This distance is irrelevant with the size of capsule, is specially adapted to be of a size of 000,00,0,1,2,3,4,5 known capsule.The length of cap is long more, and above-mentioned bulge and the distance between anchor fitting are also long more, are preferably the 3-5 millimeter, for long cap, also can be greater than 5 millimeters, and this depends on the length of cap.
If cap portion long enough, for example, if the major part or the whole length of housing of cylindrical sidewall are all surrounded by cap, this device that then makes cap and body just in time be fixed on coaxial position also can have more than two.Two bulges and/or two anchor fittings can be close to each other, but preferably are positioned at the limit of afore mentioned rules.
Body can be smooth, that is to say, does not have bulge or groove.But annular groove is preferably arranged on the outside face of body or have with the cap inside face on the groove structure of protuberance device coupling so that there be not being locked together in together fully of being out of shape between cap and the body in fact.If will make capsule sealed in advance, these thrusts groove arrangement best and body is mated, and the professional and technical personnel can easily select its size.
Ring uplift thing and groove be discontinuous preferably, and like this, when cap was connected with body, the space between the uplift sector can be used as exhausr port, makes the air exhaustion in the capsule.
Necking down or this bulge that this ring uplift thing of cap portion is equivalent to cap have two inclined-planes (plane also can be arranged in the middle of it).The angle on this inclined-plane and necking down size all do not have strict regulations, are only limited by manufacture method.But, in infusion process moulding commonly used, should avoid taking place the phenomenon of holding back of air owing to this angle, this is well-known to those skilled in the art.
As mentioned above, the size of these thrusts preferably equates.Known dissimilar thrusts all are suitable for.The bottom of thrust can be ellipse, circle or rectangle.The cross-sectional plane of this thrust can be circle or triangle or polygon, if any two inclined-planes, a plane can be arranged also in the middle of it.The angle on inclined-plane does not have strict regulations, is only limited by manufacture method.
More particularly, capsule bodies of the present invention, its open end, outer diameter is littler than the outer diameter of remainder, can make the open end of capsule body and capsule cap reduce difficulty like this when socket.The size of this necking down does not have strict regulations yet.As if capsule body is to make with the dip forming method, then wide 10-20 times of being about its degree of depth of the axle of best depression.Preferably the necking down of capsule body is complementary with the closing end of cap or the necking down of cap, so that reach automatic seal during the capsule closure.
More particularly, characteristics of the present invention are: the housing closing end has hemispheric, cylindrical-conical, steeple shape an or flat outside face, and when the cap of capsule was connected with body, its cylindrical sidewall wrapped in the inwall of cap fully.Best, the cylindrical outer side wall of housing is almost completely cladded by the inner cylindrical sidewall of cap.Can prevent that like this capsule that has engaged from separating, and can prevent that capsule from damaging.
Capsule of the present invention can be made (this method for making itself is known) by gelatin with impregnation forming method.Also available injection moulding method is by hydrophilic substance, makes (having done introduction in european patent application 83301642.1 and 89300940.8) as gelatin or starch derivative or its compound or by native starch.The most handy impregnation forming method of capsule of the present invention is made by gelatin or is made by gelatin or starch with injection moulding method.
Capsule of the present invention with gelatin or contain the capsule that the material of gelatin is made, if when sealing with liquid seal method, also can obtain fabulous result by the present invention except that having above-mentioned advantage.A kind of aquaseal of this fluid-tight process using, sealing agent preferably contain the water of 5-95% and the alcohol of 95%-5% (be preferably ethanol, such as in US Patent 3073087 or the european patent application 83305330.9 introduction).Can at room temperature seal, carry out but be preferably under the 40-80 ℃ of temperature, use hot air, infrared ray or other method of heating heat, and the most handy hot air or infrared ray heating were sealed in 1-5 minute at short notice.Owing to adopt the sealing step, but prepared capsule anti-tamper or waterproof.If closure temperature is 40-60 ℃, the ratio of alcohol and water be 40: 60 up to about 95: 5, the capsule water-proofness that makes is fabulous.Used alcohol is ethanol preferably, the compound of the ethanol/water of the most handy 75-95% ethanol, and preferably temperature is 40-60 ℃, the present invention also relates to use the sealing technology of these conditions, and has utilized this method leak free capsule.
