JPS59500431A - Device that supplies radioactive mist - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] Respiratory diseases and allergies diagnostic method and device <Technical field> This invention relates to the diagnosis of respiratory hypochromia, and more specifically, to the diagnosis of hyperdeposition. The location of liver cancer, etc. can be easily detected without any risk of In order to easily know not only the Lung ventilation that allows multiple images of relatively high @1 quadrant and high contrast l- to be obtained. A new and improved method using aerosolized radioisotopes for This is related to the Hini device.

<Background technology> Traditionally, diagnosis of respiratory diseases has been limited to perfusion lung scans and ventilation using radioactive gases. It was carried out by The use of radioactive aerosols was also considered, but This device can be used to treat the upper respiratory tract, oropharynx, or d-duct as well as airway communication. If excessive deposition or rain fall (fallout of radioactive materials) occurs even at points, I knew it would happen.

Furthermore, unequal deposition of atomized particles between the central and peripheral regions of the lung was observed. It was. Therefore, if a ventilation scan is deemed desirable, the It is relatively expensive, inconvenient for the patient, and can cause damage to the lungs! one video The time to collect the gas is limited, and the storage of the exhaled gas and the skin However, in general, radiation such as xenon and krypton I) It depended on dregs.

<Disclosure of invention> This invention overcomes the traditional problems associated with diagnosing pulmonary disease and It is possible to avoid the problems associated with the use of gas, as well as the problems associated with the use of gas. The present invention provides a removal device using a radioactive atomized body.

More specifically, aerosols with particle sizes of approximately 1.2 microns or less By using a foggy body (which behaves almost the same way, the upper respiratory tract, pharynx No rainout or excessive deposits that could cause problems in the head or airways It turned out that. Furthermore, deposits occur at airway bifurcations throughout the lungs. The patient can be in any position and scan No need to hold your breath during the procedure, allowing plenty of time for multiple scans There is. Furthermore, isotopes in aerosol form are filtered and released during exhalation. Safe storage until radioactivity reaches a safe level convenient for disposal. Can be done. However, radioactive forces are not filtered and must be contained and stored with great care. The time it takes for radioactivity to reach a safe level (l-i aerosol It requires a long period of time compared to the standard.

The purpose of this invention is to be simple and reliable, and relatively easy to operate and operate. New and improved methods and equipment for the diagnosis of lung diseases characterized by The aim is to provide a

Yet another feature of this invention is that even if the patient is in pain, the patient's lungs are affected with minimal pain. To provide a new and improved diagnostic device capable of performing many photographic observations. It is in.

Still another object of the invention (d) to provide significantly improved resolution and contrast. A new and improved method and apparatus for making video ventilation sketches of the lungs It is about providing.

This invention limits the maximum particle size to 1.2 microns, and The amount of particles larger than Unidirectional air inlet coupled to the atomizer outlet, which also has a unidirectional flow valve and a T or is connected to the mouthpiece or face mask via a Y-shaped connector, and the mouthpiece Alternatively, the patient can breathe in the mist produced by the nebulizer through the mask. Ru. A third opening, or discharge opening, is provided for the mist and air inhaled by the patient. A unidirectional flow valve is provided to remove radioactive particles, and a filter is provided to remove radioactive particles. Ru. The output from the filter is filtered until the radioactivity is attenuated to a level that is safe for disposal. , preferably in a suitable container for storage. Nebulizers are usually powered by a compressed air source. Since it is operated continuously, it is possible to prevent excessive pressure from building up during the dispensing period. Means for damping is provided at the output of the atomizer.

The above and further objects and advantages of this invention are explained below and form part of this invention. It will become clear from the accompanying drawings.

Brief description of the drawing FIG. 1 is a side elevation diagrammatically showing a portion of an embodiment of the device according to the invention; FIG. 2 is an elevational view of the surveying section graphically showing a part of the modification of the invention shown in FIG. 1. Ru.

<The best mode of carrying out this invention> Radioactive aerosols are used in the diagnosis of pulmonary diseases. In other words, the use of atomized materials is considered desirable because it is convenient and inexpensive. However, excessive aerosols may be deposited in the large airways, posterior pharynx, trachea, stomach, etc. Therefore, no treatment using this technique has been used to date. Also, generally The radioactive mist that can be added has an average mass aerodynamic diameter of 2 microns or more. It was thought that it should not contain any particles. According to the invention described here, particles Not only does the diameter of the aerosol not exceed 1.2 microns, but the diameter of the aerosol is approximately 0.05 microns. Within the range of 6 microns to 1.2 microns, approximately 90% of particles are 1 micron. It was found that the following. Under these circumstances, aerosols, like gases, Entrenchment, the desired objective is achieved.

To prepare the aerosol for radioactive scanning, use 99772 Technet. um-sulfur colloid or 99η1 technetium-diethylene triamine. Pentaacetate works well and also does a lot of video scanning It has a t-life of about 6 hours, which is sufficient for It has a decreasing period.

