JPS5944375A - α−トコフエロ−ルリン酸エステルの安定な水溶液 - Google Patents
α−トコフエロ−ルリン酸エステルの安定な水溶液Info
- Publication number
- JPS5944375A JPS5944375A JP15563782A JP15563782A JPS5944375A JP S5944375 A JPS5944375 A JP S5944375A JP 15563782 A JP15563782 A JP 15563782A JP 15563782 A JP15563782 A JP 15563782A JP S5944375 A JPS5944375 A JP S5944375A
- Authority
- JP
- Japan
- Prior art keywords
- aqueous solution
- alpha
- tocopherol
- water
- phosphoric ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007864 aqueous solution Substances 0.000 title claims abstract description 16
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 title abstract description 21
- 229940087168 alpha tocopherol Drugs 0.000 title abstract description 10
- 229960000984 tocofersolan Drugs 0.000 title abstract description 10
- 239000002076 α-tocopherol Substances 0.000 title abstract description 10
- 235000004835 α-tocopherol Nutrition 0.000 title abstract description 10
- 150000002148 esters Chemical class 0.000 title abstract description 9
- -1 alkali metal salt) Chemical class 0.000 claims abstract description 28
- 150000003839 salts Chemical class 0.000 claims abstract description 13
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 229910019142 PO4 Inorganic materials 0.000 claims description 13
- 239000010452 phosphate Substances 0.000 claims description 13
- JUIUXBHZFNHITF-IEOSBIPESA-N [(2r)-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] dihydrogen phosphate Chemical compound OP(=O)(O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C JUIUXBHZFNHITF-IEOSBIPESA-N 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 239000011732 tocopherol Substances 0.000 claims description 5
- 229960001295 tocopherol Drugs 0.000 claims description 5
- 239000002736 nonionic surfactant Substances 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 241000219109 Citrullus Species 0.000 claims 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000007951 isotonicity adjuster Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract 1
- 230000003836 peripheral circulation Effects 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
- 239000000203 mixture Substances 0.000 description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
- 239000002253 acid Substances 0.000 description 9
- 238000009472 formulation Methods 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 229930003799 tocopherol Natural products 0.000 description 4
- 235000010384 tocopherol Nutrition 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 239000000594 mannitol Substances 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- SFKTYEXKZXBQRQ-UHFFFAOYSA-J thorium(4+);tetrahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[Th+4] SFKTYEXKZXBQRQ-UHFFFAOYSA-J 0.000 description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical compound C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- GVJHHUAWPYXKBD-QLVXXPONSA-N (S,R,R)-alpha-tocopherol Chemical compound [H][C@@](C)(CCCC(C)C)CCC[C@@]([H])(C)CCC[C@@]1(C)CCC2=C(O1)C(C)=C(C)C(O)=C2C GVJHHUAWPYXKBD-QLVXXPONSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241001385733 Aesculus indica Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000238366 Cephalopoda Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 244000228957 Ferula foetida Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- 235000019687 Lamb Nutrition 0.000 description 1
- 235000019738 Limestone Nutrition 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000047703 Nonion Species 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 244000028419 Styrax benzoin Species 0.000 description 1
