JPS5946925B2 - cosmetic composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides allantoin and 2-pyrrolidone in the cosmetic base material.
The present invention relates to a cosmetic composition which is blended with a molecular compound of 5-carboxylic acid (hereinafter simply abbreviated as PCA) salt, imparts moisture to the skin after use, and suppresses skin irritation.

In recent years, cosmetic ingredients and various additives that are effective in improving the beautification of the skin have been developed.

On the other hand, problems with skin disorders due to idiosyncratic allergies have been proposed.

It is widely known that allantoin is effective against such skin disorders.

Allantoin has properties such as soothing effect on allergic skin, cell proliferation effect, lysis of keratin, and excretion of necrotic tissue.

However, allantoin has a low solubility in water, so it is difficult to add it to cosmetics.

The present inventors have conducted various studies on compounds that have the advantageous properties of allantoin and have increased solubility in water, and have found that a molecular compound of allantoin and PCA salt is effective when added to cosmetic compositions. The present invention has now been completed.

That is, the present invention is a cosmetic composition in which a molecular compound of allantoin and PCA salt obtained by reacting allantoin and PCA salt is added and blended into a cosmetic composition.

The molecular compound of allantoin and PCA salt used in the present invention has the same action 2 as allantoin, and is a harmless compound with no action on the skin, as will be described later.

Table 1 shows characteristic values showing the water solubility and moisture retaining property (the ability of a compound to retain water) of these compounds.

Reference values for moisturizing properties: 40% glycerin, 30% propylene glycol, 10% sorbitol, solubility in water?
Looking at Table 1, allantoin is 0.033 mol/l
, allantoin PCA sodium 0.077 mol/l, allantoin di(PCA) calcium 0.0
91 Mo#/, e S '7 Lantoin, Tori (PCA
) Aluminum is 0.121 mol/l, and the solubility per pure allantoin content is increased by 2.5 to 4 times DO.The product of the present invention can be used in general lotions, astringents, deodorants, aftershaves, and cleansing. There are white powders, red powders, etc., and it can be used in lotions, milky lotions, creams, powders, etc.

The salts of the molecular compound of allantoin and PCA salt added in the present invention include alkali metals such as sodium and potassium, alkaline earth metals such as calcium and magnesium, aluminum, etc., or mixtures of two or more of these. Can you name it?

Among these metal salts, aluminum salts have an astringent effect, and therefore, it is extremely effective to add them to products that take advantage of this property, such as aftershave lotions, astringents, deodorants, and the like.

As mentioned above, the molecular compound of allantoin and PCA salt has a higher solubility in water than allantoin, so when it is blended into a cosmetic base material, it dissolves in a larger amount than when added as allantoin.

When the molecular compound of allantoin and PCA salt is used as an emulsifier, it has a solubilizing effect and can be solubilized in water at a higher level than its solubility in pure water.

Therefore, the molecular compound of allantoin and PCA salt has the advantage that it is difficult to separate as a precipitate, unlike when allantoin is added as a precipitate.

When a cosmetic composition is used, it has a very good affinity for the skin surface and can be applied evenly, allowing its effects to be fully exhibited.

Kirani has a moisturizing property that is not found in allantoin, so it has the effect of moisturizing the skin surface.

Next, the test results of a continuous open patch test and a closed patch test that confirmed the safety of the allantoin/PCA sodium molecule compound on the skin are as follows.

(1) Primary skin irritation test by open patch test;
Approximately 3 x 5 c/r on the left upper arm of 40 healthy male subjects.
Mark two frames in the range of L, use Vaseline as a soft base mark within the frame, and add allantoin, P in column 10.
Kneaded with CA sodium and vaseline as a control? A sample was applied once a day for two consecutive weeks.

The application site was observed every day for 3 weeks starting from the 2nd day.

As a result, no subjects were found to have any abnormality at the application site during the entire observation period.

Therefore, it was found that this product did not cause any skin damage during two weeks of continuous open patch testing.

(2) Primary skin irritation test by closed patch test method; allantoin PCA sodium 0.5%, Section 2;
Section 8 prepared a 32% Vaseline mixture and tested 40 subjects.
A Punch Test bandage (standard size) manufactured by Torii Pharmaceutical Co., Ltd. was applied to the back of a healthy male with a normal size.

Two samples, Vaseline and free, were added as controls.

The bandage was removed 48 hours after application, and the presence or absence of skin eruption and its severity were observed.