The gas requires the patient to hold their breath during the video scan, which takes only one scan time. Not only do we have to find a suitable half of a known satisfactory gas like krypton, The decay time is less than 30 seconds, making it difficult to provide sufficient time for even one scan. Also, the form of labeled xenon (taggeCLxeno?t) has a half-life of 4. It takes up to 30 days and treatment is difficult. The radioactive technetium compound described above is used in normal clinical practice. Nuclear Medicine Department for floor diagnostic procedures (Nuclear IvjediCine De can be obtained commonly at and can also obtain aerosol for ventilation scan procedures.

See FIG. 1, which shows a schematic elevational view of a portion of the device according to the invention in diagrammatic form. do. The atomizer is indicated generally by the number lO and has a compressed gas inlet 11 and It has an outlet 12. The atomizer may be of any desired type regardless of the embodiment illustrated. The housing contains a suitable reservoir, an inhaler for the generation of the atomizer, A gas such as oxygen or air is supplied at a rate of 6 to 10 liters per minute.

In the illustrated embodiment of the invention, a four-way connector, generally designated 13, is provided with a tubular leg 14. is connected to the outlet 12 of the atomizer lO. The unidirectional air introduction valve 15 has a 4-way connection. a second unidirectional outlet valve 17 and a second unidirectional outlet valve 17; A particle filter 18 is connected to the third leg 19 of the four-way connector 13 and The fourth leg 20 of the tank 13 is a flexible leg 20 with a bellows structure that provides the aerosol to the operator. It is connected to the pipe 21. Since the nebulizer contains a radioactive liquid, the nebulizer 10 a container 22 made of lead or other radiation shielding material with a four-way connector 13. Therefore, it is desirable to contain them.

The outlet end of tube 21 is connected to a second container also made of lead or other radiation shielding material. It is connected to a third one-way valve 23 housed within the vessel 24 . Output of unidirectional valve 23 The mouth is connected to one leg 25 of a Y-shaped connector 26 located within the container 24 . Y-shaped connector 26 is connected to a flexible tube 28 similar to tube 21. patient suction An inlet 29 is fixed to one end of the tube 28 so that the patient has a single tube for introducing air. Together with the directional valve 15, the mist generated by the sprayer 10 can be easily inhaled. can. Although a single tip 29 is shown, it can be replaced with a tip if desired. A suitable face mask may also be used. The unidirectional flow valve 23 can be of any desired type. can be used to block flow while atmospheric pressure is downstream of the valve and During the period when the patient is inhaling, the downstream pressure decreases and the fluid can flow freely. It is arranged to come.

When administering an aerosol for ventilation scans, the radioactive mist is distributed throughout the lungs. The patient should aspirate and exhale several times to ensure even deposition. You may do so. During the spitting period, the patient should use a mouthpiece or, in some cases, a face mask. and exhale through tube 28. Unidirectional valve 23 prevents backflow of atomized material Therefore, the exhaled aerosol is transferred to the Y-shaped connector 26, O-leg 30% vehicle direction valve 31, and the valve 31. This discharged air and/or gas flows to the outside through the filter 32, and the discharged air and gas are It is released within 331ifi. Filter 32 retains aerosol exhaled by the patient. filtered until radioactivity levels are reduced to a safe level convenient for disposal. contain the aerosols.

During the discharge period, the valve 23 remains closed and the compressed air inlet of the atomizer 10 It is desirable to prevent excessive pressure from being created in tube 21 by 11. this For this purpose, the bellows-type tube 21 is expandable, thereby increasing the pressure. power can be limited. If necessary, use the one-way valve 17 to It can also be adjusted to act as a safety valve to limit the maximum pressure within 21. Cheap When all valves 17 are used, some of the remaining gas is delivered through the aerosol. too If desired, tubes 33 and 34 may be joined to ensure that the radioactivity is at a level that allows normal disposal. Alternatively, the gaseous substance 3 may be supplied to a holding container containing the gaseous substance 3 until it is reduced to 1.

The sprayer 10 can be of any desired type; The particles of the aerosol generated are within the range stated above. schematic above An example of a sprayer that generates a mist that meets the conditions shown in U.S. Pat. No. 4,116 , 387.

FIG. 2 shows a modified embodiment of the invention. The specific If the spray 310 may contain a large number of large particles, A trap is set.

In each drawing, the same numbers are used to identify corresponding elements.

In FIG. 2, the legs 20 extending from the four-way connector 13 are curved upwards and are It is connected to the vertical leg of the elbow tube 35 with a number of inclined baffle plates 36. fire The horizontal outlet leg of the same tube 35 is connected to the bellows tube 21 for directing the nebulized body to the patient. It is.

The baffle plate arrangement contained within the elbow tube 35 provides a detour for the atomized material and its As a result, a large particle collides with one of the baffle plates due to its mass, causing an error. removed from the rest of the arosol. These large particles reconverted into liquid is automatically recycled into the atomizer and into a liquid storage tank therein. If desirable If so, provide another outlet for this liquid to be returned directly to the storage tank or to the individual receivers. It may be provided.

