JPS6020924A - ビ−ズ状不溶性シクロデキストリンポリマ−の製法 - Google Patents
ビ−ズ状不溶性シクロデキストリンポリマ−の製法Info
- Publication number
- JPS6020924A JPS6020924A JP12818283A JP12818283A JPS6020924A JP S6020924 A JPS6020924 A JP S6020924A JP 12818283 A JP12818283 A JP 12818283A JP 12818283 A JP12818283 A JP 12818283A JP S6020924 A JPS6020924 A JP S6020924A
- Authority
- JP
- Japan
- Prior art keywords
- cyclodextrin
- crosslinking agent
- bead
- polymer
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000858 Cyclodextrin Polymers 0.000 title claims abstract description 31
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title claims abstract description 25
- 229920000642 polymer Polymers 0.000 title claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 239000006260 foam Substances 0.000 title 1
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 21
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims abstract description 8
- 150000001875 compounds Chemical class 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract description 12
- 239000000203 mixture Substances 0.000 abstract description 6
- 239000012535 impurity Substances 0.000 abstract description 2
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract description 2
- 239000012279 sodium borohydride Substances 0.000 abstract description 2
- 238000013019 agitation Methods 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 239000011324 bead Substances 0.000 description 7
- 238000003756 stirring Methods 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 239000001116 FEMA 4028 Substances 0.000 description 4
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 4
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 4
- 229960004853 betadex Drugs 0.000 description 4
- 239000012074 organic phase Substances 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- UWFRVQVNYNPBEF-UHFFFAOYSA-N 1-(2,4-dimethylphenyl)propan-1-one Chemical compound CCC(=O)C1=CC=C(C)C=C1C UWFRVQVNYNPBEF-UHFFFAOYSA-N 0.000 description 2
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241001474791 Proboscis Species 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- -1 cyclic oligosaccharide Chemical class 0.000 description 2
- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 description 2
- 239000002612 dispersion medium Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000012456 homogeneous solution Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 description 1
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 150000003926 acrylamides Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 description 1
- 229940043377 alpha-cyclodextrin Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 1
- 229910010277 boron hydride Inorganic materials 0.000 description 1
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 229940097362 cyclodextrins Drugs 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 125000005442 diisocyanate group Chemical group 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Epoxy Resins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12818283A JPS6020924A (ja) | 1983-07-14 | 1983-07-14 | ビ−ズ状不溶性シクロデキストリンポリマ−の製法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12818283A JPS6020924A (ja) | 1983-07-14 | 1983-07-14 | ビ−ズ状不溶性シクロデキストリンポリマ−の製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6020924A true JPS6020924A (ja) | 1985-02-02 |
| JPS6312490B2 JPS6312490B2 (enrdf_load_stackoverflow) | 1988-03-19 |
Family
ID=14978457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12818283A Granted JPS6020924A (ja) | 1983-07-14 | 1983-07-14 | ビ−ズ状不溶性シクロデキストリンポリマ−の製法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6020924A (enrdf_load_stackoverflow) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61283601A (ja) * | 1985-06-10 | 1986-12-13 | Nippon Junyaku Kk | ポリシクロデキストリンビ−ズの製造方法 |
| JP2006143953A (ja) * | 2004-11-24 | 2006-06-08 | Aomori Prefecture | ビーズ状シクロデキストリンポリマー製造方法 |
| JP2008246287A (ja) * | 2007-03-29 | 2008-10-16 | Aomori Prefecture | 界面活性剤の除去方法 |
| JP2011213743A (ja) * | 2010-03-31 | 2011-10-27 | Aomori Prefectural Industrial Technology Research Center | 粒状シクロデキストリンポリマーおよびその製造方法 |
| CN103756260A (zh) * | 2014-01-23 | 2014-04-30 | 苏州大学 | 一种生物质改性热固性树脂及其制备方法 |
| US9505850B2 (en) | 2012-05-30 | 2016-11-29 | National University Corporation Kumamoto University | Endotoxin adsorbent |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10113385C1 (de) * | 2001-03-16 | 2002-08-29 | Schott Glas | Stufenlinsenscheinwerfer |
| ES2310948B2 (es) | 2005-02-25 | 2009-09-16 | Universidade De Santiago De Compostela | Procedimiento de obtencion de hidrogeles de ciclodextrinas con glicidileteres, las composiciones obtenidas y sus aplicaciones. |
-
1983
- 1983-07-14 JP JP12818283A patent/JPS6020924A/ja active Granted
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61283601A (ja) * | 1985-06-10 | 1986-12-13 | Nippon Junyaku Kk | ポリシクロデキストリンビ−ズの製造方法 |
| JP2006143953A (ja) * | 2004-11-24 | 2006-06-08 | Aomori Prefecture | ビーズ状シクロデキストリンポリマー製造方法 |
| JP2008246287A (ja) * | 2007-03-29 | 2008-10-16 | Aomori Prefecture | 界面活性剤の除去方法 |
| JP2011213743A (ja) * | 2010-03-31 | 2011-10-27 | Aomori Prefectural Industrial Technology Research Center | 粒状シクロデキストリンポリマーおよびその製造方法 |
| US9505850B2 (en) | 2012-05-30 | 2016-11-29 | National University Corporation Kumamoto University | Endotoxin adsorbent |
| US10155217B2 (en) | 2012-05-30 | 2018-12-18 | National University Corporation Kumamoto | Endotoxin adsorbent |
| CN103756260A (zh) * | 2014-01-23 | 2014-04-30 | 苏州大学 | 一种生物质改性热固性树脂及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6312490B2 (enrdf_load_stackoverflow) | 1988-03-19 |
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