JPS63200066A - Automatic chemical analyzer - Google Patents

Abstract

PURPOSE:To obtain an analyzer generating no interference between reagents, by performing control for altering the measuring order of analytical items on the basis of stored interfering reagent data so as to obtain an order generating no interference relation. CONSTITUTION:When a plurality of reagents are distributed to successively perform analysis with respect to a plurality of analytical items, the interfering reagent data of the reagents in interference relation to each other among a plurality of the reagents is inputted from a keyboard 1 being an input part and stored in a memory part 3. An insertion control part 7 outputs insertion data performing control for altering the measuring order of analytical items on the basis of the interfering reagent data so as to obtain an order generating no interference relation. A control part 4 successively performs measuring control on the basis of the analytical item selection data stored in a memory part 2 and alters measuring order on the basis of the signal from the insertion control part 7. A comparing monitor part 6 has a buffer memory and judges whether the reagents contained in the analytical items successively carried out on the basis of the analytical selection data of the memory part 2 fall within the purview of the interfering reagent data with the reference to the interfering reagent data of the memory part 3.

Description

DETAILED DESCRIPTION OF THE INVENTION [Object of the Invention] (Industrial Field of Application) The present invention relates to an automatic chemical analyzer that sequentially performs a plurality of analyzes for detecting samples such as thought blood and serum.

(Prior art) Conventionally, automatic chemical analyzers have dispensed multiple different reagents using a single reagent dispensing nozzle when sequentially measuring multiple analysis items per sample. .

However, due to technological innovation in recent years, the number of measurement items has increased by 1'i'.

Due to advances in measurement methods or differences between VC reagent manufacturers, when a reagent used for one analysis item and a reagent used for another analysis item are continuously dispensed through the same reagent dispensing nozzle. , a problem arose of mutual interference.

Conventional 1. In an attempt to solve this problem, some measures have been taken to ensure complete cleaning of the reagent dispensing nozzle, but this alone does not prevent interference between reagents, and on the other hand, continuous dispensing of reagents that cause interference It is possible to consider the order of dispensing to avoid this, but it would be unrealistic to consider the interference relationships of many reagents and set the order of measurement, as it would waste a lot of effort and time. It is true.

(Problem to be solved by the invention) Although this problem has occurred in the past, there is no effective means to prevent mutual interference between reagents, which only leads to a decrease in the reliability of analysis results. Moreover, this analysis result has brought about an adverse effect that cannot be ignored, as it may lead to misdiagnosis or the like.

Therefore, an object of the present invention is to provide an automatic chemical analyzer that does not cause mutual interference between reagents in order to solve such problems.

[Structure of the Invention] (Means for Solving the Problems) The structure of the present invention for solving the above problems is based on preset analysis item selection information, and a plurality of reactions are performed from the same reagent dispensing nozzle. In an automatic chemical analyzer that sequentially measures a plurality of analytical items by dispensing reagents to be analyzed, an input section for inputting interference reagent information of reagents that interfere with each other among the plurality of reagents; a storage unit that stores interference reagent information; an insertion control unit that outputs insertion information that changes and controls the measurement order of analysis items so that an interference relationship does not occur based on the stored interference reagent information; The present invention is characterized in that it includes a control section that sequentially performs measurement control based on item selection information and changes the measurement order based on a signal from the insertion control section.

(Function) The function of the present invention having the above configuration is such that when a reagent that causes interference among the plurality of reagents used is continuously dispensed, between the analysis items using these reagents, We try to measure analytical items using reagents that do not cause interference with other reagents.

(Example) An example of the present invention will be described below with reference to the drawings.

FIG. 1 is a block diagram of an automatic chemical analyzer according to an embodiment of the present invention.

In the same figure, the automatic chemical analyzer inputs conventional information on combinations of reagents that interfere with each other, that is, interfering reagent information, and also inputs information on the combination of reagents that interfere with each other. A keyboard 1 serves as an input unit for inputting information on which analysis item to perform, that is, analysis item selection information, etc., and a keyboard 1 is provided at the rear of this keyboard 1 from, for example, RA) f, etc., which stores the analysis item selection information. a storage unit 2, for example R, which stores the interference reagent information;
A storage unit 3 consisting of an AM or the like is connected.

In this embodiment, the storage unit 2 and the storage unit 3 are shown as separate storage units, but the meaning is not limited to this. For example, they can be stored in the same storage unit and have different storage areas, respectively. It may also be used as a storage section.

Further, a control section 4 consisting of, for example, a CPU, which controls the entire device is connected to the downstream of the storage section 2, while an insertion control section 7 and a comparison monitoring section 6 are connected to the downstream of the storage section 2. is connected to the comparison section 6 and the output side of the control section 4, which includes a sampling unit 5 which is driven and controlled based on each of these output information.

