JPS59118800A - ３′，５′−ジ−ｏ−フエノキシカルボニル置換−２′−デオキシ−５−フルオロウリジン誘導体及びその製造方法並びにこれを含有する抗腫瘍剤 - Google Patents
３′，５′−ジ−ｏ−フエノキシカルボニル置換−２′−デオキシ−５−フルオロウリジン誘導体及びその製造方法並びにこれを含有する抗腫瘍剤Info
- Publication number
- JPS59118800A JPS59118800A JP22659482A JP22659482A JPS59118800A JP S59118800 A JPS59118800 A JP S59118800A JP 22659482 A JP22659482 A JP 22659482A JP 22659482 A JP22659482 A JP 22659482A JP S59118800 A JPS59118800 A JP S59118800A
- Authority
- JP
- Japan
- Prior art keywords
- group
- fluorouridine
- deoxy
- substituted
- antitumor agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- 229910000498 pewter Inorganic materials 0.000 description 1
- 239000010957 pewter Substances 0.000 description 1
- AHWALFGBDFAJAI-UHFFFAOYSA-N phenyl carbonochloridate Chemical compound ClC(=O)OC1=CC=CC=C1 AHWALFGBDFAJAI-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229940113115 polyethylene glycol 200 Drugs 0.000 description 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22659482A JPS59118800A (ja) | 1982-12-27 | 1982-12-27 | ３′，５′−ジ−ｏ−フエノキシカルボニル置換−２′−デオキシ−５−フルオロウリジン誘導体及びその製造方法並びにこれを含有する抗腫瘍剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22659482A JPS59118800A (ja) | 1982-12-27 | 1982-12-27 | ３′，５′−ジ−ｏ−フエノキシカルボニル置換−２′−デオキシ−５−フルオロウリジン誘導体及びその製造方法並びにこれを含有する抗腫瘍剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59118800A true JPS59118800A (ja) | 1984-07-09 |
| JPH0340035B2 JPH0340035B2 (enrdf_load_html_response) | 1991-06-17 |
Family
ID=16847627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP22659482A Granted JPS59118800A (ja) | 1982-12-27 | 1982-12-27 | ３′，５′−ジ−ｏ−フエノキシカルボニル置換−２′−デオキシ−５−フルオロウリジン誘導体及びその製造方法並びにこれを含有する抗腫瘍剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59118800A (enrdf_load_html_response) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013137427A1 (ja) * | 2012-03-16 | 2013-09-19 | 大鵬薬品工業株式会社 | 新規ピリミジンヌクレオシド化合物 |
-
1982
- 1982-12-27 JP JP22659482A patent/JPS59118800A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013137427A1 (ja) * | 2012-03-16 | 2013-09-19 | 大鵬薬品工業株式会社 | 新規ピリミジンヌクレオシド化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0340035B2 (enrdf_load_html_response) | 1991-06-17 |
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