JPS59116549A - Method and apparatus for monitoring analysis data for automatic analyzer - Google Patents

Abstract

PURPOSE:To enable a higher reliability by displaying a time course related to an analysis data on a monitor for each object to be measured in an automatic analyzer which analyzes it several times with distribution of a specified reaction reagent corresponding to an item to be measured after a specified amount thereof is taken into a reaction tube by measuring. CONSTITUTION:A measuring turret 12 is turned by 360 deg. during one intermittent rotation of a changer 13 synchronizing the operation thereof 13. While a reaction tube 5' is retained on the measuring turret 12, measurements are performed several times with an optical device 17. An analysis data for each time of optical measurement is sent to a memory circuit 22 for each sample memorize. After measurement is done at a necessary frequency, hourly changes in the reaction for the same sample are computed and sent to a holding circuit 24 for the same sample to hold data necessary for the display of a time course for each sample. The data held is indicated on a monitor unit CRT as time course graph at the end of optical measurement.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method and apparatus for monitoring analytical data in an automatic analyzer particularly suitable for biochemical analysis and immunological serum testing.

As is well known, automatic analyzers have attracted attention in recent years as devices that can accurately and quickly process the measurement and analysis of a large number of test samples (serum) without the need for human intervention, and many models have been developed. has been done.

By the way, in such an automatic analyzer, it is automatic to check the operating status of each device that makes up the automatic analyzer and whether or not the theoretical reaction between the analyte and the reaction reagent is occurring theoretically. This is required for measurement accuracy control in analyzers.

Among these methods, a so-called centrifugal monitor method is conventionally known as a method for confirming whether or not the reaction of a sample to be measured is progressing. This monitoring method will be explained based on FIG.
2...Sn multiple analysis data H,,
H2... Hn is displayed in a bar graph format on the monitor device every time it is measured.

However, in one such conventional monitoring method,
Increase/decrease in analysis data value? Since each measurement is simply displayed using a bar graph method, it is possible to determine whether or not the reaction of the sample to be measured is progressing, but the time course of the same sample to be measured (
(Temporal change) Since it is not possible to monitor and confirm, it is not possible to check the theoretical reaction state of the analyte to be measured, and as a result, the reliability of the measurement data cannot be ensured. It is not possible to determine whether the operating state of the system is appropriate or not, and the problem is that it is generally not a useful method for controlling measurement accuracy in automatic analyzers.

The present invention was devised in view of the current situation, and its purpose is to be able to monitor the reaction progress state and time course of the same analyte, thereby increasing the reliability of measurement and analysis data. The present invention aims to provide a method and apparatus for monitoring analytical data in an automatic analyzer, which can greatly improve the performance of the analyzer, and also facilitate confirmation of the operating status of each part of the apparatus.

In order to achieve this purpose, in the present invention, after a predetermined amount of the analyte to be measured is weighed into a reaction tube, a predetermined amount of the reaction reagent corresponding to the measurement item is dispensed, and the same is applied multiple times to the plurality of analytes to be measured. The time course of the analysis data of the specimen to be measured in the automatic analysis bag @ which is analyzed over the period of time is displayed on the monitor device for each specimen to be measured.

In addition, in this invention, in order to carry out the above method,
A means for weighing a predetermined amount of the analyte to be measured into a reaction tube, a means for dispensing a predetermined amount of a reaction reagent corresponding to a measurement item into the reaction tube, and a means for analyzing and processing the analyte multiple times. an analytical data monitoring device in an automatic analyzer comprising: a storage circuit for storing analytical data measured a predetermined number of times; and a display device for displaying the time course of these analytical data for each sample to be measured. It is equipped with the following.

Hereinafter, the present invention will be described in detail based on embodiments shown in the accompanying drawings.

Is the automatic analyzer 1 according to this embodiment the invention? , which is applied to an automatic biochemical analyzer, and as shown in FIG.
and a plurality of containers (in the example, 11 containers are arranged, including 10 containers containing general serum samples and one container containing a comparison serum sample). A plurality of sample cassettes 3 for general samples consisting of a plurality of sample cassettes 3 for general samples, a sample cassette 4 for emergency samples holding emergency samples, and a serum sample in the sample cassette 3 for general samples or the sample cassette 4 for emergency samples are predetermined. a pipette device 6 for aspirating a predetermined amount at a position and dispensing it into the reaction tube 5; and the reaction tube 5.
A turret-shaped feeding device 7 that holds multiple pieces of paper and rotates intermittently.
A first reagent is disposed concentrically on the inner circumferential side of the feeding device 7 and is removably mounted on a container 8 containing a first reaction reagent corresponding to the measurement item and a turret plate 9. A device 10, a dispensing device 11 for dispensing a predetermined amount of the first reagent into the entire reaction tube 5, and a dispensing device 11 that rotates intermittently in synchronization with the feeding device 7 from a predetermined position to transfer the sample into which the first reagent has been dispensed. A change device 13 that weighs and dispenses a predetermined amount to another reaction tube 5' held in the measurement turret 12, and a change device 13 that is arranged concentrically on the inner circumferential side of the measurement turret 12 and corresponds to the measurement item. Container 8' containing the second reagent? A second reagent device 14, which is removably mounted on the turret plate 9', and this second reagent?
a dispensing device 15 that dispenses a predetermined amount at a predetermined position; a stirring device 16 that lifts the reaction tube 5' into which the second reagent has been dispensed in synchronization with the change device 13 and stirs it by means such as ultrasonic vibration; Reaction tube 5 held in the measurement turret 12
The reaction tube 5' is composed of an optical device 17 for colorimetrically measuring the sample in the tube 5', and a cleaning device 18 for cleaning the reaction tube 5' after the measurement has been completed by the optical device 17. The measuring turret 12 is configured to rotate 360 degrees during one intermittent rotation in synchronization with the operation of the change device 13, so that the reaction tube 5' is held in the measuring turret 12. During this period, the sample in the same reaction tube 5' is measured multiple times by the optical device 17.