Furthermore, observations were made 72 hours after application (24 hours after removal of the bandage) to examine changes over time.

The observation results were divided into scores according to Table 2, tabulated, and subjected to statistical processing, and the results shown in Table 3 were obtained.

As a result, no significant difference could be found in primary skin irritation.

Examples will be described in detail below, but the present invention is not limited thereto.

In the examples, percentages are expressed as weight percent.

Example 1 Lotion allantoin/PCA sodium 0.5% propylene glycol 5.0 diethyl alcohol
5.0% preservative/antioxidant
Appropriate, fragrance, pigment, appropriate, pure water, 100%...what are the above ingredients? A lotion was obtained by mixing and dissolving.

This product has moisturizing properties and is non-irritating and can be used as a cleansing lotion.

Example 2 Lotion allantoin, tri(PCA) Aluminum 0.5% Ethyl alcohol 10th part Polyoxine ethylene sorbitan monolaure-4 (E, 0.2omol) 1.5th part Menthol 0.1st part Preservative Antiseptic Oxidizing agent as appropriate Pure water
A lotion was obtained by mixing and dissolving the above ingredients.

It has moisturizing properties, is non-irritating, and has a moderate astringent effect, making it useful as an after-shave lotion.

Example 3 Eye Makeup Remover Allantoin PCA Sodium 0.5% Salt
0.9 polyoxyethylene stearate (E, 0.2
0 mole) 0.25 factor pure water
Then, 10 tons of the above ingredients were mixed and dissolved, and sterilized and filtered to obtain a cosmetic to be used for wiping or washing eye caps.

Example 4 Emulsion [A] Liquid paraffin (HLBlo, 2) 10.0 factor Lanolin 6.0 factor Glycerin monostearate 10.0 factor Preservative Antioxidant 0.1% Fragrance 0.3 factor CB, 1 pure water 73.0 Allantoin/PCA Sodium 0.6 Oil layer (A) and aqueous layer (B) were heated and dissolved in 70', mixed and emulsified at 70°C, and heated to 30°C with stirring.
A non-irritating emulsion was obtained.

Example 5 Cream (A, l Liquid paraffin (#70) 35.5 scale solid paraffin (mp42-44°C) 5.5 scale stearyl alcohol 4.0% Rubitan monostearate 1.4 scale polyoxyethylene. Sorbitan monostearate (E, 0.20 mol) 3.6% Preservative/antioxidant 0.1% Fragrance 0.4% CB) Pure water 49.0 Allantoin tri(PCA) Aluminum 0.5% Oil layer (A) and water layer (Bl) were heated and dissolved at 80°C, and both components were mixed and emulsified at 80°C, and cooled to 30°C with stirring to obtain an astringent and non-irritating cream.

Example 6 Antiperspirant deodorant Allantoin tri(PCA) aluminum 3.5% Aerosil 200 0.4 factor Isopropyl myristate 6.1% Fragrance Appropriate Freon 12 40 factor Freon 11 50 factor Allantoin tri(PCA) aluminum The fine powder was dispersed in fluorocarbon gas and emollient oil.

This product is non-irritating and is used as an antiperspirant and deodorant.

Examples 7 and 8, Comparative Examples 1 and 2.3 Observation of appearance and use test of a lotion using the molecular compound of allantoin and PCA salt of the present invention and a lotion using sodium PCA and allantoin alone as a comparative example I did it.

In the usage test, three items were evaluated: astringent effect, rough skin, and moist feeling.

The evaluation method for each item was conducted by 10 men and women (5 men, 5 women).
Compare the sample with the sample of Comparative Example 1 and give it an evaluation score of 0 points if it is the same, +1 point if it is better, and -1 point if it is inferior. It was determined that

[Judgment criteria] -10 to -6...
・×-5～ 0・・・・・・・・・△ l～ 5・・・・・・・・・0 6～10・・・・・・・・・◎ Table 4 shows the appearance and evaluation. Show the results.

As is clear from the results in Table 4, the molecular compound of allantoin and PCA salt of the present invention has a high solubility, so it does not become cloudy even when added to lotion, and the results of the use test also show that the molecular compound of allantoin and allantoin of the present invention has a high solubility, so it does not become cloudy even when added to lotion. And both? It was found to be superior to the lotion used in combination.

Claims (1)

[Claims] 1. A cosmetic composition comprising a molecular compound of allantoin and a metal salt of 2-pyrrolidone-5-carboxylic acid.