JPS60188319A - 抗潰瘍剤 - Google Patents
抗潰瘍剤Info
- Publication number
- JPS60188319A JPS60188319A JP4429884A JP4429884A JPS60188319A JP S60188319 A JPS60188319 A JP S60188319A JP 4429884 A JP4429884 A JP 4429884A JP 4429884 A JP4429884 A JP 4429884A JP S60188319 A JPS60188319 A JP S60188319A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- agent
- niphedipine
- nifedipine
- antiulcerative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000767 anti-ulcer Effects 0.000 title abstract 3
- 239000004480 active ingredient Substances 0.000 claims abstract 2
- OJURWUUOVGOHJZ-UHFFFAOYSA-N methyl 2-[(2-acetyloxyphenyl)methyl-[2-[(2-acetyloxyphenyl)methyl-(2-methoxy-2-oxoethyl)amino]ethyl]amino]acetate Chemical compound C=1C=CC=C(OC(C)=O)C=1CN(CC(=O)OC)CCN(CC(=O)OC)CC1=CC=CC=C1OC(C)=O OJURWUUOVGOHJZ-UHFFFAOYSA-N 0.000 claims abstract 2
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims description 8
- 229960001597 nifedipine Drugs 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 239000002775 capsule Substances 0.000 abstract description 2
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 abstract description 2
- 229960001380 cimetidine Drugs 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 239000008187 granular material Substances 0.000 abstract description 2
- 239000003826 tablet Substances 0.000 abstract description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 1
- 229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 229940069428 antacid Drugs 0.000 abstract 1
- 239000003159 antacid agent Substances 0.000 abstract 1
- 230000001458 anti-acid effect Effects 0.000 abstract 1
- 239000000480 calcium channel blocker Substances 0.000 abstract 1
- 230000001079 digestive effect Effects 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
- 210000004051 gastric juice Anatomy 0.000 description 4
- 230000027119 gastric acid secretion Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 239000003699 antiulcer agent Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000004531 blood pressure lowering effect Effects 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- YLGIBCYHQZTFQL-UHFFFAOYSA-N dimethyl pyridine-2,3-dicarboxylate Chemical compound COC(=O)C1=CC=CN=C1C(=O)OC YLGIBCYHQZTFQL-UHFFFAOYSA-N 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4429884A JPS60188319A (ja) | 1984-03-07 | 1984-03-07 | 抗潰瘍剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4429884A JPS60188319A (ja) | 1984-03-07 | 1984-03-07 | 抗潰瘍剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60188319A true JPS60188319A (ja) | 1985-09-25 |
| JPH0518810B2 JPH0518810B2 (enrdf_load_stackoverflow) | 1993-03-15 |
Family
ID=12687596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4429884A Granted JPS60188319A (ja) | 1984-03-07 | 1984-03-07 | 抗潰瘍剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60188319A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000028984A1 (fr) * | 1998-11-16 | 2000-05-25 | Hokuriku Seiyaku Co., Ltd. | Remedes agissant contre un trouble fonctionnel du tractus digestif |
-
1984
- 1984-03-07 JP JP4429884A patent/JPS60188319A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000028984A1 (fr) * | 1998-11-16 | 2000-05-25 | Hokuriku Seiyaku Co., Ltd. | Remedes agissant contre un trouble fonctionnel du tractus digestif |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0518810B2 (enrdf_load_stackoverflow) | 1993-03-15 |
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