- 235000000126 Styrax benzoin Nutrition 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 235000008411 Sumatra benzointree Nutrition 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 229960002130 benzoin Drugs 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 235000019382 gum benzoic Nutrition 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000006028 limestone Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N nicotinic acid Natural products OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 239000003186 pharmaceutical solution Substances 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 238000010415 tidying Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15563782A JPS5944375A (ja) | 1982-09-06 | 1982-09-06 | α−トコフエロ−ルリン酸エステルの安定な水溶液 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15563782A JPS5944375A (ja) | 1982-09-06 | 1982-09-06 | α−トコフエロ−ルリン酸エステルの安定な水溶液 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5944375A true JPS5944375A (ja) | 1984-03-12 |
| JPH0332558B2 JPH0332558B2 (OSRAM) | 1991-05-13 |
Family
ID=15610323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15563782A Granted JPS5944375A (ja) | 1982-09-06 | 1982-09-06 | α−トコフエロ−ルリン酸エステルの安定な水溶液 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5944375A (OSRAM) |
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0236120A3 (en) * | 1986-03-04 | 1989-10-11 | Senju Seiyaku Kabushiki Kaisha Also Known As Senju Pharmaceutical Co. Ltd. | Mixed phosphoric diesters, preparation thereof, and use thereof as antiinflammatory agents |
| EP0652010A1 (fr) * | 1990-01-31 | 1995-05-10 | Lvmh Recherche | Utilisation d'un phosphate d'alpha-tocophérol, ou d'un de ses dérivés pour la préparation d'une composition cosmétique, dermatologique ou pharmaceutique, à activité anti-radicalaire ; composition ainsi obtenue |
| WO1997014705A1 (fr) * | 1995-10-17 | 1997-04-24 | Showa Denko K.K. | Phosphates de tocopherol tres purs, procedes de preparation, techniques d'analyse et produits cosmetiques correspondants |
| EP0845216A1 (en) * | 1996-11-27 | 1998-06-03 | Showa Denko Kabushiki Kaisha | A composition for administration to animals containing a tocopheryl phosphate |
| US6022867A (en) * | 1996-11-27 | 2000-02-08 | Showa Denko Kabushiki Kaisha | Method of administering vitamin E to animals and compositions containing tocopheryl phosphates and salts thereof for animals |
| WO2002040034A1 (en) * | 2000-11-14 | 2002-05-23 | Vital Health Sciences Pty Ltd. | Complexes of phosphate derivatives |
| JP2002241279A (ja) * | 2001-02-16 | 2002-08-28 | Kanebo Ltd | 包装体入り製品及び吸着防止方法 |
| JP2011184386A (ja) * | 2010-03-10 | 2011-09-22 | Nippon Menaade Keshohin Kk | 透明液状皮膚外用剤 |
| JP2011201820A (ja) * | 2010-03-26 | 2011-10-13 | Nippon Menaade Keshohin Kk | 透明液状皮膚外用剤 |
| JP2011207808A (ja) * | 2010-03-30 | 2011-10-20 | Nippon Menaade Keshohin Kk | 抗菌剤 |
| JP2014141431A (ja) * | 2013-01-23 | 2014-08-07 | Showa Denko Kk | 皮膚外用剤 |
| WO2016031634A1 (en) | 2014-08-29 | 2016-03-03 | Showa Denko K. K. | Skin color-improving agent and composition for improving skin color |
| WO2016186201A1 (ja) * | 2015-05-20 | 2016-11-24 | 昭和電工株式会社 | トコフェロールリン酸エステル塩およびその製造方法、皮膚外用剤 |
| US10071030B2 (en) | 2010-02-05 | 2018-09-11 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
| CN108601732A (zh) * | 2015-12-09 | 2018-09-28 | 磷肌酸有限公司 | 药物制剂 |
| US10188670B2 (en) | 2011-03-15 | 2019-01-29 | Phosphagenics Limited | Composition |
| WO2019073930A1 (ja) | 2017-10-11 | 2019-04-18 | 昭和電工株式会社 | ゲル組成物 |
| WO2020090881A1 (ja) | 2018-11-02 | 2020-05-07 | 昭和電工株式会社 | 水中油滴型皮膚外用剤 |
| WO2020230726A1 (ja) | 2019-05-13 | 2020-11-19 | 昭和電工株式会社 | 大気汚染物質からの保護剤及び大気汚染物質からの保護用組成物 |
| WO2020230741A1 (ja) | 2019-05-13 | 2020-11-19 | 昭和電工株式会社 | がん細胞増殖抑制剤及びがん細胞増殖抑制用組成物 |
| WO2022059775A1 (ja) | 2020-09-17 | 2022-03-24 | 昭和電工株式会社 | オートファジー活性化剤 |
| WO2022059776A1 (ja) | 2020-09-17 | 2022-03-24 | 昭和電工株式会社 | オートファジー活性化剤 |
| US11753435B2 (en) | 2016-12-21 | 2023-09-12 | Avecho Biotechnology Limited | Process |
| WO2024253199A1 (ja) | 2023-06-08 | 2024-12-12 | 株式会社レゾナック | 自己組織化構造体を含む組成物、及びその凍結乾燥物 |
-
1982
- 1982-09-06 JP JP15563782A patent/JPS5944375A/ja active Granted
