JPS59193102A - 選択透過性中空糸 - Google Patents
選択透過性中空糸Info
- Publication number
- JPS59193102A JPS59193102A JP6729683A JP6729683A JPS59193102A JP S59193102 A JPS59193102 A JP S59193102A JP 6729683 A JP6729683 A JP 6729683A JP 6729683 A JP6729683 A JP 6729683A JP S59193102 A JPS59193102 A JP S59193102A
- Authority
- JP
- Japan
- Prior art keywords
- polymer component
- hydrophilic
- hydrophobic
- membrane
- block copolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001400 block copolymer Polymers 0.000 claims abstract description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 18
- 229920001600 hydrophobic polymer Polymers 0.000 claims abstract description 18
- 229920000642 polymer Polymers 0.000 claims abstract description 10
- 238000009833 condensation Methods 0.000 claims abstract description 7
- 230000005494 condensation Effects 0.000 claims abstract description 7
- 239000012510 hollow fiber Substances 0.000 claims description 36
- 238000010521 absorption reaction Methods 0.000 claims description 15
- 239000000835 fiber Substances 0.000 claims description 2
- 230000035699 permeability Effects 0.000 abstract description 18
- 238000000502 dialysis Methods 0.000 abstract description 9
- 238000002074 melt spinning Methods 0.000 abstract description 9
- 229920001577 copolymer Polymers 0.000 abstract description 5
- 125000003118 aryl group Chemical group 0.000 abstract description 3
- 230000002209 hydrophobic effect Effects 0.000 abstract description 3
- 238000000108 ultra-filtration Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 description 62
- 238000000034 method Methods 0.000 description 36
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 30
- -1 polyethylene terephthalate-polyethylene Polymers 0.000 description 21
- 210000004369 blood Anatomy 0.000 description 17
- 239000008280 blood Substances 0.000 description 17
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
- 239000000126 substance Substances 0.000 description 12
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 11
- 229920001059 synthetic polymer Polymers 0.000 description 11
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- 238000001035 drying Methods 0.000 description 8
- 238000001631 haemodialysis Methods 0.000 description 8
- 230000000322 hemodialysis Effects 0.000 description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 6
- 239000004202 carbamide Substances 0.000 description 6
- 230000004087 circulation Effects 0.000 description 6
- 230000024203 complement activation Effects 0.000 description 6
- 230000005856 abnormality Effects 0.000 description 5
- 230000002489 hematologic effect Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 239000004677 Nylon Substances 0.000 description 4
- 229920002292 Nylon 6 Polymers 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 4
- 201000002364 leukopenia Diseases 0.000 description 4
- 231100001022 leukopenia Toxicity 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 229920001778 nylon Polymers 0.000 description 4
- 229920001281 polyalkylene Polymers 0.000 description 4
- 229920000139 polyethylene terephthalate Polymers 0.000 description 4
- 239000005020 polyethylene terephthalate Substances 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- 230000001052 transient effect Effects 0.000 description 4
- 229920002554 vinyl polymer Polymers 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 150000002334 glycols Chemical class 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 229920002635 polyurethane Polymers 0.000 description 3
- 239000004814 polyurethane Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
- 229930003451 Vitamin B1 Natural products 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- WOZVHXUHUFLZGK-UHFFFAOYSA-N dimethyl terephthalate Chemical compound COC(=O)C1=CC=C(C(=O)OC)C=C1 WOZVHXUHUFLZGK-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 229920002492 poly(sulfone) Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 2