More particularly, in the cap of these capsules of the present invention and the wall of body foam is arranged, this foam produces in the dip forming process, also the film forming compound that can be obtained by the gas (as air) that is finely dispersed in the gelatin solution and producing.This class capsule has tangible advantage, as european patent application 83304741, and 8(publication number 110502) described.
Fig. 1 a, 1b and 1c are the lateral plans of given shape capsule.
Fig. 2 is that capsule is complete when sealed, the lateral sectional view of locked portions (doing along the 2-2 axle of Fig. 1 a).
Fig. 3 is and the corresponding pre-sealed form of Fig. 2 capsule.
Fig. 4 is the lateral sectional view that open end has the body of necking down.
Fig. 5 is the lateral plan of another kind of capsule of the present invention, and wherein, cap portion clads the cylindrical wall of body fully, and body has a spherical end.
Fig. 6 is the lateral sectional view of Fig. 5.
Fig. 7 is the lateral plan with Fig. 5 and corresponding Fig. 6 different have a kind of capsule of the present invention of two loop systems.
Fig. 8 is the lateral sectional view of Fig. 7.
Fig. 9 is the lateral plan of the another kind of capsule of similar Fig. 5, and air vents is arranged, 6 thrusts, and body has one " putting down " end.
Figure 10 is the lateral sectional view of Fig. 9.
Figure 11 is the lateral plan of another kind of capsule of the present invention.
Figure 12 is the lateral sectional view of Figure 11.
Closing end 13 preferably circular or hemispheric, still, this shape does not have strict regulations.If need, the top of cap can be other shape, and the inwall 16 of cap is the shoulder line from open end 18 until this line of line 23(), except that bulge 19 and female means 24, its diameter phases down according to the rule of 0.01 centimetre of every centimetre of reduction.
Fig. 2 represents that cap and body are in sealed state fully, and Fig. 3 represents that cap and body are in the closed or pre-locked state of part.The open end of body is in the place ahead of the front bevel 20 of bulge 19.The groove 19a of body and bulge 19 couplings.Groove 19a has front bevel 20a and back bevel 21a, and both intersect near 22a.Among Fig. 2, such just as has been noted, cap and body are pressed together, can become complete closure, sealed state from closed pre-sealed or half locked state of part.At this moment, the necking down of body open end and cap coupling is to reach automatic seal.Bulge 19 and body groove 19a coupling is connected airtight or is connected airtight automatically when locked state, and these are different with frictional fit.But their corresponding inclined-planes are identical with the summit when closure.When sealed, the open end of body has entered in the cap and has takeed near the line 23, or has preferably just exceeded shoulder line 23.Body is the same with cap portion, and to the closing end direction, diameter phases down from open end, and the undergauge degree is identical.When pre-locked state (as shown in Figure 3), body dwindle gradually with the size of body with respect to cap portion dwindle size with cap portion gradually, both are reached does not have distortion and fits.Applying between cap and the body adjacent wall surface is convenient to air and is passed through.Pre-sealed applying at groove 24 places is preferably fitted (different with friction fit) automatically, therefore comes down to indeformable.
This structure has increased air passage or deflation hole 25, therefore can get rid of the pressurized air that is included in the capsule, for example, deflates when making body and cap portion be bonded into locked state suddenly, in order to avoid owing to air discharges cap and body are thrown off again after charging.
Capsule of the present invention can be used as the container of the following accurate dosing of encapsulation, such as food, medicine, chemicals, dyestuff, spices, fertilizer, seed, cosmetics and agricultural product with the matrix of food, medicine, chemicals, dyestuff, spices, fertilizer, seed, cosmetics and the agricultural product of useful form such as powdery or the various shapes of aqueous formation and size; The content of particular form is separated out from base-material as being finely dispersed in to reach by decomposition and/or separation and/or biological corrosion in the base-material and/or spread, thereby obtain the controlled release system of encapsulant and department of medicine and surgery medicine, and generate each component of encapsulant or its foam and also can pack in the capsule of the present invention.
