JPS60188316A - 口腔用抗炎症剤 - Google Patents
口腔用抗炎症剤Info
- Publication number
- JPS60188316A JPS60188316A JP4438784A JP4438784A JPS60188316A JP S60188316 A JPS60188316 A JP S60188316A JP 4438784 A JP4438784 A JP 4438784A JP 4438784 A JP4438784 A JP 4438784A JP S60188316 A JPS60188316 A JP S60188316A
- Authority
- JP
- Japan
- Prior art keywords
- guaiazulene
- inflammatory
- sodium
- inflammatory agent
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000214 mouth Anatomy 0.000 title claims description 8
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract description 14
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 claims abstract description 74
- 229960002350 guaiazulen Drugs 0.000 claims abstract description 37
- 239000004094 surface-active agent Substances 0.000 claims abstract description 15
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 8
- 239000011734 sodium Substances 0.000 claims abstract description 8
- 229950002760 sodium gualenate Drugs 0.000 claims abstract description 7
- 229960003260 chlorhexidine Drugs 0.000 claims abstract description 6
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract description 5
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims abstract description 5
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims abstract description 3
- 229960001950 benzethonium chloride Drugs 0.000 claims abstract description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 31
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 31
- VIZXMHCBZLGUET-UHFFFAOYSA-N sodium gualenate Chemical compound CC(C)C1=CC=C(C)C2=C(S(O)(=O)=O)C=C(C)C2=C1 VIZXMHCBZLGUET-UHFFFAOYSA-N 0.000 claims description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 6
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 6
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims description 2
- 229940043264 dodecyl sulfate Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 9
- -1 sodium sulfonate salt Chemical class 0.000 abstract description 5
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- PPBMNULSTRZQCG-UHFFFAOYSA-N 2-chloro-1-pyridin-1-ium-1-ylethanone Chemical compound ClCC(=O)[N+]1=CC=CC=C1 PPBMNULSTRZQCG-UHFFFAOYSA-N 0.000 abstract 1
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 abstract 1
- DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 abstract 1
- 239000002674 ointment Substances 0.000 description 10
- 206010061218 Inflammation Diseases 0.000 description 9
- 230000004054 inflammatory process Effects 0.000 description 9
- 238000002156 mixing Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 2
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 208000007565 gingivitis Diseases 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 241000700198 Cavia Species 0.000 description 1
- 206010015943 Eye inflammation Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- NEUYYGOBPJMKSK-UHFFFAOYSA-M [Cl-].ClC1=[N+](C=CC=C1)Cl Chemical compound [Cl-].ClC1=[N+](C=CC=C1)Cl NEUYYGOBPJMKSK-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 239000008311 hydrophilic ointment Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4438784A JPS60188316A (ja) | 1984-03-07 | 1984-03-07 | 口腔用抗炎症剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4438784A JPS60188316A (ja) | 1984-03-07 | 1984-03-07 | 口腔用抗炎症剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60188316A true JPS60188316A (ja) | 1985-09-25 |
| JPS6361287B2 JPS6361287B2 (enrdf_load_stackoverflow) | 1988-11-28 |
Family
ID=12690094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4438784A Granted JPS60188316A (ja) | 1984-03-07 | 1984-03-07 | 口腔用抗炎症剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60188316A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4692262A (en) * | 1986-09-18 | 1987-09-08 | Brown Robert L | Skin cleanser capable of softening and removing smegma |