The analytical data colorimetrically measured by the optical device 18 in this way is input to the signal processing device 19, as shown in FIG. This signal processing device 19 includes a logarithmic converter 2
0, a logarithmic converter 21 for converting the analysis data inputted into the logarithmic converter 4 into a digital signal, a storage circuit η for storing the digital signal inputted to the logarithmic converter 21, and a microcomputer 23. , a holding circuit 24 that holds the memorized analysis data measured multiple times for each same measurement sample, and a monitor device that displays this analysis data and the time course of the same measurement sample for each same measurement sample after the measurement is completed. It is composed of a CRT and a recording device 25.

That is, in the colorimetric measurement of the sample held in the measurement turret 12, optical measurements are performed multiple times (n times) until the reaction tube 5' is transferred from the measurement position to the cleaning position. The analysis data for each optical measurement is sent to the storage circuit 22 for each sample and is stored in the memory. When this optical measurement is performed a necessary number of times (n times), the temporal response change of the same sample is calculated and the holding circuit 24
It holds the data necessary to display the time course for each sample. The data held in the holding circuit 24 in this manner is displayed as a time course graph on the monitor device CRT as shown in FIG. 4 at the end of the optical measurement.

As shown in FIG. 4, this time course graph includes a plurality of specimens S, , S2. S... The analysis data of the group multiple times (n times) is displayed for each sample, but the monitor device G! In the illustrated example, five samples S(r 82 + 83 +
After displaying the time course of the same sample ÷ seconds, the time course of the first sample SI disappears from the monitor device υCRT, then the 6th 86 time course is displayed on the monitor device CRT, and in turn the nth time course disappears from the monitor device υCRT. Only the sample Snt is displayed.

Therefore, it is possible to monitor the time course of this same sample (thereby, it is possible to compare and monitor the progress state of the reaction between the sample and reagent and the logical reaction state. Also, it is possible to record this time course). If necessary, it is also possible to print using the recording device 25.

In the above-mentioned embodiments, the case where the specimen is measured by colorimetric measurement using an optical device has been explained as an example, but it can also be applied to a system in which measurement is performed by means such as voltage measurement. -!
Furthermore, the present invention is applicable not only to automatic biochemical analyzers but also to automatic analyzers for immune serum tests.

As explained above, this invention allows the same sample to be measured to be monitored over time, making it easy to check whether the theoretical reaction of the sample is occurring normally, and Reliability can be greatly improved along with time course abnormal reactions? If it is displayed, it is evidence that the operating state of each part of the device is abnormal, and repair work can be carried out immediately, which is extremely effective in terms of quality control of the device.

[Brief explanation of drawings]

FIG. 1 is a graph explanatory diagram showing a method of displaying analysis data using a conventional centrifugal monitor method, FIG. 2 is an explanatory diagram schematically showing the configuration of an automatic biochemical analyzer to which the present invention is applied, and FIG. The figure is a block diagram of the signal processing device, and FIG. 4 is a graph diagram showing the display mode of analysis data expressed by the present invention. 1...Biochemical automatic analyzer 5,5'...Reaction tube 1
0...First reagent device 11, 15...Dispensing device 14...Second reagent device 17...Optical device 1
9... Signal processing device 22... Memory circuit CRT
...Monitor device patent applicant Nippon Techtron Co., Ltd.

Claims (2)

[Claims] (1) In an automatic analyzer that weighs a predetermined amount of the analyte to be measured into a reaction tube, dispenses a predetermined amount of a reaction reagent corresponding to the measurement item, and performs analysis processing multiple times with multiple analytes. 1. A method for monitoring analytical data in an automatic analyzer, characterized in that the analytical data relating to the temporal reaction change of the analyte is displayed on a monitor for each analyte to be measured. (2) A means for weighing a predetermined amount of the analyte to be measured into a reaction tube, a means for dispensing a predetermined amount of a reaction reagent corresponding to the measurement item into the reaction tube, and a means for dispensing a predetermined amount of the analyte to be measured into the reaction tube; A monitoring device for analytical data in an automatic analyzer, comprising processing means, a storage circuit for storing analytical data measured a predetermined number of times, and a time course of these analytical data. Analytical data monitoring device 0 in an automatic analyzer, characterized in that it is equipped with a display device that displays each of the same specimens to be measured.