IL44109A - Capsules and their manufacture - Google Patents
Capsules and their manufactureInfo
- Publication number
- IL44109A IL44109A IL44109A IL4410974A IL44109A IL 44109 A IL44109 A IL 44109A IL 44109 A IL44109 A IL 44109A IL 4410974 A IL4410974 A IL 4410974A IL 44109 A IL44109 A IL 44109A
- Authority
- IL
- Israel
- Prior art keywords
- capsule
- cap
- film
- forming material
- pins
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title claims 16
- 238000004519 manufacturing process Methods 0.000 title claims 4
- 239000000463 material Substances 0.000 claims 14
- 238000000034 method Methods 0.000 claims 5
- 230000001464 adherent effect Effects 0.000 claims 4
- 108010010803 Gelatin Proteins 0.000 claims 3
- 238000007598 dipping method Methods 0.000 claims 3
- 238000004090 dissolution Methods 0.000 claims 3
- 229920000159 gelatin Polymers 0.000 claims 3
- 239000008273 gelatin Substances 0.000 claims 3
- 235000019322 gelatine Nutrition 0.000 claims 3
- 235000011852 gelatine desserts Nutrition 0.000 claims 3
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 2
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical compound C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 claims 2
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- ZQBAKBUEJOMQEX-UHFFFAOYSA-N phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 claims 2
- 241000272470 Circus Species 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 229920001800 Shellac Polymers 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 244000028419 Styrax benzoin Species 0.000 claims 1
- 235000000126 Styrax benzoin Nutrition 0.000 claims 1
- 235000008411 Sumatra benzointree Nutrition 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- 229960002130 benzoin Drugs 0.000 claims 1
- ULBTUVJTXULMLP-UHFFFAOYSA-N butyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCC ULBTUVJTXULMLP-UHFFFAOYSA-N 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000005520 cutting process Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 210000004051 gastric juice Anatomy 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 235000019382 gum benzoic Nutrition 0.000 claims 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 1
- 229940044600 maleic anhydride Drugs 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229960000969 phenyl salicylate Drugs 0.000 claims 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- NQLVQOSNDJXLKG-UHFFFAOYSA-N prosulfocarb Chemical compound CCCN(CCC)C(=O)SCC1=CC=CC=C1 NQLVQOSNDJXLKG-UHFFFAOYSA-N 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
- 239000004208 shellac Substances 0.000 claims 1
- 229940113147 shellac Drugs 0.000 claims 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 1
- 235000013874 shellac Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000001993 wax Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/074—Filling capsules; Related operations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/077—Manufacturing capsule shells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- General Preparation And Processing Of Foods (AREA)
Claims (13)
1. A capsule comprising a body having a closed-end v/all and a side wall having a generally cylindrical open-end portion, and a cap having a closed-end wall and a generally cylindrical side wall closely t el escopi cal ly received over the open end of the., body, said body and cap being separable and re-closable after manufacture so as to enable a product to be inserted into said body, the walls of said body and cap being composed of two layers, the materials constituting said layers being soluble at pH ranges which are different but overlapping.
2. Capsule as claimed in Claim 1, wherein the inner of said wo layers comprising the walls of the capsule is soluble in solutions of acidic and basic pH and the outer of said two layers is only soluble at a pH greater than 3.5.
3. Capsule as claimed in Claim 2, wherein said inner layer is of gelatin.
4. Capsule as claimed in Claim 2, wherein said outer layer comprises a film-forming material selected from salol , benzoin, n-butyl stearate, carnuba wax, shellac or mixtures thereof,
5. Capsule as claimed in Claim 2, wherein said outer layer comprises a synthetic film-forming material selected from methacrylic acid polymers, carboxyvinyl polymers, partial esters of maleic anhydr ide /v i ny1 alkyl ether and maleic anliydr i d e /a.lken copolymers, hydroxypropy1 methyl cellulose phthalate, cellulose benzoacetate and cellulose acetate phthalate.
6. Capsule as claimed in Claim 2, wherein said inner layer has a double wal l thickness of 0.10 to 0.20mm and is made of gelatin, and said outer layer has a double wall thickness of fro 0.020 to 0.060mm and is made of a synthetic film-forming material as defi ed in Claim 5. 44109-2 ISRAEL G.1.095
7. Capsule as claimed in claim 6, wherein said film-forming material is cellulose acetate phthalate.
8. A capsule as claimed in any one of claim 2 to 7, containing a medicament and having the junction of the cap and body of said capsule sealed by a circu ferential band which is only soluble at a pH greater than 3.5.