The storage unit 2 that stores the analysis item selection information selects an arbitrary analysis item from a plurality of preset analysis items, for example, A to H shown in FIG. 2, by pressing a predetermined key on the keyboard 1. However, it is possible to perform analysis of any combination of test liquids of samples 1 to 4. In this example, for the sake of explanation, it is assumed that one type of reagent is used for each analysis item A to H, and "○" in the figure is indicated in the upper column. "x" indicates that the analysis item is selected, and "x" indicates that it is not selected. The control unit 4 determines the reagent to be used by selecting this analysis item.

The storage unit 3 that stores the interfering reagent information stores combinations of reagents that interfere with each other (for example, reagents a and d1) among the reagents 5a to 5a used for analysis items A to H listed in FIG. and e) are stored in advance by input from the keyboard 1, and when analysis items using reagents that similarly cause interference are executed, preset analyzes are performed between these analysis items. This is used to record reagents (hereinafter referred to as designated reagents) as insertion information corresponding to the item. This designated reagent is also input from the keyboard 1. The interfering reagent information and designated reagent are stored in different memory areas in the storage unit 3, and are referenced by the insertion control unit 7 and the comparison monitoring unit 6, which will be described later.

The comparison monitoring section 6 stores the first. It has a second buffer 7 memory, etc., and by referring to the interfering reagent information among the information stored in the storage unit 3, the reagents included in the analysis items that are sequentially executed based on the analysis item selection information in the storage unit 2. The system is designed to determine whether or not the information corresponds to the interfering reagent information.

Specifically, for example, two buffers in the comparison monitoring section 6
The reagents included in the analysis items to be sequentially executed based on the analysis item selection information are stored in the memory, and the stored contents and the storage unit 3
This is done by comparing the interference reagent information stored in the . In this way, when it is determined that the reagents included in the analysis items to be executed sequentially based on the analysis item selection information correspond to the interfering reagent information, a stop signal is sent to the control unit 4 to temporarily stop the analysis items scheduled to be executed. It is set to send.

The insertion control unit 7 refers to the specified reagent as insertion information among the information stored in the storage unit 3, and when a stop signal is output from the comparison monitoring unit 6 to the control unit 4, the analysis item selection is performed. A control signal is transmitted so that the specified reagent is dispensed instead of the reagent used in the analysis item scheduled to be executed based on the information.

The control unit 4 constantly monitors the control signals from the comparison monitoring unit 6 and the insertion control unit 7 described above via the I10 port (not shown), and normally performs control signals based on the analysis item selection information stored in the storage unit 2. In order to sequentially execute analysis items, a drive signal is output to a sampling unit 5 provided at a subsequent stage.

The sampling unit 5 can be roughly divided into a sample tube holder 10 in which a fixed number of sample tubes 11 containing detected waves as samples are arranged for each subject, as shown in FIG. 3, which is a plan view of an embodiment of the device. A drive device 13 that intermittently drives the test liquid in the six directions of arrows at predetermined intervals, a sample dispensing device 12 that dispenses this test liquid into a sample tube, and a sample dispensing device 12 that is provided on the downstream side of the drive of this sample dispensing device 12 and that is prepared in advance. It has a reagent dispensing device 9 having 8 reagent dispensing nozzles for suitably dispensing a plurality of reagents into sample tubes 11 according to analysis items, and a stirring device etc. is appropriately arranged on the rear side of the drive. It is composed of

The reagent dispensing nozzle 8 provided in the reagent dispensing device @9 is
The sample tubes 11 arranged in the sample tube holder 10 are appropriately controlled by a drive control signal from the control unit 4 based on the analysis item selection information, and correspond to the corresponding sample tubes 11. I try to dispense the reagent to be used.

The functions and effects of the automatic chemical analyzer configured as above will be explained.

First, from the keyboard 1 shown in FIG.
Input analysis item selection information indicating which of the analysis items to perform each time. Specifically, as shown in Figure 2, the subject 1
Regarding analysis items A and B.

For sample 2 of E to H11, the analysis items are A to A, and so on. This information is stored in the storage section 2.

Next, interference reagent information and designated reagent are input in the same manner.

Assuming that the input of interfering reagent information occurs between two reagents, for example, specifying the analysis item will specify the reagents to be used at the same time. Enter D or analysis items B and E. .

On the other hand, when this interfering combination of reagents is executed, for example, when the comparison monitoring unit 6 determines that an analysis item A will be executed and then an analysis item D will be executed, the analysis item will be replaced with that one. The storage unit 3 stores information for inserting an item using a specified reagent, for example, b, corresponding to the analysis item to be executed next to the analysis item A. Note that this designated reagent is not limited to one designated reagent, but two or more designated reagents (analysis items) may be designated, and this judgment should be made as appropriate depending on the strength of interference between the interfering reagent phases 7i. Bye.

Once preparation for analysis is completed as described above, the device is activated.

First, the sample dispensing device 12 dispenses detected waves of one analyte into each sample tube holder 10 shown in FIG. 3 in an amount corresponding to, for example, an analysis item.