Claims (26)
1, a kind of have columniform, but the coaxial cap of socket and body portion, cap and body portion all have a sidewall, an open end and a closing end, cap and the body bonded assembly hard-shell capsule that matches each other, it is characterized by: a ring uplift thing is arranged on the inner wall surface of cap portion or a kind of structure (being preferably the structure of uplift sector and/or a plurality of thrusts) that plays the effect of ring uplift thing is arranged, and the open end from this bulge or this structure to cap portion, being furnished with every a determining deviation is enough to make cap and body just in time to be fixed on the device of coaxial position.
2, in the hard-shell capsule of claim 1, the ring uplift thing is a circumferential ridge, and this bulge can be interrupted arbitrarily.
3, in the hard-shell capsule of claim 1, the ring uplift thing is a kind of a plurality of bulges of circumferential arrangement or the structure of a plurality of thrusts.
4, arbitrary hard-shell capsule of claim 1-3 has an additional ring uplift thing or a kind of additional a plurality of bulges and/or the structure of a plurality of thrusts.
5, in arbitrary hard-shell capsule of claim 1-4, bulge (one or more) is positioned at the top of cap, and near the closing end, the total length of pressing cap calculates, and is positioned at 50% long place of cap.
6, in arbitrary hard-shell capsule of claim 1-5, make cap and body just in time be fixed on the rarest two thrusts of device of coaxial position, be preferably three thrusts, be preferably symmetric offset spread, adjacent thrust distance to each other is preferably impartial.
7, in the hard-shell capsule of claim 6, said apparatus arranges 3,4,5,6,7,8,9 or 10 thrusts arrange 6,7,8,9 or 10 thrusts are better, it is best to arrange 6 or 8 thrusts, the best symmetric offset spread of these thrusts, and all thrusts preferably have identical shape, best, adjacent thrust distance to each other is impartial.
8, in arbitrary hard-shell capsule of claim 1-5, said apparatus is an annular projection thing that can be interrupted arbitrarily.
9, in arbitrary hard-shell capsule of claim 1-8, there are two devices to make cap and body just in time be fixed on coaxial position.
10, in arbitrary hard-shell capsule of claim 1-9, the device that makes cap and body just in time be fixed on coaxial position is positioned at the 50-95% place of cap total length, 50-85%, and 55-80% is better, and 65-75% is best, counts from the closed top end of cap, to the open end of cap.
11, in arbitrary hard-shell capsule of claim 1-10, body has smooth outside face.
12, in arbitrary hard-shell capsule of claim 1-11, annular groove is being arranged on the body outside face or groove structure that a kind of and cap inside face protuberance device is complementary is being arranged so that there be not be out of shape sealed fully between cap and the housing in fact.
13, in arbitrary hard-shell capsule of claim 1-12, a plurality of ring uplift things and a plurality of groove all are interrupted, and like this, the space between the uplift sector can be used as deflation hole, when cap is connected with body, can make the air exhaustion in the capsule.
14, in arbitrary hard-shell capsule of claim 1-13, the ring uplift thing of cap is a necking down of cap.
15, in arbitrary hard-shell capsule of claim 1-14, the ring uplift thing has two inclined-planes, and an optional plane is arranged in the middle of it.
16, in arbitrary hard-shell capsule of claim 1-15, a plurality of thrusts have oval-shaped, a circular or rectangular base, and two inclined-planes are arranged in cross-sectional plane, and an optional plane is arranged in the middle of it.
17, in arbitrary hard-shell capsule of claim 1-16, the diameter of body open end outer wall is littler than the outer diameter of remainder.
