JPS5953273B2 - シアノメチルチオアセチルセフアロスポリン類の製造法 - Google Patents
シアノメチルチオアセチルセフアロスポリン類の製造法Info
- Publication number
- JPS5953273B2 JPS5953273B2 JP48087446A JP8744673A JPS5953273B2 JP S5953273 B2 JPS5953273 B2 JP S5953273B2 JP 48087446 A JP48087446 A JP 48087446A JP 8744673 A JP8744673 A JP 8744673A JP S5953273 B2 JPS5953273 B2 JP S5953273B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- thio
- formula
- solution
- cyanomethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Fodder In General (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00278168A US3855212A (en) | 1972-08-04 | 1972-08-04 | Cyanomethylth ioacetylcephalosporins |
| US278168 | 1972-08-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS50105680A JPS50105680A (US08088918-20120103-C00476.png) | 1975-08-20 |
| JPS5953273B2 true JPS5953273B2 (ja) | 1984-12-24 |
Family
ID=23063949
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP48087446A Expired JPS5953273B2 (ja) | 1972-08-04 | 1973-08-03 | シアノメチルチオアセチルセフアロスポリン類の製造法 |
| JP56002547A Expired JPS595580B2 (ja) | 1972-08-04 | 1981-01-09 | シアノメチルチオ酢酸類の製法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56002547A Expired JPS595580B2 (ja) | 1972-08-04 | 1981-01-09 | シアノメチルチオ酢酸類の製法 |
Country Status (19)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932396A (en) * | 1972-08-04 | 1976-01-13 | E. R. Squibb & Sons, Inc. | Cyanomethylthioacetylcephalosporins |
| US3944546A (en) * | 1972-08-04 | 1976-03-16 | E. R. Squibb & Sons, Inc. | Cyanomethylthioacetylcephalosporins |
| US3932397A (en) * | 1972-08-04 | 1976-01-13 | E. R. Squibb & Sons, Inc. | Cyanomethylthioacetylcephalosporins |
| US3963711A (en) * | 1973-08-17 | 1976-06-15 | Smithkline Corporation | Cyanomethyl sulfinyl- and sulfonyl-acetamido cephalosporins |
| US3963709A (en) * | 1973-08-17 | 1976-06-15 | Smithkline Corporation | Cyanomethyl sulfinyl- and sulfonyl-acetamido cephalosporins |
| US3985746A (en) * | 1975-03-25 | 1976-10-12 | E. R. Squibb & Sons, Inc. | 7-(α-Cyanomethylthio)acetamido-3-cephem carboxylates |
| GB8715925D0 (en) * | 1987-07-07 | 1987-08-12 | Shell Int Research | Thiapentanamide derivatives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR902398A (fr) * | 1942-12-22 | 1945-08-29 | Carlo Wedekind & Co | Installation d'évaporation perfectionnée à thermo-compression |
| FR1321704A (fr) * | 1962-04-03 | 1963-03-22 | Lilly Co Eli | Procédé pour préparer des dérivés 7-(mercapto-acylamido s-substitués) des céphalosporines c et nouveaux composés ainsi préparés |
| CH480365A (de) * | 1965-01-18 | 1969-10-31 | Ciba Geigy | Verfahren zur Herstellung neuer Derivate der 7-Aminocephalosporansäure |
| US3530123A (en) | 1966-11-02 | 1970-09-22 | Fujisawa Pharmaceutical Co | 3-thiolated-7-sydnone-acylamino-cephalosporanic acid derivatives |
| CH527215A (de) * | 1967-04-15 | 1972-08-31 | Fujisawa Pharmaceutical Co | Verfahren zur Herstellung von 3,7-disubstituierten Cephalosporinderivaten |
| US3641021A (en) * | 1969-04-18 | 1972-02-08 | Lilly Co Eli | 3 7-(ring-substituted) cephalosporin compounds |
-
1972
- 1972-08-04 US US00278168A patent/US3855212A/en not_active Expired - Lifetime
-
1973
- 1973-06-29 CA CA175,324A patent/CA1088518A/en not_active Expired
- 1973-07-03 IE IE01116/73A patent/IE39002B1/xx unknown
- 1973-07-03 ZA ZA734512A patent/ZA734512B/xx unknown
- 1973-07-04 GB GB3188273A patent/GB1437221A/en not_active Expired
- 1973-07-04 GB GB4091474A patent/GB1437222A/en not_active Expired
- 1973-07-09 PH PH14803*UA patent/PH9246A/en unknown
- 1973-07-19 DE DE19732336655 patent/DE2336655A1/de not_active Ceased
- 1973-07-19 DE DE2366461A patent/DE2366461C2/de not_active Expired
- 1973-07-20 CH CH174176A patent/CH587239A5/xx not_active IP Right Cessation
- 1973-07-20 CH CH1068273A patent/CH580107A5/xx not_active IP Right Cessation
- 1973-07-30 DD DD172606A patent/DD107698A5/xx unknown
- 1973-07-31 AR AR249371A patent/AR203371A1/es active
- 1973-08-02 HU HUSU832A patent/HU166316B/hu unknown
- 1973-08-02 HU HUSU867A patent/HU167055B/hu unknown
- 1973-08-03 JP JP48087446A patent/JPS5953273B2/ja not_active Expired
- 1973-08-03 SU SU731957329A patent/SU886747A3/ru active
- 1973-08-03 NL NL7310751A patent/NL7310751A/xx unknown
- 1973-08-03 FR FR7328543A patent/FR2194417B1/fr not_active Expired
- 1973-08-03 BE BE134220A patent/BE803199A/xx not_active IP Right Cessation
- 1973-08-03 ES ES417555A patent/ES417555A1/es not_active Expired
- 1973-08-03 CS CS735525A patent/CS192504B2/cs unknown
- 1973-08-06 AT AT689473A patent/AT328078B/de not_active IP Right Cessation
-
1981
- 1981-01-09 JP JP56002547A patent/JPS595580B2/ja not_active Expired
Also Published As
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| US3984404A (en) | Acylthiomethyl esters of cephalosporins |
