JPS59501214A - 持続性放出キニジン経口投与製剤 - Google Patents
持続性放出キニジン経口投与製剤Info
- Publication number
- JPS59501214A JPS59501214A JP58502667A JP50266783A JPS59501214A JP S59501214 A JPS59501214 A JP S59501214A JP 58502667 A JP58502667 A JP 58502667A JP 50266783 A JP50266783 A JP 50266783A JP S59501214 A JPS59501214 A JP S59501214A
- Authority
- JP
- Japan
- Prior art keywords
- quinidine
- pellets
- weight
- sustained release
- oral dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 title claims description 33
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 title claims description 17
- 229960001404 quinidine Drugs 0.000 title claims description 17
- 239000000203 mixture Substances 0.000 title description 6
- 238000013265 extended release Methods 0.000 title description 3
- 238000009472 formulation Methods 0.000 title description 2
- 239000008188 pellet Substances 0.000 claims description 13
- 235000009508 confectionery Nutrition 0.000 claims description 8
- 238000013268 sustained release Methods 0.000 claims description 7
- 239000012730 sustained-release form Substances 0.000 claims description 7
- AKYHKWQPZHDOBW-VJAUXQICSA-N (s)-[(2r,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid Chemical compound OS(O)(=O)=O.C([C@H]([C@H](C1)C=C)C2)CN1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 AKYHKWQPZHDOBW-VJAUXQICSA-N 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 5
- 229960002693 quinidine bisulfate Drugs 0.000 claims description 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 244000188595 Brassica sinapistrum Species 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 4
- 239000001856 Ethyl cellulose Substances 0.000 description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229920001249 ethyl cellulose Polymers 0.000 description 3
- 235000019325 ethyl cellulose Nutrition 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 206010001497 Agitation Diseases 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- -1 quinidine compound Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US396669 | 1982-07-09 | ||
| PCT/US1983/001042 WO1984000295A1 (en) | 1982-07-09 | 1983-07-08 | Sustained release quinidine dosage form |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59501214A true JPS59501214A (ja) | 1984-07-12 |
| JPH0417163B2 JPH0417163B2 (enExample) | 1992-03-25 |
Family
ID=22175337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58502667A Granted JPS59501214A (ja) | 1982-07-09 | 1983-07-08 | 持続性放出キニジン経口投与製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59501214A (enExample) |
-
1983
- 1983-07-08 JP JP58502667A patent/JPS59501214A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0417163B2 (enExample) | 1992-03-25 |
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