Cited By (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0236120A3 (en) * | 1986-03-04 | 1989-10-11 | Senju Seiyaku Kabushiki Kaisha Also Known As Senju Pharmaceutical Co. Ltd. | Mixed phosphoric diesters, preparation thereof, and use thereof as antiinflammatory agents |
| EP0652010A1 (fr) * | 1990-01-31 | 1995-05-10 | Lvmh Recherche | Utilisation d'un phosphate d'alpha-tocophérol, ou d'un de ses dérivés pour la préparation d'une composition cosmétique, dermatologique ou pharmaceutique, à activité anti-radicalaire ; composition ainsi obtenue |
| WO1997014705A1 (fr) * | 1995-10-17 | 1997-04-24 | Showa Denko K.K. | Phosphates de tocopherol tres purs, procedes de preparation, techniques d'analyse et produits cosmetiques correspondants |
| US5965750A (en) * | 1995-10-17 | 1999-10-12 | Showa Denko K.K. | High- purity tocopherol phosphates, process for the preparation thereof, methods for analysis thereof, and cosmetics |
| US6046181A (en) * | 1995-10-17 | 2000-04-04 | Showa Denko K.K. | Highly purified tocopheryl phosphate, process for producing the same, analytical method therefor and cosmetic |
| EP0845216A1 (en) * | 1996-11-27 | 1998-06-03 | Showa Denko Kabushiki Kaisha | A composition for administration to animals containing a tocopheryl phosphate |
| US6022867A (en) * | 1996-11-27 | 2000-02-08 | Showa Denko Kabushiki Kaisha | Method of administering vitamin E to animals and compositions containing tocopheryl phosphates and salts thereof for animals |
| JP2004513183A (ja) * | 2000-11-14 | 2004-04-30 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | リン酸誘導体の複合体 |
| WO2002040034A1 (en) * | 2000-11-14 | 2002-05-23 | Vital Health Sciences Pty Ltd. | Complexes of phosphate derivatives |
| JP2002241279A (ja) * | 2001-02-16 | 2002-08-28 | Kanebo Ltd | 包装体入り製品及び吸着防止方法 |
| US10071030B2 (en) | 2010-02-05 | 2018-09-11 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
| JP2011184386A (ja) * | 2010-03-10 | 2011-09-22 | Nippon Menaade Keshohin Kk | 透明液状皮膚外用剤 |
| JP2011201820A (ja) * | 2010-03-26 | 2011-10-13 | Nippon Menaade Keshohin Kk | 透明液状皮膚外用剤 |
| JP2011207808A (ja) * | 2010-03-30 | 2011-10-20 | Nippon Menaade Keshohin Kk | 抗菌剤 |
| US10188670B2 (en) | 2011-03-15 | 2019-01-29 | Phosphagenics Limited | Composition |
| JP2014141431A (ja) * | 2013-01-23 | 2014-08-07 | Showa Denko Kk | 皮膚外用剤 |
| WO2016031634A1 (en) | 2014-08-29 | 2016-03-03 | Showa Denko K. K. | Skin color-improving agent and composition for improving skin color |
| CN107531733A (zh) * | 2015-05-20 | 2018-01-02 | 昭和电工株式会社 | 生育酚磷酸酯盐及其制造方法、皮肤外用剂 |
| CN107531733B (zh) * | 2015-05-20 | 2019-08-30 | 昭和电工株式会社 | 生育酚磷酸酯盐及其制造方法、皮肤外用剂 |
| JPWO2016186201A1 (ja) * | 2015-05-20 | 2018-03-08 | 昭和電工株式会社 | トコフェロールリン酸エステル塩およびその製造方法、皮膚外用剤 |
| WO2016186201A1 (ja) * | 2015-05-20 | 2016-11-24 | 昭和電工株式会社 | トコフェロールリン酸エステル塩およびその製造方法、皮膚外用剤 |
| JP2018537534A (ja) * | 2015-12-09 | 2018-12-20 | フォスファージニクス リミテッド | 医薬製剤 |
| EP3383371A4 (en) * | 2015-12-09 | 2019-07-24 | Phosphagenics Limited | PHARMACEUTICAL FORMULATION |
| CN108601732A (zh) * | 2015-12-09 | 2018-09-28 | 磷肌酸有限公司 | 药物制剂 |
| US10973761B2 (en) | 2015-12-09 | 2021-04-13 | Phosphagenics Limited | Pharmaceutical formulation |
| US11753435B2 (en) | 2016-12-21 | 2023-09-12 | Avecho Biotechnology Limited | Process |
| WO2019073930A1 (ja) | 2017-10-11 | 2019-04-18 | 昭和電工株式会社 | ゲル組成物 |
| WO2020090881A1 (ja) | 2018-11-02 | 2020-05-07 | 昭和電工株式会社 | 水中油滴型皮膚外用剤 |
| WO2020230726A1 (ja) | 2019-05-13 | 2020-11-19 | 昭和電工株式会社 | 大気汚染物質からの保護剤及び大気汚染物質からの保護用組成物 |
| WO2020230741A1 (ja) | 2019-05-13 | 2020-11-19 | 昭和電工株式会社 | がん細胞増殖抑制剤及びがん細胞増殖抑制用組成物 |
| WO2022059775A1 (ja) | 2020-09-17 | 2022-03-24 | 昭和電工株式会社 | オートファジー活性化剤 |
| WO2022059776A1 (ja) | 2020-09-17 | 2022-03-24 | 昭和電工株式会社 | オートファジー活性化剤 |
| WO2024253199A1 (ja) | 2023-06-08 | 2024-12-12 | 株式会社レゾナック | 自己組織化構造体を含む組成物、及びその凍結乾燥物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0332558B2 (OSRAM) | 1991-05-13 |
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