18, in the hard-shell capsule of claim 17, the necking down of the necking down of body and the closing end of cap or cap is complementary, and when capsule is closed, can reach automatic seal.
19, in arbitrary hard-shell capsule of claim 1-18, when capsule engaged, cylindrical sidewall wrapped in the cap inwall fully.
20, arbitrary hard-shell capsule of claim 1-19 is all made by gelatin with impregnation forming method.
21, arbitrary hard-shell capsule of claim 1-19 is to be made by injection moulding by gelatin or starch derivative or its compound or native starch.
22, in arbitrary hard-shell capsule of claim 1-20, the wall of cap and/or body all has foam.
23, any of claim 1-22 is by gelatin or contain the hard-shell capsule that gelatin materials is made; Available liquid seal method seals.
24, the hard-shell capsule of claim 23, the available sealing fluid that contains 5-95% water and 95-5% alcohol (preferably ethanol) is being lower than under 80 ℃ the temperature, and (be preferably 40-60 ℃ temperature under) seals at short notice.
25, the hard gelatin capsule of claim 24, (alcohol is 40-60 to 95 with the ratio of water to available a kind of alcohol-aqueous mixtures: 5), under 40-60 ℃ temperature, sealed in 1-5 minute.
26, arbitrary hard-shell capsule of claim 1-25, can be used for food, medicine, pharmaceutical chemicals, dyestuff, spices, fertilizer, seed, the accurate dosing of cosmetics and far products, with food with useful form such as powdery or aqueous formation different shape and size, medicine, pharmaceutical chemicals, dyestuff, spices, fertilizer, seed, the matrix of cosmetics and far products and the content of particular form are as being finely dispersed in the matrix and by decomposition and/or separate and/or biocorrosion and/or diffusion are separated out from matrix, thereby obtain the controlled release system of sealing-in thing and department of medicine and surgery medicine, and each component or its foam that generate encapsulant.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH05101/84-9 | 1984-10-25 | ||
| CH5101/84A CH666809A5 (en) | 1984-10-25 | 1984-10-25 | Sealing coaxial telescoping cap and body of capsules |
| GB08507383A GB2172569A (en) | 1985-03-21 | 1985-03-21 | Improved capsule construction |
| GB8507383 | 1985-03-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN85103166A true CN85103166A (en) | 1986-04-10 |
| CN1003578B CN1003578B (en) | 1989-03-15 |
Family
ID=25696967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN85103166.8A Expired CN1003578B (en) | 1984-10-25 | 1985-04-23 | Improved capsule shape |
Country Status (5)
| Country | Link |
|---|---|
| CN (1) | CN1003578B (en) |
| BE (1) | BE903518A (en) |
| DE (1) | DE3537748A1 (en) |
| FR (1) | FR2572283B1 (en) |
| IT (1) | IT1214669B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102514832A (en) * | 2011-12-15 | 2012-06-27 | 谭亚辉 | Torreya capsule |
| CN102525816A (en) * | 2005-08-09 | 2012-07-04 | 比利时胶囊公司 | Container |
| CN108207534A (en) * | 2018-01-31 | 2018-06-29 | 上海应用技术大学 | The processing of state's orchid artificial endosperm seed with capsule and method for culturing seedlings |
| CN112353776A (en) * | 2020-11-18 | 2021-02-12 | 武汉智能装备工业技术研究院有限公司 | Improved capsule and packaging method |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR890003520Y1 (en) * | 1986-12-20 | 1989-05-27 | 주식회사 서흥캅셀 | Medicinal capsule |
| KR0124764Y1 (en) * | 1995-09-23 | 1998-09-15 | 양주환 | Medical capsule |
| US5769267A (en) * | 1995-11-09 | 1998-06-23 | Warner-Lambert Company | Container |