9. Method for manufacturing a capsule as claimed in any one of claims 1 to 7, characterised by the steps of : (i) dipping a capsule body pin and a capsule cap pin into a solution of a first film-forming material to a pre-determined depth; (ii) withdrawing said pins and allowing the adherent layer of said first film-forming material to set; (iii) partially or wholly drying the first adherent layer on said pins; (iv) re-dipping said pins into a solution of a second film-forming material in which said first film-forming material is substantially insoluble, said first and second film-forming materials being soluble at pH ranges which are different but overlapping; (v) withdrawing said pins and allowing the adherent layer of said seconcjl film-forming material to set; (vi ) partially or wholly drying the second adherent layer on said pins; (vii) pulling or stripping the resultant two-layer body and cap shells from their respective pins, said body and cap shells each having a closed-end wall and a generally cylindrical open-end portion; (viii) cutting said body and cap shells to the desired length; and (ix) sliding said cap shell telescopically over the open-end portion of said body shell.
10. Method according to claim 9 for manufacturitig a two-part hard gelatin capsule resistant to dissolution in gastric juices, wherein the first film-forming material is gelatin, and the second film-forming material is resistant to dissolution at pH values less than 3.5 but is soluble at higher pH values. 44109-2
11. Method as claimed in claims 9 or 10, wherein step (iv) is preceded by dipping the pins in a solution of a substance capable of promoting adhesion of the inner and outer layers.
12. Method as claimed in claims 9 or 10, wherein, prior tostep (vii), steps (iv) to (vi) are repeated.
13. Method of manufacturing a capsule according to claim 8 which method comprises separating the body and cap of said capsules, filling said pharmaceutical preparation into said body, refitting said cap to said body and sealing said cap and body together by applying a circumferential band to the external junction thereof, said band being comprised of a material resistant to dissolution at pH values less than 3.5.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB714173A GB1455884A (en) | 1973-02-14 | 1973-02-14 | Production of capsules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL44109A0 IL44109A0 (en) | 1974-05-16 |
| IL44109A true IL44109A (en) | 1976-10-31 |
Family
ID=9827403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL44109A IL44109A (en) | 1973-02-14 | 1974-01-29 | Capsules and their manufacture |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS5029734A (en) |
| AT (1) | AT336794B (en) |
| BE (1) | BE810991A (en) |
| CA (1) | CA1028951A (en) |
| CH (1) | CH592447A5 (en) |
| CS (1) | CS191908B2 (en) |
| DD (1) | DD109509A5 (en) |
| DE (1) | DE2406021A1 (en) |
| DK (1) | DK137166B (en) |
| ES (2) | ES423259A1 (en) |
| FR (1) | FR2216985B1 (en) |
| GB (1) | GB1455884A (en) |
| HU (1) | HU172393B (en) |
| IE (1) | IE38792B1 (en) |
| IL (1) | IL44109A (en) |
| NL (1) | NL7401812A (en) |
| SE (1) | SE413836B (en) |
| YU (1) | YU36774A (en) |
| ZA (1) | ZA74543B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4581875A (en) * | 1983-06-20 | 1986-04-15 | Cosden Technology, Inc. | Process for forming tamper-resistant tamper-indicative capsules |
| JPH01232963A (en) * | 1988-03-14 | 1989-09-18 | Arimento Kogyo Kk | Double-layer soft capsule and preparation thereof |
| AT397764B (en) * | 1992-07-23 | 1994-06-27 | Schlegel Christoph | Device for automatic opening and emptying of capsules |
| TW245641B (en) * | 1993-04-26 | 1995-04-21 | Takeda Pharm Industry Co | |
| FR2771660B1 (en) * | 1997-11-28 | 2000-01-14 | Industrialisation Concept Et M | PROCESS FOR FORMING AND DEPOSITING A DETERMINED DOSE OF A LIQUID OR PASTY PRODUCT AND INSTALLATION FOR IMPLEMENTING THE PROCESS |
| GB2398499B (en) * | 2000-02-16 | 2004-11-24 | Bioprogress Technology Ltd | Two layer capsules |
| GB0003424D0 (en) * | 2000-02-16 | 2000-04-05 | Bioprogress Tech Int Inc | A controlled release capsule |
| DE102009010091A1 (en) * | 2009-02-24 | 2010-08-26 | Beiersdorf Ag | Stabilized peeling capsule |
| EP2763646B8 (en) | 2011-10-06 | 2016-09-14 | Binutra Incorporated | A method and apparatus for manufacturing a capsule |
| CN104905967B (en) * | 2015-05-23 | 2019-04-16 | 浙江益立胶囊股份有限公司 | Production mould for the double-deck enteric hollow capsule |