- 229960003495 thiamine Drugs 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 239000011691 vitamin B1 Substances 0.000 description 2
- 235000010374 vitamin B1 Nutrition 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- DEUJSGDXBNTQMY-UHFFFAOYSA-N 1,2,2-trifluoroethanol Chemical compound OC(F)C(F)F DEUJSGDXBNTQMY-UHFFFAOYSA-N 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 102000000989 Complement System Proteins Human genes 0.000 description 1
- 108010069112 Complement System Proteins Proteins 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 101100263876 Homo sapiens VPS4B gene Proteins 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 101150028530 MIG1 gene Proteins 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 101100111630 Mus musculus Naip1 gene Proteins 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004734 Polyphenylene sulfide Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 102100035086 Vacuolar protein sorting-associated protein 4B Human genes 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001412 amines Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000002429 anti-coagulating effect Effects 0.000 description 1
- 229920003235 aromatic polyamide Polymers 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229920000402 bisphenol A polycarbonate polymer Polymers 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
- 150000004985 diamines Chemical class 0.000 description 1
- 125000005442 diisocyanate group Chemical group 0.000 description 1
- BTVWZWFKMIUSGS-UHFFFAOYSA-N dimethylethyleneglycol Natural products CC(C)(O)CO BTVWZWFKMIUSGS-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- VIBDJEWPNNCFQO-UHFFFAOYSA-N ethane-1,1,2-triol Chemical compound OCC(O)O VIBDJEWPNNCFQO-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010559 graft polymerization reaction Methods 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 150000003951 lactams Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 125000006353 oxyethylene group Chemical group 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920001707 polybutylene terephthalate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920001692 polycarbonate urethane Polymers 0.000 description 1
- 238000006068 polycondensation reaction Methods 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920005597 polymer membrane Polymers 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 229920006380 polyphenylene oxide Polymers 0.000 description 1
- 229920000069 polyphenylene sulfide Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6729683A JPS59193102A (ja) | 1983-04-16 | 1983-04-16 | 選択透過性中空糸 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6729683A JPS59193102A (ja) | 1983-04-16 | 1983-04-16 | 選択透過性中空糸 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS59193102A true JPS59193102A (ja) | 1984-11-01 |
JPH0475052B2 JPH0475052B2 (enrdf_load_stackoverflow) | 1992-11-27 |
Family
ID=13340883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6729683A Granted JPS59193102A (ja) | 1983-04-16 | 1983-04-16 | 選択透過性中空糸 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS59193102A (enrdf_load_stackoverflow) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61209011A (ja) * | 1985-03-07 | 1986-09-17 | ガムブロ ダイアリイサトレン コマンデイツトゲゼルシヤフト | 半透過性中空繊維膜の製造方法 |
JPS62201603A (ja) * | 1986-02-28 | 1987-09-05 | Daicel Chem Ind Ltd | 親水化ポリスルホン膜 |
US5279738A (en) * | 1990-06-26 | 1994-01-18 | Terumo Kabushiki Kaisha | Permeable membrane excellent in biocompatibility |
WO1995001218A1 (en) * | 1993-06-30 | 1995-01-12 | Biomedical Sensors, Ltd. | Biphasic material |
