JPS59501214A - 持続性放出キニジン経口投与製剤 - Google Patents
持続性放出キニジン経口投与製剤Info
- Publication number
- JPS59501214A JPS59501214A JP58502667A JP50266783A JPS59501214A JP S59501214 A JPS59501214 A JP S59501214A JP 58502667 A JP58502667 A JP 58502667A JP 50266783 A JP50266783 A JP 50266783A JP S59501214 A JPS59501214 A JP S59501214A
- Authority
- JP
- Japan
- Prior art keywords
- quinidine
- pellets
- weight
- sustained release
- oral dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 title claims description 33
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 title claims description 17
- 229960001404 quinidine Drugs 0.000 title claims description 17
- 239000000203 mixture Substances 0.000 title description 6
- 238000013265 extended release Methods 0.000 title description 3
- 238000009472 formulation Methods 0.000 title description 2
- 239000008188 pellet Substances 0.000 claims description 13
- 235000009508 confectionery Nutrition 0.000 claims description 8
- 238000013268 sustained release Methods 0.000 claims description 7
- 239000012730 sustained-release form Substances 0.000 claims description 7
- AKYHKWQPZHDOBW-VJAUXQICSA-N (s)-[(2r,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid Chemical compound OS(O)(=O)=O.C([C@H]([C@H](C1)C=C)C2)CN1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 AKYHKWQPZHDOBW-VJAUXQICSA-N 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 5
- 229960002693 quinidine bisulfate Drugs 0.000 claims description 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 244000188595 Brassica sinapistrum Species 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 4
- 239000001856 Ethyl cellulose Substances 0.000 description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229920001249 ethyl cellulose Polymers 0.000 description 3
- 235000019325 ethyl cellulose Nutrition 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 206010001497 Agitation Diseases 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- -1 quinidine compound Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1983/001042 WO1984000295A1 (en) | 1982-07-09 | 1983-07-08 | Sustained release quinidine dosage form |
| US396669 | 1999-09-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59501214A true JPS59501214A (ja) | 1984-07-12 |
| JPH0417163B2 JPH0417163B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-03-25 |
Family
ID=22175337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58502667A Granted JPS59501214A (ja) | 1982-07-09 | 1983-07-08 | 持続性放出キニジン経口投与製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59501214A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
-
1983
- 1983-07-08 JP JP58502667A patent/JPS59501214A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0417163B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1992-03-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2038245C (en) | Pharmaceutically useful micropellets | |
| SU1706373A3 (ru) | Способ получени средства с регулируемым высвобождением активного соединени | |
| TWI239838B (en) | Fluoxetine enteric pellets | |
| US3432593A (en) | Delayed and sustained release type pharmaceutical preparation | |
| EP0013263B1 (en) | A pharmaceutical preparation comprising a cardiac glycoside in combination with a polymer, and a process for preparation thereof | |
| JPH09500914A (ja) | 粉末被覆経口投与剤形 | |
| CZ656388A3 (en) | Pharmaceutical preparation consisting of granules containing tetracyclin compound | |
| TW201022235A (en) | New use of dabigatran | |
| US5026709A (en) | Method for the preparation of a theophylline sustained release pharmaceutical composition and the composition prepared thereby | |
| EP0083372A1 (en) | EXTENDED RELEASE THEOPHYLLIN. | |
| JPS5818318A (ja) | キサンチン誘導体の胃受容性薬剤の製法 | |
| EP0546846B1 (en) | Programmed-release pharmaceutical compositions | |
| JPH08175983A (ja) | ジクロフェナクナトリウム持続性製剤およびその製法 | |
| JPS59501214A (ja) | 持続性放出キニジン経口投与製剤 | |
| EP0113373B1 (en) | Sustained release quinidine dosage form | |
| CN103054835A (zh) | 一种文拉法辛缓释胶囊及其制备工艺 | |
| JPH02501738A (ja) | 改良された乾燥持続放出性テオフィリン経口製剤 | |
| IE38614B1 (en) | Orally administrable corticosteroid preparations | |
| JP3456211B2 (ja) | 持続性製剤 | |
| JPH03193733A (ja) | テオフィリンの徐放性製剤 | |
| JPH06128147A (ja) | 水難溶性薬品の溶解性改善方法およびそれにより得られた薬品組成物 | |
| JPS615010A (ja) | 水素添加麦角アルカロイド徐放性製剤及びその製法 | |
| JPH0559098B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| JPH01501936A (ja) | 持続放出型薬理組成物の製法およびこれにより得られる組成物 | |
| KR100501827B1 (ko) | 다층 코팅법을 이용한 멜라토닌 함유 타게팅 약물 전달 기구 |