| EP4464313A3 (en) | 2020-11-25 | 2025-02-26 | Capsugel Belgium NV | Double layered delayed-release hard capsules |
| EP4559458A1 (en) | 2022-07-22 | 2025-05-28 | Qualicaps Co., Ltd. | Multilayered enteric rigid capsule |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB493934A (en) * | 1936-01-17 | 1938-10-17 | Hugo Remmler Ag Dr | Improvements in and relating to methods of treating medicaments |
| GB638284A (en) * | 1946-03-25 | 1950-06-07 | Parke Davis & Co | Improvements in or relating to enteric capsules |
-
1973
- 1973-02-14 GB GB714173A patent/GB1455884A/en not_active Expired
-
1974
- 1974-01-22 CA CA190,680A patent/CA1028951A/en not_active Expired
- 1974-01-24 IE IE143/74A patent/IE38792B1/en unknown
- 1974-01-25 ZA ZA00740543A patent/ZA74543B/en unknown
- 1974-01-29 IL IL44109A patent/IL44109A/en unknown
- 1974-02-04 HU HU74LI00000249A patent/HU172393B/en unknown
- 1974-02-07 FR FR7404059A patent/FR2216985B1/fr not_active Expired
- 1974-02-08 DE DE19742406021 patent/DE2406021A1/en not_active Ceased
- 1974-02-11 NL NL7401812A patent/NL7401812A/xx not_active Application Discontinuation
- 1974-02-11 SE SE7401793A patent/SE413836B/en unknown
- 1974-02-12 DD DD176513A patent/DD109509A5/xx unknown
- 1974-02-13 YU YU00367/74A patent/YU36774A/en unknown
- 1974-02-13 BE BE6044458A patent/BE810991A/en not_active IP Right Cessation
- 1974-02-13 JP JP49017489A patent/JPS5029734A/ja active Pending
- 1974-02-13 AT AT113274A patent/AT336794B/en not_active IP Right Cessation
- 1974-02-14 ES ES423259A patent/ES423259A1/en not_active Expired
- 1974-02-14 DK DK78174AA patent/DK137166B/en not_active IP Right Cessation
- 1974-02-14 CS CS741086A patent/CS191908B2/en unknown
- 1974-02-14 CH CH207474A patent/CH592447A5/xx not_active IP Right Cessation
-
1976
- 1976-03-16 ES ES1976219627U patent/ES219627Y/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2216985A1 (en) | 1974-09-06 |
| YU36774A (en) | 1983-02-28 |
| GB1455884A (en) | 1976-11-17 |
| FR2216985B1 (en) | 1977-06-10 |
| DK137166B (en) | 1978-01-30 |
| CA1028951A (en) | 1978-04-04 |
| CS191908B2 (en) | 1979-07-31 |
| IE38792B1 (en) | 1978-06-07 |
| HU172393B (en) | 1978-08-28 |
| ES219627U (en) | 1976-11-01 |
| ATA113274A (en) | 1976-09-15 |
| BE810991A (en) | 1974-08-13 |
| JPS5029734A (en) | 1975-03-25 |
| DE2406021A1 (en) | 1974-08-29 |
| DD109509A5 (en) | 1974-11-12 |
| DK137166C (en) | 1978-07-03 |
| ES423259A1 (en) | 1976-11-16 |
| CH592447A5 (en) | 1977-10-31 |
| IE38792L (en) | 1974-08-14 |
| ZA74543B (en) | 1975-09-24 |
| AU6506474A (en) | 1975-07-31 |
| AT336794B (en) | 1977-05-25 |
| IL44109A0 (en) | 1974-05-16 |
| ES219627Y (en) | 1977-03-01 |
| SE413836B (en) | 1980-06-30 |
| NL7401812A (en) | 1974-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3927195A (en) | Production of capsules | |
| US4250997A (en) | Locking capsule filled with viscous material | |
| US3823816A (en) | Water-soluble package | |
| US4247006A (en) | Capsule body, in particular for use with a joined capsule for a pharmaceutical preparation, and method of and apparatus for producing it | |
| IL44109A (en) | Capsules and their manufacture | |
| US7770361B2 (en) | Powder compaction and enrobing | |
| US4196564A (en) | Method of manufacturing a joined capsule filled with viscous material | |
| JP4510149B2 (en) | Solid dosage form with capsules wrapped in capsules | |
| KR100838831B1 (en) | Improved powder compaction and coating device | |
| JPH01207068A (en) | Double immersion of gelatin coated tablet | |
| JPS60222060A (en) | Die pressing and molding capsule | |
| US5770224A (en) | Capsule construction | |
| EP0401832A3 (en) | Method for preparing hard capsules for medicaments | |
| EP0781541A3 (en) | Method and apparatus for manufacturing pharmaceutical cellulose capsules - sizing the capsule | |
| EP0435726B1 (en) | Capsule and caplet combination | |
| JPS60109520A (en) | Multilocular soft capsule agent | |
| JPS63117761A (en) | Method for coating gelatin hard capsule with film | |
| CN205145146U (en) | Acidproof membrane clothing capsule structure | |
| JP2001288075A (en) | Ultrathin-walled soft capsule | |
| GB1596008A (en) | Sealed capsule | |
| WO2017136903A2 (en) | Capsule for two incompatible drugs | |
| HK40071872A (en) | Capsule with reduced powder leakage | |
| CN114746061A (en) | Capsule with reduced powder leakage | |
| KR790000287B1 (en) | Improvement in produstion of capsules | |
| TH24389A (en) | A process for encapsulating caplets in capsules and solid size variations obtained by such processes. |