EP0781795A3 (en) * | 1995-12-26 | 1997-12-03 | Teijin Limited | Application of sulfone, ketone and ester containing polyalkyl ethers to medical materials |
EP0840759A4 (en) * | 1995-07-27 | 1998-10-07 | Grace W R & Co | BLOCK COPOLYMERS |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4971076A (enrdf_load_stackoverflow) * | 1972-09-21 | 1974-07-09 | ||
JPS5170190A (ja) * | 1974-12-17 | 1976-06-17 | Mitsubishi Petrochemical Co | Kotokaseimaku |
JPS5424987A (en) * | 1977-07-27 | 1979-02-24 | Teijin Ltd | Photopolymerizable composition |
JPS551887A (en) * | 1979-04-09 | 1980-01-09 | Toyobo Co Ltd | Preparing membrane by removing component from multiple component material |
JPS584810A (ja) * | 1982-03-26 | 1983-01-12 | Toyobo Co Ltd | 微孔性中空繊維 |
-
1983
- 1983-04-16 JP JP6729683A patent/JPS59193102A/ja active Granted
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4971076A (enrdf_load_stackoverflow) * | 1972-09-21 | 1974-07-09 | ||
JPS5170190A (ja) * | 1974-12-17 | 1976-06-17 | Mitsubishi Petrochemical Co | Kotokaseimaku |
JPS5424987A (en) * | 1977-07-27 | 1979-02-24 | Teijin Ltd | Photopolymerizable composition |
JPS551887A (en) * | 1979-04-09 | 1980-01-09 | Toyobo Co Ltd | Preparing membrane by removing component from multiple component material |
JPS584810A (ja) * | 1982-03-26 | 1983-01-12 | Toyobo Co Ltd | 微孔性中空繊維 |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61209011A (ja) * | 1985-03-07 | 1986-09-17 | ガムブロ ダイアリイサトレン コマンデイツトゲゼルシヤフト | 半透過性中空繊維膜の製造方法 |
JPS62201603A (ja) * | 1986-02-28 | 1987-09-05 | Daicel Chem Ind Ltd | 親水化ポリスルホン膜 |
US5279738A (en) * | 1990-06-26 | 1994-01-18 | Terumo Kabushiki Kaisha | Permeable membrane excellent in biocompatibility |
WO1995001218A1 (en) * | 1993-06-30 | 1995-01-12 | Biomedical Sensors, Ltd. | Biphasic material |
EP0840759A4 (en) * | 1995-07-27 | 1998-10-07 | Grace W R & Co | BLOCK COPOLYMERS |
EP0781795A3 (en) * | 1995-12-26 | 1997-12-03 | Teijin Limited | Application of sulfone, ketone and ester containing polyalkyl ethers to medical materials |
US6166168A (en) * | 1995-12-26 | 2000-12-26 | Teijin Limited | Application of sulfone, ketone and ester containing polyalkyl ether units to medical materials |
Also Published As
Publication number | Publication date |
---|---|
JPH0475052B2 (enrdf_load_stackoverflow) | 1992-11-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR100432464B1 (ko) | 폴리술폰 중공사 반투막 | |
US5258149A (en) | Process of making a membrane for high efficiency removal of low density lipoprotein-cholesterol from whole blood | |
AU660425B2 (en) | High efficiency removal of low density lipoprotein-cholesterol from whole blood | |
US5187010A (en) | Membrane having high affinity for low density lipoprotein-cholesterol from whole blood | |
JP4534486B2 (ja) | 親水性材料及びその製造方法 | |
US5418061A (en) | Microporous polysulfone supports suitable for removal of low density lipoprotein-cholesterol | |
KR20010031000A (ko) | 불소원자를 갖는 폴리설폰을 포함하는, 항혈전성이 우수한의료용 재료 | |
JP3617194B2 (ja) | 選択透過性分離膜及びその製造方法 | |
WO2018062451A1 (ja) | 分離膜モジュール | |
JP3966481B2 (ja) | 半透膜 | |
CA1107467A (en) | Polycarbonate membranes for use in hemodialysis | |
JPS59193102A (ja) | 選択透過性中空糸 | |
JP3714686B2 (ja) | ポリスルホン系中空糸膜及びその製造方法 | |
JP2703266B2 (ja) | ポリスルホン中空繊維膜およびその製法 | |
US4705632A (en) | Hollow fiber membrane formed from a block copolymer of aromatic polyester and polyoxyethylene for dialysis of blood | |
JP2000126286A (ja) | 血液処理装置 | |
JPS63130103A (ja) | ポリアクリロニトリル系半透膜及びその製造法 | |
JPH09308685A (ja) | 血液浄化用中空糸膜及び血液浄化器 | |
JPH0536065B2 (enrdf_load_stackoverflow) | ||
Paul | Polymer hollow fiber membranes for removal of toxic substances from blood | |
US4274965A (en) | Lactam terpolymer membranes | |
JP3836204B2 (ja) | 血液適合性に優れた医療用材料 | |
JP4830181B2 (ja) | 過酸化脂質吸着用中空糸膜およびそれを用いたモジュール | |
JPH02273522A (ja) | ポリアクリロニトリル系中空糸膜およびその製造法 | |
HK1008879A (en) | Polysulfone hollow fiber semipermeable membrane |