Methods and devices for performing lung scans using aerosols are available at low cost. This is important not only from the standpoint of reducing the lung burden and making it more comfortable for the patient, but also from the perspective of accurate diagnosis that includes the entire lung. Significantly improved video scanning is now possible, making it extremely easy to scan It turned out to be extremely effective.

Although this invention is particularly effective for performing lung image scans, it is Medicinal treatment of persimmons (but of course effective. For example, this method and device can be used to treat persimmons with fungicides, It is also effective in treating the lungs with antifungal agents, labeled anticancer drugs, etc. This issue Ming's method and apparatus also target antigens such as histamine, such as pigweed. It is also effective in irritant allergy tests to determine the body's response.

While only certain embodiments of the invention have been illustrated and described, the true scope of the invention is , it goes without saying that changes, transformations, and modifications can be made within the scope of the spirit. Nor.

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Claims (1)

[Claims] 1. Including the step of creating a mist by sucking out the radioactively labeled liquid, and this mist The diameter of the particles that make up the body does not exceed 1.2 microns, and most of the particles is usually in the range of 0.056 micron to 1 micron, and the atomized material is heated with oxygen. The mixture is mixed with a gas containing gas and the patient inhales and exhales the above mixture exclusively during the patient's natural breathing process. delivering the mixture to the patient by ejecting the mixture to the patient, whereby the atomized material is delivered to the lung area. substantially uniformly spread throughout the entire lung passageway, yet substantially uniformly throughout the lung passageway. A method for diagnosing lung diseases that involves depositing radioactive substances in the lungs and performing radiographic imaging scans of the lungs. 2. A claim comprising the step of filtering large particles from the mixture after forming the atomized substance. The diagnostic method described in Scope 1. 3. Distribute the above mixture towards the patient through the outlet passage, and the exhaled mixture 2. The diagnostic method of claim 1, further comprising the step of flowing through the second unidirectional passageway. 4. Aspirate liquid that can be used for video scanning, including the use of radioactivity. The diameter of the particles constituting this atomization is 1.2. The majority of particles are usually between 0.056 microns and 1 micron. Mix the above atomized material with a gas within the micron range and inject this mixture into the patient's cavity. so that the atomized material (d) is uniformly distributed throughout the cavity and its inner surface A method for diagnosing diseases that deposits in the body and performs an image scan of its inner surface. (11) 5. Most of the particles are less than 1 micron, ranging from 0.056 micron to 1.2 micron. The liquid is heated using the gas pressure in the tank to create a negative atomized body with particles within the range of means having a sump outlet for sucking out the pressure and a pressure limiting hand connected at one end to the outlet; a conduit including a stage; a unidirectional flow valve communicating with said conduit to permit entry of atmospheric air; a second unidirectional flow valve connected to the other end of the conduit to facilitate patient inhalation of the mist; a second unidirectional flow valve connected to said second unidirectional flow valve and terminating in an outlet; a second conduit, connected to the second conduit and opposite the first and second valves; a third unidirectional flow valve arranged to provide flow in the direction; The patient draws the mist from the suction means by inhalation and by exhalation. The atomized material and gas exhaled by the patient are released through the third flow valve. is inhaled and deposited substantially uniformly throughout the airways, allowing for infiltration throughout the lungs. A device that generates a mist with gas-like properties that can be easily dispersed. 6. against large particles located between said suction means and said first conduit; 6. The mist generating device according to claim 5, further comprising means for serving as an obstacle. 7. The gas pressure is in the range of 6 to 10 liters per minute, and the pressure limiting means The atomized body generating device according to claim 5, wherein said first conduit-like corrugated bellows-like wall comprises: Device. 8. The pressure limiting means is connected to a pressure safety valve communicating with the outlet of the suction means. The mist (12) according to claim 5, generator. 9) - The atomized substance mentioned above was left unattended in four cases, and the third case mentioned above was that it was mixed with the atomized substance. The filter removes radioactive atomized air while the oxygen is released. The mist generating device according to claim 5, comprising: ]-C), J. The pressure limiting means is a pressure relief valve and air or air mixed with atomized material. The device is equipped with a filter that removes radioactive particles while releasing gases such as oxygen. The mist generating device according to claim 9. ]l Most of the powder is 1 micron or less, 0.056 micron 7'l ¥, 1.2 Utilizes the gas pressure of the tank to create a mist with particles in the micron range. means with an outlet for sucking out liquid and a conduit connected at one end to said outlet; A unidirectional flow valve connected to the above conduit allows the patient to enter the atomized body. means coupled to said conduit for facilitating the inhalation of said conduit; connected and arranged to allow flow in the opposite direction to the first flow valve. The first time It consists of two unidirectional flow valves, which allow the above-mentioned hemp to flow upward by the suction depression. The atomized material is drawn out from the suction means, and the gas exhaled by exhalation and The mist is released through the second flow valve and is inhaled by the patient and distributed throughout the airway. a gas that is deposited substantially uniformly throughout the body and readily penetrates the lungs A device that generates mist with similar properties.