| JPS6348211A (ja) * | 1986-08-19 | 1988-02-29 | Lion Corp | アズレン系抗炎症剤 |
| US4737307A (en) * | 1986-09-18 | 1988-04-12 | Brown Robert L | Skin cleanser capable of removing smegma and surface bacteria, fungus and viruses from surface of skin |
| JP2013043869A (ja) * | 2011-08-25 | 2013-03-04 | Lion Corp | 口腔用軟膏組成物及び口腔バイオフィルム殺菌剤 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5151531A (en) * | 1974-08-26 | 1976-05-07 | Blendax Werke Schneider Co | Haoyobi kokohogozai |
| JPS5420138A (en) * | 1977-07-11 | 1979-02-15 | Sunstar Inc | Oral cavity agent composition |
| JPS5839614A (ja) * | 1981-09-03 | 1983-03-08 | Lion Corp | 口腔用組成物 |
| JPS59157041A (ja) * | 1983-02-28 | 1984-09-06 | Showa Denko Kk | アリ−ルジフルオロメチルエ−テル類の製造法 |
-
1984
- 1984-03-07 JP JP4438784A patent/JPS60188316A/ja active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5151531A (en) * | 1974-08-26 | 1976-05-07 | Blendax Werke Schneider Co | Haoyobi kokohogozai |
| JPS5420138A (en) * | 1977-07-11 | 1979-02-15 | Sunstar Inc | Oral cavity agent composition |
| JPS5839614A (ja) * | 1981-09-03 | 1983-03-08 | Lion Corp | 口腔用組成物 |
| JPS59157041A (ja) * | 1983-02-28 | 1984-09-06 | Showa Denko Kk | アリ−ルジフルオロメチルエ−テル類の製造法 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6348211A (ja) * | 1986-08-19 | 1988-02-29 | Lion Corp | アズレン系抗炎症剤 |
| US4692262A (en) * | 1986-09-18 | 1987-09-08 | Brown Robert L | Skin cleanser capable of softening and removing smegma |
| US4737307A (en) * | 1986-09-18 | 1988-04-12 | Brown Robert L | Skin cleanser capable of removing smegma and surface bacteria, fungus and viruses from surface of skin |
| JP2013043869A (ja) * | 2011-08-25 | 2013-03-04 | Lion Corp | 口腔用軟膏組成物及び口腔バイオフィルム殺菌剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6361287B2 (enrdf_load_stackoverflow) | 1988-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0336901B1 (en) | Anesthetic skin moisturizing composition and method of preparing same | |
| US4309989A (en) | Topical application of medication by ultrasound with coupling agent | |
| US4607101A (en) | Method of treating acne vulgaris with a composition containing carbamide peroxide | |
| DE3779999T2 (de) | Erhoehung des penetrationsvermoegens mittels eines aus die zellhuelle veraendernden substanzen und kurzkettigen alkoholen bestehenden binaeren systems. | |
| US4514384A (en) | Hemorrhoid treatment method | |
| JPH085785B2 (ja) | 魚鱗癬の治療剤 | |
| KR880000091A (ko) | 국소용 약제학적 조성물 이의 제조방법 및 이의 용도 | |
| EP0336902A2 (en) | Antiinflammatory skin moisturizing composition and method of preparing same | |
| US4853388A (en) | Method for treating psoriasis with cytotoxic agents | |
| US4820711A (en) | Method for treating actinic keratosis with cytotoxic agents | |
| DE60004786T2 (de) | Verfahren und zusammensetzung zur behandlung von akne | |
| US5547657A (en) | Low-irritation anesthetic and antiseptic mouth rinse | |
| US3395236A (en) | Composition comprising oleic acid, polyethylene glycol, and gelating for treating nail infections | |
| US4518583A (en) | Hemorrhoid and anorectal disease treatment method | |
| JP2002212107A (ja) | 局所適用組成物 | |
| JPS60188316A (ja) | 口腔用抗炎症剤 | |
| EP1318801B1 (en) | Topical analgesic compositions containing aliphatic polyamines and methods of using same | |
| US4035510A (en) | Treatment of acne utilizing N-methyldiethanolamine | |
| US5552436A (en) | Process for treating hemangioma | |
| JPH03120230A (ja) | 薬効成分の経皮吸収促進剤及び経皮吸収型製剤 | |
| DE3006024C2 (de) | Topisches, Indomethacin enthaltendes Arzneimittel in Salbenform | |
| US3026247A (en) | Pharmaceutical preparation | |
| JPS6028927A (ja) | 皮膚外用剤 | |
| JPH08165244A (ja) | 皮膚疾患治療剤 | |
| RU2190388C1 (ru) | Средство на основе масла чайного дерева (варианты) |