When the above operations are completed, the reagent is intermittently driven in the direction of arrow N, and the reagent is dispensed via the reagent dispensing device 9 and the reagent dispensing nozzle 8.

This dispensing of the reagent is executed for the analysis items stored in the storage section 2, and this execution is constantly monitored by the comparison monitoring section 6 and compared with the interfering reagent information stored in the storage section 3.

The specific order of the analysis items is shown in FIG.

In addition, in the same figure, "knee" indicates dispensing of reagent to the test solution of the same analyte, and "=" indicates dispensing of reagent to the detection of another different analyte. Cover with things.

The process will be explained below with reference to the flowchart shown in FIG.

In step ST1, a reagent is dispensed based on the item selection information, that is, a sample ¥a corresponding to the first analysis item for the subject 1 is dispensed.

In step ST2, the reagent dispensed in step ST1 is stored in the first buffer memory of the comparison monitoring section 6.

In step ST3, it is determined whether there is an analysis item to be read next. Here, if it is determined that there is no analysis item to be executed next, the process ends, and if it is determined that there is an analysis item to be executed next, the process proceeds to step ST4.

In step ST4, reagents corresponding to the next analysis item are read out. Then, the process advances to step ST5.

In step ST5, the reagent read out in step ST4 is stored in the second buffer 7 memory. Then, the process proceeds to step ST6.

In step ST6, the storage contents of the first buffer memory and the storage contents of the second buffer memory are compared, and if it is determined that there is an interference relationship, the process proceeds to step ST8, and if it is determined that there is no interference relationship, the process proceeds to step ST7. move on.

In step ST7, the reagent stored in the second buffer 7 memory is dispensed and the process returns to step ST2.

In step ST2, the reagent dispensed in step ST7 is stored in the first buffer memory, and the process proceeds as described above.

On the other hand, in step ST8, the designated reagent is read out. Then, the process proceeds to step ST9.

In step ST9, the designated reagent is dispensed. Then, the process proceeds to step 5T10.

In step 5T10, it is determined whether the specified reagent, that is, the insertion item still exists, and if there is not, the process proceeds to step ST7.
If there is, the process returns to step ST8 to read out the specified reagent and proceed as described above.

As detailed above, since we do not perform consecutive analysis items using interfering reagents, and insert reagents corresponding to analysis items that do not cause other interference in the middle, reagent dispensing Mutual interference of reagents within the nozzle can be avoided.

Incidentally, in the above example, other analysis items for detection of the same object are inserted between analysis items that cause interference, but the invention is not limited to this, and the following may be used.

In FIG. 4, interference also occurs between the reagents used for analysis items B and E of the analysis items for detection of the sample 3. In this case, insert the first analysis item A of the subject 4 to be performed after the analysis of the sample liquid of this subject 3 is completed between the analysis items B and E to be performed on the subject 3. and run it. Then, after dispensing the reagent for the analysis item A to the subject 4, the reagent for the analysis item E to the subject 3 is dispensed. In this case as well, mutual interference between reagents can be avoided.

It should be noted that the present invention is not limited to the above-mentioned embodiments, and various modifications can be made within the scope of the gist thereof.

In the above-described embodiments, the reagents corresponding to the analysis items that do not interfere with each other are inserted between the analysis items that interfere with each other. An operation for dispensing the washing liquid between analysis items may be inserted.

[Effects of the Invention] As described above, according to the present invention, it is possible to provide an automatic chemical analyzer that does not cause interference between the plurality of reagents used.

[Brief explanation of the drawing]

FIG. 1 is a block diagram of the configuration of an automatic chemical analyzer according to an embodiment of the present invention, FIG. 2 is an explanatory diagram showing the selection of analysis items for each specimen, and FIG. 3 is a partial plan view of the sampling unit.
FIG. 4 is an explanatory diagram showing the progress of the analysis when the analysis item shown in FIG. 2 is selected, and FIG. 5 is a flowchart for determining whether or not the reagent corresponds to an interfering reagent. DESCRIPTION OF SYMBOLS 1... Input part, 2, 3... Storage part, 4... Control part, 5... Sampling unit, 6... Comparison monitoring part, 7... Insertion control part, 8... Reagent dispensing nozzle, 9... reagent dispensing device.

Claims (2)

[Claims] (1) In an automatic chemical analyzer that sequentially measures a plurality of analysis items by dispensing a plurality of corresponding reagents from the same reagent dispensing nozzle based on preset analysis item selection information, the plurality of reagents an input section for inputting interfering reagent information of reagents that have an interfering relationship with each other, a storage section for storing the input interfering reagent information, and an order in which no interfering relationship occurs based on the stored interfering reagent information. an insertion control unit that outputs insertion information for changing and controlling the measurement order of analysis items so that An automatic chemical analyzer characterized by comprising a control section. (2) The insertion control section adjusts the number of insertion items depending on the degree of interference between reagents in an interference relationship.
Automated chemical analyzer as described in section.