| DE10154702B4 (en) * | 2001-11-09 | 2006-02-16 | Sartorius Ag | Filter Module Packaging |
| DE10161441A1 (en) * | 2001-12-14 | 2003-06-18 | Triton Umweltschutz Gmbh | Metering system for delivering plant-growth modifiers, useful for supplying e.g. mycorrhiza, nutrients, stabilizers and disease-protection agents, comprises capsule having controlled release rate in soil |
| US8741321B2 (en) | 2003-08-27 | 2014-06-03 | Beiersdorf Ag | Capsule whose envelope is separately imperceptible during the topical use thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3508678A (en) * | 1968-04-29 | 1970-04-28 | Parke Davis & Co | Locking capsule |
| US3823843A (en) * | 1972-10-26 | 1974-07-16 | Lilly Co Eli | Locking capsule |
| DE2333753A1 (en) * | 1973-07-03 | 1975-01-30 | Basf Ag | CANTILEVER CAPSULE |
| US4040536A (en) * | 1975-05-05 | 1977-08-09 | R. P. Scherer Corporation | Locking hard gelatin capsule |
| US4026986A (en) * | 1975-05-22 | 1977-05-31 | The Dow Chemical Company | Capsule shell |
| DE2729007A1 (en) * | 1977-06-28 | 1979-01-18 | Rainer Dr Med Liedtke | Medicine capsule with two chambers - comprises bottom part with caps pushed on both ends |
| US4281763A (en) * | 1979-10-31 | 1981-08-04 | Pace Joseph A | Two-piece hardshell, soluble and digestible liquid containing gelatin capsule |
| EP0110502B1 (en) * | 1982-10-29 | 1990-02-07 | Warner-Lambert Company | Foam capsules and their production |
| US4522666A (en) * | 1982-11-09 | 1985-06-11 | Warner-Lambert Company | Apparatus and method for sealing capsules by application of vacuum and steam thereto |
| US4656066A (en) * | 1982-12-20 | 1987-04-07 | Warner-Lambert Company | Apparatus and method for sealing capsules |
| EP0116744A1 (en) * | 1982-12-20 | 1984-08-29 | Warner-Lambert Company | Apparatus for and method of sealing capsules |
| US4539060A (en) * | 1983-02-18 | 1985-09-03 | Warner-Lambert Company | Apparatus and method of sealing capsules |
| BG46154A3 (en) * | 1983-02-18 | 1989-10-16 | Warner Lambert Co | Method for preparing of capsules |
-
1985
- 1985-04-23 CN CN85103166.8A patent/CN1003578B/en not_active Expired
- 1985-10-17 FR FR8515405A patent/FR2572283B1/en not_active Expired
- 1985-10-23 DE DE19853537748 patent/DE3537748A1/en not_active Ceased
- 1985-10-24 IT IT8548715A patent/IT1214669B/en active
- 1985-10-24 BE BE6/48156A patent/BE903518A/en not_active IP Right Cessation
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102525816A (en) * | 2005-08-09 | 2012-07-04 | 比利时胶囊公司 | Container |
| CN102525816B (en) * | 2005-08-09 | 2014-12-17 | 比利时胶囊公司 | Container |
| CN102514832A (en) * | 2011-12-15 | 2012-06-27 | 谭亚辉 | Torreya capsule |
| CN108207534A (en) * | 2018-01-31 | 2018-06-29 | 上海应用技术大学 | The processing of state's orchid artificial endosperm seed with capsule and method for culturing seedlings |
| CN112353776A (en) * | 2020-11-18 | 2021-02-12 | 武汉智能装备工业技术研究院有限公司 | Improved capsule and packaging method |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3537748A1 (en) | 1986-05-15 |
| IT8548715A0 (en) | 1985-10-24 |
| FR2572283B1 (en) | 1988-11-25 |
| IT1214669B (en) | 1990-01-18 |
| FR2572283A1 (en) | 1986-05-02 |
| BE903518A (en) | 1986-04-24 |
| CN1003578B (en) | 1989-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C13 | Decision | ||
| GR02 | Examined patent application | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C35 | Partial or whole invalidation of patent or utility model | ||
| IW01 | Full invalidation of patent right |
Decision date of declaring invalidation: 19940623 Decision number of declaring invalidation: 488 |